916 research outputs found
Letter by Niccoli et al regarding article, "intracoronary versus intravenous administration of abciximab in patients with st-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention with thrombus aspiration: the comparison of intracoronary versus intravenous abciximab administration during emergency reperfusion of st-segment elevation myocardial infarction (CICERO) trial"
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Cronologia. Note e notizie sui testi. Bibliografia
No full textLa Cronologia presenta vita e opere di Bohumil Hrabal alla luce di un'attenta analisi di fonti edite e inedite. Le Note e notizie sui testi costituiscono il primo commento esauriente delle opere hrabaliane, pubblicate finora - anche nell'edizione ceca delle Opere complete (Sebrané spisy Bohumila Hrabala) - senza apparati; nella Notizia su ogni testo ne sono dettagliatamente descritte genesi ed evoluzione; le Note contengono informazioni di ordine storico, culturale e filologico. La Bibliografia comprende l'elenco completo dei titoli italiani e una selezione della copiosa bibliografia sull'opera di Hrabal in varie lingue.A detailed scientific commentary, the first ever written of this kind, to a large selection od Bohumil Hrabal's works in Italian translation. The commentary includes a biography of the author and a bibliography
Premessa
No full textPremessa al volume in cui, attraverso l’analisi degli scritti sull’arte di Josef Čapek, vengono ricostruite le dominanti fondamentali nella ricerca espressiva e nell’elaborazione filosofica ed estetica del grande artista: fino a tempi recenti considerato il più grande pittore cubista ceco, ma scrittore di rilievo solo in secondo luogo, e spesso all’ombra del celebre fratello Karel Čapek. Negli scritti sull’arte e nelle prose filosofiche degli anni Trenta le due componenti si compenetrano raggiungendo una sintesi efficace, probabilmente la più originale ai margini dell’intera esperienza avanguardistica ceca.
Il volumetto è arricchito inoltre da un saggio dello stesso Josef Čapek, Terribile il volto della morta..., pubblicato per la prima volta in traduzione italiana.The preface introduces to the book, containing a detailed analysis of Josef Čapek's writings on arts, in which the author shows how Čapek's narrative and essays are strictly connected. Moreover, the book contains the short essay How terrible the face of the dead woman, for the first time in Italian
Nondestructive strain depth profiling with high energy X-ray diffraction: System capabilities and limitations
No full textLimited by photon energy, and penetration capability, traditional X-ray diffraction (XRD) strain measurements are only capable of achieving a few microns depth due to the use of copper (Cu Kα1) or molybdenum (Mo Kα1) characteristic radiation. For deeper strain depth profiling, destructive methods are commonly necessary to access layers of interest by removing material. To investigate deeper depth profiles nondestructively, a laboratory bench-top high-energy X-ray diffraction (HEXRD) system was previously developed. This HEXRD method uses an industrial 320 kVp X-Ray tube and the Kα1 characteristic peak of tungsten, to produces a higher intensity X-ray beam which enables depth profiling measurement of lattice strain. An aluminum sample was investigated with deformation/load provided using a bending rig. It was shown that the HEXRD method is capable of strain depth profiling to 2.5 mm. The method was validated using an aluminum sample where both the HEXRD method and the traditional X-ray diffraction method gave data compared with that obtained using destructive etching layer removal, performed by a commercial provider. The results demonstrate comparable accuracy up to 0.8 mm depth. Nevertheless, higher attenuation capabilities in heavier metals limit the applications in other materials. Simulations predict that HEXRD works for steel and nickel in material up to 200 µm, but experiment results indicate that the HEXRD strain profile is not practical for steel and nickel material, and the measured diffraction signals are undetectable when compared to the noise.This proceeding may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This proceeding appeared in Zhang, Zhan, Scott Wendt, Nicholas Cosentino, and Leonard J. Bond. "Nondestructive strain depth profiling with high energy X-ray diffraction: System capabilities and limitations." AIP Conference Proceedings 1949, no. 1 (2018): 190001. DOI: 10.1063/1.5031635. Posted with permission.</p
Americké dětství dobrého vojáka Švejka
No full textStudie představuje nový příspěvek k vyjasnění genéze Haškovy proslulé postavy dobrého vojáka Švejka. Porovnáním určitých typologických rysů v charakteru Švejka a Georgie, hrdiny románu pro děti z péra americké spisovatelky Metty Fullerové Victorové (1831–1885), lze ukázat na nápadnou příbuznost: zřejmě se nápad popsat osudy “pitomce u kumpanii” nezrodil u českého spisovatele úplně nezávisle od starších vzorů. Americkou inspiraci potvrzuje epizoda, která se vyskytuje v obou románech. Podobnost lze najít nejen mezi postavami, ale také mezi jejich autory: oba psali pro výdělek, pravidelně a hodně, a literární kritika je nemilovala; byli šikovní stylisté, schopní reprodukovat různé jazykové rejstříky a hlavně hovorový jazyk.The study represents a new contribution to the clarification of the genesis of Jaroslav Hašek's renowned character of the Good Soldier Švejk. Through a comparison of certain typological traits in the characters of Švejk and Georgie, the hero of a children's book which sprung from the pen of author Metta Fuller Victor, it is possible to prove a striking similarity: clearly the idea to describe the adventures of "the Blockhead within the Company" was not born with Czech writers, but arouse completely independentely from older sources
Dataset of mRNA levels for dopaminergic receptors, adrenoceptors and tyrosine hydroxylase in lymphocytes from subjects with clinically isolated syndromes
No full textThis data article presents a dataset of mRNA levels for dopaminergic receptors, adrenoceptors and for tyrosine hydoxylase, the rate-limiting enzyme in the synthesis of catecholamines, in peripheral blood mononuclear cells as well as in CD4+ T effector and regulatory cells from subjects with clinically isolated syndromes (CIS), which is a first episode of neurological disturbance(s) suggestive of multiple sclerosis. CIS subjects are divided into two groups according to their eventual progression, after 12 months from CIS, to clinically established multiple sclerosis. The data reported are related to the article entitled "Dopaminergic receptors and adrenoceptors in circulating lymphocytes as putative biomarkers for the early onset and progression of multiple sclerosis" (M. Cosentino, M. Zaffaroni, M. Legnaro, R. Bombelli, L. Schembri, D. Baroncini, A. Bianchi, R. Clerici, M. Guidotti, P. Banfi, G. Bono, F. Marino, 2016
Chvála blbosti. Z Prahy do Irkutska a zpět v patnácti stech povídkách a jednom románu
No full textPředkládaná studie je pokusem o výklad poetiky děl Jaroslava Haška. Systematicky analyzuje spisovatelovy práce od raných črt a povídek až k notorickým (a nedokončeným) Osudům dobrého vojáka Švejka za světové války. S rozborem uměleckého textu, v němž mj. sledujeme postupný vývoj literární postavy dobrého vojáka, se prolínají pasáže o Haškově biografii. Střídající se pásma postupují v zásadě chronologicky, a když Hašek přibližně v polovině knihy „umírá“, rozvíjí autorka původní interpretaci velkého románu, při níž věnuje zvláštní pozornost prostoru a času, povaze vyprávění a jazyku. Jako jednu z možných „švejkovských“ filiací nabízí americký typ kolportážní literatury pro děti a mládež, který se v osmdesátých a devadesátých letech 19. století překládal do němčiny i češtiny, a náruživý čtenář Jaroslav Hašek některé tituly tohoto žánru mohl znát. V závěru práce rekapituluje autorka nejvlivnější interpretace Osudů v literatuře předmětu a sleduje Švejkovy metamorfózy v dalších druzích umění, na divadle a ve filmu.The book’s aim is to delineate the development and unfolding of Jaroslav Hašek’s poetics. Best known as the author of The Adventures of the Good Soldier Švejk (1921–1923), Hašek, who had started to publish in 1901, was a prolific writer. In order to understand and subsequently describe Hašek’s poetics in its main features, the beginnings of his career as a storyteller and journalist are investigated. Short stories from the provinces of the Habsburg monarchy, urban myths of conflicts and struggles between anarchists, priests and police, records and accounts of Prague everyday life constitute the background of Hašek’s major narratives, such as The Adventures of the Good Soldier Švejk and its first outline, The Good Soldier Švejk in Captivity (1917). Thanks to Hašek’s reporting skills, the celebrated novel can be read as a witness of the “great times” depicted in it. Its main character, the well-known soldier Švejk, whose fictional life extends beyond this single novel as well as the confines of Czech literature (the best known example of its vitality outside of Czech environment is
Bertolt Brecht’s remake of the story), reveals itself as a cluster of features bound in a complex, even intricate structure. The search for a proper clue to the character leads us to its probable ancestors in dime novels, popular entertainment and slapstick. The old dilemma – whether Švejk is completely stupid, or rather exceedingly clever – is rejected here in favour of a more complex interpretation, which considers the affinity between foolishness and folly, idiocy and madness. The outline of Hašek’s poetics intertwine with an account of his biography. The book closes with a selected bibliography and an index of proper names
Úvodem: Kouzlo pražské alchymie
No full textThe paper deals with the History of Contemporary Czech Poetry (Storia della poesia ceca contemporanea), the first book by Italian Bohemist and Russianist Angelo M. Ripellino, which appeared in four hundred numbered copies in Rome in 1950. It was a period in which many of the poets, critics and artists the author was writing about were persecuted by the
Communist regime and left for forgotten. This seventy-yearold study is interesting today not for its content so much as its style and composition. Ripellino’s understanding and interpretation of Czech culture is shaped by the link between art and literature (the book, dedicated to “Ela and friends of Group 42,” contains 19 reproductions of paintings). It was here that the young scholar first applied a critical method which remains largely his own, and which would become a central feature of his “essay-novel” Magic Prague (Praga magica, 1973). Ripellino built his critical discourse as a mosaic of critical meditations, citations, and contributions, and it is not by chance that after many years Ripellino would begin Magic Prague with a reference to Arcimboldo as his teacher – a painter he first learned about through Karel Teige. The History of Contemporary Czech Poetry represents a sort of precursor in embryo to Magic Prague, a work which Ripellino first considered calling Alchimia di Praga (Alchemy of Prague) – references to the “alchemy of the city” can be found throughout The History of Contemporary Czech Poetry
ppGpp is a bacterial cell size regulator
No full textGrowth and division are central to cell size. Bacteria achieve size homeostasis by dividing when growth has added a constant size since birth, termed the adder principle, by unknown mechanisms.1,2 Growth is well known to be regulated by guanosine tetraphosphate (ppGpp), which controls diverse processes from ribosome production to metabolic enzyme activity and replication initiation and whose absence or excess can induce stress, filamentation, and small growth-arrested cells.3, 4, 5, 6 These observations raise unresolved questions about the relation between ppGpp and size homeostasis mechanisms during normal exponential growth. Here, to untangle effects of ppGpp and nutrients, we gained control of cellular ppGpp by inducing the synthesis and hydrolysis enzymes RelA and Mesh1. We found that ppGpp not only exerts control over the growth rate but also over cell division and thus the steady state cell size. In response to changes in ppGpp level, the added size already establishes its new constant value while the growth rate still adjusts, aided by accelerated or delayed divisions. Moreover, the magnitude of the added size and resulting steady-state birth size correlate consistently with the ppGpp level, rather than with the growth rate, which results in cells of different size that grow equally fast. Our findings suggest that ppGpp serves as a key regulator that coordinates cell size and growth control
ALLOPURINOL AND FEBUXOSTAT EFFECT ON TOTAL MORTALITY IN HYPERURICEMIC PATIENTS AFFECTED BY MILD-TO-MODERATE HEART FAILURE
No full textLATE-BREAKERS: SESSION 3: PDF Only
ALLOPURINOL AND FEBUXOSTAT EFFECT ON TOTAL MORTALITY IN HYPERURICEMIC PATIENTS AFFECTED BY MILD-TO-MODERATE HEART FAILURE
Cosentino, E.R.; Cicero, A.F.G.; Esposti, D. Degli; Bentivenga, C.; Magri, G.; Veronesi, M.; Borghi, C.
Author Information
Journal of Hypertension 36():p e239, June 2018. | DOI: 10.1097/01.hjh.0000539673.42228.0a
Abstract
Objective:
Hyperuricemia is an emerging risk factor for heart failure (HF) development and negative prognosis. Some data suggest that reducing serum uric acid by inhibiting xanthine oxidase (XO) could reverse the negative impact of uric acid on HF patient prognosis. Our aim is to evaluate if treatment with different XO inhibitors could have a different impact on the HF prognosis in a setting of clinical care.
Design and method:
We prospectively considered a cohort of 255 outpatients affected by chronic HF and pharmacologically treated with SUA lowering drugs, currently attending the HF clinic of the Internal Medicine Dept. at the S. Orsola-Malpighi University Hospital (Bologna, Italy). The sample included only non-previously hospitalized outpatients with mild-to-moderate HF secondary to chronic arterial hypertension or coronary artery disease, after exclusion of patients with HF related to congenital heart diseases, valvulopathies, or cardiomyopathies. We also excluded those patients with a diagnosis of gout, with severe kidney disease or malignancy in order to exclude SUA outliers. Subjects were treated with allopurinol or, if intolerant to allopurinol, with febuxostat.
Results:
Febuxostat (N. 120) and allopurinol (N. 135) patient groups were balanced for a large number of categorical and continuous variables. No statistically significant difference has been observed as it regards the distribution of CVD risk factors, echocardiographic parameters and cardiopreventive drug used. As it regards NYHA class, at the beginning of the observation febuxostat treated patients were respectively 19.2%, 46.7% and 34.2% in class I, II and III, while allopurinol treated patients 13.3%, 54.8% and 31.9% in class I, II and III, without significant difference between groups. This distribution did not significantly change over the observation period. After a mean follow-up period of 6.2 years, the cumulative survival of febuxostat treated patients was 0.96 (95%CI 0.93 to 0.99), while the one of allopurinol treated patients was 0.89 (95%CI 0.84 to 0.93). The between group difference was statistically significant (p = 0.04).
Conclusions:
In conclusion, from our data it appears that the use of febuxostat, a more selective XO inhibitor than allopurinol, is associated to a reduced risk of all cause death in HF patients
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