276 research outputs found
’Until Death Do Us Apart’ and Even Longer: Demographic and Social Disapproval of Remarriage in 19th Century Italy
No full text«Note di ricerca», 2, Dipartimento di Scienze statistiche, Università degli Studi di Udin
Band discontinuity fluctuations and local chemistry at the GaSe-Si interface
No full textPhotoemission spectromicroscopy data on Si-GaSe with 0.2 mu m lateral resolution revealed laterally inhomogeneous interface Se-Si chemical reactions. The local Si 2p fits agrees with interface Si selenide parameters; the Se 3d peaks indicate a Si-selenide component; the Ga 3d peaks exhibit a metallic component whose intensity increases with Si coverage. This local interface reaction is related to lateral changes in the band lineup. (C) 1998 American Institute of Physics. [S0003-6951(98)02839-3].LSELPRXEcole Polytech Fed Lausanne, Inst Phys Appl, CH-1015 Lausanne, Switzerland. Sincrotrone Trieste, I-34012 Trieste, Italy. Zacchigna, M, Ecole Polytech Fed Lausanne, Inst Phys Appl, CH-1015 Lausanne, Switzerland.ISI Document Delivery No.: 124J
Polarized high-brilliance and high-resolution soft x-ray source at ELETTRA: The performance of beamline BACH
No full text
CHOLANE AND LANOSTANE DERIVATIVES: ANTIMICROBIAL EVALUATION
No full textSteroids are natural compounds with several important applications in many fields of research, such as
medicinal chemistry, pharmacology, supramolecular chemistry and nanotechnology.In particular, bile
acids such as lithocholic acid (LCA) and ursodeoxycholic acid (UDCA) have been considered quite useful as
starting points for a rich and different set of medicinal chemistry activities.
Besides, the discovery of bioactive ingredients from plants and fungi is always the main target in medicinal
chemistry. The lanostane-type triterpenoid 3b-hydroxylanosta-8,24-diene-21-oic acid (Trametenolic acid,
TMA) was the main bioactive component of Gloeophyllum odoratum, which was reported to possess widely
bioactivities, including tumor cell anti-proliferation effects (for example, human HL-60 leukemia, human KB
epidermoid carcinoma, murine L1210 leukemia cells, Caski, HT-3, T-24, etc.), inhibition of enzyme activity
(human thrombin, bovine trypsin and so on).Nevertheless, trametenolic acid was scarcely investigated as
antimicrobial agent.
Structurally, bile acids (LCA and UDCA) and trametenolic acid are similar since they may be regarded as
consisting of two components, a rigid steroid nucleus and an aliphatic side chain possessing a carboxyl
group. On the basis of these considerations, six new compounds bearing a guanidine moiety in their side
chain were synthesized using LCA, UDCA and TMA as starting materials. The parent bile acids,
TMA and their resulting derivatives were evaluated for antimicrobial activity against S. aureus, B. subtilis
and M. smegmatis. The derivative 3a-hydroxy-23-guanidino-5b-cholane showed the best activity, with MIC
values of 12.5 μM against S. aureus, 5 μM against B. subtilis and 50 μM against M. smegmatis. The cytotoxic
activity of bile acids, trametenolic acid and derivatives was also evaluated against HT-29 cell lin
Crystal-field and Zhang-Rice-singlet excitations in CuGe1-xSixO3 (x=0, 0.05, and 0.1) from temperature-, angle-, and polarization-dependent resonant soft x-ray emission
No full text
- …
