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Ivor Sharp and Leland M. Perry [1]
No full textPhoto portrait of Ivor Sharp seated at right, with Leland M. Perry
Ivor Sharp and Leland M. Perry [2]
No full textPhoto portrait of Ivor Sharp seated at right, with Leland M. Perry
The Life and Letters of William Sharp and "Fiona Macleod"
No full text"William Sharp (1855-1905) conducted one of the most audacious literary deceptions of his or any time. Sharp was a Scottish poet, novelist, biographer and editor who in 1893 began to write critically and commercially successful books under the name Fiona Macleod. This was far more than just a pseudonym: he corresponded as Macleod, enlisting his sister to provide the handwriting and address, and for more than a decade ""Fiona Macleod"" duped not only the general public but such literary luminaries as William Butler Yeats and, in America, E. C. Stedman.
Sharp wrote ""I feel another self within me now more than ever; it is as if I were possessed by a spirit who must speak out"". This three-volume collection brings together Sharp’s own correspondence – a fascinating trove in its own right, by a Victorian man of letters who was on intimate terms with writers including Dante Gabriel Rossetti, Walter Pater, and George Meredith – and the Fiona Macleod letters, which bring to life Sharp’s intriguing ""second self"".
With an introduction and detailed notes by William F. Halloran, this richly rewarding collection offers a wonderful insight into the literary landscape of the time, while also investigating a strange and underappreciated phenomenon of late-nineteenth-century English literature. It is essential for scholars of the period, and it is an illuminating read for anyone interested in authorship and identity.
PS-SHARP
No full textMATLAB implementation of the SHARP technique for polarization-sensitive optical coherence tomography [described in "Computational refocusing in phase-unstable polarization-sensitive optical coherence tomography" by Ruiz-Lopera et al. 2023]. Includes the functions to apply SHARP to an Jones OCT tomogram, and a demo script that applies SHARP to an exemplary dataset
Physiological sharp wave-ripples and interictal events in vitro: What’s the difference?
No full textSharp wave-ripples and interictal events are physiological and pathological forms of transient high activity
in the hippocampus with similar features. Sharp wave-ripples have been shown to be essential in memory
consolidation, while epileptiform (interictal) events are thought to be damaging. It is essential to grasp the
difference between physiological sharp wave-ripples and pathological interictal events in order to
understand the failure of control mechanisms in the latter case. We investigated the dynamics of activity
generated intrinsically in the CA3 region of the mouse hippocampus in vitro, using four different types of
intervention to induce epiletiform activity. As a result, sharp wave-ripples spontaneously occurring in CA3
disappeared, and following an asynchronous transitory phase, activity reorganized into a new form of
pathological synchrony. During epileptiform events, all neurons increased their firing rate compared to sharp
wave-ripples. Different cell types showed complementary firing: parvalbumin-positive basket cells and
some axo-axonic cells stopped firing due to a depolarization block at the climax of the events in high
potassium, 4-aminopyridine and zero magnesium models, but not in the gabazine model. In contrast,
pyramidal cells started firing maximally at this stage. To understand the underlying mechanism we
measured changes of intrinsic neuronal and transmission parameters in the high potassium model. We found
that the cellular excitability increased and excitatory transmission was enhanced, whereas inhibitory
transmission was compromised. We observed a strong short-term depression in parvalbumin-positive basket
cell to pyramidal cell transmission. Thus, the collapse of pyramidal cell perisomatic inhibition appears to be
a crucial factor in the emergence of epileptiform events
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A letter from John Sharp to Dr. Hector P. Garcia.
No full textA letter from John Sharp, Texas State Senator, to Dr. Hector P. Garcia, thanking him for supporting Senator Sharp in his race for the Texas Railroad Commission
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