340 research outputs found
Entrepreneurship studies
No full textOver the last decade, international entrepreneurship has become a key emerging issue in international business studies. A growing number of recent contributions has made the subject topical and lively but it lacks a common framework. This book starts from the foundations of the subject, rooted in entrepreneurship, strategic management and international business studies, and proposes an innovative and integrated interpretative framework. The approach is applied to case studies, in order to reconcile theories and practices of international entrepreneurship.
Antonella Zucchella has contributed to International Entrepreneurship: Theoretical Foundations and Practices as an author. Antonella Zucchella is full professor of Marketing and Innovation Management at Pavia University, Italy, and Director of the Business Research Department there. She is author of four books and more than thirty articles, ranging from entrepreneurship to international marketing and management.
Paolo Scabini has been researcher at the University of Pavia, Italy, in international entrepreneurship and is currently a consultant in these same areas for a consulting firm in Mila
Congruence on child rearing in families with early adolescent and middle adolescent children
No full textThis study investigates the extent to which parents' and adolescent's reports of parental child-rearing behaviour are in agreement with each other. The aim of this study is twofold. The first aim is to verify whether familial congruence (congruence between family members) about child rearing exists. The second aim is to verify whether the level of congruence varies with the stage of the adolescent (early and middle) and gender of parent or child. The sample consists of 788 families with a child between the ages of 9 and 16 years. Congruence scores were computed on diverse aspects of child rearing: material rewarding, expression of affection, conformity, autonomy, ignoring, and punishment. The results show that familial congruence exists, not only between father and mother but also between parents and their children. A second result is that congruence between parents and their children increases from early to middle adolescence indicating that children become more competent interpreting their parents' behaviour
Effects of parietal lesions in humans on color and location priming
No full textTo determine whether the parietal lobes contribute to the selection of nonspatial features known to be processed in the ventral stream, the current study examined the effect of chronic unilateral parietal lobe lesions in humans on color and location priming. Patients and normal controls performed a go/no-go color discrimination task in which either the same color and different color pairs of stimuli (prime and probe) were projected sequentially either in the same hemifield or in opposite hemifields. Control subjects and patients both showed independent effects of color and location priming. In the patients, primes in either field produced color priming for target probes in the ipsilesional field but not for probes in the contralesional field. This observation implicates the parietal cortex in processing activated codes of stimulus attributes not only for spatial information but also for visual features processed in the ventral visual pathways
Three new Alpha1-Antitrypsin deficiency variants help to define a C-Terminal region regulating conformational change and polymerization
No full textAlpha1-antitrypsin (AAT) deficiency is a hereditary disorder associated with reduced AAT plasma levels, predisposing adults to pulmonary emphysema. The most common genetic AAT variants found in patients are the mildly deficient S and the severely deficient Z alleles, but several other pathogenic rare alleles have been reported. While the plasma AAT deficiency is a common trait of the disease, only a few AAT variants, including the prototypic Z AAT and some rare variants, form cytotoxic polymers in the endoplasmic reticulum of hepatocytes and predispose to liver disease. Here we report the identification of three new rare AAT variants associated to reduced plasma levels and characterize their molecular behaviour in cellular models. The variants, called Mpisa (Lys259Ile), Etaurisano (Lys368Glu) and Yorzinuovi (Pro391His), showed reduced secretion compared to control M AAT, and accumulated to different extents in the cells as ordered polymeric structures resembling those formed by the Z variant. Structural analysis of the mutations showed that they may facilitate polymerization both by loosening ‘latch’ interactions constraining the AAT reactive loop and through effects on core packing. In conclusion, the new AAT deficiency variants, besides increasing the risk of lung disease, may predispose to liver disease, particularly if associated with the common Z variant. The new mutations cluster structurally, thus defining a region of the AAT molecule critical for regulating its conformational state
INFUSIONE SISTEMICA CRONOBIOLOGICA DI FUDR IN PAZIENTI AFFETTI DA CARCINOMA COLORETTALE AVANZATO
No full textIl laboratorio di analisi di impresa e l'elaborazione di un nuovo modello di rating per le piccole imprese rapporto finale di ricerca
No full textLaboratory diagnosis of alpha1-antitrypsin deficiency.
No full textThe laboratory diagnosis of alpha(1)-antitrypsin (AAT) deficiency (AATD) has evolved over the last 40 years since the first cases of the disorder were reported. It is currently performed in specialized centers, and it requires a combination of different biochemical methods: nephelometric AAT concentration, isoelectric focusing, genotyping, and sequencing. The availability of matrices such as the dried blood spot have facilitated the implementation of laboratory analyses for AATD, but they have also challenged laboratories to develop more reliable and reproducible techniques starting from dried blood. In this article, we describe the protocols we have optimized for AATD diagnosis from dried blood spot, in an attempt to hopefully provide useful information for physicians and scientists involved in this diagnostic line. We also describe the diagnostic flowchart for AATD detection that we have developed accordingly
Valutazione trifasica con TC multi-slice angiograhy 8MSTCA) e ricostruzioni MPR e 3D nei pazienti affetti da carcinoma epatocellulare in previsione di intervento resettivo
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