1,720,976 research outputs found
TESI DI DOTTORATO: Hereditary and familial breast and ovarian cancer: spectrum of related tumors. CANDIDATO: M.Pensabene. RELATORE: S.Pepe
No full textThis dissertation is focused on the evaluation of cancer spectrum related to
hereditary and familial breast cancer. In BRCA1 mutation carriers, mean
cumulative risk at age 70 years is 57% (95% CI, 47% to 66%) for breast cancer
and 40% (95% CI, 35% to 46%) for ovarian cancer. Moreover, in BRCA2
mutation carriers mean cumulative risk at age 70 years is 49% (95% CI, 40%
to 57%) for breast cancer and 18% (95% CI, 13% to 23%) for ovarian cancer.
Various studies reported contradictory data concerning risk of cancer at sites
different than breast and ovary in both of carriers of mutations in BRCA1 and
BRCA2 genes.
We selected families referred to “Screening and follow-up for hereditary
and familial cancers” Unit of University “Federico II” in Naples for
oncogenetic counseling. Families were analyzed in order to evaluate the cancer
spectrum related with inherited and familial breast and ovarian cancer. We
examined 104 pedigrees for a total of 4100 individuals (2117 females, 1983
males), all of Caucasian ethnicity. Based on family history of breast cancer
and/or ovarian cancer and on clinical characteristics at diagnosis, pedigrees
were classified according to Modena model in: hereditary with clustering (41
families; 39%), hereditary without clustering (27 families; 26%) and familial
(36 families; 35%).
A total of 587 independent events of cancer have been detected in the 104
families on study. In particular among the three major categories in which
individuals have been grouped, 294 cases (17.6%) of tumors were registered in
the category of hereditary with clustering constituted of a cohort of 1670
individuals, 103 cases (9.8%) of tumors in the category of hereditary without
clustering constituted of a cohort of 1053 individuals and 190 cases (13.8%) of
tumors in the familial category constituted of a cohort of 1377 individuals.
In the hereditary with clustering group a high frequency emerges for cancer
of ovary (2%), uterus (1,4%), prostate (1,4%) and lung (0,9%). A moderate
frequency emerges for colon-rectum (0,8%) and stomach (0,7%) cancers. In
the hereditary without clustering group a similar association has not been
revealed except for colon-rectum cancer ((0,8%). In the familial group a high
frequency has been registered for cancers of ovary (1,3%), uterus (2%), and
colon-rectum (1,3%). A moderate frequency has been registered for prostate
cancer (0,9%).
We also determined frequency of tumors in families with mutations of
BRCA1/2 genes. In the 10 families with BRCA1 mutations, 76 events of
cancers have been detected in a total of 486 individuals. It emerges a clustering
with ovarian (4.9%), uterine (1.2%) and bladder cancer (0.8%). In the 6
families with BRCA2 genotype, 33 events of cancers have been registered in a
total of 185 individuals. It emerges a clustering with ovarian (2.8%), uterine
(2,8%), colon-rectum (1%) and prostate cancers (2,6%).
At least, the statistical analysis have not revealed a typical cancer spectrum,
because differences of statistical value have not been gained for any specific
site other than breast in our series among risk categories and sex
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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