4,855 research outputs found
Role of chemotherapy for advanced/recurrent gastric cancer: an individual-patient-data meta-analysis
No full textRole of chemotherapy for advanced/recurrent gastric cancer: an individual-patient-data meta-analysis.
GASTRIC (Global Advanced/Adjuvant Stomach Tumor Research International Collaboration) Group1, Oba K, Paoletti X, Bang YJ, Bleiberg H, Burzykowski T, Fuse N, Michiels S, Morita S, Ohashi Y, Pignon JP, Rougier P, Sakamoto J, Sargent D, Sasako M, Shitara K, Tsuburaya A, Van Cutsem E, Buyse M.
Collaborators (54)
Buyse M, Michiels S, Oba K, Paoletti X, Rougier P, Yamamoto S, Nakamura K, Bang YJ, Bleiberg H, Burzykowski T, Buyse M, Delbaldo C, Michiels S, Morita S, Oba K, Ohashi Y, Paoletti X, Pignon JP, Rougier P, Sakamoto J, Sargent D, Sasako M, Van Cutsem E, Ajani J, Boku N, Barone C, Borner M, Bouche O, Bugat R, Coombes C, Cullinan S, Dank M, Douglass H, Fuse N, Glimelius B, Hawkins R, Kanzler S, Koizumi W, Kim TW, Lordick F, Moehler M, Nio Y, Ohtsu A, Pozzo C, Reichardt P, Roth A, Schumacher C, Shitara K, Thuss-Patience P, Tsuburaya A, Van Cutsem E, Vanhoefer U, Wils J, Yamamura Y.
Author information
Abstract
We conducted an individual-patient-data meta-analysis of the efficacy of chemotherapy on overall survival (OS) and progression-free survival (PFS) in advanced/recurrent gastric cancer (AGC). Our primary research question was whether the experimental arms of the trials included in the meta-analysis showed a benefit as compared with their corresponding control arms. MEDLINE (up to 2010), Cochrane Central Register of Controlled Trials, National Institutes of Health (NIH) trial registry and proceedings of major oncologic and gastrointestinal cancer meetings were searched. Randomised controlled trials for AGC closed to patient accrual before the end of 2006 were eligible. As of December 2010, individual patient data were available from 22 trials (4245 patients, representing 47% of the targeted data) of 55 eligible trials. The overall comparison of experimental arms with the corresponding control arms showed statistically significant differences in terms of both OS and PFS. Hazard ratio was 0.88 (95% confidence interval 0.82-0.94, P<0.0001) for OS and 0.81 (0.76-0.88, P<0.0001) for PFS. The results of the sub-analysis of adding a given chemotherapeutic agent to any chemotherapy confirm the results of the overall analysis, with a hazard reduction of 11% for OS (P<0.01) and 26% for PFS (P<0.0001). This meta-analysis of individual patient data shows that the additions of experimental chemotherapeutic agents to pre-existing control or standard regimens have produced a modest improvement in OS and PFS. Median survival remained below 1 year for all investigated chemotherapy regimens and none emerged as a clear standard
Pengaruh Online Behavioural Advertising (Oba) Terhadap Sikap Dan Dampaknya Pada Minat Beli (Survei Pada Pengguna Situs Jejaring Sosial Facebook.com Yang Pernah Melihat Tampilan Oba)
No full textThis researcheaims to clarify the influence of online behavioural advertising (OBA) to attitude, the influence of online behavioural advertising (OBA) to purchase intention, and the influence of attitude to purchase intention. This type of research is explanatory with quantitativeeapproach. Variableein this research is online behavioural advertising (OBA), attitude, and purchase intention. Populationein this researcheis Facebook users who have seen impression of OBA aged above 18 years old and evereonline shopping in past six months. The sampleeused in thiseresearch was 145 people chosenewith purposive sampling and data collection methids in questionnaire. Analysis of data used descriptive analysis and path analysis. The resulteof path analysis shows that OBA significantly influence the attitude, OBA significantly influence the purchase intention, attitude significantly influence the purchase intention. Based on thid research's result Facebook should consider about users's privacy that related tracking and profiling for OBA purpose, the display of OBA must be improved to attract attention and reach high click-through-rate
Superfast line profiles variability in spectra of OBA stars
No full textWe present new results of our Large Project for revealing the superfast line profile variations (sfLPVs) in spectra of bright OBA stars. The regular variations of the line profiles with periods ranging from a few hours to days in spectra of all massive OBA stars are well known. Recent observations of the A0 supergiant HD 92207 using FORS 2 spectrograph in spectropolarimetric mode mounted on the 8-m VLT telescope showed moderate line profile variations of various lines on a time-scale of minutes. Such short time-scale LPVs were also detected in our spectral time series for HD 93521 (O9.5III), rho Leo (B1Iab), alpha2 CVn (A0VpSiEu), gamma UMi and other stars obtained with the multi-mode focal reducer SCORPIO at the 6-meter telescope (Northern Caucasus, Russia). Both regular LPVs with periods from 1 to 90 minutes and non-regular LPVs with amplitudes of 1-2% of the continuum level were detected. Our spectral observations of rho Leo at the 1.25-m telescopes of Crimean Astronomical Station of the Sternberg Astronomical Institute (Russia) also lets to detection of sfLPVs in spectra of rho Leo. The presence of the short-term spectral variability in massive OBA stars, which are (at least partly) suggested to be the progenitors of Type II supernova, was not studied in the past and can be crucial for the current theoretical understanding of the supernova physics and for modeling the stellar evolution. We plan to increase the number of telescopes used for observations of OBA stars with ultra-high temporal resolution
BENIN Culture of Arts from Western Africa, bordering the Bight of Benin, between Nigeria and Togo - ( Oba\u27s Mask)
No full textThe mask is believed to have been produced in the early sixteenth century for the King or ObaEsigie, the king of Benin, to honor his mother, Idia. The oba may have worn it at rites commemorating his mother, although today such pendants are worn at annual ceremonies of spiritual renewal and purification.
The mask is said to represent Idia, the mother of Oba Esigie who ruled in the sixteenth century.https://digitalcommons.pvamu.edu/african-sculptures-and-masks/1022/thumbnail.jp
Infrared photometry and mass loss rates for OBA supergiants and Of stars
No full textWe present infrared observations of 34 OBA supergiants and 10 Of and Oe stars. Excess free- free emission is detectable at 10 m but not at shorter wavelengths for the supergiants. From our 2.2 and 3.6 t m photometry of the supergiants, in conjunction with existing UBV data, we derive an invariant ratio of total to selective extinction, R = 3.10 + 0.03. Using published radio and infrared data, we derive the velocity law for the mass loss outflow from P Cygni, and we apply this velocity law to the measured 10 m excess fluxes from our sample of supergiants in order to derive mass loss rates. Our preliminary survey of Of and Oe stars shows excess free-free emission to be common at 3.6 m and sometimes detectable at 2.2 t m. Using our 2.2-10 m data, we derive mass loss rates for several 0 stars. Our results are consistent with radiation pressure being the driving mechanism for mass loss from OBA supergiants and Of stars. Subject headings: interstellar: matter - stars: circumstellar shells - stars: early-type - stars: mass loss - stars: Of-type - stars: supergiant
BENIN Culture of Arts from Western Africa, bordering the Bight of Benin, between Nigeria and Togo - (Shrine Oba head)
No full textThe head is an idealized image of an oba, or king, of the Kingdom of Benin. portrait cast in bronze and placed on an altar at the palace. The altar constitutes an important site of palace ritual and is understood to be a means of incorporating the ongoing influence of past kings in the affairs of their descendants.
The placement of brass heads on the ancestral altar is a vivid reminder of the oba\u27s role in successfully guiding the kingdom throughout his reign.https://digitalcommons.pvamu.edu/african-sculptures-and-masks/1023/thumbnail.jp
Erratum: The Operative management in Bariatric Acute abdomen (OBA) Survey: Long-term complications of bariatric surgery and the emergency surgeon's point of view (World J Emerg Surg (2020) 15 (2) DOI: 10.1186/s13017-019-0281-y)
No full textThe original article [1] contained an error in authorship whereby author, Fausto Catena was mistakenly listed as part of the institutional authorship of the OBA trial supporters instead of in the correct position of final author. As such, the original article has since been corrected to reflect the correct authorship. Furthermore, this error was mistakenly introduced by the production team handling this article and, as such was not the fault of the authors
Nihilism And Its Destructive Effect On Oba Yozo In No Longer Human By Osamu Dazai
No full textThis research study about novel entitled “No Longer Human” using theory of Nihilism by Friedrich Nietzsche. This study aims to 1) describe characterization of Oba Yozo, 2) reveal the idea of nihilism as reflected in Oba Yozo, and 3) find the destructive effect of nihilism in Oba Yozo’s life. This research is qualitative research. The data is collected by note-taking and the technique of analyzing data is using 3 stages of data analyze by Miles & Huberman called data reduction, data display, and conclusion drawing. To determine the accuracy of this research, the theory triangulation is used as data validity. The researcher finds the characterization of Oba Yozo through Murphy’s method of analyzing character. The nihilism idea such as insecurity, lack of gaining composure, ashamed of oneself, negate all meaning in life, and believe in nothings is occurred in Oba Yozo’s life which caused some destructive effect includes alcohol and drugs addict, prostitution, and suicidal attempt
A 100% waste-based alkali-activated material by using olive-stone biomass ash (OBA) and blast furnace slag (BFS)
No full text[EN] This study presents the use of olive-stone biomass ash (OBA) as an alkali source in alkali-activated materials (AAM) based on blast furnace slag (BFS). The OBA was physically and chemically characterized. It presented high K2O and CaO contents, and yielded high alkalinity in water medium. The newly designed OBA + BFS mixes (a 100% waste-based AAM) reached a compressive strength of 30 MPa after 7 days of curing at 65 ºC, which was higher than for BFS activated with KOH solution. Thermogravimetric studies showed the formation of C-S-H/(C,K)-A-S-H gels and hydrotalcite. The OBA presented excellent performance as a component in AAM and a good valorisation was achievedFont-Pérez, A.; Soriano Martínez, L.; Moraes, J.; Tashima, M.; Monzó Balbuena, JM.; Borrachero Rosado, MV.; Paya Bernabeu, JJ. (2017). A 100% waste-based alkali-activated material by using olive-stone biomass ash (OBA) and blast furnace slag (BFS). Materials Letters. 203:46-49. https://doi.org/10.1016/j.matlet.2017.05.129S464920
Gestão do trabalho e participação: Chega de oba-oba?
No full textThis article aims at investigating the work management in the advertising agencies in the city of
Belo Horizonte. The scope for the analysis was the work developed by Meir (2005) in the book “End
of the fun”. The repercussion aroused by the considerations in the book was the reason to choose
this author, because she proposes a return to the old fashion way of managing the work. The
authors discusses that the forms of managing work are not suitable for the advertisement agencies
and the professional that work for them. She believes that the office cannot be an extension of the
home and the leisure. The qualitative research developed for this investigation presents data
related to the ways of working of these organizations and corroborates with the author’s
statements. It was observed that the employees of the agencies fall into two categories of workers:
a rigid group, that works under strict and well definite rules, and the other group that performs the
tasks in accordance with the demands of the client’s advertising campaign. The results point out to
other issues such as “the lack of creativity toward the administrative procedures” and the clear
division of the work relations in only one organization.Esse artigo tem por finalidade investigar a gestão do trabalho nas agências de publicidade do município de Belo Horizonte. O escopo para a análise da pesquisa foi o trabalho desenvolvido por Meir (2005), no livro “Chega de oba-oba”. A escolha pela autora foi proveniente da repercussão causada por suas considerações, visto que ela propõe um retorno às estruturas antigas nas formas de gerir o trabalho. A autora argumenta que as novas formas de gerir o trabalho não são adequadas para as agências e nem para os profissionais que nelas trabalham. Isto porque acredita que o local de trabalho não pode ser uma extensão do lar e do lazer. A pesquisa de cunho qualitativo, desenvolvida para essa investigação, apresenta dados sobre as formas de se trabalhar e corrobora com as teses da autora. Observou-se que os empregados das agências se enquadram em dois grupos de trabalhadores: um rígido, que trabalha sob regras muito definidas, e um outro que desempenha suas funções em acordo com as exigências demandadas pelas campanhas publicitárias dos clientes da organização. Os resultados apontam para outras questões tais como a “falta de criatividade dos procedimentos administrativos” e da nítida divisão das relações de trabalho nas empresas
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