21 research outputs found

    Digital transformation of the Pharmaceutical Industry: A future research agenda for management studies

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    Despite the widespread attention given to Digital Transformation (DT), there is a notable lack of comprehensive knowledge concerning its implications within the Pharmaceutical Industry (PI), particularly from a Management Studies perspective. This research employs a Systematic Literature Review approach, utilizing an initial review of 404 articles (which resulted in the identification of 35 relevant papers) to propose a comprehensive Future Research Agenda focusing on key technologies driving PI-DT and addressing the major gaps in current literature. Specifically, four primary research directions are delineated in the areas of (I) Operations Management, (II) Strategic Management, (III) Organization's Theory, and (IV) Stakeholder's Theory. In conclusion, the Literature Review addresses the underdeveloped field of PI-DT in Management Studies, offering the theoretical foundation for further scholarly inquiry and knowledge development in this field

    Charged pion albedo induced by cosmic antiproton interactions with the lunar surface

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    We report the calculations of the energy spectra and fluxes of single and double albedo charged pions generated by cosmic proton and antiproton interactions with the lunar surface. Properties of such spectra and related fluxes are investigated in order to clarify some important facets of the antiproton detection via charged pion albedo flux from the lunar surface. Pion albedo measurement may represent a novel approach for the identification of cosmic antiprotons using the lunar surface as a calorimeter. Future scientific programs on the Moon designed to measure antiproton flux may benefit from the results of these calculations

    Performance of a time-of-flight silicon strip telescope in the temperature range 20oC20^{o}C to 55oC-55^{o}C

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    A cold silicon strip telescope for time-of-flight determination at −55°C has been tested using a hadron beam at Saturne II. Saclay. We present performance tests of the telescope, the time-of-flight distributions between pairs of silicon hodoscopes and their dependence on temperature. A detailed description of the apparatus, the refrigerator system and the calibration procedures is also reported. A linear relationships between the time resolution and the temperature of the apparatus is measured. An improvement of a factor 2 in the time-of-flight resolution is observed when the temperature decreases from +20°C to −55°

    Cold silicon detectors for time-of-flight measurements

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    The advantages of using cold silicon detectors and cold electronic readout for time-of-flight measurements are presented. We show how the operation of silicon strip detectors and associated electronic readout at low temperature (−55°C) allows the reduction of several noise components with respect to the operation at room temperature. Measurements are reported for single silicon strip detectors displaying the compression of the rise time of charge pulse at low temperature. A noise reduction with temperature of a cold silicon detector was also measured in a testing device operated at −20°C. The measured width of the energy loss distribution of90Sr electrons traversing 300 μm silicon detector thickness improves by 10% for temperature variations from +20°C to −20°C

    Fast preamplifier for time-of-flight silicon strip detectors operating in the temperature range from 20°C to -55°C

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    A fast preamplifier for time-of-flight measurements has been constructed and operated at low temperature (−55°C). The design criteria and performance tests are presented. The measured rise time with a silicon strip detector with a capacitance of 15 pF is 3.2 ns. This preamplifier is employed in a cold silicon strip time-of-flight apparatus which has a time resolution of 120±6 ps at −55°C for minimum ionizing particles of unitary charge

    Readout architecture of a highly segmented silicon calorimeter operating in space

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    We present the design of a readout system for a silicon calorimeter with 12800 readout channels, to be operated on satellite or balloon-borne experiments for cosmic antiproton and antihelium search. A prototype of the calorimeter digital readout system has been designed and constructed. It may be subdivided into two main parts: the storage modules and the controller. Performance tests of the prototype at the acquisition rate of 8 MHz result in a very limited power consumption, amounting to 0.1 mW per channel for the Storage Modules and 0.5 W for the controller. The acquisition rate can be further enhanced by simple modifications of the transmission protocol between the storage modules and the controller. This readout system can be easily adapted to other detectors to be operated on space vehicles. An enhanced version of this prototype is presently used in a γ spectroscopy balloon-borne experimen

    A Moon orbiting observatory for the measurement of the elemental and isotopic composition in the primary cosmic radiation

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    We describe a project for the measurement of elemental composition of the primary cosmic radiation to be performed by a space observatory orbiting around the Moon. The absence of atmosphere and the low intrinsic magnetic field of the Moon give access to the very low energy component of the cosmic radiation, allowing the search for rare events. The quest for antinuclei, the determination of the lunar lepton albedo and the abundance measurement of galactic radioactive clocks (Be10, C14, Al26) are the major tasks of the ANTARES apparatus (ANTimatter Assessment RESearch). We report details of the instrument design, the expected performance for single detectors, their capability to accomplish the proposed measurements and the characteristics of the space mission
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