203 research outputs found
Correction to:Minimizing a Wireless Passive LC-Tank Sensor to Monitor Bladder Pressure: A Simulation Study (Journal of Medical and Biological Engineering, (2017), 37, 6, (800-809), 10.1007/s40846-017-0244-2)
No full textThe article “Minimizing a Wireless Passive LC-Tank Sensor to Monitor Bladder Pressure: A Simulation Study”, written by Jacob Melgaard, Johannes J. Struijk, Nico J. M. Rijkhoff was originally published Online First without open access. After publication in volume [37], issue [6], page [800–809] the author decided to opt for Open Choice and to make the article an open access publication. Therefore, the copyright of the article has been changed to</p
A new approach to quantum scattering near the lowest Landau threshold for a Schrödinger operator with a constant magnetic field
No full textFor a fixed magnetic quantum number m results on spectral properties and scattering theory are given for the three-dimensional Schrödinger operator with a constant magnetic field and an axisymmetrical electric potential V. Asymptotic expansions for the resolvent of the Hamiltonian H m ?=?H om ?+?V are deduced as the spectral parameter tends to the lowest Landau threshold E 0. In particular it is shown that E 0 can be an eigenvalue of H m . Furthermore, asymptotic expansions of the scattering matrix associated with the pair (H m , H om ) are derived as the energy parameter tends to E 0
Nintedanib in Idiopathic Pulmonary Fibrosis: practical Management Recommendations for Potential Adverse Events.
No full textIdiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a dismal survival rate of only 3 years and no curative pharmacological therapy. The recent approval of 2 anti-fibrotic drugs (nintedanib and pirfenidone) that slow disease progression has provided some hope for patients. However, effectively managing anti-fibrotic treatment can be a challenge due to tolerability issues, the presence of pulmonary and extra-pulmonary comorbidities, and the need for concomitant medications in many patients. In general, making clear evidence-based decisions can be difficult for physicians because patients with comorbidities are often excluded from clinical trials. Since currently anti-fibrotic drugs are the only effective therapeutics capable of slowing disease progression, it is imperative that all treatment options are thoroughly evaluated and exhausted in each individual, irrespective of complicating factors, to permit the best outcome for the patient. In this review, we present data from clinical trials, post hoc analyses, post-marketing surveillance, and real-world studies that are relevant to the management of nintedanib treatment. In addition, we also provide practical recommendations developed by a multidisciplinary panel of experts for the management of nintedanib treatment in patients with IPF associated complications and those experiencing gastrointestinal side effects
Towards automated fault detection and diagnosis in district heating customers: generation and analysis of a labeled dataset with ground truth
No full textThis study aims to develop a framework for automated fault detection and diagnosis (AFDD) in district heating (DH) substations by comprehensively understanding typical faults. AFDD is presently dependent on manual detection and diagnosis, leading to limitations. To address this issue, the study utilized data from 158 fault reports and smart heat meter data from residential buildings in Denmark to investigate common faults and conduct a fault impact assessment. The study suggests additional indicators for use by DH utility companies to detect anomalies in the future. The findings indicate that greater attention to fault detection and diagnosis can decrease energy usage and return temperatures, demonstrating the significance of AFDD implementation
Herceptest: HER2 expression and gene amplification in non-small cell lung cancer
No full textHER2 is an erbB/HER type I tyrosine kinase receptor that is frequently over-expressed in malignant epithelial tumours. Herceptin, a humanised mouse monoclonal antibody to HER2, is proven therapeutically in the management of metastatic breast cancer, significantly prolonging survival when combined with cytotoxic chemotherapeutic agents. Immunohistochemical studies suggest that non-small-cell lung cancer (NSCLC) tumours may over-express HER2. Our aim was to evaluate HER2 gene amplification and semi-quantitative immuno-expression in NSCLC. A total of 344 NSCLC cases were immunostained for HER2 expression in 2 centres using the HercepTest. Fluorescence in situ hybridisation (FISH) analysis for HER2 gene amplification was performed on most positive cases and a subset of negative cases. Fifteen cases (4.3%) demonstrated 2+ or 3+ membranous HER2 immuno-expression. There was no correlation between immuno-expression and tumour histology or grade. Tumours from higher-stage disease were more often HercepTest-positive (p < 0.001). All 4 HercepTest 3 + cases demonstrated gene amplification. One of the 5 2+ cases tested for gene amplification showed areas of borderline amplification and areas of polyploidy. None of the 19 HercepTest-negative cases demonstrated gene amplification or polyploidy (p < 0.001). Gene amplification was demonstrated in all HercepTest 3+ scoring NSCLC cases. Unlike breast cancer, gene amplification and HER2 protein over-expression assessed by the HercepTest appeared to be uncommon in NSCLC. Herceptin may therefore target only a small proportion of NSCLC tumours and be of limited clinical value in this disease, particularly in the adjuvant setting. © 2001 Wiley-Liss, Inc
General overview of the problems, needs and solutions in the Italian urban building envelopes
No full textThis paper describes the contents of the respective tables on the problems, needs and solutions of the housing developments built after the Second World War in Italy, with examples of the solutions in accordance with present-day standards. © 2007 IOS Press and the Authors. All rights reserved
On bound states for systems of weakly coupled Schrödinger equations in one space dimension
No full textWe establish the Birman–Schwinger relation for a class of Schrödinger operators -d2/dx2?1H+V on L2(math,H), where H is an auxiliary Hilbert space and V is an operator-valued potential. As an application we give an asymptotic formula for the bound states which may arise for a weakly coupled Schrödinger operator with a matrix potential (having one or more thresholds). In addition, for a two-channel system with eigenvalues embedded in the continuous spectrum we show that, under a small perturbation, such eigenvalues turn into resonance
Spectral Properties at a Threshold for Two-Channel Hamiltonians II. Applications to Scattering Theory
No full textAbstractSpectral properties and scattering theory in the low-energy limit are investigated for two-channel Hamiltonians with Schrödinger operators as component Hamiltonians. In various, mostly fairly “singular” settings asymptotic expansions of the resolvent are deduced as the spectral parameter tends to the threshold zero. Furthermore scattering theory for pairs of two-channel Hamiltonians is established. As an application of the expansions of the resolvent, asymptotic expansions of the scattering matrix are derived as the energy parameter tends to the threshold zero
Spectral properties at a threshold for two-channel Hamiltonians. I. Abstract theory
No full textAbstractSpectral properties at thresholds are investigated for two-channel Hamiltonians in various, mostly fairly “singular” settings. In an abstract framework we deduce asymptotic expansions of the resolvent as the spectral parameter tends to a threshold. The results are based on given asymptotic expansions of the component Hamiltonians. Applications to scattering theory are given in a companion paper
Bound States for the Three-Dimensional Aharonov-Bohm Quantum Wire
No full textThe existence of bound states for the three-dimensional Aharonov-Bohm quantum wire, suggested by Dunne and Jaffe, is established provided the wire is thin enough. Recent results on the Aharonov-Bohm Schrödinger operator on a disk are used
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