328 research outputs found
ChemInform Abstract: Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors
No full textProgress in the Development of Lysine Methyltransferase SETD8 Inhibitors —
[34 refs. + subrefs.]. — (MILITE, C.; FEOLI, A.; VIVIANO, M.; RESCIGNO, D.;
MAI, A.; CASTELLANO, S.; SBARDELLA*, G.;
ChemMedChem 11 (2016) 16, 1680-1685, http://dx.doi.org/10.1002/cmdc.201600272
; Dip. Farm., Univ. Studi Salerno, I-84084 Fisciano, Salerno, Italy; Eng.) —
Koehle
Dynamic simulation of virtual prototypes in immersive environment
No full textVirtual Reality (VR) became a very common mean during the development of the industrial products. One of the main applications of VR in the industrial field is the validation of Virtual Prototypes (VP). The user of the VR application can interact with the Virtual Prototype in a very natural way. A virtual prototype should be able to reproduce, as realistically as possible, the behaviour of the product from any point of view. In this paper we propose an unexploited approach to the simulation of a VP in VR. A high level software library for the inter-process communication (IPC) has been developed to let the multi-body solver communicate with the VR environment. Such approach allows the designer to use different software frameworks for the simulation and the visualisation. The test case provided regards an excavator machine. It is possible to simulate the action of the actuators to move arms and bucket, and also perform visibility analyses discovering the viewing volume of the operator
Vita Jacobi Henrici Zerneckii, Præconsulis Thoruniensis : Scriptis, Fatorumque Fama Nobilitati, Exposita A M. Joanne Benjamin Dragheim, Dantiscano ; Accedunt Duæ Amplissimi Viri Disputationes, Altera Theologica, De Statu Infantium A Gentilibus Progenitorum, Cum In Infantia Decedunt ; Altera Juridica, De Milite Desertore
No full textVITA JACOBI HENRICI ZERNECKII, PRÆCONSULIS THORUNIENSIS : SCRIPTIS, FATORUMQUE FAMA NOBILITATI, EXPOSITA A M. JOANNE BENJAMIN DRAGHEIM, DANTISCANO ; ACCEDUNT DUÆ AMPLISSIMI VIRI DISPUTATIONES, ALTERA THEOLOGICA, DE STATU INFANTIUM A GENTILIBUS PROGENITORUM, CUM IN INFANTIA DECEDUNT ; ALTERA JURIDICA, DE MILITE DESERTORE
Vita Jacobi Henrici Zerneckii, Præconsulis Thoruniensis : Scriptis, Fatorumque Fama Nobilitati, Exposita A M. Joanne Benjamin Dragheim, Dantiscano ; Accedunt Duæ Amplissimi Viri Disputationes, Altera Theologica, De Statu Infantium A Gentilibus Progenitorum, Cum In Infantia Decedunt ; Altera Juridica, De Milite Desertore (1)
Cover (1)
Title page (3)
Frontispiz (Portr.) (6)
Titelblatt (7)
Widmung (9)
Ad Lectorem (11)
Index Capitum (13)
Vitae Doctorum Virorum (14)
Vita Zerneckiana (15)
Dissertatio Theologica De Statu Infantium (79)
Dissertatio Juridica De Milite Desertore (162)
In Curriculo Vitae Sequentia sunt corrigenda (219
Short-term Arterial Blood Reperfusion of Normothermic Kidney in Renal Artery and Abdominal Aorta Reconstructive Surgery
No full textAbstractObjective to prevent kidney injury in renal artery and juxta-renal aortic surgery. After 30 min of cross-clamping ischaemia, renal arterial inflow is temporary re-established for 3 min. The aim of the study was to retrospectively analyse the results of this original technique. Methods between January 1987 and May 1999, 48 patients underwent kidney short-term arterial blood reperfusion, directly or through the Pruitt–Inahara shunt. The reperfusion was repeated every 30 min of ischaemia, whenever necessary. Fifty control patients underwent <30 min of kidney ischaemia. Patients were assessed by serum creatinine, digital angiography and radioisotope renography using technecium99. Results in the study group one patient developed an acute renal failure and died (2% (−95% CI: 0–11%)). In both study and control groups patients showed a similar and moderate but temporary decline in renal function, which returned to preoperative levels after 1 week. Conclusions the results of this study indicate that kidney short-term reperfusion may protect renal tissue from prolonged cross-clamping ischaemia (up to 100 min), also in patients considered at high risk for acute renal failure
Model Strategy For Redevelopment Of Closed Landfill
No full textThis paper elaborates on two-years research done under the Sufalnet project in the field of redevelopment of former and abandoned landfill. Sufalnet (Sustainable Use of Former and Abandoned Landfills Network) is an EU part financed project (INTERREG IIIC) that aims to identify and bring together expertise and best practice and promote joint development of policy programmes available in Europe on redevelopment and aftercare of landfills, so that closed landfills might finally be dealt with. This contribute gives back the progress of the cooperation experience focusing on the proposal of a model strategy that could drive public and private sectors toward a successful re-use that enhances environment and creates job opportunities for local communities. In the frame of Sufalnet objectives, model strategy has been identified as a logical approach to the complexity of redevelopment plan, a sort of common minimum denominator of the decision process that facilitates a better assessment of the re-use feasibility
Microwave-Assisted Aminoalkylation of Phenols via Mustard Carbonate Analogues
No full textA microwave-assisted chlorine-free direct phenol substitution is presented, which is indicated as a key green chemistry research area for pharmaceuticals manufacturers. The reaction of -aminocarbonates (mustard carbonates) with several substituted phenols in the presence of a polar solvent (acetonitrile or butanol) led to the related aminoalkylated products via the anchimeric assistance of the nitrogen incorporated in the organic carbonate backbone. The aminoalkylation required short reaction time (7 min) and the related products were isolated in high yields (90%) via quick liquid-liquid extraction or column chromatography depending on the solvent employed. Furthermore, microwave irradiation also promoted the one-pot aminoalkylation of phenol in excellent yield. In this approach a -aminoalcohol was reacted with phenol in the presence of diethyl carbonate, used for the in situ formation -aminocarbonate, key intermediate in the consequent anchimerically driven alkylation. The resulting product, namely N,N-dimethyl-2-phenoxyethanamine, was isolated as pure in almost quantitative yield
Straightforward, Metal-free, and Stereoselective Synthesis of 9-Oxo- and 10-Hydroxy-2(E)-decenoic acids, Important Components of Honeybee (Apis mellifera) secretions
No full text10-Hydroxy-2E-decenoic (10-HDA) and 9-oxo-2E-decenoic (9-ODA) acids, two components identified in honeybee secretions, have both received considerable recent interest due to their involvement in caste switch and maintenance. Herein we report for the first time a metal-free, gram scale, and stereoselective synthesis of these honeybee secretion components by TEMPO catalyzed oxidation of readily available alcohols and subsequent Doebner–Knoevenagel reactions between the resulting aldehydes and malonic acid. Mechanistic investigations undertaken highlighted the crucial role of the Doebner–Knoevenagel reaction in the high yielding and selective preparation of the α,β-unsaturated acids 10-HDA and 9-ODA. The combination of inexpensive and environmentally friendly reagents with simple synthetic procedures renders this approach a valuable green strategy for the gram scale preparation of these biologically relevant natural molecules
Open and endovascular repair of infected femoral artery pseudoaneurysms in intravenous drug abusers: results from the Italian "IN-FEMS" (INfected Femoral artery psEudoaneurysMs in drug addictS) multicentric Registry
No full textObjective: Infected femoral artery pseudoaneurysms (IFAPs) are threatening complications of voluntary drug injections in the groin. The purpose of this study is to report the results of open and endovascular repair of IFAPs in intravenous drug abusers. Methods: The IN-FEMS (INfected Femoral artery psEudoaneurysMs in drug addictS) is a physician-initiated, multicenter and retrospective registry of patients treated for native IFAPs between 2010 and 2023 in 18 different Italian Vascular Surgery Departments. Primary endpoints included perioperative death rates, surgical reconstructions durability, major amputation rates and reintervention rates. Additionally, antimicrobial activity of different biological and synthetic vascular grafts was tested using agar plates seeded with methicillin-resistant staphylococcus aureus. Results: 100 consecutive procedures (94 patients, 6 with bilateral IFPAs) were included in the study. Two groups were analized: open repair group (A, n= 83) and endovascular repair group (B, n= 17). Medium age of the patients was 41.7 ± 9.2, with a high percentage of patients positive for drug related infectious diseases. The most frequent surgical procedures included common femoral artery (CFA) reconstruction with a single straight tube (n= 24, 24.0%), followed by external iliac artery (EIA) - CFA bypass (n= 18, 18.0%). 8 patients were treated with arterial ligation (8%). 12 (12.0%) patients received a stenting of the EIA-CFA. Perioperative death rate was 2.0%. The overall survival rate after 48 months was 76.5% (standard error 0.06). A statistically significant difference in terms of grafts durability was observed among 3 subgroups of patients treated with open surgery with different conduits (autologous vein/cryopreserved allografts; pericardium/biosynthetic composite grafts; prosthetic grafts - respectively 78.4%, 80% and 33.5%; log rank p=0.024). Major amputation was similar for both open and endovascular groups (respectively 1.2% and 5.9%, p= .313). A significant difference was observed in terms of reintervention rates: group A showed a lower rate of reinterventions compared with group B (37.4% vs 64.7%, p= .037). Microbiological evaluation showed that autologous great saphenous vein (GSV) and reinforced cryopreserved saphenous vein (CSV) present a strong intrinsic antimicrobial activity compared to prosthetic grafts. Conclusions: Endovascular repair appears a technically feasible solution that doesn't compromise the limb salvage rates; however, the reintervention rates are significantly higher in patients treated with endovascular techniques, which should be considered as "bridge therapy". Open surgery seems to be the safest and most durable solution to treat these complex cases. The use of synthetic grafts should be limited to those patients "without alternative options", when autologous or biosynthetic materials are not available
Burst-Mode Equalization Strategies in 25 Gbps US-PON using Duobinary and 10G-Class APD for 20-km in C-Band
No full text25 Gbps burst-mode upstream duobinary transmission in C-band using 10G optoelectronics and APD-based adaptive equalization receiver is analyzed and experimentally demonstrated. We show a memory-aided alternative that avoids the long training preambles (>2600 bits) needed in commonly proposed memoryless approaches
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