707 research outputs found
Fyffe, R M, NX23055
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/386600Surname: FYFFE. Given Name(s) or Initials: R M. Military Service Number or Last Known Location: NX23055. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 10143.208370
Item: [2016.0049.18893] "Fyffe, R M, NX23055
3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer
No full textChanse Fyffe, Marco Falasca Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, Inositide Signallling Group, London, UK Abstract: It should be noted that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is a protein encoded by the PDPK1 gene, which plays a key role in the signaling pathways activated by several growth factors and hormones. PDK1 is a crucial kinase that functions downstream of phosphoinositide 3-kinase activation and activates members of the AGC family of protein kinases, such as protein kinase B (Akt), protein kinase C (PKC), p70 ribosomal protein S6 kinases, and serum glucocorticoid-dependent kinase, by phosphorylating serine/threonine residues in the activation loop. AGC kinases are known to play crucial roles in regulating physiological processes relevant to metabolism, growth, proliferation, and survival. Changes in the expression and activity of PDK1 and several AGC kinases have been linked to human diseases including cancer. Recent data have revealed that the alteration of PDK1 is a critical component of oncogenic phosphoinositide 3-kinase signaling in breast cancer, suggesting that inhibition of PDK1 can inhibit breast cancer progression. Indeed, PDK1 is highly expressed in a majority of human breast cancer cell lines and both PDK1 protein and messenger ribonucleic acid are overexpressed in a majority of human breast cancers. Furthermore, overexpression of PDK1 is sufficient to transform mammary epithelial cells. PDK1 plays an essential role in regulating cell migration, especially in the context of phosphatase and tensin homologue deficiency. More importantly, downregulation of PDK1 levels inhibits migration and experimental metastasis of human breast cancer cells. Thus, targeting PDK1 may be a valuable anticancer strategy that may improve the efficacy of chemotherapeutic strategies in breast cancer patients. In this review, we summarize the evidence that has been reported to support the idea that PDK1 may be a key target in breast cancer management. Keywords: 3-phosphoinositide-dependent protein kinase-1, phosphoinositide 3-kinase, AGC protein kinases, oncogenic kinase, cell signaling, breast cancer therap
A distributed energy-balance melt model of an alpine debris-covered glacier
No full textDistributed energy-balance melt models have rarely been applied to glaciers with extensive supraglacial debris cover. This paper describes the development of a distributed melt model and its application to the debris-covered Miage glacier, western Italian Alps, over two summer seasons. Sub-debris melt rates are calculated using an existing debris energy-balance model (DEB-Model), and melt rates for clean ice, snow and partially debris-covered ice are calculated using standard energy-balance equations. Simulated sub-debris melt rates compare well to ablation stake observations. Melt rates are highest, and most sensitive to air temperature, on areas of dirty, crevassed ice on the middle glacier. Here melt rates are highly spatially variable because the debris thickness and surface type varies markedly. Melt rates are lowest, and least sensitive to air temperature, beneath the thickest debris on the lower glacier. Debris delays and attenuates the melt signal compared to clean ice, with peak melt occurring later in the day with increasing debris thickness. The continuously debris-covered zone consistently provides ~30% of total melt throughout the ablation season, with the proportion increasing during cold weather. Sensitivity experiments show that an increase in debris thickness of 0.035 m would offset 1°C of atmospheric warmin
A Life Managed or a Life Lived? A parental view on case management
No full textThe author describes a common case management model where a worker in an accommodation support service doubles as a case manager. Knox demonstrates the role of parents as advocates in case management processes while also illustrating the care required to ensure it is the voice of her son and his views, rather than her own, that dominate. She traces the fine line parents and case managers must tread between upholding a person's right to autonomy by ensuring their wishes and needs are met and that of prtoecting the individual from poor choices and harm. Importantly, too, she draws attention to the fear of retribution confronted by parents and other allies when they challenge or push a service system that potentially wields much power over the life of the person they seek to represent
Implications and Possible Solutions for Mountain Bike Trails in Kokanee Creek Provincial Park
No full textThe popularity of mountain bike riding has been steadily increasing since the introduction of the mountain bike in the 1980's. With the introduction of a sport such as mountain biking, controversy usually follows. In the case of mountain bikes, the main issue of controversy is the building of illegal trails on private and public lands. Land managers are now faced with new sets of concerns such as liability, public safety, and environmental impacts. These new concerns are issues that the managers of Kokanee Creek Provincial Park are being faced with in regards to two mountain bike trails that run through sections of the park.
Kokanee Creek Provincial Park is located nineteen kilometers Northeast of the city of Nelson on highway 3A. The park was established in 1955 and is two hundred and sixty hectares in size. It offers front country camping opportunities along with easy access to moderate hiking and walking trails. The park is a popular destination for campers and outdoor recreation enthusiasts from around the world, as well as being a popular recreation area for locals.Student paper submitted for Wildlife Recreation
Moore, Melvin Charles (Birth, 1905-06-23)
No full textAddress: Fyffe & McHenry Avenues5888/Pg. 140/1905/M W/Louisville, Ky./Cincinnati, Ohio/Carroll DeCourcy, 210 W. 9th St./Filed 12-3-41, Jos. Back, RegistrarOriginal record filed in drawer labeled 'MOORE, J-MORLEY'
Model output data to "Land surface modeling in the Himalayas: on the importance of evaporative fluxes for the water balance of a high elevation catchment"
No full text<p>We provide i) gridded initial conditions (.tif), ii) modeled gridded monthly outputs (.tif), and iii) modeled hourly outputs at the station locations (.txt) for the hydrological year 2019. Information about the variables and units can be found in the figures (.png) associated to each dataset. Details about the datasets can be found in the original publication by Buri and others (2023).</p><p> </p><p>Buri, P., Fatichi, S., Shaw, T. E., Miles, E. S., McCarthy, M. J., Fyffe, C. L., ... & Pellicciotti, F. (2023). Land Surface Modeling in the Himalayas: On the Importance of Evaporative Fluxes for the Water Balance of a High‐Elevation Catchment. <i>Water Resources Research</i>, <i>59</i>(10), e2022WR033841. DOI: <a href="https://doi.org/10.1029/2022WR033841"><strong>10.1029/2022WR033841</strong></a></p>
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