575 research outputs found
Lietopis’: 26-29 September, 1979, Shumen: International Symposium on "John, Exarch of Bulgaria"
No full textThis feature "ЛѢТОПИСЬ" ('Chronicle') reports on recent events in the field of Early Slavic studies, e.g., celebrations, conferences, symposia, announcements of forthcoming colloquia, and past study groups, etc.The International Symposium "John Exarch of Bulgaria" was held on September 26-29, 1979, in Shumen, Bulgaria. This announcement summarizes and evaluates one third of the papers presented at the symposium on topics ranging from the homilies attributed to John Exarch (JE), John Exarch’s historical and literary context, and translations and normalized editions of works by John Exarch. It is noted that a summary of the other symposium papers could not be published due to time constraints. "Jean L'Exarque en tant que compilateur et traducteur: Problèmes historico-littéraires, textologiques, linguistiques" by Mario Capaldo. Sommaire: 1. Pour le dépassement de l'antithèse influence (traductions) / originalité dans l'étude de JE; 2. JE dans la situation littéraire et linguistique contemporaine (R. Aitzermueller); 3. Les sources des homélies attribuées à JE (F. Thomson et M. Capaldo); 4. De l'édition normalisée à la reconstruction de l'original (A. Mladenović et M. Capaldo); 5. A propos de la double traduction (Doppelübersetzung, двойной перевод) chez JE (E. Hansack et J . Reinhart
G. Capaldo, Autonomia privata e responsabilità patrimoniale nelle nuove figure di patrimoni destinati
No full textL'analisi del potere dell'autonomia privata nella creazione di figure di destinazione patrimoniale nelle operazioni di cartolarizzazion
Libri sloveni pubblicati nel 2004. A cur di M. Capaldo e J. Jerkov
No full textRecensioni e segnalazioni di 331 posizioni bibliografiche distinte. La paternita' delle singole voci e' ricavabile dalle sigle apposte a ciascuna sched
La Slavia antica e altomedievale di fronte al mondo romano-germanico
No full textStoria dei rapporti slavi con i Germani. Una inconciliabile inimicizia
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Global trends ::law, policy & justice : essays in honour of professor Giuliana Ziccardi Capaldo /
No full text"Global Trends: Law, Policy & Justice is a Festschrift for Professor Giuliana Ziccardi Capaldo which offers a broad and challenging view of the changing world society and the implications of globalization for the content and structure of the law, the development of judicial institutions and the shaping of world policies. Contributions made by judges of international tribunals, scholars, and practitioners offers insights into different aspects of globalization and its implications on changes in the world system. It examines a variety of current issues relating to international law, judicial institutions and global policies, focusing on different aspects of globalization and its implications on key areas of the world system, with a particular focus on issues such as, human rights, global justice, global politics global environment and public goods. This special edition of The Global Community Yearbook of International Law and Jurisprudence presents not only a systemic approach to changes in the world system but gives us the outline of the future evolution of the role of law, justice and policy in tomorrow's increasingly globalized society. Global Trends: Law, Policy & Justice offers the advantage of simultaneously covering new insights into the meaning and function of the concept of globalization, combined with a thorough analysis of the evolutionary trends in key areas of the world system to provide a unified vision. Global Trends: Law, Policy & Justice is a special edition of The Global Community Yearbook of International Law and Jurisprudence, written in honor of Professor Giuliana Ziccardi Capaldo."--Publisher's website
Environmental effects of cocaine addiction: the muscle of the European eel (Anguilla anguilla) exposed to environmental cocaine concentrations
No full textObjective: Cocaine is a common organic contaminant of the aquatic environment (Pal et al. 2013). Due to its pharmacological activity, its presence in surface waters suggests new hazards, still unknown, for fish, living in contaminated waters. A chronic exposure to environmental cocaine concentrations (20 ng/l) alters the endocrine system of European eels (Gay et al. 2013) that accumulate cocaine into their tissues, especially muscle (Capaldo et al. 2012), the edible part of the animal, suggesting risks for this species and potentially for humans, consuming contaminated fish. Therefore, we aimed to verify whether environmental cocaine concentrations could damage the muscle of the European eel.
Method: Adult eels were divided into four groups (control, carrier, treated, post-exposure recovery), each containing ten specimens. A stock solution of 3 mg/500 ml cocaine free-base in ethanol was prepared. Control, treated and carrier groups were exposed daily, during 50 days, to: tap water; 20 ng/l cocaine; ethanol, respectively; a post-exposure recovery group was exposed to cocaine, as treated group, and then deprived of cocaine and exposed to tap water, during ten days. Plasma levels of the following enzymes and hormones were determined: lactate dehydrogenase (LDH) and M1 muscle-specific creatine kinase (M1-CK), well-known indicators of tissue injury; growth hormone- releasing hormone (GHRH) and corticotrophin- releasing hormone (CRH), regulating in the eel growth hormone (GH) release; GH and insulin-like growth factor 1 (IGF-1), involved in eel muscle metabolism. Samples of muscles were fixed in Bouin solution, embedded in Paraplast and stained with Mallory trichromic stain for histological examination.
Results: Cocaine significantly (P < 0.001) increased the levels of LDH (from 45.30 U/ml in controls to 62.60 U/ml in treated); M1-CK (from 38.52 U/ml to 151.28 U/ml); GHRH (from 2.15 ng/ml to 7.33 ng/ml); CRH (from 50.13 ng/ml to 82.13 ng/ml); GH (from 0.90 ng/ml to 3.27 ng/ml); IGF-1 (from 0.28 ng/ml to 0.85 ng/ml). All the values in post-exposure recovery eels were still significantly (P < 0.001) higher than control values (LDH: 102.50 U/ml; M1-CK: 188.78 U/ml; GHRH: 4.31 ng/ml; CRH: 93.81 ng/ml; GH: 5.37 ng/ml; IGF-1: 0.71 ng/ml). Histological examination revealed striated muscle damages in both treated and post-exposure recovery eels.
Conclusion: The present results show that cocaine, at environmental concentrations, damages the eel muscle physiology and morphology, as shown by the strong increase in plasma enzyme and hormone levels and the alterations of the muscle, also evident in the recovery eels. These results agree with those of previous studies, showing the presence of cocaine (20,17 ± 0.47 pg/g) in the muscle of eels chronically exposed to environmental cocaine concentrations (Capaldo et al. 2012) and showing human muscle damages induced by cocaine (Tóth and Varga, 2009). Moreover, these results indicate that cocaine addiction is not only a human, but also an environmental problem, since cocaine (and probably the other illicit drugs) directly affects fish health, disrupting their muscle and endocrine system. Finally, taken together, the presence of cocaine in the eel muscle, and the alterations, cocaine-induced, in this tissue, suggest probable risks to the human health, through the food chain
Cocaine-induced liver disease in the European eel, Anguilla anguilla.
No full textCocaine is a potent psychostimulant and highly addicting drug, causing hepatotoxicity in humans, laboratory animals and fish1. Due to the worldwide use of cocaine, it is detected in surface waters2; despite its low concentrations, cocaine induces toxic effects in the European eel3,4. In this study, the effect of cocaine on
the liver of the European eel was evaluated. A stock solution of 0.006 mg/mLcocaine free-base in ethanol was prepared. Male silver eels were exposed for fifty days to 20 ng/ Lof cocaine; untreated control, vehicle control and two post-exposure recovery groups (exposed to cocaine and then deprived of it and only exposed to tap following parameters were evaluated: liver morphology; cytochrome oxidase (COX) activity, as a marker of oxidative
metabolism5; caspase-3 activity, as a marker of apoptosis activation6; GRP78 expression, as a marker of the unfolded protein response7; blood glucose level, as a marker of stress8; serum levels
of alanine aminotransferase (ALT) and C-reactive protein (CRP), markers of liver injury8,9. In the exposed eels, loss of parenchymal cells and lipid content, and necrotic areas were observed. COX and caspase-3 activities, GRP78 expression, blood glucose level, ALT and CRP levels increased. In the post-exposure recovery eels COX
returned to control values, caspase-3 activity was lower whereas GRP78 expression, blood glucose level, ALT and CRP levels were higher than controls. These results show that even low cocaine concentrations
affect the eel liver, suggesting potential impact on the survival of this species.
References
1. Arinç E, Bozcaarmutlu A. J Biochem Mol Toxicol 2003;17:169-76.
2. Rosi Marshall EJ, et al. J Hazard Mater 2015;282:18-25.
3. Capaldo A, et al. Sci Tot Environ 2018;640-641:862-73.
4. Capaldo A, et al. Ecotoxicol Environ Saf 2019;169:112-9.
5. Lionetti L, et al. Cell Mol Life Sci 2004;61:1366-71.
6. Brentnall M, et al. BMC Cell Biol 2013;14:32.
7. Kaufman RJ. Genes & Devel 1999;13:1211-33.
8. Banaee M, et al. Pest Biochem Physiol 2011;99:1-6.
9. Giannini EG, et al. CMAJ 2005;172:367-79
Due anomalie degli studi di Riccardo Picchio sullo Slovo o polku Igoreve
No full textviene messa in discussione la tesi che nello Slovo o polku Igoreve ci siano all'inizio due chiavi tematiche biblicheThe author criticizes Picchio's opinion that there is a biblical thematic clue at the beginning of Slovo o polku igorev
Young technological entrepreneurship in less developed European regions: preliminary results of a comparative study of software firms in Protugal and Southern Italy
No full textDue noterelle idiosincratiche
No full textRiflessione sulle inconguenze della legge che istituisce il Giorno del ricordo. Risposta alla recensione di M. Garzaniti su Lo spazio lettearior nel Medioev
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