61 research outputs found

    The IUO/BU Archaeological Project at Bieta Giyorgis (Aksum), Ethiopia: Archaeological Results and Computer Applications

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    The paper deals with the main results of the Italian-American archaeological research project at Bieta Giyorgis, N of Aksum (Tigrai, Ethiopia). The computer applications used in the management and interpretation of the collected data are discussed

    From heterogeneous modeling and analysis to an on line prediction tool to improve QoS of interdependent networks

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    The work presented in this paper is in the frame of MICIE EU FP7 project (Tool for systemic risk analysis and secure mediation of data exchanged across linked CI information infrastructures), which has the main aim of designing and implementing a so- called MICIE alerting system to identify, in real time, the level of possible threats induced on a given Critical Infrastructure (CI) by undesired events happened in the same CI and/or in other interdependent CIs. Heterogeneous models, as the ones presented in this paper, are under development to perform short term predictions of the QoS of the CIs according to the services of the CI, the level of interdependences between the CIs, and the undesired events identified in the reference scenario

    Improving the EHMRG Prognostic Evaluation of Acute Heart Failure with TAPSE/PASp: A Sequential Approach

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    The Emergency Heart Failure Mortality Risk Grade (EHMRG) can predict short-term mortality in patients admitted for acute heart failure (AHF) in the emergency department (ED). This paper aimed to evaluate if TAPSE/PASp, an echocardiographic marker of ventricular desynchronization, can improve in-hospital death prediction in patients at moderate-to-high risk, according to EHMRG score classification. From 1 January 2018 to 30 December 2019, we retrospectively enrolled all the consecutive subjects admitted to our Internal Medicine Department for AHF from the ED. We performed bedside echocardiography within the first 24 h of admission. We evaluated EHMRG and NYHA in the ED, days of admission in Internal Medicine, and in-hospital mortality. We assessed cutoffs with ROC curve analysis and survival with Kaplan–Meier and Cox regression. We obtained a cohort of 439 subjects; 10.3% underwent in-hospital death. Patients with normal TAPSE/PASp in EHMRG Classes 4, 5a, and 5b had higher survival rates (100%, 100%, and 94.3%, respectively), while subjects with pathologic TAPSE/PASp had lower survival rates (81.8%, 78.3%, and 43.4%, respectively) (p < 0.0001, log-rank test). TAPSE/PASp, an echocardiographic marker of ventricular desynchronization, can further stratify the risk of in-hospital death evaluated by EHMRG

    Safety and efficacy of fluticasone propionate in the topical treatment of skin diseases

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    Fluticasone propionate - the first carbothioate corticosteroid - has been classified as a potent anti-inflammatory drug for dermatological use. It is available as 0.05% cream and 0.005% ointment formulations for the acute and maintenance treatment of patients with dermatological disorders such as atopic dermatitis, psoriasis and vitiligo. This glucocorticoid is characterized by high lipophilicity, high glucocorticoid receptor binding and activation, and a rapid metabolic turnover in skin. Although skin blanching following fluticasone propionate exceeds that of corticosteroids of medium strength, several clinical trials demonstrate a low potential for cutaneous and systemic side-effects, even in difficult-to-treat areas like the face, the eyelids and intertriginous areas. Even among paediatric patients with atopic dermatitis, fluticasone propionate proved to be safe and effective. These pharmacological and clinical properties are reflected by the high therapeutic index of this glucocorticoid
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