2,078 research outputs found
STRATEGI CAMPAIGN KOMUNIKASI KPAID KAB. TASIKMALAYA TENTANG PERLINDUNGAN ANAK MELALUI FILM “ARUL HADIAH TERBAIK”
No full textBased on the real-time report of the Ministry of Women's Empowerment and Child Protection in the period from January 1 to the end of May 2024, there were more than 8,900 cases of violence in Indonesia. West Java occupies the top position in Indonesia in terms of the level of violence against children. The film "Arul Hadiah Terbaik" is the first film in Indonesia made by KPAID Tasikmalaya Regency in collaboration with the Police with the theme of education about the Child Protection Law. The purpose of this study is to know, analyze and describe how the KPAID Communication Campaign Strategy of Tasikmalaya Regency on Child Protection through the Film "Arul Hadiah Terbaik". In this study, the author uses a type of qualitative research. Data collection techniques are carried out by interviews, observations, documentation and literature studies. Theoretical triangulation was carried out to test the validity of the data used. This study discusses the process of delivering messages or information with campaign communication which is carried out through three processes, namely, awareness, attitudes and opinions, and behavior. This study uses a SWOT analysis method consisting of strengths, weaknesses, opportunities, and threats. The results of this study based on the delivery process with campaign communication show that this film plays an important role in raising awareness, forming attitudes and encouraging positive behaviors related to child protection. And based on the SWOT analysis of this study, it shows that the filming of Arul Hadiah Best is based on a true story, played by the original cast and directed by a local artist. The production and promotion process also faces challenges such as limited budgets and production fittings. However, with these limitations, this film maximizes the value contained in the storyline
Scheduled Dataflow: Execution paradigm, architecture, and performance evaluation
No full textIn this paper the Scheduled Dataflow (SDF) architecture - a decoupled memory/execution, multithreaded architecture using non-blocking threads - is presented in detail and evaluated against Superscalar architecture. Recent focus in the field of new processor architectures is mainly on VLIW (e.g. IA-64), superscalar and superspeculative designs. This trend allows for better performance but at the expense of increased hardware complexity, and possibly higher power expenditures resulting from dynamic instruction scheduling. Our research deviates from this trend by exploring a simpler, yet powerful execution paradigm that is based on dataflow and multithreading. A program is partitioned into non-blocking execution threads. In addition, all memory accesses are decoupled from the thread's execution. Data is pre-loaded into the thread's context (registers), and all results are post-stored after the completion of the thread's execution. While multithreading and decoupling are possible with control-flow architectures, SDF makes it easier to coordinate the memory accesses and execution of a thread, as well as eliminate unnecessary dependencies among instructions. We have compared the execution cycles required for programs on SDF with the execution cycles required by programs on SimpleScalar (a superscalar simulator) by considering the essential aspects of these architectures in order to have a fair comparison. The results show that our architecture can outperform the superscalar. SDF performance scales better with the number of functional units and allow for a good exploitation of Thread Level Parallelism (TLP) and available chip area
BIOINFORMATICS ANALYSIS OF OMICS DATA TOWARDS CANCER DIAGNOSIS AND PROGNOSIS
No full textI would first like to thank my mentor, Dr. Arul M. Chinnaiyan, for his expert guidance, support, encouragement, and inspiration. I would also like to thank Dr. Debashis Ghosh for his continuous statistical support and great advice, Dr. David G. Beer, Dr. Jill A. Macoska, and Dr. Kerby A. Shedden for serving on my Doctoral committee and giving me valuable suggestions on this thesis work. I would like to thank Jindan Yu, Xiaoju Wang, Guoan Chen, Saravana Dhanasekaran, Daniel Rhodes, Scott A. Tomlins, and Sooryanarayana Varambally, who have contributed to most of the work described here. I would like to express my gratitude to all the members in the Chinnaiyan lab for their support. Without them, none of the work described here could have been completed. I would also like to thank William P. Worzel and Arpit A. Almal for their support on genetic programming project. I would like to express my deepest gratitude to my wife and my love, Yipin, without whom I would be nowhere. Thanks for putting up with my late nights and giving me unconditional love and encouragement through my Doctoral study and the writing of this work. I would also like to thank my parents, my sister, and my grandparents for giving constant support and love. And last but not least, I would like to thank my friends and all whose support helped me completing this thesis in time. ii TABLE OF CONTENT
Performance Evaluation of a Non-Blocking Multithreaded Architecture for Embedded, Real-Time and DSP Applications
No full textThis paper presents the evaluation of a non-blocking, decoupled/memory execution, multithreaded architecture known as the Scheduled Dataflow (SDF). Our research explores a simple, yet powerful execution paradigm that is based on non-blocking threads, and decoupling of memory accesses from execution pipeline. This paper compares the execution cycles required for programs on SDF with the execution cycles required by programs on Superscalar and VLIW architectures
Critical Perspectives on Open Development
No full textCross-cutting theoretical frameworks and analyses examine how open innovations in international development can empower poor and marginalized populations. Over the last ten years, “open” innovations—the sharing of information and communications resources without access restrictions or cost—have emerged within international development. But do these innovations empower poor and marginalized populations? This book examines whether, for whom, and under what circumstances the free, networked, public sharing of information and communication resources contribute (or not) toward a process of positive social transformation. The contributors offer cross-cutting theoretical frameworks and empirical analyses that cover a broad range of applications, emphasizing the underlying aspects of open innovations that are shared across contexts and domains. The book first outlines theoretical frameworks that span knowledge stewardship, trust, situated learning, identity, participation, and power decentralization. It then investigates these frameworks across a range of institutional and country contexts, considering each in terms of the key emancipatory principles and structural impediments it seeks to address. Taken together, the chapters offer an empirically tested theoretical direction for the field. Contributors Juan Pablo Alperin, Caitlin M. Bentley, Bidisha Chaudhuri, Nandini Chami, Arul Chib, Purnabha Dasgupta, Andy Dearden, Melissa Densmore, Helani Galpaya, Piyumi Gamage, Anita Gurumurthy, Onkar Hoysala, Linus Kendall, Rich Ling, Goodiel Moshi, Chiranthi Rajapakse, Katherine Reilly, Paul Mungai, Priya Parekh, Chiranthi Rajapakse, Anuradha Rao, Katherine Reilly, David Sadoway, Deo Shao, Parminder Jeet Singh, Matthew L. Smith, Janaki Srinivasan, Bernd Carsten Stahl, Satyarupa Shekhar Swain, John Traxler, Jean-Paul Van Belle, Marion Walton, Yingqin Zhen
Critical Perspectives on Open Development
No full textCross-cutting theoretical frameworks and analyses examine how open innovations in international development can empower poor and marginalized populations. Over the last ten years, “open” innovations—the sharing of information and communications resources without access restrictions or cost—have emerged within international development. But do these innovations empower poor and marginalized populations? This book examines whether, for whom, and under what circumstances the free, networked, public sharing of information and communication resources contribute (or not) toward a process of positive social transformation. The contributors offer cross-cutting theoretical frameworks and empirical analyses that cover a broad range of applications, emphasizing the underlying aspects of open innovations that are shared across contexts and domains. The book first outlines theoretical frameworks that span knowledge stewardship, trust, situated learning, identity, participation, and power decentralization. It then investigates these frameworks across a range of institutional and country contexts, considering each in terms of the key emancipatory principles and structural impediments it seeks to address. Taken together, the chapters offer an empirically tested theoretical direction for the field. Contributors Juan Pablo Alperin, Caitlin M. Bentley, Bidisha Chaudhuri, Nandini Chami, Arul Chib, Purnabha Dasgupta, Andy Dearden, Melissa Densmore, Helani Galpaya, Piyumi Gamage, Anita Gurumurthy, Onkar Hoysala, Linus Kendall, Rich Ling, Goodiel Moshi, Chiranthi Rajapakse, Katherine Reilly, Paul Mungai, Priya Parekh, Chiranthi Rajapakse, Anuradha Rao, Katherine Reilly, David Sadoway, Deo Shao, Parminder Jeet Singh, Matthew L. Smith, Janaki Srinivasan, Bernd Carsten Stahl, Satyarupa Shekhar Swain, John Traxler, Jean-Paul Van Belle, Marion Walton, Yingqin Zhen
Collection, focusing, and metering of DNA in microchannels using addressable electrode arrays for portable low-power bioanalysis
No full textAlthough advances in microfluidic technology have enabled increasingly
sophisticated biosensing and bioassay operations to be performed at the microscale,
many of these applications employ such small amounts of charged biomolecules (DNA,
proteins, peptides) that they must first be pre-concentrated to a detectable level.
Efficient strategies for precisely handling minute quantities of biomolecules in
microchannel geometries are critically needed, however it has proven challenging to
achieve simultaneous concentration, focusing, and metering capabilities with currentgeneration
sample injection technology. Using microfluidic chips incorporating arrays
of individually addressable microfabricated electrodes, we demonstrate that DNA can be
sequentially concentrated, focused into a narrow zone, metered, and injected into an
analysis channel.
The technique used in this research transports charged biomolecules between
active electrodes upon application of a small potential difference (1 V), and is capable of
achieving orders of magnitude concentration increases within a small device footprint.
The collected samples are highly focused, with sample zone size and shape defined solely by electrode geometry. In addition to achieving the objectives of the research
project, this setup was found to provide added functionality as a label-free biomolecule
detection technique due to the formation of light scattering phases of charged
biomolecules on top of the capture electrode
Multivortex micromixing: novel techniques using Dean flows for passive microfluidic mixing
No full textMixing of fluids at the microscale poses a variety of challenges, many of which
arise from the fact that molecular diffusion is the dominant transport mechanism in the
laminar flow regime. The unfavorable combination of low Reynolds numbers and high
P������clet numbers implies that cumbersomely long microchannels are required to achieve
efficient levels of micromixing. Although considerable progress has been made toward
overcoming these limitations (e.g., exploiting chaotic effects), many techniques employ
intricate 3-D flow networks whose complexity can make them difficult to build and
operate. In this research, we show that enhanced micromixing can be achieved using
topologically simple and easily fabricated planar 2-D microchannels by simply
introducing curvature and changes in width in a prescribed manner. This is
accomplished by harnessing a synergistic combination of (i) Dean vortices that arise in
the vertical plane of curved channels as a consequence of an interplay between inertial,
centrifugal, and viscous effects, and (ii) expansion vortices that arise in the horizontal
plane due to an abrupt increase in a conduit��������s cross-sectional area. We characterize these effects using top-view imaging of aqueous streams labeled with tracer dyes and
confocal microscopy of aqueous fluorescent dye streams, and by observing binding
interactions between an intercalating dye and double-stranded DNA. These mixing
approaches are versatile, scalable, and can be straightforwardly integrated as generic
components in a variety of lab-on-a-chip systems
Exhibiting environment sensitive optical properties through multiscale modelling: A study of photoactivatable probes
No full textTo assess a tumor biomarker like the cyclooxygenase-2 enzyme (COX-2), non-invasive imaging techniques are powerful tools. The (non-) linear optical properties of activatable fluorescent probes which are selectively bound to the biomarker can therefore be exploited. The here presented molecular modelling results based on multi-scale modelling techniques highlight the importance of the conformational versatility and of changes in the electronic interactions of such probes when they are embedded in water or in the COX-2 homodimer enzyme. The ANQIMC-6 probe, which combines the binding domain/scaffold of indomethacin (IMC) on COX-2 with the optical properties of acenaphtho[1,2-b]quinoxaline (ANQ), is found to be folded in the solvent and unfolded in the enzyme. A concerted movement of the probe and the protein is seen, while the rotational autocorrelation function exhibits also the intrinsic properties of the probe. Hybrid Quantum Mechanics/Molecular Mechanics (QM/MM) calculations are used to simulate the one-photon and two-photon absorption spectra along with the first hyperpolarizability. The transition has a local character in vacuum, but changes to a charge transfer one in the presence of the microenvironment of the enzyme. This is also visible through a change of the shape of the absorption spectrum, while at the same time the simulated signals of second harmonic generation experiments are strongly enhanced. The results of this work prove that an environment sensitive probe with an anchoring group and an optical active part can be constructed for use in absorption spectroscopy, without the need to revert to fluorescence experiments.S.O. thanks the Polish National Science Centre for funding (grant no. UMO-2018/31/D/ST4/01475). The authors acknowledge the Swedish (SNIC) and Flemish (VSC) national computer infrastructures. This research was carried out with the support of the Interdisciplinary Center for Mathematical and Computational Modeling at the University of Warsaw (ICM UW) under grant no G83-28
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