789 research outputs found
Correlation of MTS1/p16 and nm23 mRNA expression with survival in patients with peripheral synovial sarcoma
No full textBACKGROUND AND OBJECTIVES:
Tumor suppressor gene MTS1/p16 (cyclin-dependent kinase-4 inhibitor) and a putative tumor metastasis suppressor gene nm23 (nucleoside diphosphate A kinase) have been identified in a variety of human tumors but have not been well studied in mesenchymal neoplasms.
METHODS:
Expression of nm23 and MTS1 mRNA was determined by quantitative analysis from paraffin-embedded tumor tissue. The series comprised 31 patients with localized primary synovial sarcoma of soft tissues who were followed for a median of 83 months.
RESULTS:
Neither MTS1 nor nm23 expression levels correlated with the patient's age or sex, tumor type, depth, size, mitotic rate, or extent of tumor necrosis. In addition, there was no correlation between MTS1 and nm23 levels. Patients' survival was not related to sex, age, tumor type, location, mitotic rate, or MTS1 mRNA level. The only factors that correlated with poor survival in multivariate analysis were the presence of extensive tumor necrosis (> 15%) and higher levels of nm23 mRNA.
CONCLUSIONS:
Our results suggest that increased expression level of nm23 mRNA may be implicated in the mechanism of tumor progression and is associated with poor survival in patients with synovial sarcoma
Mesenchimal stem cells are mobilized, together with hematopoietic stem cells and endothelial progenitor sells, into the periferal blood acutely after a myocardial infarction
No full textCONTRIBUCIÓN AL CONOCIMIENTO DE LA COMPOSICIÓN FLORÍSTICA DEL DEPARTAMENTO DE HUÁNUCO, PERÚ
No full textRealizamos un inventario florístico de las plantas del departamento de Huanuco, Perú basado en 30 unidades de muestreo (9 parcelas de 50 x 20 m, 4 parcelas de 50 x 10 m y 17 trayectos de 10 a 80 m de largo). Se reportó un total de 1423 individuos que corresponde a 756 especies (354 especies y 402 morfoespecies), en 403 géneros y 130 familias. Uniendo nuestros resultados con la información publicada por Bracko & Zaruchi (1993), Arévalo (1998), Ulloa et al. (2004), Salinas (2005), León et al. (2006), Salvador et al. (2006), Cachique (2009), Castillo (2009), Salvador et al. (2009) y otros, se reporta para el departamento de Huánuco 4712 especies incluidas en 1443 géneros y 226 familias de plantas (Licofitas, Pteridofitas, Gimnospermas y Angiospermas). Los resultados de estos inventarios florísticos muestran que el departamento de Huánuco es uno más diversos del Perú en especies de plantas junto con Loreto, Junín y Cuzco.</jats:p
Measurements of the forward-backward asymmetry of bottom Quarks around the peak with the DELPHI detector at LEP
No full text3-Nitropropionic acid-induced ischemia tolerance in the rat brain is mediated by reduced metabolic activity and cerebral blood flow
No full textTissue tolerance to ischemia can be achieved by noxious stimuli that are below a threshold to cause irreversible damage ('preconditioning'). Understanding the mechanisms underlying preconditioning may lead to the identification of novel therapeutic targets for diseases such as stroke. We here used the oxidative chain inhibitor 3-nitropropionic acid (NPA) to induce ischemia tolerance in a rat middle cerebral artery occlusion (MCAO) stroke model. Cerebral blood flow (CBF) and structural integrity were characterized by longitudinal magnetic resonance imaging (MRI) in combination with behavioral, histologic, and biochemical assessment of NPA-preconditioned animals and controls. Using this approach we show that the ischemia-tolerant state is characterized by a lower energy charge potential and lower CBF, indicating a reduced baseline metabolic demand, and therefore a cellular mechanism of neural protection. Blood vessel density and structural integrity were not altered by NPA treatment. When subjected to MCAO, preconditioned animals had a characteristic MRI signature consisting of enhanced CBF maintenance within the ischemic territory and intraischemic reversal of the initial cytotoxic edema, resulting in reduced infarct volumes. Thus, our data show that tissue protection through preconditioning occurs early during ischemia and indicate that a reduced cellular metabolism is associated with tissue tolerance to ischemia.Journal of Cerebral Blood Flow & Metabolism advance online publication, 18 June 2014; doi:10.1038/jcbfm.2014.112
Multi-Stage 20-m Shuttle Run Fitness Test, Maximal Oxygen Uptake and Velocity at Maximal Oxygen Uptake.
No full textThe multi-stage 20-m shuttle run fitness test (20mMSFT) is a popular field test which is widely used to measure aerobic fitness by predicting maximum oxygen uptake (VO2max) and performance. However, the velocity at which VO2max occurs (vVO2max) is a better indicator of performance than VO2max, and can be used to explain inter-individual differences in performance that VO2max cannot. It has been reported as a better predictor for running performance and it can be used to monitor athletes' training for predicting optimal training intensity. This study investigated the validity and suitability of predicting VO2max and vVO2max of adult subjects on the basis of the performance of the 20mMST. Forty eight (25 male and 23 female) physical education students performed, in random order, a laboratory based continuous horizontal treadmill test to determine VO2max, vVO2max and a 20mMST, with an interval of 3 days between each test. The results revealed significant correlations between the number of shuttles in the 20mMSFT and directly determined VO2max (r = 0.87, p<0.05) and vVO2max (r = 0.93, p<0.05). The equation for prediction of VO2max was y = 0.0276x + 27.504, whereas for vVO2max it was y = 0.0937x + 6.890. It can be concluded that the 20mMSFT can accurately predict VO2max and vVO2max and this field test can provide useful information regarding aerobic fitness of adults. The predicted vVO2max can be used in monitoring athletes, especially in determining optimal training intensity
Long term prognostic value of Nottingham histological grade and its components in early (pT1N0M0) breast carcinoma
No full textData from: A pilot study investigating the effects of voluntary exercise on capillary stalling and cerebral blood flow in the APP/PS1 mouse model of Alzheimer’s disease
No full textAdditional authors are listed at: https://humancomputation.org/sc-running/Exercise exerts a beneficial effect on the major pathological and clinical symptoms associated with Alzheimer’s disease in humans and mouse models of the disease. While numerous mechanisms for such benefits from exercise have been proposed, a clear understanding of the causal links remains elusive. Recent studies also suggest that cerebral blood flow in the brain of both Alzheimer’s patients and mouse models of the disease is decreased and that the cognitive symptoms can be improved when blood flow is restored. We therefore hypothesized that the mitigating effect of exercise on the development and progression of Alzheimer’s disease may be mediated through an increase in the otherwise reduced brain blood flow. To test this idea, we examined the impact of three months of voluntary wheel running in ~1 year old APP/PS1 mice on short-term memory function, brain inflammation, amyloid deposition, and cerebral blood flow. Our findings that exercise led to improved memory function, a trend toward reduced brain inflammation, markedly increased neurogenesis in the dentate gyrus, and no changes in amyloid-beta deposits are consistent with other reports on the impact of exercise on the progression of Alzheimer’s related symptoms in mouse models. Notably, we did not observe any impact of wheel running on overall cortical blood flow nor on the incidence of non-flowing capillaries, the mechanism we recently identified as the cause of cerebral blood flow deficits in mouse models of Alzheimer’s disease. We did, however, note that running mice had, on average, slightly larger diameter capillaries in the cortex. Overall, our results replicate previous findings that exercise is able to ameliorate certain aspects of Alzheimer’s disease pathology, but show that this benefit does not appear to act though increases in cerebral blood flow. The dataset supports the findings of this study.DFG German Research Foundation, National Science Foundation Graduate Research Fellowship, the German National Academic Scholarship Foundation, Affinito-Stewart Grant of the President’s Council of Cornell Women, the National Institutes of Health grants AG049952 and NS108472, and the BrightFocus Foundation
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