235,601 research outputs found

    Faust / W. Pilgram; Nisle. Lith. v. C. W. Müller

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    FAUST / W. PILGRAM; NISLE. LITH. V. C. W. MÜLLER Faust / W. Pilgram; Nisle. Lith. v. C. W. Müller (1) Der Pakt (1) Auerbachs Keller (3) Der Mord (5) Der Tanz (7

    Karl August, Großherzog von Sachsen-Weimar / nach einer Zeichn. von F. Jagemann gestochen von C. Müller

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    KARL AUGUST, GROSSHERZOG VON SACHSEN-WEIMAR / NACH EINER ZEICHN. VON F. JAGEMANN GESTOCHEN VON C. MÜLLER Karl August, Großherzog von Sachsen-Weimar / nach einer Zeichn. von F. Jagemann gestochen von C. Müller (1) Illustration: Karl August (1

    Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific

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    Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells. It is typically assumed that photoreceptor loss leads to an upregulation of glial fibrilliary acidic protein (Gfap) and other intermediate filament proteins, together with other gliosis-related changes, including loss of integrity of the outer limiting membrane (OLM) and deposition of proteoglycans. However, this is based on a mix of both injury-induced and genetic causes of photoreceptor loss. There are very few longitudinal studies of gliosis in the retina and none comparing these changes across models over time. Here, we present a comprehensive spatiotemporal assessment of features of gliosis in the degenerating murine retina that involves Müller glia. Specifically, we assessed Gfap, vimentin and chondroitin sulphate proteoglycan (CSPG) levels and outer limiting membrane (OLM) integrity over time in four murine models of inherited photoreceptor degeneration that encompass a range of disease severities (Crb1rd8/rd8, Prph2+/Δ307, Rho-/-, Pde6brd1/rd1). These features underwent very different changes, depending upon the disease-causing mutation, and that these changes are not correlated with disease severity. Intermediate filament expression did indeed increase with disease progression in Crb1rd8/rd8 and Prph2+/Δ307, but decreased in the Prph2+/Δ307 and Pde6brd1/rd1 models. CSPG deposition usually, but not always, followed the trends in intermediate filament expression. The OLM adherens junctions underwent significant remodelling in all models, but with differences in the composition of the resulting junctions; in Rho-/- mice, the adherens junctions maintained the typical rod-Müller glia interactions, while in the Pde6brd1/rd1 model they formed predominantly between Müller cells in late stage of degeneration. Together, these results show that gliosis and its associated processes are variable and disease-dependent

    Arnheim / Gest. v. H. Müller

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    ARNHEIM / GEST. V. H. MÜLLER G. D. Reymann's topographische Special-Karte von Central-Europa (-) Arnheim / Gest. v. H. Müller (84) ( -

    Eintrag von J[ohann] v[on] Müller und A. C. [?] / Einschlagblatt mit redaktionellen Anmerkungen

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    EINTRAG VON J[OHANN] V[ON] MÜLLER UND A. C. [?] / EINSCHLAGBLATT MIT REDAKTIONELLEN ANMERKUNGEN Eintrag von J[ohann] v[on] Müller und A. C. [?] / Einschlagblatt mit redaktionellen Anmerkungen ( -

    De remedio l. diffamari 5. C. de ingen. manumissis

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    quam ... pro consequendis in utroque iure honoribus, privilegiis & immunitatibus, doctoralibus, d. 17. Maii anno M DC LXXVIII publico ... submittit Petrus Müller Hamburg. ...Datum hs. eingefügt: 17. MaiiEnthält 45 ThesenDiss. iur. Basel, 167

    C. Müller - verso

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    Botanico: Müller, Karl. Titolo manoscritto sul recto, dove compaiono anche le note: f. 1901; autogr.; Racc. [Raccolta] Levier, 1912. Nota manoscritta sul verso: Herrn Dr. Levier in Florenz von seinem dankberen 26 Okt. 1901 C. Müller. Montata su cartoncino 102 x 62 mm. 1 fotografia : aristotipo? ; 90 x 58 mm. Vai alla scheda bibliografica: https://galileodiscovery.unipd.it/discovery/fulldisplay?context=L&vid=39UPD_INST:VU1&search_scope=MyInst_and_CI&tab=Everything&docid=alma990015147700206046Botanico: Müller, Karl. Titolo manoscritto sul recto, dove compaiono anche le note: f. 1901; autogr.; Racc. [Raccolta] Levier, 1912. Nota manoscritta sul verso: Herrn Dr. Levier in Florenz von seinem dankberen 26 Okt. 1901 C. Müller. Montata su cartoncino 102 x 62 mm. 1 fotografia : aristotipo? ; 90 x 58 mm. Vai alla scheda bibliografica: https://galileodiscovery.unipd.it/discovery/fulldisplay?context=L&vid=39UPD_INST:VU1&search_scope=MyInst_and_CI&tab=Everything&docid=alma99001514770020604
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