1,630 research outputs found
Relationship between biodistribution of a novel thymidine phosphorylase (TP) imaging probe and TP expression levels in normal mice
No full textObjective: Thymidine phosphorylase (TP) is a key enzyme in the pyrimidine nucleoside salvage pathway and its expression is upregulated in a wide variety of solid tumors. In mice, we previously observed high and specific accumulation levels of our TP imaging probe, radioiodinated 5-iodo-6-[(2-iminoimidazolidinyl)methyl]uracil (IIMU) not only in high-TP-expressing tumors, but also in the liver and small intestine. To clarify the reason for the high accumulation levels of radioiodinated IIMU in the liver and small intestine, we investigated the expression levels of TP in mice in comparison with the biodistribution of radioiodinated IIMU (123I-IIMU). Methods: BALB/cCrSlc mice were injected with 123I-IIMU, and the radioactivity levels [%ID/g (normalized to a mouse of 25 g body weight)] in the tissues of interest were determined 0.5, 1, 3 and 24 h after the injection (n = 5, each time point). To determine the expression levels of TP, BALB/cCrSlc and ddy mice (n = 3/each strain) were euthanized, and the heart, liver, lung, spleen, kidney, stomach, small intestine, large intestine and brain were collected. The mRNA and protein expression levels of TP in these organs were examined by quantitative reverse transcription-polymerase chain reaction and western blot analyses, respectively. Results: In BALB/cCrSlc mice administered 123I-IIMU, markedly high radioactivity levels were observed in the liver [1.568 ± 0.237 (%ID/g)] and small intestine [0.506 ± 0.082 (%ID/g)], whereas those in the other tissues were fairly low [<0.010 ± 0.003 (%ID/g)] 30 min after the injection. The highest expression levels of TP mRNA were also observed in the liver and small intestine among the tissues tested. Immunoblotting showed intense immunoreactive bands of the TP protein for the liver and small intestine, whereas no notable bands were detected for other tissues. Similar expression profiles of TP mRNA and protein were observed in ddy mice. Conclusion: We confirmed TP expression in various tissues of mice at the mRNA and protein levels: high TP expression levels were observed in the liver and small intestine. These high TP expression levels are consistent with the high accumulation levels of 123I-IIMU in these tissues. Our results may provide important information about the physiological accumulation of 123I-IIMU, which may be useful for the clinical diagnostic imaging of TP
TP-model transformation-based-control design frameworks
No full textThis book covers new aspects and frameworks of control, design, and optimization based on the TP model transformation and its various extensions. The author outlines the three main steps of polytopic and LMI based control design: 1) development of the qLPV state-space model, 2) generation of the polytopic model; and 3) application of LMI to derive controller and observer. He goes on to describe why literature has extensively studied LMI design, but has not focused much on the second step, in part because the generation and manipulation of the polytopic form was not tractable in many cases. The author then shows how the TP model transformation facilitates this second step and hence reveals new directions, leading to powerful design procedures and the formulation of new questions. The chapters of this book, and the complex dynamical control tasks which they cover, are organized so as to present and analyze the beneficial aspect of the family of approaches (control, design, and optimization). Additionally, the book aims to convey simple TP modeling; a new convex hull manipulation based possibilities for optimization; a general framework for stability analysis; standardized modeling and system description; relaxed and universal LMI based design framework; and a gateway to time-delayed systems
The prediction theory of stationary random fields. III. Fourfold Wold decompositions
No full textAbstractIn this paper, we investigate various fourfold Wold-type decompositions of stationary random fields under different hypotheses of commutation properties. Spectral characterizations of the three multiplicities of the innovation subspaces are obtained. The equivalence relations between the weak commutation property, fourfold Wold-type decomposition, and quarter-plane moving average representation are proved. A complete spectral characterization of the weak commutation property is also given
IGD-TP Competence Maintenance, Education and Training Strategy and Action Plan for 2013-2016: DELIVERABLE (D-N°:3.2) Work Package 3
No full textThe purpose of this document is to define how the working group on Competence Maintenance, Education and Training (CMET) can support the IGD-TP Vision "2025". Also it was and it is still intended for outlining the activities of this working group and Joint Activity (no 14) during 2013-2016. In connection with its Vision statement (IGD-TP 2009 Vision Report) the IGD-TP committed to among its other goals to "Facilitate access to expertise and technology and maintain competences in the field of geological disposal for the benefit of Member States". The CMET working group was established in 2012 when its first Terms of Reference (ToR) version was approved by the IGD-TP Executive Group (EG). During 2013-2015 resourcing to support the group was received under SecIGD2 project with the EURATOM FP7 grant and with a direct contribution from the IGD-TP Executive Group members. This document was planned for production already during the first SecIGD2 project year. It was to be based on the needs of the IGD-TP's Joint Activities that were already deployed or planned to start in 2012, and on the needs of the CMET group members. The role of CMET group was to address Competence Maintenance, Education and Training needs from the demand side. However, at the early stage of deployment, it was somewhat difficult to express or the identify competence gaps in the activities or they had already been identified and resourced at the beginning of the joint activity. Thus there was not adequate amount of input for the first CMET working group meeting as a direct basis for a strategy formulation beyond the action plan, which had been prepared for the SecIGD2 project proposal. The SecIGD2 project's Work Package 3 in the project's description of work (DoW) that was originally prepared in alignment with the CMET Terms of Reference included the main action plan for the CMET group. With the exception of this document, the actions foreseen to be carried out by the CMET in the action plan have been implemented according to the original timetable. The actions are described in this report and two other public project documents, which are included in this report's references. The CMET working group members have contributed to the content of this report either directly via email commenting or by participating in the work group meeting discussion providing input to this report. The editors mentioned on this report's front page have been the persons who have produced this report document itself. The document represents the views of the authors and of the CMET working group. This document does not represent the views of the IGD-TP Executive Group.Geo-engineerin
The design and validation of a low-cost trans perineal (TP) prostate biopsy simulator for training: improving trainees' confidence and cognitive targeting skills.
No full textThe aim of this research was to create a novel and low-cost TP prostate biopsy simulator that has face, content and construct validity with high educational value. This research developed a trans perineal prostate (TP) biopsy simulator using 3D-printed moulds and tissue-mimicking materials. Important regions (anterior, mid, and posterior zones) were coded with different colours. Ultrasound visible abnormal lesions were embedded in the prostate phantom. Expert and novice participants in TP biopsies were recruited. Essential skills were identified through the consensus of six experts. These skills were assessed through tasks performed by participants. This included the accuracy and timing of systematic and target biopsies. Immediate feedback was determined by the colour of the biopsy cores taken. A survey was distributed to evaluate its realism and educational value. The material cost of one simulator was £7.50. This simulator was proven to have face, content, and construct validity. There was a significant difference (p = 0.02) in the accuracy of systematic biopsies between both experts and novices. Significant difference was also observed (p = 0.01), in accurately identifying target lesion on ultrasound between both groups. Participants rated the overall realism of the simulator 4.57/5 (range 3-5). 100% of the experts agreed that introducing this simulator to training will be beneficial. 85.7% of the participants strongly agree that the simulator improved their confidence in TP biopsies. There is value in integrating this proof-of-concept TP prostate biopsy simulator into training. It has highly rated educational value and has face, content, and construct validity. [Abstract copyright: © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
ĐỘNG CƠ HỌC TẬP NGOẠI NGỮ THỨ HAI - TIẾNG TRUNG QUỐC CỦA SINH VIÊN NGÀNH NGÔN NGỮ ANH, TRƯỜNG ĐẠI HỌC NGÂN HÀNG TP. HỒ CHÍ MINH
No full textBài viết sử dụng phương pháp điều tra bằng bảng hỏi, khảo sát động cơ học tập ngoại ngữ thứ hai – tiếng Trung Quốc của sinh viên ngành Ngôn ngữ Anh, Trường Đại học Ngân hàng TP. Hồ Chí Minh. Kết quả khảo sát cho thấy, sinh viên có động cơ học tập tương đối tích cực. Trong ba phạm vi động cơ học tập, động cơ học tập của sinh viên trên phạm vi môi trường học tập là cao nhất, kế đến là động cơ học tập trên phạm vi ngôn ngữ và trên phạm vi người học. Trong mối quan hệ giữa thành tích và động cơ học tập, động cơ xuất phát từ niềm đam mê ngôn ngữ và văn hoá Trung Quốc là yếu tố ảnh hưởng đến thành tích học tập của sinh viên.</jats:p
Risk management and regulations for lower limb medical exoskeletons: a review
No full textYongtian He, David Eguren, Trieu Phat Luu, Jose L Contreras-Vidal Laboratory for Noninvasive Brain-Machine Interface Systems, Department of Electrical and Computer Engineering, University of Houston, Houston, TX, USA Abstract: Gait disability is a major health care problem worldwide. Powered exoskeletons have recently emerged as devices that can enable users with gait disabilities to ambulate in an upright posture, and potentially bring other clinical benefits. In 2014, the US Food and Drug Administration approved marketing of the ReWalk™ Personal Exoskeleton as a class II medical device with special controls. Since then, Indego™ and Ekso™ have also received regulatory approval. With similar trends worldwide, this industry is likely to grow rapidly. On the other hand, the regulatory science of powered exoskeletons is still developing. The type and extent of probable risks of these devices are yet to be understood, and industry standards are yet to be developed. To address this gap, Manufacturer and User Facility Device Experience, Clinicaltrials.gov, and PubMed databases were searched for reports of adverse events and inclusion and exclusion criteria involving the use of lower limb powered exoskeletons. Current inclusion and exclusion criteria, which can determine probable risks, were found to be diverse. Reported adverse events and identified risks of current devices are also wide-ranging. In light of these findings, current regulations, standards, and regulatory procedures for medical device applications in the USA, Europe, and Japan were also compared. There is a need to raise awareness of probable risks associated with the use of powered exoskeletons and to develop adequate countermeasures, standards, and regulations for these human–machine systems. With appropriate risk mitigation strategies, adequate standards, comprehensive reporting of adverse events, and regulatory oversight, powered exoskeletons may one day allow individuals with gait disabilities to safely and independently ambulate. Keywords: FDA, ReWalk, Indego, Ekso, HAL, Re
TP-Blend: Textual-Prompt Attention Pairing for Precise Object-Style Blending in Diffusion Models
No full textTP-Blend: Textual-Prompt Attention Pairing for Precise Object-Style Blending in Diffusion Models
Authors: Xin Jin; Yichuan Zhong; Yapeng Tian.
This OSF project hosts the publicly available full-text PDF of the paper for stable access and indexing. The PDF here is the same as arXiv:2601.08011v3.
Canonical record (DOI): 10.48550/arXiv.2601.08011
arXiv abstract: https://arxiv.org/abs/2601.08011
OpenReview / TMLR page: https://openreview.net/forum?id=q6M73uOBZE
Recommended citation (BibTeX):
@misc{jin2026tpblendtextualpromptattentionpairing,
title={TP-Blend: Textual-Prompt Attention Pairing for Precise Object-Style Blending in Diffusion Models},
author={Xin Jin and Yichuan Zhong and Yapeng Tian},
year={2026},
eprint={2601.08011},
archivePrefix={arXiv},
primaryClass={cs.CV},
url={https://arxiv.org/abs/2601.08011},
A Critique of Foucault’s Conception and Predictions of the Author-Function
No full textIn this paper, we appraise the thoughts of Foucault on the relationship between the author, work, and text, and the future of that relationship. In Foucault’s view, the text points to an author who is anterior to it, but this relationship is more complex than ‘traditionally’ understood because of the asymmetrical relationship between the concepts of author/writer and text/work. Although the author-function entails a form of individualization of text and ideas, Foucault argues that this has varied across disciplines, cultures, and time. In any case, the author-function determines the process of authentication, mode of circulation, and valorization. From the analysis of the relationship between the author and text in the premodern and modern eras, Foucault extrapolates that in the postmodern era the author-function will be transformed and diminished because language assumes the dominant role of determining the form and content of viable discourse. Foucault’s conception of the author-function is post-modernist and consequently eschews the author-figure, grand narratives, progressive and systematic evaluation of texts, values and ideology, and temporality. However, contemporary trends in the understanding of the author-function do not fully bear out his predictions. Besides, intellectual property rights are more institutionalized and the boundary between authorized and unauthorized valorization and modification is intensely contested. The contestations are over valuable creations and, whether originating from an author or authors, this affirms the viability of projects such as Sage Philosophy. Key Words Author-function, work, text, discourse, postmodernism, valorizatio
Long-term effects of total vs. partial pancreatectomy among patients with pancreatic cancer: a population-based study
No full textBACKGROUND: Total pancreatectomy (TP) for pancreatic cancer (PC) has been limited historically for fear of elevated perioperative morbidity and mortality. With advances in perioperative care, TP may be an alternative option to partial pancreatectomy (PP). Limited evidence clarified the indication for these two procedures in PC patients, especially in patients with different tumor staging and location. Thus, this study aims to compare the outcomes after TP and PP for PCs of different T stages and locations. METHODS: The study identified 14,456 PC patients with potentially curable primary tumor (T1–3) who received TP or PP from the Surveillance, Epidemiology, and End Results (SEER) database during 2000 to 2016. Detailed clinical and tumor covariates were all collected. Overall survival (OS) and cancer-specific survival (CSS) were the primary endpoints of interest in this study. OS and CSS were compared between patients after TP and PP using log-rank analysis. RESULTS: For all patients, except for tumor location, TP group was comparable to the PP group. OS and CSS of the TP group were worse than of the PP group (median OS: 19 vs. 20 months, P=0.0058; median CSS: 24 vs. 26 months, P=0.00098, respectively). In stratifying analyses, TP was significantly related to worse OS and CSS than PP in pancreatic head and neck cancer patients with T2-stage tumors (median OS: 18 vs. 19 months, P=0.0016; median CSS: 22 vs. 24 months, P=0.00055, respectively), whereas for patients with T1- or T3-stage pancreatic head and neck cancer as well as T1- to T3-stage pancreatic body and tail cancer or overlapping location cancer, OS and CSS of the two groups were similar (all P>0.05). CONCLUSIONS: Compared with PP, TP offered worse prognosis in pancreatic head and neck cancer patients with T2-stage tumors, furthermore, TP and PP achieved comparable prognosis in patients with T1- or T3-stage pancreatic head and neck cancer as well as T1- to T3-stage pancreatic body and tail cancer or overlapping location cancer
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