1,720,966 research outputs found
Determinazione rapida di residui di fitofarmaci nel miele mediante SPME-HRGC con rivelazione NPD ed ECD
No full textAn approach to study the structure of isounsaturated sub-fractions from triacylglycerols obtained by biocatalyzed synthesis
No full textPlant extracts in swine nutrition: effects on some hematochemical parameters and sensory characteristics
No full textThere is an increasing public interest in the use of plant extracts in livestock feed. The objective of this study was to investigate the
effects of inclusion of oregano (Origanum vulgare L) and chestnut wood (Castanea sativa) extract in pig diets, on some blood
parameters, and chemical and sensory characteristics of the meat pork
Synthesis and Pharmacological Characterization of All Sixteen Stereoisomers of 2-(2'-Carboxy-3'-phenylcyclo-propyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine, a Novel and Selective Group II Metabotropic Glutamate Receptors Antagonist
No full textAll 16 2-(2′-carboxy-3′-phenylcyclopropyl)glycine (PCCGs) stereoisomers 32-47 have been prepared from the corresponding racemic aldehydes 12-15 following an enantiodivergent synthetic protocol. Compounds 32-47 were evaluated by a number of binding and functional experiments as potential ligands for several classes of excitatory amino acid receptors, including metabotropic glutamate receptors (mGluR1a, mGluR2, mGluR4) and ionotropic glutamate receptors (NMDA, KA, AMPA) as well as sodium-dependent and calcium/chloride-dependent glutamate transport systems. The stereolibrary of compounds 32-47 appears to be endowed with a peculiar pharmacological profile. PCCG-2 (33) and PCCG-3 (34) displaced labeled kainate at low micromolar concentration; PCCG-9 (40) and PCCG-11 (42) weakly interacted with the NMDA site; PCCG-5 (36), PCCG-10 (41), and PCCG-12 (43) showed to be potent inhibitors of Ca2+/Cl--dependent glutamate transport system. Most interestingly, PCCG-4 (35) has been shown to be able to antagonize (IC50 = 8 μM) the effects of glutamate on forskolin-stimulated cAMP formation in BHK cells expressing mGluR2. Uneffective at mGluR1, 35 is a weak mGluR4 agonist (EC50 = 156 μM) and has no effect on either ionotropic receptors or glutamate transport systems, thus demonstrating to be a novel selective mGluR2 antagonist with a 6-fold increase in potency over previously reported antagonists
An approach to study the structure of isounsaturated sub-fractions from triacylglycerols obtained by biocatalyzed synthesis
No full text
Postharvest dehydration of wine white grapes to increase genistein, daidzein and the main carotenoids
No full textWine white grape bunches of the Grechetto variety were dehydrated at 10, 20 and 30 C, RH 45% and
forced air ventilation of 1.5 m/s. Chemical and metabolic changes due to the effect of dehydration were
studied at various stages of weight loss: 10%, 20%, 30% and 40%. Berry colour at 10 and 20 C tended to
become greener with dehydration but at 30 C, at the final sampling, the colour darkened. Acidity
decreased in all samples, while sugars increased. Total phenol content increased at 10 C until 30% weight
loss was reached and then declined, while at 20 and 30 C the concentration decreased immediately. The
contents of lutein and b-carotene (respectively 68 and 58 mg/kg d.w.), representing the 80% of total
carotenoids, did not change significantly until the 30% of weight loss, when at 30 C the value increased
above all for lutein while at 10 and 20 C, the contents decreased significantly. Daidzein, at 10 C, rose
significantly from about 150 lg/kg d.w. to 1434 lg/kg d.w. at 20% weight loss and then declined; at
the same weight loss percentage, the genistein concentration began to increase. At 20 C both isoflavones
rose until the end of the experiment, reaching values similar to the sample at 10 C. A temperature of
30 C was deleterious to grape isoflavones. A discussion on the changes in isoflavones related to temperature
and time is repor
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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