70 research outputs found
Gianfranco Marrone, Gustoso e saporito. Introduzione al discorso gastronomico, Milano, Bompiani, 2022, 350 p.
No full textItalian semiologist Gianfranco Marrone has just published a new book on the semiotics of gastronomy. The book, in Italian, is part of the ‘Campo Aperto’ series edited by Stefano Bartezzaghi for the publisher Bompiani. Rather than choosing a predictable title such as ‘Semiotics of Gastronomy’, the author has opted for a title defined in the pages of the book as ‘referential’.Le nouvel ouvrage du sémiologue italien Gianfranco Marrone sur la sémiotique de la gastronomie vient d’être publié. Le livre, en italien, fait partie de la série « Campo Aperto » dirigée par Stefano Bartezzaghi pour l’éditeur Bompiani. Plutôt que de choisir un titre prévisible tel que « Sémiotique de la gastronomie », l’auteur a opté pour un titre défini dans les pages du livre comme « référentiel »
Middle cerebral artery dolichoectasia in a young woman with a previous stroke
No full textWe observed a 32-year-old female who had suffered from a left hemisphere ischemic stroke with right hemiparesis at the age of seven. At that time, a CT scan demonstrated a left ischemic lesion in nucleo-capsular region and a cerebral angiogram documented a complete occlusion of the supraclinoid segment of the internal carotid artery. When we observed the patient neurological examination demonstrated a moderate right brachio-crural hemiparesis. A brain MRI showed an old ischemic lesion involving the left nucleo-capsular and 'flow voids' suggestive for a vascular malformation in the left sylvian region. A cerebral rotational angiogram with 3-D reconstructions demonstrated a dolichoectatic left middle cerebral artery with an unusual 'corkscrew' aspect. Middle cerebral artery dolichoectasia is a rare pathological condition that may manifest with a stroke. The patients with intracranial arterial dolichoectasia (IADE) are most often hypertensive elderly men, and, to the best of our knowledge, an ischemic stroke associated with IADE has never been reported in children
Innate immunity and cellular senescence: The good and the bad in the developmental and aged brain
No full textOngoing studies evidence cellular senescence in undifferentiated and specialized cells from tissues of all ages. Although it is believed that senescence plays a wider role in several stress responses in the mature age, its participation in certain physiological and pathological processes throughout life is coming to light. The "senescence machinery" has been observed in all brain cell populations, including components of innate immunity (e.g., microglia and astrocytes). As the beneficial versus detrimental implications of senescence is an open question, we aimed to analyze the contribution of immune responses in regulatory mechanisms governing its distinct functions in healthy (development, organogenesis, danger patrolling events) and diseased brain (glioma, neuroinflammation, neurodeneration), and the putative connection between cellular and molecular events governing the 2 states. Particularly this review offers new insights into the complex roles of senescence both as a chronological event as age advances, and as a molecular mechanism of brain homeostasis through the important contribution of innate immune responses and their crosstalk with neighboring cells in brain parenchyma. We also highlight the impact of the recently described glymphatic system and brain lymphatic vasculature in the interplay between peripheral and central immune surveillance and its potential implication during aging. This will open new ways to understand brain development, its deterioration during aging, and the occurrence of several oncological and neurodegenerative diseases
A donor splice site mutation in CISD2 generates multiple truncated, non-functional isoforms in Wolfram syndrome type 2 patients
No full textBackground: Mutations in the gene that encodes CDGSH iron sulfur domain 2 (CISD2) are causative of Wolfram syndrome type 2 (WFS2), a rare autosomal recessive neurodegenerative disorder mainly characterized by diabetes mellitus, optic atrophy, peptic ulcer bleeding and defective platelet aggregation. Four mutations in the CISD2 gene have been reported. Among these mutations, the homozygous c.103 + 1G > A substitution was identified in the donor splice site of intron 1 in two Italian sisters and was predicted to cause a exon 1 to be skipped. Methods: Here, we employed molecular assays to characterize the c.103 + 1G > A mutation using the patient's peripheral blood mononuclear cells (PBMCs). 5'-RACE coupled with RT-PCR were used to analyse the effect of the c.103 + 1G > A mutation on mRNA splicing. Western blot analysis was used to analyse the consequences of the CISD2 mutation on the encoded protein. Results: We demonstrated that the c.103 + 1G > A mutation functionally impaired mRNA splicing, producing multiple splice variants characterized by the whole or partial absence of exon 1, which introduced amino acid changes and a premature stop. The affected mRNAs resulted in either predicted targets for nonsense mRNA decay (NMD) or non-functional isoforms. Conclusions: We concluded that the c.103 + 1G > A mutation resulted in the loss of functional CISD2 protein in the two Italian WFS2 patients
O CÍRIO DE NAZARÉ EM 140 CARACTERES E 10 SEGUNDOS: : Análise da cobertura jornalística nas redes sociais
No full textEste artigo analisa a cobertura jornalística, por meio do microblog Twitter e do aplicativo Snapchat, da maior festa religiosa do Brasil. Uma análise de conteúdo que parte das contas utilizadas nas redes sociais – @CirioOficial (Twitter) e ciriodenazare (Snapchat), mantidas pela diretoria da festa – escolhidas pelo seu caráter informacional. Assim, priorizando a análise da cobertura através das redes sociais e o discurso empregado pelos canais oficiais durante o evento, verificando os conteúdos postados, a interação com o público e sua influência para com outras mídias partindo do pensamento de autores como Raquel Recuero, Lucia Santaella, Manuel Castells e Pierre Levy
Prophylactic Drain Placement and Postoperative Invasive Procedures After Gastrectomy: The Abdominal Drain After Gastrectomy (ADIGE) Randomized Clinical Trial
No full text
Protective role of the longevity-associated BPIFB4 gene on cardiac microvascular cells and cardiac aging
No full textIn recent years, the role of the cardiac microvasculature in modulating the symptoms and disease progression of patients affected by cardiac pathology has been reconsidered. The term cardiac microvascular disease (CMD) describes the set of functional and/or structural alterations of the cardiac microvasculature that reduce the ability of the heart to adequately increase its coronary blood flow to keep up with increased metabolic demand. CMD is involved in the evolution of heart disease of both ischemic and non-ischemic origin as well as in cardiac aging. The primary actors involved in this process are the cells of the stromal compartment, whose nature and biology are now investigated to a new level of detail thanks to single-cell omics studies. Recent studies on the genetics of extreme longevity have identified a polymorphic haplotype variant of the BPIFB4 gene that confers prolonged life span and health span, atheroprotective advantages, and an improved immune response. The aim of this review was to focus on the beneficial effects of the longevity-associated variant (LAV) of BPIFB4 on cardiac microvascular cell biology, providing novel and exciting mechanisms of its action directed against the development or progression of many age-related cardiovascular diseases, thus emphasizing its translational therapeutic potential
Natural anticoagulants deficiencies and transient ischemic attacks
No full textCerebrovascular ischemic disorders are caused by the release of various materials into the arteries that supply the brain. Recent findings have reported an association between familial hemostatic abnormalities and ischemic stroke. The aim of our study was to investigate the role of protein C (PC) and protein S (PS) in juvenile Transient Ischemic Attacks (TIAs). Sixty-eight patients (s 45 years old) with a diagnosis of TIA in anterior or posterior brain territory were admitted into the study. One hundred and three healthy subjects acted as a control group Subjects on oral anticoagulation and oral contraceptives were not studied. All patients and control subjects had a physical examination, clinical chemestry and radiologic work-up We defined as deficiency of PC and PS activity or antigen levels below 60% (<2.5th centile) and as activated protein C (APC) -resistance an APC ratio below 2.20. The number of patients with PC or PS deficiency was higher in cases than in controls (8 vs 2, p< 0.01; 10 vs 2, p< 0.002 respectively, Fisher Exact Test). However, there was no difference in the distribution of APC-resistance between cases and controls. The levels of PC and PS activity, PC and PS antigens and APC-resistance were significantly lower in cases than in controls. No differences in fibrinogen concentrations, antithrombin III (either antigen or activity) and plasminogen activity were found After multivariate analysis the number of subjects with a family history of TIA and stroke or with hypertension was significantly higher in the group of patients as compared to controls. TIA patients showed significantly higher levels of tryglicerides compared to controls. PC and PS were both positively correlated with HDL and negatively correlated with total cholesterol, LDL and tryglicerides plasma levels. The association between PC/PS deficiency and TIA persisted in multivariate analysis controlling for age, sex, smoke, hypertension, diabetes and tryglicerides. Our findings suggest that PC and PS deficiencies are risk factors for TIAs and are strongly associated with a family history of cerebrovascular ischemic disease
Expression of tissue factor on endothelial and epithelial cells from breast proliferation, as assessed by immunohistochemistry, correlates with a malignant phenotype
No full text- …
