1,721,043 research outputs found
L’internazionalizzazione nel business aeronautico: il challenge di Alenia Aeronautica quale global player
Full text linkIl lessico del Supply Chain Management
No full textCUEIM (F. POLESE – L. PROIETTI), Il lessico del Supply Chain Management, in Professione Alenia, n. 2, 2007
Volume senza attribuzione ai singoli AutoriCUEIM (POLESE F. - L. Proietti), The lexicon of Supply Chain Management Profession in Alenia, n. 2, 2007 Volume without attribution to author
Mechanisms by which nuclear A-type lamins are downregulated in neuroblastoma
Full text linkLamin A/C are essential components of the nuclear lamina. Together with B-type lamins and other structural components, they form the network which is located in the inner side of the nuclear membrane. It is now clear that lamins exert many different functions within the cell, most of them still largely unknown. Lamin A/C are absent in embryonic stem cells but are expressed in the majority of adult cell types, thereby suggesting their crucial role in differentiation. In addition, their expression is reduced or absent in several human malignancies, even though their role in the tumorigenesis has not been completely characterized yet. A down regulation of Lamin A/C could result in increased nuclear deformability thereby facilitating transit of cells through the capillaries and favouring cell invasive capacity. In a previous paper we demonstrated that LMNA gene knock-down inhibits differentiation in a cellular model of neuroblastoma and increases tumor progression. In this project I investigated some of the possible mechanisms by which Lamin A/C is down-regulated in neuroblastoma cells. As cellular models I employed two neuroblastoma cell lines showing different level of Lamin A/C expression (LAN-5 and SH-SY5Y cells). The analysis of the nascent transcripts of LMNA gene in both cell lines demonstrated that the transcriptional rate of this gene was reduced in the LAN-5 cells, indicating that the protein is regulated at transcriptional level. In addition, I observed that there is a minor recruitment of Sp1 transcription factor on the LMNA promoter of LAN-5 cells, as evaluated by ChIP assay. Moreover, even though the chromatin configuration upstream the LMNA gene promoter is open in both cell lines, as evidenced by a similar enrichment of the H3K4me3 histone marker in both cell lines, we found a different configuration in the coding sequence region (CDS), as shown by a reduced enrichment in LAN-5 cells of the histone marker H3K36me3 which is associated with transcriptional activation. We then tried to exogenously express the LMNA gene in LAN-5 cells, in which the protein is not detectable. In spite of a very high upregulation of LMNA gene, I did not observed any detectable expression of Lamin A/C protein. I hypothesized that the protein could be regulated by a miRNA-mediated post-transcriptional mechanism. An in silico analysis of the miRNAs predicted by miRWalk database to significantly target LMNA transcripts, have evidenced a unique miRNA, the has-miR-539-5p. However, the inhibition of the expression of such miRNA was not able to rescue the expression of Lamin A/C protein in LAN-5 cells. At the moment I can conclude that the regulation of Lamin A/C protein in neuroblastoma cells is mainly to be ascribed to a transcriptional mechanism. However, I cannot exclude the existence of an additional regulation mechanism occurring at post-transcriptional and/or post-translation level that have to be further investigated
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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