2,403 research outputs found
Emerging therapeutic options for sporadic inclusion body myositis
No full textLindsay N Alfano, Linda P Lowes Nationwide Children’s Hospital, Center for Gene Therapy, Columbus, OH, USA Abstract: Sporadic inclusion body myositis is the most common inflammatory muscle disorder preferentially affecting males over the age of 40 years. Progressive muscle weakness of the finger flexors and quadriceps muscles results in loss of independence with activities of daily living and eventual wheelchair dependence. Initial signs of disease are often overlooked and can lead to mis- or delayed diagnosis. The underlying cause of disease is unknown, and disease progression appears refractory to available treatment options. This review discusses the clinical presentation of inclusion body myositis and the current efforts in diagnosis, and focuses on the current state of research for both nonpharmacological and pharmacological treatment options for this patient group. Keywords: myositis, inclusion body myositis, inflammatory myopathy, treatment, function, outcome
LP Decoding Excess over Symmetric Channels
No full textWe consider the problem of Linear Programming (LP) decoding of binary linear codes. The LP excess lemma was introduced by the first author, B. Ghazi, and R. Urbanke (IEEE Trans. Inf. Th., 2014) as a technique to trade crossover probability for 'LP excess' over the Binary Symmetric Channel. We generalize the LP excess lemma to discrete, binary-input, Memoryless, Symmetric and LLR-Bounded (MSB) channels. As an application, we extend a result by the first author and H. Audah (IEEE Trans. Inf. Th., 2015) on the impact of redundant checks on LP decoding to discrete MSB channels. © 2015 IEEE
A Sobolev estimate for radial lp-multipliers on a class of semi-simple lie groups
No full textLet G be a semi-simple Lie group in the Harish-Chandra class with maximal compact subgroup K. Let ΩK be minus the radial Casimir operator. Let 1 4 dim(G/K) < SG < 1 2 dim(G/K), s ∈ (0, SG] and p ∈ (1,∞) be such that(1 p - 1 2 )< s 2SG . Then, there exists a constant CG,s,p > 0 such that for every m ∈ L∞(G) ∩ L2(G) bi-K-invariant with m ∈ Dom(Ωs K) and Ωs K(m) ∈ L2SG/s(G) we have, (0.1) ∥Tm : Lp(G) → Lp( G)∥ ≤ CG,s,p∥Ωs K(m)∥ L2SG/s(G), where Tm is the Fourier multiplier with symbol m acting on the noncommutative Lp-space of the group von Neumann algebra of G. This gives new examples of Lp-Fourier multipliers with decay rates becoming slower when p approximates 2.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Analysi
Stability properties of stochastic maximal Lp-regularity
No full textIn this paper we consider Lp-regularity estimates for solutions to stochastic evolution equations, which is called stochastic maximal Lp-regularity. Our aim is to find a theory which is analogously to Dore’s theory for deterministic evolution equations. He has shown that maximal Lp-regularity is independent of the length of the time interval, implies analyticity and exponential stability of the semigroup, is stable under perturbation and many more properties. We show that the stochastic versions of these results hold
PROPAGATION OF LP//0//1 AND LP//1//1 MODES IN COUPLED OPTICAL FIBERS.
No full textThe author studied the propagation of the fundamental mode, called the LP//0//1 mode, of a single-mode optical fiber and the LP//1//1 mode, the next higher-order mode, in two long lengths of fiber coupled together. This was done by launching light having a wavelength below the cut-off wavelength of the fiber. The effect of lateral misalignment at the coupled junctions was investigated. The results are explained in terms of excitation of the modes at this junction
Life of a Yellow Kid: an audiovisual electro-pop LP
No full textThe basis of this project is to compose, record, produce and mix an eleven song album (LP) with a visualizer, logo and design for each track. The author designed all of the artworks for the songs and LP and produced videos and content for said LP. Also, the author combined all of his influences from electronic music and other genres to create something new to expand the limits of electronic music. This album was influenced by works of artists like Madeon, Porter Robinson, Louis The Child, Urboi, Medasin, Fred Again.. and The Weeknd. Song-writing, recording, sound design, creative production techniques, mixing, graphic design and audiovisual production were the skills and tools necessary for the completion of this LP. The main focus of the LP was to combine different genres of music, like Electro-pop, UK Garage, Pop, House and Drum and Bass. Also this album is about personal experiences of the author and it covers different feelings throughout the LP, creating a sunset literally and figuratively within the album.
This paper was written without any assistance from generative artificial intelligence.https://remix.berklee.edu/graduate-studies-production-technology/1378/thumbnail.jp
Tеорема Литтлвуда - Пелі про простори Lp(t)(ℝⁿ)
No full textWe point out that if the Hardy–Littlewood maximal operator is bounded on the space Lp(t)(ℝ), 1 1 , the Littlewood–Paley operator is bounded on Lp(t) (ℝⁿ), 1 1, оператор Літтлвуда - Пелі обмежений на Lp(t)(Rⁿ),1 < a ≤ p(t) ≤ b<∞,t ∈ R, тоді і тільки тоді, коли p(t)= const.The author was supported by grant GNSF / STO 7 / 3-171
Tеорема Литтлвуда - Пелі про простори Lp(t)(ℝⁿ)
No full textWe point out that if the Hardy–Littlewood maximal operator is bounded on the space Lp(t)(ℝ), 1 1 , the Littlewood–Paley operator is bounded on Lp(t) (ℝⁿ), 1 1, оператор Літтлвуда - Пелі обмежений на Lp(t)(Rⁿ),1 < a ≤ p(t) ≤ b<∞,t ∈ R, тоді і тільки тоді, коли p(t)= const.The author was supported by grant GNSF / STO 7 / 3-171
Positive Definite Functions for the Class Lp(G
No full textTitle: Positive Definite Functions for the Class Lp(G), Author: Shaunkat A. Warsi, Location: ThodeThis thesis contains four main theorems on Positive definite functions for the class Lp(G) over compact and locally compact groups. Information as to how the class P(F) varies with F is provided by those theorems. Some topological properties of the set P(Lp) ∩ Lq have been considered. Two results analogous to those of E. Hewitt and H. A. Naimark have also been proved.ThesisMaster of Science (MS
Resolvent Estimates in (weighted) Lp spaces for the Stokes Operator in Lipschitz Domains
No full textRecently, by Z. Shen, resolvent estimates for the Stokes operator were established in Lp(Ω) when Ω is a Lipschitz domain in Rd, with d≥3 and |1/p-1/2|<1/(2d)+ε. This result implies that the Stokes operator generates a bounded analytic semigroup in Lp(Ω) in the case that Ω is a three-dimensional Lipschitz domain and 3/2-ε<p<3+ε. To fully understand the work of Z. Shen, a lot of background information is needed. In this thesis the resolvent estimates are studied in detail in the case d=3. In the end the results of Shen are extended to resolvent estimates in Lp(w,Ω), where Ω is a three-dimensional Lipschitz domain, |1/p-1/2|<1/6, and w∈A2p/3∩RH3/(3-p) is a weight function that belongs to an intersection of a Muckenhoupt weight class and satisfies a reverse Hölder inequality
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