1,721,035 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Microphysiological Tumor-on-Chip Models Recapitulating Tumor-Microenvironment Interaction Applicable for Cell Therapy Testing
No full textDie Dissertation ist gesperrt bis zum 24. Juli 2026 !The tumor microenvironment (TME) plays a crucial role in tumor growth and treatment response. Traditional animal models fail to accurately replicate the human TME, carcinogenesis, immune responses, metabolism, pathophysiology, and adverse events, limiting their usefulness in studying cancer development and therapies, especially those involving the immune system. To address these limitations, this thesis aimed to develop microphysiological tumor-on-chip models that closely mimic human TME and immune responses, enabling detailed studies of cancer-TME interactions and immunotherapy responses. The first part of the work focused on the development and utilization of a tumor-on-chip model for evaluating the efficacy and safety of chimeric antigen receptor (CAR)-T cell immunotherapy in a solid TME. This model examined CAR-T cell responses in relation to target antigen levels, tumor size, and TME components, such as endothelial barriers and macrophages. Excessive antitumor response by CAR-T cells was captured through the monitoring of inflammatory cytokine release kinetics, which allowed the testing of acute safety intervention strategy on the chip. This model offers a rapid and adaptable platform for comparing different CAR-T cell products and exploring strategies to overcome TME barriers. The second part of the work focused on establishing a breast cancer-on-chip model to recreate the breast TME for studying interactions between breast tumors and white adipose tissue (WAT). This platform uniquely integrated breast cancer spheroids or patient-derived organoids central to the surrounding WAT-associated cells in a perfusable microfluidic chamber, allowing long-term co-culture that lasted for up to two weeks. Using this model, it was demonstrated that the presence of breast cancer increased lipolytic activity in adipocytes and that WAT increased lipid accumulation and promoted growth of breast cancer cells. Notably, WAT protected breast cancer cells from the chemotherapeutic agent daunorubicin, highlighting the TME's critical role in modulating cancer treatment efficacy. Overall, this thesis established tumor-on-chip models to study tumor-TME interactions and cancer immunotherapies, laying the foundation for mechanistic research and clinical translation of therapies designed to overcome TME barriers
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Modelling Sensory Innervation of Cancer Using Organ-on-Chip Technology
No full textResearch contained in this thesis focuses on the advancement of organ-on-chip technology for the exploration of peripheral sensory innervation in cancer. Simultaneously, it describes an extensive attempt at creating a practical platform that can be leveraged to uncover novel approaches in combating cancer-induced pain and gain insight into the intricate relationship between diseased tissues and pain development at a cellular level. Development of this platform is also expected to produce a versatile system capable of addressing the often-neglected importance of peripheral innervation of various kinds in various organs and tissues. Peripheral nerves are essential in modulating tissue responses to environmental changes and maintaining tissue homeostasis, consequently, when innervation maladapts in conditions such as cancer, it has been associated with the development of pain states and tissue dysfunction. Having a technology that can accurately replicate these processes could prove valuable in facilitating the development of therapeutics aimed at alleviating pain and restoring tissue integrity
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
WAT-liver chip with integrated sensors to study human white adipose and hepatic tissue crosstalk
No full textOrgan-on-chip (OoC) technology has made rapid progress over the last decade with advances in microfabrication techniques, cell culture, biomarker analysis techniques and more importantly, considerations about the predictability, scalability, and standardization of the models. Given the complex and chronic nature of metabolic diseases involving the interactions of multiple organs, MOCs represent a new class of preclinical models aimed at fulfilling the 3Rs (reduction, replacement, refinement) of animal testing for mechanistic toxicity or disease modelling. The goal of this thesis was the development of novel MOC platform technology to connect two organ-chips with integrated sensors and ancillary features to introduce biological complexity in the model. A modular, flexible MOC connection platform with 3D printed modular inserts and chips was developed and characterized. Sensors were integrated into the platform, which also supported a recirculation perfusion regime. The WAT- and liver-chips were designed and standardized to fit into the cassette, where tissue channels were scaled relative to each other, and tissue structure enabled vascular connection in the cassette. Both chips were fabricated from rigid plastics and TPE considering minimal small molecule absorption. The system could measure glucose and oxygen consumption in the cassette during perfusion relative to blank chips without hepatocytes. When the liver-chip were connected to the WAT-chips, lipid droplets accumulated to a higher extent in the hepatocytes of the connected setup compared to those in unconnected liver-chips. A liver-sinusoid-on-chip model was developed to add a gradient of dissolved species (glucose, insulin, glucagon and oxygen) into media perfused across hepatocytes. To support long-term circulation of immune cells across the MOC platform, a prototype of an immune cell reservoir was designed and fabricated to allow for simple integration with the platform. Finally, considerations were made about requirements for the preparation of documentation according to regulatory guidelines keeping the goal of the 3Rs in view. The topics of this thesis collectively address the long-term culture and interaction of tissues (in this case white adipose tissue and hepatic tissue), with ancillary features, facilitating real-time monitoring of the onset and development of chronic metabolic diseases, and investigations of potential therapies for them
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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