196,502 research outputs found
Use of Rituximab in autoimmune hemolytic anemia associated with non-hodgkin lymphomas
No full textThe association between non-Hodgkin lymphomas and autoimmune disorders is a well-known event. Also autoimmune hemolytic
anemia (AHA), although much more frequent in patients with chronic lymphocytic leukemia (CLL), has been described in this
group of patients. In recent years, among the more traditional therapeutic options, rituximab, an anti-CD20monoclonal antibody,
has shown interesting results in the treatment of primary AHA. Although this drug has been frequently used for AHA in patients
with CLL, much less data are available on its use in NHL patients. However, considering that the main pathogenetic mechanism
of AHA in course of lymphoproliferative disorders seems to be an antibody production directly or indirectly mediated by the
neoplastic clone, this monoclonal antibody represents an ideal therapeutic approach. In this paper we will briefly describe some
biological and clinical features of NHL-patients with AHA. We will then analyze some studies focusing on rituximab in primary
AHA, finally reviewing the available literature on the use of this drug in NHL related AHA
Computational investigation of structure, dynamics and nucleation kinetics of a family of modified Stillinger-Weber model fluids in bulk and free-standing thin films
No full textIn recent years, computer simulations have found increasingly widespread use as powerful tools for studying phase transitions in wide variety of systems. In the particular and very important case of aqueous systems, the commonly used force-fields tend to offer quite different predictions with respect to a wide range of thermodynamic and kinetic properties, including the ease of ice nucleation, the propensity to freeze at a vapor-liquid interface, and the existence of a liquid-liquid phase transition. It is thus of fundamental and practical interest to understand how different features of a given water model affect its thermodynamic and kinetic properties. In this work, we use the forward-flux sampling technique to study the crystallization kinetics of a family of modified Stillinger-Weber (SW) potentials with energy (ε) and length (σ) scales taken from the monoatomic water (mW) model, but with different tetrahedrality parameters (λ). By increasing λ from 21 to 24, we observe the nucleation rate increases by 48 orders of magnitude at a supercooling of ζ = T/Tm = 0.845. Using classical nucleation theory, we are able to demonstrate that this change can largely be accounted for by the increase in Δμ, the thermodynamic driving force. We also perform rate calculations in freestanding thin films of the supercooled liquid, and observe a crossover from surface-enhanced crystallization at λ = 21 to bulk-dominated crystallization for λ ≥ 22.Fil: Gianetti, Melisa Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Haji Akbari, Amir. University of Princeton; Estados UnidosFil: Longinotti, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Debenedetti, Pablo Gastón. University of Princeton; Estados Unido
Hodgkin's Disease With Amyloid Deposition. Report Of A Case And Discussion On Its Pathogenesis
No full text[Asymptomatic cholelithiasis in patients with digestive neoplasms: an epidemiologic study].
No full textUN'ULTERIORE INDICAZIONE ALLA CHIRURGIA DELLA COLELITIASI ASINTOMATICA. L'AUMENTATO RISCHIO DI NEOPLASIE DIGESTIVE.
No full textPROFILASSI ANTIBIOTICA PREOPERATORIA, BACTIBILIA E COMPLICANZE SETTICHE IN CHIRURGIA BILIARE.L. Sarli, M.Gafa', M.Lupi, E.Longinotti, M.Saragoni.
No full textThe Quasi-Liquid Layer of ice revisited: the role of temperature gradients and tip chemistry in AFM studies
No full textIn this work, we present new results of atomic force microscopy (AFM) force curves over pure ice at different temperatures, performed with two different environmental chambers and different kinds of AFM tips. Our results provide insight to resolve the controversy on the interpretation of experimental AFM curves on the ice–air interface for determining the thickness of the quasi-liquid layer (QLL). The use of a Mini Environmental Chamber (mEC) that provides an accurate control of the temperature and humidity of the gases in contact with the sample allowed us for the first time to get force curves over the ice–air interface without jump-in (jump of the tip onto the ice surface, widely observed in previous studies). These results suggest a QLL thickness below 1 nm within the explored temperature range (−7 to −2 ∘C). This upper bound is significantly lower than most of the previous AFM results, which suggests that previous authors overestimate the equilibrium QLL thickness, due to temperature gradients, or indentation of ice during the jump-in. Additionally, we proved that the hydrophobicity of AFM tips affects significantly the results of the experiments. Overall, this work shows that, if one chooses the experimental conditions properly, the QLL thicknesses obtained by AFM lie over the lower bound of the highly disperse results reported in the literature. This allows estimating upper boundaries for the QLL thicknesses, which is relevant to validate QLL theories and to improve multiphase atmospheric chemistry models.Fil: Gelman Constantin, Julián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; ArgentinaFil: Gianetti, Melisa Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Longinotti, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Corti, Horacio Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentin
Cytogenetic and hematological spontaneous remission in a case of acute myelogenous leukemia. Eur J Haematol 2004: 73: 219–222. Blackwell Munksgaard 2004.
No full textCytogenetic and hematological spontaneous remission in a case of acute myelogenous leukemia.
Fozza C, Bellizzi S, Bonfigli S, Campus PM, Dore F, Longinotti M.
Source
Institute of Hematology, University of Sassari, Italy. [email protected]
Abstract
Several cases of spontaneous remission (SR) interrupting the invariably progressive course of untreated acute myeloblastic leukemia (AML) have been reported so far. We shall add to this series the hematological and cytogenetic SR occurring in a 72-yr-old man affected by AML following myelodysplastic syndrome. At diagnosis cytogenetic analysis showed the 48, xy, del (6) (p22-pter), +13, +14 karyotype. Owing to a lobar pneumonia, the chemotherapy was deferred and a broad spectrum antibiotic therapy was established. Supportive care included red cells and platelet transfusions and low-dose corticosteroid. Two months later, after the pneumonia had completely disappeared, a complete remission, lasting about 5 months, was documented on bone marrow morphological and cytogenetical examination, although some degree of myeloid dysplasia persisted. Possible mechanisms of the various SRs described during the course of AML are discussed with a review of the literature.
Copyright Blackwell Munksgaard 2004
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