305,370 research outputs found
Is fludeoxyglucose-fluorodeoxyglucose-positron emission tomography/computed tomography ( 18 F-FDG-PET/CT) really useless in staging pulmonary carcinoid tumors and in discriminating histological subtypes? Controversial points and future perspectives
No full textLa FDG-PET è molto limitata nella stadiazione linfonodale dei carcinoidi polmonar
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A bicenter study on adjuvant surgery following treatment with tyrosine kinase inhibitors in patients with advanced lung adenocarcinoma
No full textOBJECTIVES A small number of patients with advanced pulmonary adenocarcinomas treated with tyrosine kinase inhibitors (TKIs) was subsequently considered eligible for surgery. Our goal was to report the clinical characteristics, pathological features and prognosis of these patients with the aim of exploring the feasibility of this strategy of care. METHODS We retrospectively reviewed the medical files of 19 patients in whom systemic treatment, including TKIs, resulted in a possible stabilization of the disease such that they were considered eligible for surgery (adjuvant surgery). RESULTS Lobectomy, pneumonectomy or segmentectomy was performed in 68.4%, 26.3% and 5.3% of cases, respectively. Limited fibrotic tissues were detected intraoperatively in 8 patients who received TKIs as the sole systemic treatment. The postoperative course in the hospital was uneventful in 13 (68.4%) cases; 3 (15.8%) patients suffered major complications. The post-pneumonectomy early morbidity rate was 60%. A pathological analysis of the tumours showed that the median rate of fibrosis was 32.5% (0-100); of viable neoplastic tissue, 25.0% (0-90); and of necrosis, 12.5% (0-80%). Four tumours (21.1%) exhibited no viable tumour cells. The fibrosis ratio was higher in patients older than 60 years (P = 0.01) and in those treated with erlotinib (P = 0.03). The 3- and 5-year overall survival and disease-free survival rates were 79.5%/39.8% and 44.4%/29.6%, respectively. Pneumonectomy and <50% fibrosis or >30% viable tumour cells in the pathological specimens were factors significantly associated with lower disease-free survival. CONCLUSIONS In a subset of highly selected patients, adjuvant lung surgery following treatment with TKI showed a large spectrum of histological changes in the pathological specimens and encouraging preliminary survival results. Pending further research, it may prove a relatively reliable and safe therapeutic choice, except when an extensive resection like a pneumonectomy is planned
Severe breathing and swallowing difficulties during routine restorative dentistry
No full textUna donna di 57 anni si sottoponeva ad trattamento odontoiatrico per una carie del secondo molare superiore di destra. Durante la visita odontoiatrica veniva utilizzato uno strumento ad aria compressa, secondo lo standard di cura. Improvvisamente, la paziente accusava deglutizione e difficoltà respiratorie ed un notevole gonfiore del viso che coinvolgeva il collo e parzialmente il volto. La paziente veniva pertanto trasportata d’urgenza al Pronto Soccorso con il sospetto di reazione allergica. L’esame clinico rivelava un crepitio palpabile a livello dei tessuti sottocutanei del volto, del collo e della regione pre- sternale senza però rilevare nessun segno di infiammazione, trisma o raccolta di liquidi. Una radiografia del torace prima ed una tomografia computerizzata successivamente confermavano la presenza d’aria nei tessuti molli delle regioni profonde dagli spazi peri-mandibolare e retro-mandibolari e nella zona sub-mascellare e latero –cervicale estendendosi lungo il solco vascolare e nello spazio retrofaringeo discendente fino a livello del mediastino. La paziente veniva quindi sottoposta ad osservazione clinica e monitoraggio respiratorio, e si cominciava la somministrazione endovenosa di antibiotici ad ampio spettro ed analgesici. Il successivo decorso ospedaliero risultava regolare e la paziente veniva dimessa in 5° giornata di ricovero dopo miglioramento del quadro clinico e radiologico. Tre mesi dopo la dimissione, la paziente risultava in buone condizioni cliniche in assenza di recidiva. Come risulta nel caso sopra riportato, l’enfisema sottocutaneo e lo pneumomediastino, sebbene raramente possono essere legati ad alcune manovre odontoiatriche che utilizzano sistemi ad immissione di aria ad alta pressione. Nonostante l’esordio acuto ed la sintomatologia spesso allarmante (al punto da poter essere erroneamente scambiata per una reazione allergica), si tratta di una condizione benigna e sostanzialmente ad auto-risoluzione pur necessitando di un breve periodo di osservazione clinica e profilassi antibiotica.UNLABELLED: Although sporadically reported after dental examination, subcutaneous emphysema may be erroneously confused with an allergic, or anaphylactic, reaction. We herein report a case of a 57-year-old Caucasian woman who came to our attention after restorative treatment for a carious mandibular right second primary molar. During dental examination, an air driven hand-piece was used to restore occlusal caries. Suddenly, swallowing and breathing difficulties and a facial swelling involving the neck and, partially, the face occurred. She was urgently transported to the Emergency Department with the suspicious of allergic reaction. Clinical examination revealed palpable crepitus at the level of the head, neck and pre-sternal region but no inflammation, trismus or fluid collection was detected. A Chest X-ray first and a computed tomography scan later showed air in the deeper regions from the peri-mandibular and retro-mandibular spaces to the sub-maxillary and latero-cervical area along the vascular sulcus and retropharyngeal space descending into the mediastinal space. So, the patient was admitted for respiratory monitoring and started intravenous administration of largespectrum antibiotics and analgesics. Her hospital course was unremarkable and 5 days later she was discharged after regression of symptoms and complete radiological resolution. Three months after discharge, the patient was clinically free of recurrence.KEY WORDS: Dental care, Pneumomediastinum, Restorative dentistry
Pulmonary metastases in a patient with an aggressive infiltrative basal cell carcinoma of the scalp
No full textN/
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
Get PDFThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
68Ga-DOTATOC PET/CT imaging in solitary fibrous tumor of the Pleura
No full textHere we describe a 77-year-old man with a solitary fibrous tumor of the pleura showing increasing tracer uptake at 68Ga-DOTATOC PET/CT, demonstrating that solitary fibrous tumor of the pleura may overexpress so-matostatin receptors, therefore mimicking neuroendocrine tumors at somatostatin receptor PET/CT
Endobronchial Hamartoma Subtotally Occluding the Right Main Bronchus and Mimicking Bronchial Carcinoid Tumor
No full textHamartomas are very rarely identified as an endobronchial lesion. Herein, we describe a peculiar case of a 55-year-old woman with persistent cough and increasing dyspnea and radiological detection of a solid lesion subtotally occluding the main right bronchus. Despite the radiological and radiometabolic (18-fluoro-2-deoxy-d-glucose positron emission tomography/computer tomography scan) features were highly suspected for bronchial carcinoid, the definitive diagnosis after endoscopic removal was indicative of an endobronchial hamartoma. When considering differential diagnosis of an endobronchial lesion, the physicians should take firmly in mind such rare entity and, accordingly, bronchoscopy and bronchoscopic biopsy should be done as first step in management of all cases presenting with endobronchial lesions
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