2,426 research outputs found
Supplemental Material, ESI - Peptide-coated palladium nanoparticle for highly sensitive bioanalysis of trypsin in human urine samples
No full textSupplemental Material, ESI for Peptide-coated palladium nanoparticle for highly sensitive bioanalysis of trypsin in human urine samples by Guohua Zhou, Huimin Jiang, Yanfang Zhou, Peilian Liu, Yongmei Jia, and Cui Ye in Nanomaterials and Nanotechnology</p
On First-Order Definability and Computability of Progression for Local-Effect Actions and Beyond
No full textIn a seminal paper, Lin and Reiter introduced the
notion of progression for basic action theories in
the situation calculus. Unfortunately, progression is
not first-order definable in general. Recently, Vassos,
Lakemeyer, and Levesque showed that in case
actions have only local effects, progression is firstorder
representable. However, they could show
computability of the first-order representation only
for a restricted class. Also, their proofs were quite
involved. In this paper, we present a result stronger
than theirs that for local-effect actions, progression
is always first-order definable and computable. We
give a very simple proof for this via the concept
of forgetting. We also show first-order definability
and computability results for a class of knowledge
bases and actions with non-local effects. Moreover,
for a certain class of local-effect actions and
knowledge bases for representing disjunctive information,
we show that progression is not only firstorder
definable but also efficiently computable
Decentralization, Democracy, and Development : Recent Experience from Sierra Leone
No full textIn 2004, the government of Sierra Leone
opted for a rethink of its national governance arrangement
by embarking on the resuscitation of democratically elected
local government after 32 years experimenting with central
government appointed district and municipal governments. The
decision by the government and the people of Sierra Leone
was driven by a primary consideration to address the
country's seeming nonperformance in the areas of
citizens' participation in governance and responding to
the needs of citizens as it relates to attainment of the
Millennium Development Goals (MDGs) as well as ensuring
poverty reduction in the country. This book is a
retrospective of the decentralization reform process in
Sierra Leone from 2003-07. During this period, the
Government of Sierra Leone (GoSL) reestablished elected
district and urban councils across the country, transferred
certain responsibilities for primary services and local
investment and some financial resources to the new councils,
and invested heavily in building the administrative
infrastructure and capacity of the local councils. The
author is partners who were intimately involved in the
reform. Through recording various aspects of the process and
reflecting on the observations and learning during that
time, the author hope to contribute to the debates on the
merits and risks of decentralization in general and its
desirability and viability in post-conflict countries
Supplementary_Data_1 - Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for <i>GNG4</i> and <i>KCNQ2</i> Genes
No full textSupplementary_Data_1 for Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes by Luke W. Bonham, Daniel S. Evans, Yongmei Liu, Steven R. Cummings, Kristine Yaffe, and Jennifer S. Yokoyama in American Journal of Alzheimer’s Disease & Other Dementias</p
Supplemental_Figure_1 - Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for <i>GNG4</i> and <i>KCNQ2</i> Genes
No full textSupplemental_Figure_1 for Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes by Luke W. Bonham, Daniel S. Evans, Yongmei Liu, Steven R. Cummings, Kristine Yaffe, and Jennifer S. Yokoyama in American Journal of Alzheimer’s Disease & Other Dementias</p
Marker Controlled Superpixel Nuclei Segmentation and Automatic Counting on Immunohistochemistry Staining Images
No full textsj-pdf-1-msj-10.1177_13524585211032800 – Supplemental material for Structural and functional hippocampal alterations in Multiple sclerosis and neuromyelitis optica spectrum disorder
No full textSupplemental material, sj-pdf-1-msj-10.1177_13524585211032800 for Structural and functional hippocampal alterations in Multiple sclerosis and neuromyelitis optica spectrum disorder by Fenglian Zheng, Yuxin Li, Zhizheng Zhuo, Yunyun Duan, Guanmei Cao, Decai Tian, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Haiqing Li, Yongmei Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Xuemei Han, Sven Hallar, Frederik Barkhof and Yaou Liu in Multiple Sclerosis Journal</p
Recyclable three-dimensional Ag nanoparticle-decorated TiO2 nanorod arrays for surface-enhanced Raman scattering
No full textGenetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
No full textThe QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD
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