1,362,833 research outputs found
Emil G. Linke Papers, 1900-1930
No full textThe Emil G. Linke Papers document a rural Cass County, North Dakota building contractor and carpenter during the first two decades of the twentieth century. The business ledgers document in good detail Linke?s building projects and those employed by him, together with costs and wages paid. The complimenting architectural drawings document only a portion of all his contractor work, but give a view into the building trends during this time period in North Dakota
Titin Gene and Protein Functions in Passive and Active Muscle
No full text The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein titin, which is a scaffolding filament, signaling platform, and provider of passive tension and elasticity in myocytes. This review summarizes recent insight into the mechanisms behind how titin gene mutations cause hereditary cardiomyopathy and how titin protein is mechanically active in skeletal and cardiac myocytes. A main theme is the evolving role of titin as a modulator of contraction. Topics include strain-sensing via titin in the sarcomeric A-band as the basis for length-dependent activation, titin elastic recoil and refolding of titin domains as an energy source, and Ca2+-dependent stiffening of titin stretched during eccentric muscle contractions. Findings suggest that titin stiffness is a principal regulator of the contractile behavior of striated muscle. Physiological or pathological changes to titin stiffness therefore affect contractility. Taken together, titin emerges as a linker element between passive and active myocyte properties. </jats:p
BRIGEP - the BRIDGE-based genome-transcriptome-proteome browser
No full textGoesmann A, Linke B, Bartels D, et al. BRIGEP - the BRIDGE-based genome-transcriptome-proteome browser. Nucleic Acids Research. 2005;33(Web Server):W710-W716.The growing amount of information resulting from the increasing number of publicly available genomes and experimental results thereof necessitates the development of comprehensive systems for data processing and analysis. In this paper, we describe the current state and latest developments of our BRIGEP bioinformatics software system consisting of three web-based applications: GenDB, EMMA and ProDB. These applications facilitate the processing and analysis of bacterial genome, transcriptome and proteome data and are actively used by numerous international groups. We are currently in the process of extensively interconnecting these applications. BRIGEP was developed in the Bioinformatics Resource Facility of the Center for Biotechnology at Bielefeld University and is freely available. A demo project with sample data and access to all three tools is available at https://www.cebitec.uni-bielefeld.de/groups/brf/software/brigep/. Code bundles for these and other tools developed in our group are accessible on our FTP server at ftp.cebitec.uni-bielefeld.de/pub/software/
[Hilda Linke, Bernice Linke, and Leo Linke standing in front of Linke home]
No full textPhotograph (copy) of a man and woman standing on either side of a young bride. Written on back of photograph in pencil: "Bernice Linke's Wedding Day" April 15, 1950 In front of Linke House on FM 762 (L to R) Hilda Linke, Bernice Linke, Leo Linke". Hilda is wearing a dark cap sleeve dress with v- neckline. The dress is belted at the waist and has large fabric covered buttons from left of waist to thigh. She is wearing a dark hat. Bernice is wearing a long, white wedding dress with tiers of lace, and she has a white tulle veil. She is holding a bouquet. Leo is wearing a light colored suit, white shirt, and light colored tie. He has a boutonni�re on his left lapel. The three are standing outdoors in front of a white wooden house; vining plant on right
Historische Semiotik des Leibes in der Kommunikation: Zur Dynamisierung von Körper und Sprache im ausgehenden 17. und im 18. Jahrhundert
No full textDie Wahrnehmung menschlicher Kommunikation ist historisch geprägt; entsprechend veränderlich sind die Normen und Werte, an denen kommunikatives Verhalten zu unterschiedlichen Zeiten gemessen wird. So führt die „Entdeckung“ der Multimodalität menschlicher Kommunikation in der gegenwärtigen Gesprächsforschung und die damit verbundene neue Aufmerksamkeit auf die Zeichenhaftigkeit des Körpers wie auf die Dimension des Raumes zu einem neuen Verständnis von Kommunikation und zu einer veränderten Beurteilung sprachlicher Phänomene.
Doch schon in frühmoderner Zeit war der gesellschaftliche Blick auf den kommunizierenden Menschen in einer für heutige Maßstäbe bemerkenswerten Weise auf die „Beredsamkeit des Leibes“ (Kemp 1975, S. 111) gerichtet. Sprachlichkeit wird als an Leiblichkeit gebunden wahrgenommen, als Teil eines komplexen, raumbezogenen kommunikativen Auftritts, der ständisch geregelt und normiert ist. Dies gilt für das 17. und auf weite Strecken auch noch für das 18. Jahrhundert – erst das bürgerliche Sprachprojekt löst in der Wahrnehmung die Sprache zunehmend vom Leib.
Vom 17. ins 18. Jahrhundert hinein lassen sich allerdings Veränderungen im Beschreibungsvokabular für den körperlich-sprachlichen Auftritt beobachten, und in Text- wie Bildzeugnissen zeigt sich ein Wandel in diesem Auftritt bzw. im Blick der Zeitgenossen darauf. Diese Veränderungen werden im Folgenden als (kollektiv) stilistischer Wandel beschrieben und der Zeichenwert dieses Wandels wird als ,Verschlankung‘ und ,Dynamisierung‘ bestimmt. Und insofern diese (kollektiv) stilistischen Veränderungen als Medium der Selbstformierung der tragenden Sozialformation der Zeit, d.h. der Adelsgesellschaft um 1800, verstanden werden, wird der beobachtete Stilwandel als Prozess der Selbst-Dynamisierung der gesellschaftlichen Leitformation der Epoche gedeutet
Learning from Lilo Linke: Unearthing Her Authentic Autobiographies for an Emancipatory Pedagogy
No full textThis essay uncovers the once known but now obscure writer Lilo Linke (1906–63), her autobiographies based on her lived experiences, and her work for social justice across the geographies through which she journeyed. The author believes that it is necessary to excavate Linke's life to know what authentic authorship is and to read it as an emancipatory pedagogy of a life lived purposefully. © 2017 The Autobiography Society
[Nelson Linke and Bernice Linke at the Albert Eben house]
No full textPhotograph (copy) of a young man and a young lady. They are identified as Nelson Linke and Bernice Linke. Written on back of photo in pencil: "Nelson Linke, Bernice Linke circa (1943) wearing Richmond H. S. football jacket Taken at Albert Eben house on FM 762 (Next house South of Linke's house)". In this outdoor full length photograph, Bernice is wearing a dark knee length pleated skirt, sweater, and pearls around the rounded neckline of her sweater. Nelson is wearing dark colored slacks, white shirt, and jacket with an "R" on the left just below shoulder. Foliage in the background forms an arch with view of a white house in distance
Emerging importance of oxidative stress in regulating striated muscle elasticity
No full textThe contractile function of striated muscle cells is altered by oxidative/nitrosative stress, which can be observed under physiological conditions but also in diseases like heart failure or muscular dystrophy. Oxidative stress causes oxidative modifications of myofilament proteins and can impair myocyte contractility. Recent evidence also suggests an important effect of oxidative stress on muscle elasticity and passive stiffness via modifications of the giant protein titin. In this review we provide a short overview of known oxidative modifications in thin and thick filament proteins and then discuss in more detail those oxidative stress-related modifications altering titin stiffness directly or indirectly. Direct modifications of titin include reversible disulfide bonding within the cardiac-specific N2-Bus domain, which increases titin stiffness, and reversible S-glutathionylation of cryptic cysteines in immunoglobulin-like domains, which only takes place after the domains have unfolded and which reduces titin stiffness in cardiac and skeletal muscle. Indirect effects of oxidative stress on titin can occur via reversible modifications of protein kinase signalling pathways (especially the NO-cGMP-PKG axis), which alter the phosphorylation level of certain disordered titin domains and thereby modulate titin stiffness. Oxidative stress also activates proteases such as matrix-metalloproteinase-2 and (indirectly via increasing the intracellular calcium level) calpain-1, both of which cleave titin to irreversibly reduce titin-based stiffness. Although some of these mechanisms require confirmation in the in vivo setting, there is evidence that oxidative stress-related modifications of titin are relevant in the context of biomarker design and represent potential targets for therapeutic intervention in some forms of muscle and heart disease
[Bernice Linke and Albert Lee Linke]
No full textPhotograph of a young woman and a boy. Written on back of photo in pencil: "Bernice Linke Albert Lee Linke (younger cousin) (1943) In front of house on FM 762". In this full length outdoor photograph, Bernice is wearing a cap sleeve print dress with belted waist. She has her hand on the back of Albert. Albert is wearing long pants, suspenders, and short sleeved button up shirt (comb (?) in pocket). Foliage in background surrounds a brick and wooden support post of a porch; wooden structure on ground at left
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