61,622 research outputs found
Designing role-based view for object-relational databases
No full textIn a federated database system, a view mechanism is crucial since it is used to define exportable subsets of data ; to perform a virtual restructuring d ataset; and to construct the integrated schema. The view service in federated databa se systems must be capable of retaining as much semantic information as possible. The object-oriented ( 0 - 0 ) model was considered the suitable canonical data model since it meets the original criteria for canonical model selection. However, with the emergence of stronger object-relational (0 -R ) model, the re is a clear argument for using an 0 - R canonical model in the federation. Hence, research should now focus on th e development of semantically powerful view mechanism for th e newer model. Meanwhile, the availability of real 0 -R technologies offers researchers the opportunity to develop different forms of view mechanisms.
The concept of roles has been widely studied in 0 - 0 modelling and development. The role model represents some characteristics that the traditional 0-0 model lacked, such as object migration, multiple occurrences and context-dependent access. While many forms of 0-0 views were designed for the 0-0 canonical model, one option was to extend the 0-0 model to incorporate a role model. In a role model, the real entity is modelled in the form of a role rather than an object. An object represents the permanent properties of an entity is a root object; and an object represents the temporary properties of an entity is a role object.
The contribution of this research is to design a view system that employees the concept of roles for the 0 -R canonical model in a federated database system. In this thesis, an examination of the current 0 -R metamodel is provided first in order to provide an environment for recognising the roleview metadata and measuring the view performance; then a Roleview Definition Language (RDL) is introduced, along with the semantics for defining virtual classes and generating virtua l extents; finally, a working prototype is provided to prove th e role-based view system is implementable and the syntax is semantically correct
Aportaciones ling\ufc\uedsticas al problema del g\ue9nero del evangelio de Marcos
No full textEl g\ue9nero del evan-
gelio de Marcos sigue siendo un
problema abierto con varias solu-
ciones propuestas, pero est\ue1 lejos
de encontrar un consenso. Este
art\uedculo presenta la importancia
de tener en cuenta el estudio sobre
los g\ue9neros literarios realizados
por la ling\ufc\uedstica en la actualidad,
despu\ue9s del estancamiento de los
estudios literarios sobre los mis
-
mos. Estas perspectivas ling\ufc\uedsti-
cas sobre el g\ue9nero se aplican al
evangelio de Marcos para destacar
la importancia de la intenci\uf3n del
mismo, la comunidad discursiva, su
cosmovisi\uf3n, etc., como elementos
privilegiados para comprender su
g\ue9nero. Marcos encuentra en los
libros de la LXX su referente m\ue1s
cercano en relaci\uf3n a su dialecto,
registro, vocabulario, intenci\uf3n y
cosmovisi\uf3
Centrifuge modeling of earth-reinforced retaining walls
No full textThis paper is on the centrifuge modeling of reinforced soil retaining walls with modular blocks facing. The influence of design parameters, such as length and vertical spacing of reinforcement, on the behaviour of the structure was
investigated. A total of 11 models were tested, each one with different length of reinforcement or spacing. Each model was constructed and then placed in the centrifuge in order to increase gravitational acceleration up to 35 g, reproducing the
soil behaviour of a 5-m high wall. Vertical and horizontal displacements were recorded by means of a laser profiler which enabled tracking of deformations in the structure along its longitudinal cross section, essentially drawing its deformed
shape.
As expected, the results confirmed reinforcement parameters to be the governing factor in the behaviour of reinforced soil structures since increasing length and reducing spacing improved structural stability. However, the influence
of the length was found to be the leading factor that reduced facial deformations up to five times, and the spacing playing an important role especially in unstable configurations. The failure surface was characterised by the same shape (circular)
and depth, regardless of the reinforcement configuration. Furthermore, the results confirmed the over- conservatism of design codes, since models with reinforcement layers 0.3H long showed almost negligible deformations. The test results may be used to set up further numerical modeling in order to investigate on other issues, such as the influence of the reinforcement stiffness and varying backfill
Application of Ling Zhi-8 (rLZ-8) and polysaccharide (PS-G) from Ganoderma lucidum as immunomodulators for alleviation of airway inflammation in mite-induced murine model of asthma
No full text靈芝(Ganoderma Lucidum) 為一種在中國及其他亞洲國家中被廣為使用的古老漢方中藥。Ling Zhi-8 (LZ-8)為從靈芝中純化出的蛋白分子，研究發現其具有免疫調節功能。另外，多醣體(PS-G)為靈芝的另一生物活性物質。目前發現其免疫調節功能包括促進抗原呈現細胞功能、加強單核球細胞吞噬功能、提高體液性免疫力及細胞性免疫力。 氣喘為目前世界上最普遍發生的過敏性疾病，約有數百萬的兒童及成人面臨此種疾病。過敏性氣喘通常伴隨有呼吸到過度反應、嗜酸性白血球在肺部的浸潤、呼吸道黏液分泌過多等症狀。家塵螨Dermatophagoides pteronyssinus 第二群過敏原 (Der p2)為主要過敏原。因此綜合先前的研究，我們期望rLZ-8及PS-G免疫調節功能將可作為治療過敏性疾病的一個方法。此研究中，我們給予樹突細胞rLZ-8及PS-G刺激，發現rLZ-8及PS-G可以增加IL-12p40之產生，並且促進樹突細胞成熟表現CD86, CD83, and MHC Ⅱ分子。此外rLZ-8及PS-G刺激後的樹突細胞與T細胞共同培養，可以增加T細胞增生能力及產生IFN-γ及IL-4。在中和反應實驗中發現，給予TLR-4抗體可以明顯抑制樹突細胞分泌IL-12p40，顯示IL-12p40的訊息傳導是經由TLR-4路徑。更進一步地，我們利用家塵螨誘導小鼠氣喘模式來研究rLZ-8及PS-G的免疫調節能力。實驗一，小鼠致敏後連續鼻腔給予rLZ-8及PS-G研究其治療效果。實驗二，致敏時混合抗原與rLZ-8或PS-G同時給予小鼠研究其預防效果，小鼠犧牲後同樣分析呼吸道阻力、肺功能、第一型輔助型T細胞激素及第二型輔助型T細胞激素及rDer p2專一性抗體。我們的研究發現，rLZ-8及PS-G在體外實驗確實可以促進樹突細胞的成熟與活化，顯示這兩個分子具有免疫調節能力。動物實驗結果顯示，rLZ-8及PS-G可抑制呼吸道阻力產生及血清的IgE。PS-G可減少肺沖洗液及胰臟細胞IL-4和IL-5之產生，而rLZ-8可減少肺沖洗液IL-5產生。因此rLZ-8及PS-G可改善氣喘的徵狀，但其作用機制則需要更進一步地釐清。Ganoderma Lucidum, a China herb, has been widely used in China and other Asian countries. G. Lucidum has been reported to be effective in modulating immune functions. Ling Zhi-8 (LZ-8) is a protein derived from the fungus Ganoderma lucidum and the polysaccharide from Ganoderma Lucidum (PS-G) is a branched (1 → 6)-β-D-glucan moiety. Asthma is one of the most prevalent chronic airway inflammatory diseases in the world. The house dust mite, Dermatophagoides pteronyssinus (Der p), is the major allergen, and is the dominant species collected in Taiwan. Therefore, we like to investigate whether rLZ-8 and PS-G might exert a regulatory role in the treatment of allergic diseases. In this study, we first investigated the immunomodulatory effects of rLZ-8 and PS-G on BMDCs. The result showed that rLZ-8 and PS-G enhanced the expression of cell surface markers including CD86, CD83, and MHC Ⅱ, as well as the enhanced production of IL-12 p40 and IL-10. In addition, rLZ-8 or PS-G-treated BMDCs could promote T cell proliferation capacity, and increased T cell secretion of IFN-y. In animal Experiment Ⅰ, immunized female BALB/c mice were consistently intranasally received rLZ-8 and PS-G for treatment. In Experiment Ⅱ, mice were immunized (i.p.) injection of rDer p2 admixed with rLZ-8 or PS-G for investigating the preventive effect. Further, airway hyperresponsiveness, pulmonary function, TH1/TH2 cytokine production, and immunoglobulin levels will be followed. In conclusion, we demonstrated that rLZ-8 and PS-G effectively promoted the activation and maturation of immature BMDCs, suggesting that rLZ-8 and PS-G may possess a potential effect in regulating immune responses. In vivo result showed that both rLZ-8 and PS-G reduced airway hyperresponsiveness and serum IgE level. Moreover, PS-G could decrease the level of IL-4, IL-5 in BALF and splenocyte. rLZ-8 reduced IL-5 level in BALF. Although rLZ-8 and PS-G could modulate the response of asthma, the effect of these two molecules should be clarified in the future.封面
口試委員審定書
授權書
誌謝…………………………………………………………………..Ⅰ
中文摘要……………………………………………………………..Ⅲ
Abstract…………………………………………………………...IV
Contents…………………………………………………………………ⅥContents of Figures……………………………………………ⅧChapter Ⅰ. General Introduction……………………………………………… 1
1. Characterization of asthma…………………………………………. 2
2. The role of dendritic cells (DCs) and interleukin (IL)-12…………...8
3. Characterization of Der p2 allergen………………………………….9
4. Ganoderma (G.) lucidum………………………………….………...11
5. Aims of the study…………….…………………………….………..12
Chapter Ⅱ. Materials and Methods………..…………………………………...15
1. Reagents…..………………………….……………………...…...…16
2. Generation of recombinant Der p2 (rDer p2) protein..……..………19
3. Purification of rLZ-8 protein…..……………………………..…….23
4. Purification of fusion protein rDer p2-rLZ-8 ………………...……24
Chapter Ⅲ. Result of rDer p2 protein purification and rDer p2-rLZ8
fusion protein expression………….……………………………………………28
1. Expression of rDer p2 protein in yeast…..…………………….…29
2. Small-scale expression of rDer p2-rLZ8 fusion protein in yeast…29
Chapter Ⅳ. Investigate the effect of rLZ-8 and PS-G in vitro study…………31
1. Experimental propose …………………………………………….32
2. Materials and methods…………...………………………………..32
3. Result of in vitro study……………………………………………37
Chapter Ⅴ. Evaluate the effect of rLZ-8 and PS-G in vivo study…...........…41
1. Experimental propose…..………………………….…..………....42
2. Materials and methods…..………………………….………….....43
3. Result of in vivo Experiment Ⅰand Ⅱ.......………………….…..51
Chapter Ⅵ. Disscussion…………………………………………………...……56
Figures…………………………………………………………………..……….63
References………………………………………………………………..……...9
Designes for Ling Gang-Tianjin
No full textIL TESTO APPROFONDISCE IL TEMA DELLA FORMA DELLE NUOVE CITTA' ATTRAVERSO L'APPROFONDIMENTO DI UN PROGETTO PER LA FASCIA COSTIERA DELLA CITTA' DI LING GANG-TIANJI
Performance Analysis of M/G/1 Queue with Capacity C
No full text[[abstract]]In contrast to the conventional queueing system assuming a server can serve custom at a given time, an alternative queueing system in which a server is assumed to be able to serve customs concurrently is proposed in this thesis. In practical applications, the central processor unit with multi-task capacity is a good example of the proposed system. We call this system a queueing system with capacity . This thesis deals with the mathematical analysis of the M/G/1 queue with capacity , with focus on the derivation of mean waiting time for a given set of parameters. In addition, we use the M/M/1 queue to do numerical computation so as to evaluate the impacts of arrival rate and service rate on the mean waiting time and system?s stability
G. M. Hopkins
No full text[sound recording] / Brendan O'Grady. G. B. Shaw by Fran Frazer.; 1 sound cassette (60 minutes); Broadcast on CFCY Radio, Charlottetown, March 07 & 11, 1974.; G. B. ShawSource type: Electronic(1
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
The M&G Drive
No full textabstract: The M&G Drive is a proposed venture project lead by Barrett seniors, Elijah Smith and Jenna Fitzgerald. This project aims to educate Arizona State University (ASU) students on the issues of food insecurity around the Phoenix valley and facilitate their involvement in helping alleviate this pressing social matter. Scientific research has shown significant inverse relationships between food insecurity and the following: mental and physical health, social skills, and academic achievement. As the largest public university in the nation, Arizona State holds a self-ascribed responsibility for the health of its communities. In order to address this issue on behalf of Arizona State and from the standpoint of college students, this proposed venture will encourage the ASU student population to reallocate their unused M&G Dollars (ASU’s on-campus currency) to go toward this cause. Rather than being absorbed back by the university system, unused M&G Dollars can instead be used to purchase non-perishables that will then be donated to the local Phoenix community in order to help fight against food insecurity
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