1,099 research outputs found
Touching Freud's dog: H.D.'s tactile poetics
No full text"Do not touch me", Frau Emmy warns Freud in 1889. "Do not touch", Freud echoes in 1933. This time, he is referring to his pet chow, Yofi, warning H.D. that "she snaps - she is very difficult with strangers". Examining the prohibition in light of work by Jacques Derrida and Jean-Luc Nancy, this article charts the withdrawal that always interrupts touch. Despite Freud's taboo, however, H.D.'s writing seeks to make contact in strange and unnerving ways. Developing Julia Kristeva's account of the semiotic, this paper proposes a literature of touch. Reading H.D.'s poems, alongside Tribute to Freud, and her letters, the author demonstrates that H.D.'s poetics are always haunted by the very (im)possibility of contact
Lin-ni's problem for mean convex domains
No full textInternational audienceWe prove some refined asymptotic estimates for postive blowing up solutions to ∆u+u = n(n−2)u n+2 n−2 on Ω, ∂ν u = 0 on ∂Ω; Ω being a smooth bounded domain of R n , n ≥ 3. In particular, we show that concentration can occur only on boundary points with nonpositive mean curvature when n = 3 or n ≥ 7. As a direct consequence, we prove the validity of the Lin-Ni's conjecture in dimension n = 3 and n ≥ 7 for mean convex domains and with bounded energy. Recent examples by Wang-Wei-Yan [32] show that the bound on the energy is a necessary condition. Frédéric Robert dedicates this work to Clémence Climaqu
The theory of justice in Nancy Fraser
No full textDesde las diferentes interpretaciones sobre de la justica en la contemporaneidad, pretende este escrito evidenciar la pertinencia de los postulados de Nancy Fraser en la concepción de lo justo. Téngase claro que la aspiración no es proponer un nuevo concepto de justicia, sino reescribir la propuesta de la justicia de nuestra autora para acentuar su importancia en las distintas perspectivas de la justicia actual. De este modo, se evidencia en este trabajo investigativo que la justicia redistributiva, de reconocimiento y representativa como nos lo plantea la autora, es eje trasversal en nuestra cotidianeidad y fundamento de la estructura social. Así, el problema de esta investigación versó sobre ¿cuál es la pertinencia de la propuesta postsocialista de Nancy Fraser en la concepción de la justicia social contemporánea? Y se desarrolló con la metodología crítica reconstructiva, que consiste en la reconstrucción conceptual del mundo de la vida a partir de la comprensión hermenéutica de las intuiciones práctico-morales. Estos saberes reconstructivos, los denomina Habermas como aquellos en los cuales la explicación teórica del objeto exige reproducir conceptualmente su génesis dentro de las experiencias vitales del sujeto. Ahora bien, las concepciones de la justicia contemporánea requieren superarse en cuanto a sus limitaciones metafísicas enmarcadas en los debates filosóficos de corte rawlsiano, que dejan de lado problemáticas fundamentales en torno al reconocimiento, la redistribución, y por ende, la justicia social, reiteradas en las situaciones de inequidad y discriminación de los constructos sociales. Por ello, se hace necesario acudir al redireccionamiento metodológico que propone Nancy Fraser para el estudio de la justicia, a partir de las tres categorías desde la cuales la autora define la justicia, a saber: redistribución, representación y reconocimiento. Con ellas concibe la lucha que se convierte cada día en el paradigma del conflicto político. De manera que, dicha tríada problemática estructura las reivindicaciones políticas actuales: la redistribución en la esfera económica, el reconocimiento en el ámbito socio-cultural y la representación en lo político.From the different interpretations of justice in contemporaneity, this writing intends to show the relevance of Nancy Fraser's postulates in the conception of fairness. Be clear that the aspiration is not to propose a new concept of justice, but to rewrite the proposal of justice of our author to emphasize its importance in the different perspectives of current justice. In this way, it is evidenced in this investigative work that redistributive, recognition and representative justice, as the author proposes, is a transversal axis in our daily lives and the foundation of the social structure. Thus, the problem of this research was about what is the relevance of Nancy Fraser's post-socialist proposal in the conception of contemporary social justice? And it was developed with the critical reconstructive methodology, which consists of the conceptual reconstruction of the world of life from the hermeneutical understanding of practical-moral intuitions. These reconstructive knowledges, Habermas calls them as those in which the theoretical explanation of the object requires conceptually reproducing its genesis within the life experiences of the subject. However, the conceptions of contemporary justice require overcoming their metaphysical limitations framed in the Rawlsian philosophical debates, which leave aside fundamental problems around recognition, redistribution, and therefore, social justice, reiterated in situations of inequity and discrimination of social constructs. Therefore, it is necessary to resort to the methodological redirection that Nancy Fraser proposes for the study of justice, based on the three categories from which the author defines justice, namely: redistribution, representation and recognition. With them he conceives the struggle that every day becomes the paradigm of political conflict. Thus, this problematic triad structures the current political demands: redistribution in the economic sphere, recognition in the socio-cultural sphere and representation in the political sphere
Modification of Loop 1 Affects the Nucleotide Binding Properties of Myo1c, the Adaptation Motor in the Inner Ear
No full textMyo1c is one of eight members of the mammalian myosin I family of actin-associated molecular motors. In stereocilia of the hair cells in the inner ear, Myo1c presumably serves as the adaptation motor, which regulates the opening and closing of transduction channels. Although there is conservation of sequence and structure among all myosins in the N-terminal motor domain, which contains the nucleotide- and actin-binding sites, some differences include the length and composition of surface loops, including loop 1, which lies near the nucleotide-binding domain. To investigate the role of loop 1, we expressed in insect cells mutants of a truncated form of Myo1c, Myo1c1IQ, as well as chimeras of Myo1c1IQ with the analogous loop from other myosins. We found that replacement of the charged residues in loop 1 with alanines or the whole loop with a series of alanines did not alter the ATPase activity, transient kinetics properties, or Ca2+ sensitivity of Myo1c1IQ. Substitution of loop 1 with that of the corresponding region from tonic smooth muscle myosin II (Myo1c1IQ-tonic) or replacement with a single glycine (Myo1c1IQ-G) accelerated the release of ADP from A.M 2?3-fold in Ca2+, whereas substitution with loop 1 from phasic muscle myosin II (Myo1c1IQ-phasic) accelerated the release of ADP 35-fold. Motility assays with chimeras containing a single ?-helix, or SAH, domain showed that Myo1cSAH-tonic translocated actin in vitro twice as fast as Myo1cSAH-WT and 3-fold faster than Myo1cSAH-G. The studies show that changes induced in Myo1c via modification of loop 1 showed no resemblance to the behavior of the loop donor myosins or to the changes previously observed with similar Myo1b chimeras
sj-docx-1-tam-10.1177_17588359221113269 – Supplemental material for Early on-treatment transcriptional profiling as a tool for improving pathological response prediction in HER2-positive inflammatory breast cancer
No full textSupplemental material, sj-docx-1-tam-10.1177_17588359221113269 for Early on-treatment transcriptional profiling as a tool for improving pathological response prediction in HER2-positive inflammatory breast cancer by Sonia Pernas, Jennifer L. Guerriero, Sergey Naumenko, Shom Goel, Meredith M. Regan, Jiani Hu, Beth T. Harrison, Filipa Lynce, Nancy U. Lin, Ann Partridge, Aki Morikawa, John Hutchinson, Elizabeth A. Mittendorf, Artem Sokolov and Beth Overmoyer in Therapeutic Advances in Medical Oncology</p
Application of electromagnetic-bandgap structures to power distribution network design
No full textThis thesis provides a detailed literature review and an original pattern design example of the application of an electromagnetic bandgap structure which suppresses the simultaneous switching noise in a power distribution network. By accommodating a metalized periodic pattern on either power or ground plane, the performance of multilayer digital circuit boards can be enhanced with minimized electromagnetic interference. Both numerical and analytical validation are demonstrated to show the effectiveness of the new pattern implementation.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2021-12-01The student, Yixuan Nancy Zhao, accepted the attached license on 2019-11-08 at 15:37.The student, Yixuan Nancy Zhao, submitted this Thesis for approval on 2019-11-08 at 15:45.This Thesis was approved for publication on 2019-11-11 at 14:16.DSpace SAF Submission Ingestion Package generated from Vireo submission #14535 on 2020-02-28 at 17:21:59Made available in DSpace on 2020-03-02T22:12:16Z (GMT). No. of bitstreams: 2
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Previous issue date: 2019-11-11Embargo set by: Seth Robbins for item 113880
Lift date: 2022-03-02T22:12:26Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 113880
Lift date: 2022-03-02T22:15:21Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 113880
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Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 113880 on 2022-03-03T10:15:16Z
Les capteurs à ondes élastiques de surface (applications pour la mesure des basses pressions et des hautes températures)
No full textLa thèse traite des capteurs à ondes élastiques de surface (SAW) et plus particulièrement de leur application pour la mesure des basses pressions et des hautes températures. Le premier chapitre est consacré à l histoire des dispositifs SAW, depuis 1965. Les principes de fonctionnement des capteurs SAW sont décrits, ainsi que leurs avantages concurrentiels. La seconde partie du document concerne les outils théoriques utilisés pour la modélisation des ondes élastiques et pour la prévision de leur sensibilité aux perturbations. Des formules pour le calcul de la sensibilité à la déformation ou à la variation de température sont démontrées. Les approches de Nalamwar/Epstein et Tiersten sont toutes deux présentées pour le calcul de l effet des déformations. La troisième partie de la thèse est consacrée à l étude théorique et expérimentale d un nouveau concept de capteur SAW de pression (proposé par l auteur), pour la mesure précise du vide primaire et secondaire. Les résultats expérimentaux confirment l ensemble des prévisions théoriques. Cette innovation a été brevetée fin 2006. Un design ultime de type MEMS est proposé pour maximiser les performances du capteur. Enfin, la dernière partie du document traite des capteurs SAW wireless passifs comme une solution prometteuse pour la mesure des hautes températures. La problématique des matériaux est abordée, ainsi que celle du calcul du TCD pour des structures bicouche. L effet du champ de déformations généré par la dilatation thermique différente des couches est pris en compte pour améliorer la précision du calcul théorique du TCD. Cette approche est étayée par des résultats théoriques et expérimentaux.The thesis deals with the application of SAW sensors for low pressure and high temperature measurements. The first chapter is devoted to the history of SAW devices, from 1965. The principles of SAW sensors are described, as well as their industrial and economical potentials. The second part is devoted to the theoretical tools, used to model the basic properties of elastic waves as well as their sensitivity to external disturbances. Formulas for calculating the sensitivity of devices under strain or temperature changes are inferred. The approaches of Nalamwar/Epstein and Tiersten to take into account the effect of strain fields are both presented. The third part is devoted to the study of a new SAW pressure sensor concept (suggested by the author), for the accurate measurement of primary and secondary vacuum. The experimental results confirm the theoretically predicted sensor parameters: measuring range, sensitivity, precision and response time. A patent is pending for this innovation. A more efficient MEMS-type design is elaborated to maximize the level of performances. Finally, the thesis deals with wireless passive SAW sensor as a very promising solution for measurement at high temperature. The issue of materials is discussed, as well as the classical way to calculate the Temperature Coefficient of Delay (TCD) for multilayered structures. The effect of the strain field induced in the SAW structure by the differential thermal expansion of the different layers is taken into account to improve the accuracy of TCD calculations. This original theoretical approach is supported by experimental and theoretical results.NANCY1-Bib. numérique (543959902) / SudocSudocFranceF
Education policy networks in a comparative perspective: Germany, Switzerland, Great Britain and New Zealand
No full textInternational initiatives in education, such as PISA and the Bologna Process, have distinctly changed conditions framing domestic policy-making. This paper sheds light on the territorial and modal dispersion of national education policy networks by means of a systematic network analytical description. The focus is on changing patterns of interactions and coalitions between international and national as well as private and public actors. Therefore, we analyse four countries, i.e. Germany, Switzerland, Great Britain and New Zealand, in a comparative perspective. The findings show that in most countries there is indeed an internationalization of education politics taking place in the sense of an increasing participation of international actors. These actors apply a more and more diversified portfolio of governance instruments. At the same time, however, domestic veto players develop a rich set of strategies to cope, compete or collaborate with international actors. -- Internationale Initiativen, wie z.B. der Bologna Prozess oder die PISA-Studien, haben die Rahmenbedingungen nationaler Bildungspolitik grundlegend verändert. In diesem Arbeitspapier wird die Internationalisierung von Bildungspolitik aus netzwerkanalytischer Perspektive beleuchtet. Ziel ist es, den Wandel von Formen politischer Interaktion und Koalitionen zwischen internationalen und nationalen sowie privaten und öffentlichen Akteuren zu beschreiben. Dazu werden Politiknetzwerke in vier Ländern - Deutschland, Schweiz, Großbritannien und Neuseeland - vergleichend analysiert. Anhand der Befunde lässt sich eine Internationalisierung des Politikfelds Bildung erkennen, d.h. internationale Akteure treten im Kontext nationaler politischer Interaktion zunehmend in Erscheinung. Gleichzeitig zeigt sich, dass auch nationale Vetospieler Strategien entwickeln, um dieser neuen Konstellation in der Bildungspolitik zu begegnen.
Impact of Prior Authorization on Patient Access to Cancer Care
No full textPrior authorization (PA) is a type of utilization review that health insurers apply to control service delivery, payments, and reimbursements of health interventions. The original stated intent of PA was to ensure high-quality standards in treatment delivery while encouraging evidence-based and cost-effective therapeutic choices. However, as currently implemented in clinical practice, PA has been shown to affect the health workforce, adding administrative burden to authorize needed health interventions for patients and often requiring time-consuming peer-to-peer reviews to challenge initial denials. PA is presently required for a wide range of interventions, including supportive care medicines and other essential cancer care interventions. Patients who are denied coverage are commonly forced to receive second-choice options, including less effective or less tolerable options, or are exposed to financial toxicity because of substantial out-of-pocket expenditures, affecting patient-centric outcomes. The development of tools informed by national clinical guidelines to identify standard-of-care interventions for patients with specific cancer diagnoses and the implementation of evidence-based clinical pathways as part of quality improvement efforts of cancer centers have improved patient outcomes and may serve to establish new payment models for health insurers, thereby also reducing administrative burden and delays. The definition of a set of essential interventions and guidelines- or pathways-driven decisions could facilitate reimbursement decisions and thus reduce the need for PAs. Structural changes in how PA is applied and implemented, including a redefinition of its real need, are needed to optimize patient-centric outcomes and support high-quality care of patients with cancer
Topological Similarity of Protein Interaction Network and its Correlation with Gene Expression Profiles
No full text在不同物種之基因體中搜尋功能性基因及鑑定其性質(Protein annotation)是後基因體時代一個具挑戰性的工作。因此開發功能有效的生物資訊方法，以鑑定蛋白質功能是生命科學研究重要的一環。目前已有許多方法利用已有的基因序列(Sequences)、基因表現圖譜(Gene expression profiles)、或蛋白質相互作用數據(Protein interaction)來鑑定未知蛋白質的功能。在此，我們提供一個新觀念，即蛋白質若在蛋白質交互作用的網路拓樸圖譜(Topological map)具有相似度，則它們可能擁有功能類似性。我們提出方法評估蛋白質作用網路中任何蛋白質的拓樸類似度，以找出兩個蛋白質相互作用網路與整體基因表現之相關係數。
爲了量度在這個基因相互作用網路的兩個蛋白質類似度，我們提供了兩個新方法。第一種是最直接相互作用之鄰近蛋白質比較(First neighbor comparison)，另一種為拓樸近似法(Topological similarity)。第一種是用來比較這兩種蛋白質與任何第三蛋白質作用圖譜，並根據Pearson correlation coefficients計算相關係數。拓樸近似法分數的計算是根據圖形理論(Graph theory)中兩個圖形頂點的相似度。這些方法能夠給予我們蛋白質互相作用網路的每對蛋白質的一個數目，不管有相互作用或沒有，並且能給予統計評估加權。爲了找出蛋白質相互作用網路與基因表現圖譜之間的關係，我們蒐集大量能夠公開取得的基因微陣列(Microarray)數據，並根據Pearson、Spearman、與Kendall計算表現圖譜而取得每對基因之相關係數。這個相關係數可認為是一種對每對基因表現圖譜的相似度之測量。利用矩陣代表蛋白質相互作用和基因表現圖譜的相似度，我們結合運用矩陣代數和統計方法以獲得蛋白質相互作用網路與基因表現圖譜之間的相關係數。這樣的方法已應用在大腸桿菌、酵母菌、及胃幽門桿菌上。
本實驗結果也顯示蛋白質相互作用網路與基因表現圖譜之間具有正相關性。由這些研究顯示拓樸相似度能夠反應蛋白質之間的相關性。這個嶄新的研究方法在基因體的功能鑑定和蛋白質家族的分類可能提供重要的貢獻。Search of functional genes among the whole genome and their annotation is one of the most challenging problems in the post-genomic era. In this context, development of meaningful bioinformatics methods of assigning protein functions is important in the study of life science. Many approaches are available for assigning putative functions to un-annotated proteins using information from sequences, gene expression profiles, or protein-protein interaction data. Herein, we propose that the proteins with similar topological map in a protein interaction network may share similar biological functions and demonstrate methods of measuring the topological similarity between two proteins in the entire network and their correlation with gene expression profiles.
In order to measure the topological similarity between two proteins in an interaction network, we propose two scoring methods, one is called first neighbor comparison and the other is topological similarity score. The first neighbor comparison method is to compare the interacting profile of two proteins with any other third protein and calculate their Pearson correlation coefficient. The topological similarity score is calculated based on a measure of similarity between graph vertices in graph theory. These methods are able to provide us with a numerical value to each pair of proteins in the network, whether interactive or not, assigning statistical evaluation weights to them. In order to find the correlation between protein interaction network and gene expression profiles, we have collected a large amount of publicly accessible gene expression microarray data and calculated the correlation coefficients of expression profiles between all pairs of genes based on Pearson, Spearman, and Kendall methods. The correlation coefficients of gene expression profiles are regarded as a measure of the expression similarity between a pair of genes. With the matrices representing the topological similarity of protein interaction and the gene expression similarity between each pair of genes and their corresponding proteins, both matrix algebra and statistical methods are combined to obtain the correlation coefficient between gene expression profiles and protein-protein interactions within the proteomes of Escherichia coli, yeast, and Helicobacter pylori.
Our results reveal a strong positive relationship between the topological similarity scores of protein interaction networks and the correlation coefficients of gene expression profiles. This indicates that the topological similarity can reflect the functional association between proteins. There are some important applications of this novel approach when used in function annotation of genomes and clustering of protein families.Table of Contents
中文摘要………………………………………………………………………..V
English Abstract…………………………………………………………………VII
Chapter 1: Introduction 1
1.1 Protein Interaction Network 2
1.2 Gene Expression Profiles 3
1.3 Topological Similarity of Protein Interaction 4
1.4 Organization 5
Chapter 2: Materials 6
2.1 Protein Interaction Network 7
2.2 Gene Expression Profiles 7
2.3 Protein Function/Gene Annotation 8
Chapter 3: Analysis 9
3.1 Implementation of Graph 11
3.2 Protein Interaction Network 12
3.3 Gene Expression Profiles 12
3.4 First Neighbors Comparison 12
3.4.1 Pearson Correlation Coefficients 13
3.4.2 Spearman Correlation Coefficients 13
3.4.3 Kendall Correlation Coefficients 13
3.5 Construction of Matrices 14
3.5.1 Removal of the non-interactive nodes 14
3.5.2 Taking the absolute values of correlation coefficients 14
3.5.3 Removal of all the diagonal elements of matrices 15
3.5.4 Taking the logarithm of unevenly distributed topological similarity scores of proteins 15
3.5.5 Taking the average 15
3.6 First Neighbors Comparison 16
3.7 Topological Similarity Scores 16
3.7.1 Derivation of topological similarity scores from the generalization of hub and authority scores 18
3.8 Matrices Comparison 21
3.9 Hierarchical Clustering 21
3.9.1 Hierarchical clustering based on gene expression profiles 21
3.9.2 Hierarchical clustering based on topological similarity scores 21
Chapter 4: Results 23
4.1 Yeast 24
4.2 Escherichia coli 36
4.3 Helicobacter pylori 42
Chapter 5: Discussions 48
5.1 Comparison of different methods of calculating correlation coefficients 49
5.2 Topological similarity scores 50
5.3 Topological similarity scores and first neighbors comparison 50
5.4 Hierarchical clustering 51
5.5 Unsatisfactory results of H. pylori 51
Chapter 6: Conclusions and Future Perspectives 53
References 5
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