137,576 research outputs found
A comment on "Intergenerational equity: sup, inf, lim sup, and lim inf"
No full textWe reexamine the analysis of Chambers (Social Choice and Welfare, 2009), that produces a characterization of a family of social welfare functions in the context of intergenerational equity: namely, those that coincide with either the sup, inf, lim sup, or lim inf rule. Reinforcement, ordinal covariance, and monotonicity jointly identify such class of rules. We show that the addition of a suitable axiom to this three properties permits to characterize each particular rule. A discussion of the respective distinctive properties is provided.Social welfare function; Intergenerational equity; Lim sup ; Lim inf
Four and a half LIM protein 1C (FHL1C)
No full textFour-and-a-half LIM domain protein 1 isoform A (FHL1A) is predominantly expressed in skeletal and cardiac muscle. Mutations in the FHL1 gene are causative for several types of hereditary myopathies including X-linked myopathy with postural muscle atrophy (XMPMA). We here studied myoblasts from XMPMA patients. We found that functional FHL1A protein is completely absent in patient myoblasts. In parallel, expression of FHL1C is either unaffected or increased. Furthermore, a decreased proliferation rate of XMPMA myoblasts compared to controls was observed but an increased number of XMPMA myoblasts was found in the G(0)/G(1) phase. Furthermore, low expression of K(v1.5), a voltage-gated potassium channel known to alter myoblast proliferation during the G(1) phase and to control repolarization of action potential, was detected. In order to substantiate a possible relation between K(v1.5) and FHL1C, a pull-down assay was performed. A physical and direct interaction of both proteins was observed in vitro. In addition, confocal microscopy revealed substantial colocalization of FHL1C and K(v1.5) within atrial cells, supporting a possible interaction between both proteins in vivo. Two-electrode voltage clamp experiments demonstrated that coexpression of K(v1.5) with FHL1C in Xenopus laevis oocytes markedly reduced K(+) currents when compared to oocytes expressing K(v1.5) only. We here present the first evidence on a biological relevance of FHL1C
Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development
No full textThe crucial involvement of CLIM/NLI/Ldb cofactors for the exertion of the biological activity of LIM homeodomain transcription factors (LIM-HD) has been demonstrated. In this paper we show that CLIM cofactors are widely expressed during zebrafish development with high protein levels in specific neuronal cell types where LIM-HD proteins of the Isl class are synthesized. The overexpression of a dominant-negative CLIM molecule (DN-CLIM) that contains the LIM interaction domain (LID) during early developmental stages of zebrafish embryos results in an impairment of eye and midbrain-hindbrain boundary (MHB) development and disturbances in the formation of the anterior midline. On a cellular level we show that the outgrowth of peripheral but not central axons from Rohon Beard (RB) and trigeminal sensory neurons is inhibited by DN-CLIM overexpression. We demonstrate a further critical role of CLIM cofactors for axonal outgrowth of motor neurons. Additionally, DN-CLIM overexpression causes an increase of Isl-protein expression levels in specific neuronal cell types, likely due to a protection of the DN-CLIM/LIM-HD complex from proteasomal degradation. Our results demonstrate multiple roles of the CLIM cofactor family for the development of entire organs, axonal outgrowth of specific neurons and protein expression levels
Il Gradus as Parnassum di Fedele Fenaroli
No full textIllustrates the structure and goals of the treatise Regole e partimenti by Fedele Fenarol
Elektron ta‟lim resurslari to„g„risida asosiytushunshalar: Elektron ta‟lim resurslari to„g„risida asosiytushunshalar
No full textTa‗lim islohotlarining zamonaviy bosqichi jamiyatda yuz berayotgan yangilanishlarning tezkorligi, ta‗limmuassalariga qo‗yilayotgan yangi, yanada yuqori talablarga tezroq moslashish bilan bog‗lik dolzarbvazifalarni ilgari surmoqda. Bunday sharoitlarda ta‗lim muassasasini rivojlantirish va zamon talabdarajasida faoliyat ko‗rsatishini ta‗minlashga qaratilgan tadbirlar salmog‗i uzluksizortib boradi.Ta‗lim muassasasining elektron axborot ta‗lim resurslarini yaratish sof texnikmasala bo‗lib qolmasdan,balki buning uchun muassasaning ilmiy -metodik, tashkiliy va pedagogik imkoniyatlarini tizimli yondashuv asosida ishga solish talabetiladi
G-protein-coupled receptor signaling to phospholipase D1 mediated by G 12-type G proteins, LIM-kinase and cofilin
No full textThe M3 muscarinic acetylcholine receptor (mAChR), a typical G protein-coupled receptor, expressed in HEK-293 cells stimulates phospholipase D in a pertussis toxin (PTX)-insensitive manner and the PLD response to the M3 mAChR requires ARF and Rho GTPases and the Rho-activated Rho-kinase. However, Rho-kinase did not phosphorylate PLD enzymes directly, suggesting additional components mediate the PLD regulation by Rho/Rho-kinase. In this thesis, first, by transient expression of a-subunits of the PTX-resistant G proteins, Gq, G12 and G13 (wild-type, constitutively active and dominant-negative mutants), evidence is provided that the M3 mAChR specifically couples to PLC via Gaq and to PLD via the G12-type G proteins, Ga12 and Ga13, which are apparently both required for full PLD stimulation. These data were confirmed by expression (transient or by infection with recombinant adenoviruses) of RGS4 or Lsc-RGS, which act as specific GTPase-activating proteins for Gaq- and Ga12-type G proteins, respectively. Second, the expression of catalytically inactive PLD1 reduced specifically PLD stimulation by M3 mAChR, whereas its counterpart of PLD2 inhibited only PLD stimulation by PKC and EGF, suggesting that the G protein-coupled receptors signals primarily to PLD1, whereas the tyrosine kinase receptors signal via PKC to PLD2. Third, expression of wild-type and constitutively active LIM-kinase, a Rho-kinase effector, potentiated PLD stimulation by the M3 mAChR, whereas kinase-deficient LIM-kinase had the opposite effect. Purified recombinant LIM-kinase stimulated PLD activity in cell membranes, similar as but not additive with activated RhoA or Rho-kinase. In addition, PLD stimulation by constitutively active LIM-kinase, but not by wild-type LIM-kinase, was resistant to inactivation of Rho and Rho-kinase, whereas PLD stimulation by constitutively active Rho-kinase was fully abolished by kinase-deficient LIM-kinase. Furthermore, LIM-kinase neither directly interacts with nor phosphorylates PLD enzymes, suggesting that some undefined component is involved in PLD regulation by Rho-kinase/LIM-kinase. We found that expression of wild-type cofilin, an actin depolymerization factor (LIM-kinase substrate) potentiated PLD stimulation by the M3 mAChR, whereas the nonphosphorylatable cofilin mutant, S3A cofilin, reduced the receptor response. And this PLD stimulation by cofilin was suppressed by inactivation of Rho or Rho-kinase. In vitro, cofilin protein, but not its S3A mutant, specifically interacts with PLD1 and strongly increases the activity of PLD1 upon phosphorylation by LIM-kinase. In addition, expression of wild-type cofilin, but not S3A cofilin, specifically redistributed PLD1 to the plasma membrane. Taken together, we demonstrated that stimulation of PLD by G protein-coupled receptors, known to involve ARF and Rho GTPases and the Rho-activated Rho-kinase, is mediated specifically by heterotrimeric G proteins of the G12-subtype (Ga12 and Ga13), the Rho-kinase effector, LIM-kinase, and the LIM-kinase substrate, cofilin, which apparently in its phosphorylated form interacts with and stimulates PLD1 activity
Goniozus koreanus Lim, sp. nov.
No full textGoniozus koreanus Lim, sp. nov. (Figs 17–24) Type material. Holotype, Ƥ. KOREA: CN: Mangilsa, Daesan, Daesan, Seosan, N 36 ° 56 ' 29.8 " E 126 ° 26 ' 85.1 ", Alt. 184 m, 20.v. 2006, S.W. Park leg. (SNU). Paratypes. KOREA: Seoul: Ƥ, Cheongyangri, Dongdaemun, MT, 25.vii– 1.viii. 2005, D.P. Lyu leg. (KFRI); Ƥ, ditto, 15–22.viii. 2005, D.P. Lyu leg. (KFRI); Ƥ, Mt. Surak, Sanggye, Nowon, MT, 18.vii– 24.viii. 2007, J. O. Lim leg. (SNU); Ƥ, Seoul National University campus, Daehak, Gwanak, 4.viii. 2008, J. O. Lim leg. (SNU); Ƥ, Mt. Bulam, Gongreung, Nowon, MT, 11–25.v. 2008, S.W. Park leg. (SNU). GG: Ƥ, Yongin, 21.v. 1989, S.B. Han leg. (SNU); Ƥ, Mt. Yeogi, Seodun, Gwonseon, Suwon, 16.iv. 1994, J. Y. Choi leg. (SNU); Ƥ, Mt. Cheonggae, Gwacheon, 22.ix. 2000, H. G. Kang leg. (SNU); Ƥ, Yeongjusa, Annyeong, Taean, Hwaseong, MT, 22–29.viii. 2005, Y.D. Kwon leg. (KFRI); 2 Ƥ, ditto, 5 – 2.ix. 2005, Y.D. Kwon leg. (KFRI); 2 Ƥ, ditto, 12–20.ix. 2005, Y.D. Kwon leg. (KFRI); Ƥ, Sihwado, Namyangju, MT, N 37 ° 40 ' 6 " E 127 ° 18 ' 39 ", Alt. 238 m, 27.v. 2007, S.W. Park leg. (SNU); Ƥ, Gwanak arboretum, Anyang, Manan, Anyang, MT, 26.vi– 4.vii. 2007, J. O. Lim leg. (SNU); Ƥ, ditto, MT, N 37 ° 25 ' 15.6 " E 126 ° 56 ' 44.3 ", Alt. 126 m, 18.iv– 2.v. 2008, J. O. Lim leg. (SNU); Ƥ, Suwon arboretum, Seodun, Gwonseon, Suwon, 1.vi. 2009, J. O. Lim leg. (SNU); Ƥ, Mt. Ungil, Songchon, Choam, Namyangju, MT, N 37 ° 34 ' 43.3 " E 127 ° 18 ' 37.5 ", Alt. 134 m, 18–31.iv. 2009, J. O. Lim leg. (SNU); Ƥ, ditto, MT, 1–26.v. 2009, J. O. Lim leg. (SNU); Ƥ, ditto, MT, 27.v– 10.vi. 2009, J. O. Lim leg. (SNU); Ƥ, Mt. Homyeong, Goseong, Cheongpyeong, Gapyeong, MT, N 37 ° 43 '15.0" E 127 ° 29 ' 18.9 ", Alt. 168 m, 18–31.iv. 2009, J. O. Lim leg. (SNU); 2 Ƥ, ditto, MT, 1–6.v. 2009, J. O. Lim leg. (SNU). GW: Ƥ, Jinae, Dong, Chuncheon, MT, 16–22.viii. 2005, S.J. Jang leg. (KFRI); Ƥ, ditto, MT, 31.vii– 7.viii. 2008, S.J. Jang leg. (KFRI); Ƥ, Jukheon, Gangreung, N 37 ° 46 ' 55 " E 128 ° 51 ' 35 ", Alt. 57 m, 29.v. 2009, S.W. Park leg. (SNU); Ƥ, Chundang, Cheongil, Hoengseong, N 37 ° 36 ' 36 " E 128 ° 8 ' 36 ", Alt. 249 m, 7.vi. 2009, S.W. Park leg. (SNU). CB: Ƥ, Mt. Wolak, Susan, Jecheon, MT, N 36 ° 52 ' 4 " E 128 ° 8 ' 57 ", 1.ix. 2006, J. C. Jeong leg. (SNU); Ƥ, Namdaemun, Hoenam, Boeun, N 36 ° 26 ' 27 " E 127 ° 34 ' 25 ", Alt. 104 m, 24.ix. 2009, S.W. Park leg. (SNU). CN: Ƥ, Donam, Banpo, Gongju, MT, 23–30.viii. 2005, J.H. Han leg. (KFRI); 2 Ƥ, Gahak, Songak, Dangjin, N 36 ° 55 ' 17.5 " E 126 ° 42 ' 33 ", Alt. 34 m, 19.v. 2006, S.W. Park leg. (SNU); Ƥ, Baekja, Susin, Cheonan, 6.vi. 2008, S.W. Park leg. (SNU); 2 Ƥ, Annyeong, Tancheon, Gongju, 24.v. 2009, S.W. Park leg. (SNU); Ƥ, Hwaam, Cheongra, Boryeong, 14.vi. 2009, S.W. Park leg. (SNU); Ƥ, Hanseo Univ., Daegok, Haemi, Seosan, MT, N 36 ° 41 ' 30 " E 126 ° 34 ' 50 ", 11.vi– 8.vii. 2009, J.W. Lee leg. (YNU); Ƥ, Masan, Seocheon, 12.vi. 2010, S.W. Park leg. (SNU). Daejeon: 3 Ƥ, Wolpyeong, Seo, MT, 20.vi– 10.vii. 2008, J.W. Lee leg. (YNU). JB: Ƥ, Majeong, Bug, Jeongeub, MT, 19–26.vii. 2005, J.W. Park leg. (KFRI); Ƥ, ditto, 2–9.viii. 2005, J.W. Park leg. (KFRI); Ƥ, ditto, 30.viii– 6.ix. 2005, J.W. Park leg. (KFRI); Ƥ, Majeong, Bug, Jeongeub, MT, 19.iv– 8.v. 2007, J.W. Park leg. (KFRI); [JN] Ƥ, Pungsan, Dado, Naju, MT, 25.vii– 8.viii. 2005, S.B. Yu leg. (KFRI); Ƥ, ditto, 9–30.ix. 2005, S.B. Yu leg. (KFRI); 2 Ƥ, Pungsan, Dado, Naju, MT, 27.iv– 17.v. 2007, S.B. Yu leg. (KFRI); 2 Ƥ, ditto, 17.v– 7.vi. 2007, S.B. Yu leg. (KFRI); Ƥ, Mt. Naejang, Ssangung, Bukha, Jangseong, MT, N 35 ° 25 ' 31.6 " E 126 ° 51 ' 46.9 ", 13.v. 2007, J.W. Lee leg. (YNU); 2 Ƥ, Pungsan, Dado, Naju, MT, 26.v– 2.vi. 2008, S.B. Yu leg. (KFRI); Ƥ, Mt. Naejang, Sinseong, Bukha, Jangseong, N 35 ° 27 ' 17.9 " E 126 ° 50 ' 38.8 ", Alt. 161 m, 3.vii. 2009, J. O. Lim leg. (SNU). GB: Ƥ, Yeungnam Univ., Dae, Gyeongsan, MT, 30.iv– 7.v. 2007, J.W. Lee leg. (YNU); Ƥ, Namsa, Hyeongok, Kyeongju, MT, 30.vi– 14.vii. 2005, J.T. Mun leg. (KFRI); 2 Ƥ, Namsan, Gakbuk, Cheongdo, MT, N 35 ° 41 ' E 128 ° 35 ', 9–19.viii. 2007, J.W. Lee leg. (YNU); Ƥ, ditto, 15.x– 4.xi. 2007, J.W. Lee leg. (YNU); Ƥ, Yeongnam Univ., Dae, Gyeongsan, MT, 30.iv– 7.v. 2007, J.W. Lee leg. (YNU); Ƥ, ditto, MT, N 35 ° 58 ' E 128 ° 47 ', 12–21.vii. 2007, J.W. Lee leg. (YNU); Ƥ, Namsan, Gakbuk, Cheongdo, N 35 ° 41 ' E 128 ° 35 ' 23 ", 5.x– 2.xi. 2008, J. O. Lim leg. (SNU); Ƥ, Mt. Unmun, Cheongdo, MT, N 35 ° 38 ' 45 " E 128 ° 57 ' 33 ", 23.v. 2008, J.W. Lee leg. (YNU); Ƥ, ditto, MT, N 35 ° 38 ' 19 " E 128 ° 57 ' 40 ", 30.v– 16.vi. 2009, C. J. Kim leg. (YNU); Ƥ, Sangju campus, Gyeongbuk Univ., Gajang, Sangju, MT, 28.v– 4.vi. 2009, S.W. Park leg. (SNU). GN: Ƥ, Dapcheon, Ibanseong, Jinju, MT, 1–9.viii. 2005, B.G. Ahn leg. (KFRI). Busan: Ƥ, Daemadeung, Nakdonghagu, Myeongji, Gangseo, 22.viii. 2006, T. H. Kim leg. (SNU). JJ: Ƥ, Donggye, Jeju, MT, 27.vi– 18.vii. 2007, C. H. Shin leg. (KFRI). Diagnosis. This species is mostly similar to Goniozus japonicus Ashmead, 1904 by having mandible yellow; by fore wing without areolet; by flagellomere 3–5 longer than wide respectively; by propodeal disc with complete transverse carina; by ratio of head and propodeal disc. However, this species can be distinguished from G. japonicus by short antennal segments, by pedicel to flagellomere 2 less than 1.5 × as long as wide, by flagellomere 11 1.5 × as long as wide (long antennal segments, pedicel to flagellomere 2 longer than 2.0 × as long as wide, flagellomere 11 2.0 × as long as wide in G. japonicus); by median and submedian cell of fore wing with relatively denser hairs (very sparse hairs in G. japonicus). Description. FEMALE (holotype). Body length 4.1 mm. LFW 2.5 mm. Color. Head: mandible yellow, antenna yellow, from flagellomeres 6–11 pale castaenous. Mesosoma black; fore wing subhyaline, veins pale castaenous; legs yellow except coxa and femora dark castaenous, tarsal claw dark castaenous. Metasoma black except distal margin of terga 4–7 pale castaenous. Head (Figs 18–20): 1.0 × as long as wide, coriaceous; lateral margin convex, posterior margin straight, postero-lateral corner forming round angle in dorsal view; lateral surface smooth and polished. Mandible with four acute teeth. Clypeus well-developed, frontal angle right; fronto-clypeal median longitudinal carina developed, exceeding antennal socket. First antennal segment in ratio of 2.3: 1.0: 1.0: 1.1: 1.2 in length; from scape to flagellomere 3 and 11 2.0, 1.3, 1.2, 1.2, 1.3 and 1.6 × as long as wide, respectively. Frons and vertex coriaceous with sub-erect hairs and sparse moderate punctures, aparted from each other 2.0–3.0 × as wide as their maximum diameter. WF 1.1 × LE, WF 0.6 × WH. Compound eye 0.37 mm long without hairs. LE 1.8 × OOL, WF 1.7 × WOT. Frontal angle of ocellar triangle obtuse, POL 2.1 × AOL, OOL 0.8 × WOT. Vertex coriaceous without conspicuous long hairs. Mesosoma (Figs 21–23): Pronotum coriaceous, 0.4 × as long as wide with sparse hairs, antero-lateral corner obtuse. Mesoscutum coriaceous; notauli absent; parapsidal furrows thin and anteriorly divergent. Scutellum polish and coriaceous with sparse small punctures; scutellar pit elliptical, oblique and connected by 3.9 × as wide as their maximum diameter. Propodeal disc 0.6 × as long as wide, lateral and transverse carina complete; medial basal triangle smooth and polished, extending mid-length of disc, connected to transverse carina with thin longitudinal carina in areolate surface. Disc areolate-rugose; declivity coriaceous with complete marginal carina; lateral surface coriaceous. Fore wing without closed areolate; median and submedian cell with two rows of hairs; radial vein curved outward at apex with obtuse angle; pterostigma 0.29 mm long; metacarpo absent. Metasoma (Fig. 24): Tergite 1 smooth and polished without fine puncture and microreticulation. Terga 2–4 smooth and micoreticulation on anterior half with some hairs on dorso-lateral surface. Terga 5–7 microreticulate with sparse hairs on distal surface. MALE. Unknown. Distribution. Korea (Busan, CB, CN, Daejeon, GB, GG, GN, GW, JB, JJ, JN, Seoul).Published as part of Lim, Jongok & Lee, Seunghwan, 2012, Review of Goniozus Förster, 1856 (Hymenoptera: Bethylidae) of Korea, with descriptions of two new species, pp. 43-57 in Zootaxa 3414 on pages 49-51, DOI: 10.5281/zenodo.21079
Dataset for "Experimental investigation of scalar dispersion in indoor spaces"
No full textData supports: H.D. Lim, Timothy G. Foat, Simon T. Parker, Christina Vanderwel, Experimental investigation of scalar dispersion in indoor spaces, Building and Environment, 2024, 111167, ISSN 0360-1323,
https://doi.org/10.1016/j.buildenv.2024.111167
(https://www.sciencedirect.com/science/article/pii/S036013232400009X)
This dataset contains PIV-PLIF experimental data in the folder. Readme files are provided in the zip folder explaining the data fields and how to interpret them. The data files are in .mat format. </span
LA LAVAGNA INTERATTIVA MULTIMEDIALE (LIM) A SUPPORTO DEGLI STUDENTI DISLESSICI
No full textL'Università di Modena e Reggio Emilia offre pari opportunità di formazione a tutti gli studenti, compresi quelli con DSA. Gli strumenti adottati per favorire l'apprendimento di questi ultimi sono, innanzitutto, l'utilizzo di ausili dispensativi e la concessione di misure compensative. In particolare, tra i possibili ausili utilizzati per la didattica universitaria l'Ateneo di Modena e Reggio Emilia ha impiegato un numero consistente di Lavagne interattive Multimediali (LIM) all'interno di un progetto valutato positivamente dal MIUR. Scopo di tale progetto era quello di adottare una nuova serie di strumenti informatici che favorissero l'apprendimento di alunni con DSA
A characterization of graphs G with G ≈ K2(G)
No full textAbstractA graph G is called a D-graph if for every set of cliques of G whose pairwise intersections are nonempty there is a vertex of G common to all the cliques of the set. A D-graph G is called a D1-graph if it has the T1 property: for any two distinct vertices x and y of G, there exist cliques C and D of G such that x ∈ C but y ∉ C and y ∈ D but x ∉ D.Lim proved that if G is a D1-graph, then G ≅ K2(G). Motivated by this result of Lim, we ask the following question:Can one characterize those graphs G with G ≅ K2(G)?In this paper, we prove that in the class of D-graphs,G ≅ K2(G) if and only if G has the T1 property
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