358,376 research outputs found
Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development
No full textThe crucial involvement of CLIM/NLI/Ldb cofactors for the exertion of the biological activity of LIM homeodomain transcription factors (LIM-HD) has been demonstrated. In this paper we show that CLIM cofactors are widely expressed during zebrafish development with high protein levels in specific neuronal cell types where LIM-HD proteins of the Isl class are synthesized. The overexpression of a dominant-negative CLIM molecule (DN-CLIM) that contains the LIM interaction domain (LID) during early developmental stages of zebrafish embryos results in an impairment of eye and midbrain-hindbrain boundary (MHB) development and disturbances in the formation of the anterior midline. On a cellular level we show that the outgrowth of peripheral but not central axons from Rohon Beard (RB) and trigeminal sensory neurons is inhibited by DN-CLIM overexpression. We demonstrate a further critical role of CLIM cofactors for axonal outgrowth of motor neurons. Additionally, DN-CLIM overexpression causes an increase of Isl-protein expression levels in specific neuronal cell types, likely due to a protection of the DN-CLIM/LIM-HD complex from proteasomal degradation. Our results demonstrate multiple roles of the CLIM cofactor family for the development of entire organs, axonal outgrowth of specific neurons and protein expression levels
Scrittura e identità in Among the White Moon Faces di Shirley Geok-lin Lim
No full textIl testo si sofferma sull'analisi della problematica femminile, dell'articolazione dell'identità e del rapporto tra donne e scrittura nel testo intitolato "Among the White Moon Faces" dell'autrice Shirley Geok-lin Lim
LA LAVAGNA INTERATTIVA MULTIMEDIALE (LIM) A SUPPORTO DEGLI STUDENTI DISLESSICI
No full textL'Università di Modena e Reggio Emilia offre pari opportunità di formazione a tutti gli studenti, compresi quelli con DSA. Gli strumenti adottati per favorire l'apprendimento di questi ultimi sono, innanzitutto, l'utilizzo di ausili dispensativi e la concessione di misure compensative. In particolare, tra i possibili ausili utilizzati per la didattica universitaria l'Ateneo di Modena e Reggio Emilia ha impiegato un numero consistente di Lavagne interattive Multimediali (LIM) all'interno di un progetto valutato positivamente dal MIUR. Scopo di tale progetto era quello di adottare una nuova serie di strumenti informatici che favorissero l'apprendimento di alunni con DSA
Epanerchodus gangwonus Mikhaljova & Lim 2002
No full textEpanerchodus gangwonus Mikhaljova & Lim, 2002 Epanerchodus gangwonus Mikhaljova & Lim, 2002: 19 –21, 20: figs 1–8. Remarks. Originally described from Gangwon-do, South Korea (Mikhaljova & Lim, 2001), this species has since never been rediscovered. Distribution. South Korea.Published as part of M, E L E N A V., Va, I K H A L J O & Lim, Kil-Young, 2006, The millipede genus Epanerchodus Attems, 1901 in the Korean Peninsula, with a description of a new species (Diplopoda, Polydesmida, Polydesmidae), pp. 45-53 in Zootaxa 1350 on page 48, DOI: 10.5281/zenodo.17451
Strumenti di valutazione e progettazione delle attività con la LIM
No full textIl capitolo presenta le nuove forme di comunicazione introdotte dalla LIM e le organizzazioni didattiche innovative relative a progettazione e valutazione
Strumenti di valutazione e progettazione delle attività con la LIM
No full textIl capitolo presenta le nuove forme di comunicazione introdotte dalla LIM e le organizzazioni didattiche innovative relative a progettazione e valutazione
On Being Diasporic: an Interview with Shirley Geok-lin Lim
No full textIntervista commentata alla scrittrice Shirley Geok-lin Lim sul concetto di diaspora e identità
Four and a half LIM protein 1C (FHL1C)
No full textFour-and-a-half LIM domain protein 1 isoform A (FHL1A) is predominantly expressed in skeletal and cardiac muscle. Mutations in the FHL1 gene are causative for several types of hereditary myopathies including X-linked myopathy with postural muscle atrophy (XMPMA). We here studied myoblasts from XMPMA patients. We found that functional FHL1A protein is completely absent in patient myoblasts. In parallel, expression of FHL1C is either unaffected or increased. Furthermore, a decreased proliferation rate of XMPMA myoblasts compared to controls was observed but an increased number of XMPMA myoblasts was found in the G(0)/G(1) phase. Furthermore, low expression of K(v1.5), a voltage-gated potassium channel known to alter myoblast proliferation during the G(1) phase and to control repolarization of action potential, was detected. In order to substantiate a possible relation between K(v1.5) and FHL1C, a pull-down assay was performed. A physical and direct interaction of both proteins was observed in vitro. In addition, confocal microscopy revealed substantial colocalization of FHL1C and K(v1.5) within atrial cells, supporting a possible interaction between both proteins in vivo. Two-electrode voltage clamp experiments demonstrated that coexpression of K(v1.5) with FHL1C in Xenopus laevis oocytes markedly reduced K(+) currents when compared to oocytes expressing K(v1.5) only. We here present the first evidence on a biological relevance of FHL1C
Corelli ‘inedito’: composizioni dubbie o senza numero d’opera. Percorsi tra fonti, attribuzioni e fortuna della trasmissione
No full textThe study of Corelli’s compositions not included in his six printed collections is still at its beginnings. Fifty years after cataloguing Corelli’s works for the new critical edition, an examination of some of his sonatas considered to be doubtful reveals that there is an urgent need for rethinking both the classification criteria and the boundaries that have been established between the dubious compositions and the ones without opus number, at least as far as the oldest, most authentic sources are concerned. In this study, I present arguments to confirm authorship of some of Corelli’s unpublished works (e.g., Anh. 19 and Anh. 33), based in the first place on data gathered from the material transmission of the compositions under consideration. In addition, I propose a few basic premises to tackle the study of the large body of English sources, including some of the earliest manuscripts that contain unpublished Corelli sonatas that can be dated with some precision. These English sources offer, in addition to trio sonatas (including Corelli’s WoO 5), several ‘sonate a violino solo e basso’ not found on the continent: their attribution to Corelli seems in many cases to be correct, or at least plausible; in any case, it should be pondered seriously in light of the extensive musical exchanges between Rome and England
Lim colim versus colim lim. I
No full textWe study a model situation in which direct limit () and inverse
limit () do not commute, and offer some computations of their
"commutator".
The homology of a separable metrizable space has two well-known
approximants: ("\v{C}ech homology") and ("\v{C}ech homology
with compact supports"), which are not homology theories but are nevertheless
interesting as they are and applied to
homology of finite simplicial complexes. The homomorphism , which is a special case of the natural map
, need not be either injective (P. S.
Alexandrov, 1947) or surjective (E. F. Mishchenko, 1953), but its surjectivity
for locally compact remains an open problem. In the case we obtain an
affirmative solution of this problem.
For locally compact , the dual map in cohomology is
shown to be surjective and its kernel is computed, in terms of and a
new functor . The original map is surjective and
its kernel is computed when is a "coronated polyhedron", i.e. contains a
compactum whose complement is a polyhedron.Comment: 32 pages, 3 figures; v3: Updated reference
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