1,720,962 research outputs found
Pengaruh Pemberian Sari Kering Lidah Buaya (Aloe Vera L.) terhadap Profil Lipid Mencit Jantan (Mus Musculus) Strain DD Webster
No full textThe coronary heart disease in Indonesia seems recently increasing and one of the causes is atherosclerosis. Atherosclerosis is caused by fat which is consumed excessively in food, it can cause hyperlipidemia in the body. Aloe vera L. is one of the Indonesian traditional herbs with effect to decrease the lipid concentration in blood. The aim of this research is to reveal the influence of the treatment with dried Aloe vera L. m decreasing the blood lipid concentration. The method of this research was experimental method, namely as to study or reveal the influence of the treatment with dried Aloe vera L. in decreasing the blood lipid profile of mice with three groups of male mice winch had been made to undergo hyperlipidemia; group I as a control, for group II simvastatin were given, ior group III dried Aloe vera L, were given with dosage A, for group 3V dried Aloe vera L. were given with dosage B, and for group V dried Aloe vera L. were given with dosage C, namely equivalent dosage of 100 mg, 250 mg, and 500 mg for human beings.
The influence of the treatment for 14 days of the dried Aloe vera L. indicated the decreasing of the concentration of cholesterol with dosage A 49.67 mg/dl; with dosage B 32.67 mg/dJ and with dosage C 61,17 mg/dl. The influence of the treatment for 14 days of the dried A toe vera L. indicated the decreasing of the concentration of LDL-cholesterol with dosage A 3.S3 mg/dl, with dosage B 3.50 mg/dl, but on the other hand with dosage C indicated the increasing 2,00 mg/dL The influence of the treatment for 14 days of the dried Aloe vera, L. indicated the decreasing of the concentration of HDL-cholcsterol with dosage A 27.34 mg/dl; with dosage B 29,67 mg/dl and with dosage C 30,33 mg/dl. The influence of the treatment for 14 days dried Aloe vera L. indicated the decreasing the concentration of triglyceride with dosage A 137.33 mg'dl; wit it dosage B 127.17 mg/dl and with dosage C 148.67 mg/dh
The influence of the treatment for 28 days of the dried Aloe vera L.wiih do sage A 0.33 mg/dJ, with dosage B 10.67 mg/dl and with dosage C 6.67 mg/dl. The influence of the treatment for 2% days indicated the decreasing of the concentration of LDL-cholesterol with dosage A 0.33 mg/di, wth dosage B 9.17 mg/dl, and with dosage C 4.84 mg/dl. The influence of the treatment for 2S days indicated the decreasing of the concentration of HDL-cholesterol with dosage A 1.00 mg/dl, with dosage B 1-17 mg/dl, and with dosage C 1.67 mg/dl. The dreasing of the concentration of triglicerides with dosage B for 2B days indicated the decreasing as much as 2.00 mg/dl, with exception on the treatment as long as 28 days of the dried Aloe vera L. with dosage A indicated the increasing of the concentration of the triglyceride as much as 4 mg/dl and the treatment as long as 28 days of the dried Aloe vera L. with dosage C indicated the increasing of the concentration of the triglyceride as much as 6 mg/di. The results of the decreasing of the concentration of lipid profile with the treatment of the dried Aloe vera L. indicated that the activities were lower if compafred with the treatment with simvastatin.
The results of the research of the influence of the treatment as long as 14 days and 28 days of the dried Aloe vera L. with dosages A, B and C indicated the decreasing of the concentration of the lipid profiles of mice. The higher the dose and the longer the time of the treatment, so the lower the concentration of the lipid component would be.Penyakit jantung koroner di Indonesia pada akhir-akhir ini semakin meningkat dan salah satu penyebabnya adalah aterosklerosis. Aterosklerosis diakibatkan oleh lemak yang dikonsumsi dalam makanan secara berlebihan, di dalam tubuh dapat menyebabkan hiperlipidemia. Lidah buaya adalah salah satu tanaman obat tradisional di Indonesia yang mempunyai manfaat untuk menurunkan kadar lipid dalam darah. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian sari kering Lidah buaya (Aloe vera L.) untuk menurunkan komponen lipid darah. Metode penelitian ini adalah metode eksperimental yaitu untuk meneliti pengaruh pemberian sari kering lidah buaya {Aloe vera (L) Burm. F.) terhadap profil lipid mencit dengan liga perlakuan kelompok meneit jantan yang telah dibuai hiperiipidemia; kelompok l sebagai kontroL, kelompok II diberi simvastatin, kelompok Il( diberi sari kering Lidah buaya (Aloe vera L.) dosis A, kelompok tVdiberi sari kering Lidah buaya (Aloe vera L.) dosis B, dan kelompok V diberi sari kering Lidah buaya (Aloe vera L.) dosts C yaitu dosis yang setara dengan 100 mg, 250 mg, dan 500 mg pada manusia.
Pengaruh pemberian 14 hari terjadi penurunan kadar kolesterol dosis A 49,67 mg/dt, dosis B 32,67 mg/dL dan dosis C 61,17 ntg/dL Pengaruh pemberian 14 hari terjadi penurunan kadar kolesterol-LDI. dosis A 3,83 mg/dl; dosis B 3,50 mg/dl tetapi dosis C terjadi kenaikan 2,00 mg/dl. Pengaruh pemberian 14 hari terjadi penurunan kadar kolestcroI-HDL dosis A 27,34 mg/dl; dosis B 29,67 mg/dl dan dosis C 30,33 mg/dL Pengaruh pemberian 14 hari terjadi penurunan kadar trigliserida dosis A 137,33 mg/dl; dosis B 127,17 mg/dl dan dosis C 148,67 mg/dl.
Pengaruh pemberian 2S hari terjadi penurunan kadar kolesterol dosis A 0,33 mg/dl, dosis B 10,67 mg/dl, dan dosis C 6,67 mg/dl. Pengaruh pemberian 28 hari terjadi penurunan kadar kolesterot-LDL dosis A 0,33 mg/dl, dosis B 9,17 mg/dL dan dosis C 4,84 mg/dl. Pengaruh pemberian 28 hari terjadi penurunan kadar kolesterol-HDL dosis A 1,00 mg/dl, dosis B 1,17 mg/dl, dosis C 1,67 mg/dl. Penurunan trigliserida dengan pemberian dosis B selama 28 hari menunjukkan penurunan 2.00 mg/dL kecuali pada pemberian 2 S hari sari kering Lidah buaya dosis A terjadi kenaikan kadar trigliserida 4 mg/dl dan pada pemberian 28 hari sari kering Lidah buaya dosis C terjadi kenaikan kadar trigliserida 6 mg/dl. Hasil penurunan kadar profil lipid dengan pemberian sari kering Lidah buaya (Aloe vera L.) ini daya kerjanya lebih kecil dibandingkan dengan pemberian simvastatin.
Hasil penelitian menunjukkan bahwa pengaruh pemberian 14 hari dan 28 hari sari kering Lidah buaya dosis A, dosis B dan dosis C menunjukkan penurunan kadar profil lipid meneit. Semakin linggi dosis dan semakin lama pemberian maka kadar komponen lipid semakin menurun.104 HalamanTesis Magiste
Pengaruh Pemberian Jus Buah Pepaya (Carica Papaya l.) terhadap Kadar Kolesterol dan Tingkat Oksidasi Plasma Darah Tikus Putih Wistar Jantan Hiperkolesterolemik yang Diinduksi dengan Kuning Telur
No full textCardiovascular diseases is the most common cause of death in various countries. Etiology of cardiovascular diseases are atherosclerosis process in blood vessels that resulting disfuction of organ. Phatogenesis of atherosclerosis has been evidenced begins from oxidative stress on lipid plasma in blood which causes increasing malondialdehyde level in blood plasma which indicates oxidation level. Oxidative stess trigerring inflammatory reaction chain on the blood vessels walls which in turn atherosclerosis. There ware many method of treatment has been done to prevent and treating for atherosclerosis process,but the current methods are relatively expensive so that we need natural methods with the daily diet approach to prevent the atherosclerosis process. Papaya fruit (Carica papaya L.) is one of the famous fruit in Indonesia country and can be obtained in all area in Indonesia. It makes papaya fruit become a favourite fruit at home in Indonesian people. Papaya fruit contains vitamin C,vitamin E, fibers and plavanoid who belived can reduce cholesterol level and oxidative stess level in blood vessels.
In this research,reseacher try to prove effect of Papaya fruit (Carica papaya L.)juice to reducting cholesterol and oxidative stess level in blood plasma from male Wistar rats with measuring total cholesterol level and malondialdehyde level.
This research design is experimental research with pre and post with control grup design. 25 male Wistar rats have been grouped in 5 groups, there were negatif control grup, positif control grup, fist intervention group, second intervention group and third intervention group. To measuring the cholesterol total level we used enzimatically with electrochemical apherometric method and we measuring malodialdehyde level use TBARS method. Measuring result data have been processed by Repeted Anova test for normally distributed data and we used Friedman test for abnormally distributed data and than the data have been processed by Post Hoc test in SPSS.
Administration of egg yolk intervention for two weeks has been showen significant increas in total cholesterol level and malondialdehyde level in positif control grup, fist intervention group, second intervention group and third intervention group (p<0,05). Significant reduction has been shown from total cholesterol and malondialdehyde level after administratin of papaya fruit juice feeding on fist intervention group, second intervention group and third intervention group (p<0,05).
The research result has been shown that administration of papaya (Carica papaya L.) fruit juice has been able to reduced total cholesterol level and malondialdehyde level in male Wistar rats blood plasma.Penyakit kardiovaskular merupakan penyebab kematian terbanyak di berbagai negara. Etiologi penyakit kardiovaskular adalah terjadinya aterosklerosis pada pembuluh darah yang mengakibatkan gangguan fungsi pada organ yang diperdarahinya. Patogenesis terjadinya aterosklerosis telah dibuktikan didahului dengan terjadinya stres oksidatif pada lipid dimana peningkatannya dapat dilihat pada kadar malondialdehyde di dalam plasma darah yang menandakan tingkat oksidasi, stres oksidatif ini memicu terjadinya reaksi inflamasi yang berantai pada dinding pembuluh darah yang lama kelamaan menyebabkan ateroskerosis. Banyak metode pengobatan yang dilakukan sebagai usaha preventif dan kuratif untuk mencegah terjadinya proses aterosklerosis namun pengobatan yang ada saat ini masih relatif mahal sehingga diperlukan suatu metode alamiah dengan pendekatan pola makan sehari hari sebagai usaha pencegahan. Buah pepaya (Carica papaya L.) merupakan buah yang sangat dikenal di Indonesia dan ada hampir di seluruh daerah di Indonesia, hal ini menjadikan buah pepaya menjadi buah meja hampir di sebagian besar penduduk di Indonesia, Kandungan vitamin C, vitamin E, serat dan plavanoid di dalam buah pepaya diyakini dapat membantu menurukan kadar kolesterol dan tingkat stres oksidatif di dalam darah.
Pada penelitian ini, peneliti mencoba untuk membuktikan efek penurunan kadar kolesterol dan stres oksidatif dari jus buah pepaya (Carica papaya L.) pada plasma darah tikus Wistar dengan mengukur kadar kolesterol total dan kadar malondialdehyde.
Desain penelitian ini adalah penelitian eksperimental dengan pre and post with control grup design. 25 ekor tikus Wistar jantan dibagi dalam lima kelompok, yaitu kelompok kontrol negatif, kontrol positif dan kelompok perlakuan satu, dua dan tiga. Dilakukan pengukuraan kadar kolesterol total secara enzimatik dengan metode elektrokimia amperometrik dan pengukuran kadar MDA menggunakan metoda TBARS. Data pengukuran diolah dan diuji dengan menggunakan uji Repeated Anova untuk data yang terdistribusi normal dan menggunakan uji Friedman untuk data yang distribusinya tidak normal kemudian dilanjutkan dengan uji Post Hoc dengan menggunakan SPSS.
Pemberian induksi kuning telur selama dua minggu menunjukkan peningkatan kadar kolesterol total dan MDA yang bermakna pada kelompok kontrol positif, perlakuan satu, dua dan tiga (p < 0,05). Penurunan kadar kolesterol total dan MDA pada pengukuran setelah induksi jus pepaya menunjukan hasil yang bermakna ( p<0,05) pada kelompok perlakuan satu, dua dan tiga.
Hal ini membuktikan bahwa pemberian jus buah pepaya memiliki efek penurunan kadar kolesterol total dan kadar MDA plasma darah tikus Wistar jantan.152 HalamanTesis Magiste
Hubungan Polimorfisme Glutathion S- Transferase P-1 (GSTP1) dengan Insidensi dan Derajat Mielosupresi pada Pasien Kanker Payudara yang Diterapi dengan Regimen Mengandung Siklofosfamid
No full textAs one of mast intportant breast c(mcer treatments, chemotherapy ofien
complicated by hematopoettc toxictty. Toduy, Genetic polymorphism has been
linlred to inter individual dffirences in terms af toric severtty of various cytotoxic
ogent. Glutathion S-Traruferase (GSTs) en4ntes detoxifies the chemotherayy
drugs otrd their metabolites. However,AlG polymorphism at mtcleotide 313in
exon 5 of GSTPI gene leads taan amino ocid substitution of isoleusin Qle) by
Volin (VaI) dt 105 amina acid position (Itel05Val).This substitution result in
diminishing the enrymatic activityof Yaline amino acidwhich lead to a reduction
of daoxtfication ability, Hence, the aim of this study wos to invesfigate the
associatio,n between GSTPI 3l3AGpolynorphism and the ircidence and severity
of myerysuppression in breast cancir patient treatedwith CAFiCEF regimen.
Sl9I Indonesian breast cancer patients of Haii Adam Malik Hospttal who
had been diagnosed and treated with Cycloplnspantide,DoxarubicidEpirubicia
5-FU regimen (CAF/CEF) were selectedfor this cohort retrospecttve stady. DNA
was extracted from pheripheral leucoqttes and the status of GSTPI i13 AG
polymorphism was determined using Polynerase Chain Reaetion Restriction
Fragment Length Polynorphism (PCR-fuFLP) method. The incidence and grades
myelosupression (anemia,leucopenta,neutropenia and thrombocytopenia) were
collected from patient's medical record. Tlw association of GSTPI gerntypes on
the dffirences and grades myelosupression post-chemotherapy in the first and
third cycle was dssessed using Chisquare. Logistic regression analysisi was used
to assess the influence of GSTPI Polymorphism and other coyariat on the
incidence of nryelosupr ession-
The proportion of A3|3A,A3L3G,G?I3G gerntype GSTPI are 60,40/o,,
29,795 and 9,9 96 respectively. There wos no association between the incidence of
myelosupression from post chemotlwrapy in the first and third cycle in G3l3G
GSTPI polymorphism (p:0,372 vs 0,930). GSTPI mutant (A313G GSTPT and
GSTPI) were associatedsignificantly wtth leucopenia severity post chemotherapy
of the third q,cle qs cot"4wred wtth GSTPI A3l jA genofi,pe (wildtype) (p:0,008).
No associatton wos found between the incidence af myelosupresstan with the age
of patienls, tumor stagingliverfunction, renalfunction and nutrition state.
In concluston, Ihis study showed that GSTPI polymorphism was not
associoted with incidence of myelosupression in breast cancer patients receiving
cyclophosphamide-contoined chemaotherapeutic regimen,however,it was
associatedwith the severity of grade myelosuppression97 HalamanTesis Magiste
Hubungan Polimorfisme Glutathion S Transferase P-1 (GSTPl) dengan Insidensi dan Derajat Mielosupresi pada Pasien Kanker Payudara yang Diterapi dengan Regimen Mengandung Siklofosfamid
No full textAs one of most important breast cancer treatments, chemotherapy often complicated by hematopoetic toxicity. Today, Genetic polymorphism has been linked to inter individual differences in terms of toxic severity of various cytotoxic agent Glutathion S-Transferase (GSTs) enzymes detoxifies the chemotherapy drugs and their metabolites. However,AG polymorphism at nucleotide 313in exon 5 of GSTP1 gene leads toan amino acid substitution of isoleusin (Ile) by Valin (Val) at 105 amino acid position (Ile105Val). This substitution result in diminishing the enzymatic activity of Valine amino acid which lead to a reduction of detoxification ability, Hence, the aim of this study was to investigate the association between GSTP1 313AG polymorphism and the incidence and severity of myelosuppression in breast cancer patient treated with CAFICEF regimen.
91 Indonesian breast cancer patients of Haji Adam Malik Hospital who had been diagnosed and treated with Cyclophospamide, Doxorubicin/Epirubicin, 5-FU regimen (CAF/CEF) were selected for this cohort retrospective study. DNA was extracted from pheripheral leucocytes and the status of GSTP1 313 AG polymorphism was determined using Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP) method. The incidence and grades myelosupression (anemia, leucopenia,neutropenia and thrombocytopenia) were collected from patient's medical record. The association of GSTP1 genotypes on the differences and grades myelosupression post-chemotherapy in the first and third cycle was assessed using ChiSquare. Logistic regression analysisi was used to assess the influence of GSTP1 Polymorphism and other covariat on the incidence of myelosupression.
The proportion of A313A,A313G,G313G genotype GSTP1 are 60,4%,, 29,7% and 9,9% respectively. There was no association between the incidence of myelosupression from post chemotherapy in the first and third cycle in G313G GSTPI polymorphism (p>0.05). GSTP1 mutant (A313G GSTP1 and GSTPI) were associated significantly with leucopenia severity post chemotherapy of the third cycle as compared with GSTP1 A3134 genotype (wildtype) (p<0,05)). No association was found between the incidence of myelosupression with the age of patients, tumor staging liver function, renal function and nutrition state.
In conclusion, This study showed that GSTP1 polymorphism was not associated with incidence of myelosupression in breast cancer patients receiving cyclophosphamide-contained chemaotherapeutic regimen, however, it associated with the severity of grade myelosuppression.113 HalamanTesis Magiste
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
