1,581 research outputs found

    Unexpectedly large O37ClO/O35ClO intensity ratios of the fluorescence from the low-energy vibrational levels of OClO (Ã 2A2)

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    The fluorescence intensity ratios of (OClO)-Cl-37/(OClO)-Cl-35 excited to the (A) over tilde (2)A(2) state have been found to be much larger than that expected from the Cl-37/Cl-35 natural abundance ratio for several low-energy vibrational levels. For instance, the (OClO)-Cl-37/(OClO)-Cl-35 ratios are 1.67 and >10 for the (0,0,0) and (1,1,0) bands, respectively, which are 5 and 30 times larger than those expected from the natural abundance ratio. These unusual isotope effects are observed in a narrow energy region within similar to 1000 cm(-1) above the electronic origin. It is likely that the isotopomer-selective, near-resonant spin-orbit coupling of the low-energy vibrational levels of the (2)A(2) state with those of the (2)A(1) state, which provides a decay channel for the (2)A(2) state via spin-orbit coupling, is responsible for the unusual isotope effect. (C) 1999 American Institute of Physics. [S0021-9606(99)02126-1].Korean Science and Engineering Foundation Inha University Research Fun

    Expression of LIM kinase I is associated with reversible GI/S phase arrest, chromosomal instability and prostate cancer

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    Background: LIM kinase I (LIMKI), a LIM domain containing serine/threonine kinase, modulates actin dynamics through inactivation of the actin depolymerizing protein cofilin. Recent studies have indicated an important role of LIMKI in growth and invasion of prostate and breast cancer cells; however, the molecular mechanism whereby LIMKI induces tumor progression is unknown. In this study, we investigated the effects of ectopic expression of LIMKI on cellular morphology, cell cycle progression and expression profile of LIMKI in prostate tumors. Results: Ectopic expression of LIMKI in benign prostatic hyperplasia cells (BPH), which naturally express low levels of LIMKI, resulted in appearance of abnormal mitotic spindles, multiple centrosomes and smaller chromosomal masses. Furthermore, a transient GI/S phase arrest and delayed G2/M progression was observed in BPH cells expressing LIMKI. When treated with chemotherapeutic agent Taxol, no metaphase arrest was noted in these cells. We have also noted increased nuclear staining of LIMKI in tumors with higher Gleason Scores and incidence of metastasis. Conclusion: Our results show that increased expression of LIMKI results in chromosomal abnormalities, aberrant cell cycle progression and alteration of normal cellular response to microtubule stabilizing agent Taxol; and that LIMKI expression may be associated with cancerous phenotype of the prostate

    High field-effect mobility ZnO thin-film transistors with Mg-doped Ba0.6Sr0.4TiO3 gate insulator on plastic substrates

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    The authors report on the influence of Mg acceptor doping on the markedly reduced leakage current characteristics (< 5x10(-8) A/cm(2) at 2 MV/cm) of Ba0.6Sr0.4TiO3 thin films. The suitability of room temperature deposited Mg-doped Ba0.6Sr0.4TiO3 films as gate insulators for low-voltage ZnO thin-film transistors (TFTs) (< 6 V) was investigated. All room temperature processed ZnO-TFTs on plastic substrates exhibited a high field-effect mobility of 16.3 cm(2)/V s and a current on/off ratio of 6.4x10(4). The threshold voltage and subthreshold swing were 2.8 V and 400 mV/decade, respectively. (c) 2007 American Institute of Physics

    Extending Protection at the WTO to Products Other Than Wines and Spirits: Who Will Benefit?

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    The issue of extending geographic indicator protection to products other than wines and spirits has created wide divergences between demandeurs and opponent countries at the WTO. This article examines the economic impacts of the proposals submitted at the WTO by these two groups of countries, focusing mainly on market access, generic names and impacts for the consumer in North America. Results from our survey show that reducing tariff and non-tariff barriers in North America would be more important in improving market access for EU geographical indications (GIs) than would GI extension. In addition, it would appear that North American consumers may not benefit from extension of protection to products other than wines and spirits..generic names, geographical indications, market access, WTO, International Relations/Trade,

    Cooperative Electronic Structure Modulator of Fe Single‐Atom Electrocatalyst for High Energy and Long Cycle Li–S Pouch Cell

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    High-energy and long cycle lithium-sulfur (Li-S) pouch cells are limited by the insufficient capacities and stabilities of their cathodes under practical electrolyte/sulfur (E/S), electrolyte/capacity (E/C), and negative/positive (N/P) ratios. Herein, an advanced cathode comprising highly active Fe single-atom catalysts (SACs) is reported to form 320.2 W h kg(-1) multistacked Li-S pouch cells with total capacity of approximate to 1 A h level, satisfying low E/S (3.0), E/C (2.8), and N/P (2.3) ratios and high sulfur loadings (8.4 mg cm(-2)). The high-activity Fe SAC is designed by manipulating its local environments using electron-exchangeable binding (EEB) sites. Introducing EEB sites comprising two different types of S species, namely, thiophene-like-S (-S) and oxidized-S (-SO2), adjacent to Fe SACs promotes the kinetics of the Li2S redox reaction by providing additional binding sites and modulating the Fe d-orbital levels via electron exchange with Fe. The -S donates the electrons to the Fe SACs, whereas -SO2 withdraws electrons from the Fe SACs. Thus, the Fe d-orbital energy level can be modulated by the different -SO2/-S ratios of the EEB site, controlling the electron donating/withdrawing characteristics. This desirable electrocatalysis is maximized by the intimate contact of the Fe SACs with the S species, which are confined together in porous carbon.

    GI Justice in Vietnam: An Interview with the Lawyers Military Defense Committee

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    According to Catch-22, they can do anything you cannot stop them from doing. In a war zone, the range of anythings expands to diabolical extremes. The Lawyers Military Defense Committee originated to un-catch Gis snarled in court-martial prosecutions in Vietnam. Their mission has made the attorneys of LMDC about as popular with the U. S. Command as General Giap. Early this year one of LMDC attorneys representing a black GI charged with murder argued that the GI was being deprived due process of law because the U. S. Command prevented the LMDC from operating effectively. Because the command allowed no military telephone lines to the defense group, the attorney claimed, he had to try 233 times to complete just four telephone calls to his military co-counsel in the case. The command also refused to grant the group mail and priority travel privileges. A full-colonel military judge hearing the attorney\u27s claims said he agreed that the GI\u27s right to civilian counsel had been abridged but that\u27s just a fact of life in Vietnam. Since then things have gotten more pleasant for the LMDC. The difficulty of getting justice for servicemen in Vietnam remains. Several members of the group this fall discussed their difficulties and achievements in response to questions by the Yale Review of Law and Social Action. The following is a transcription of their discussion

    Recent Results From the EU POF-PLUS Project: Multi-Gigabit Transmission Over 1 mm Core Diameter Plastic Optical Fibers

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    Recent activity to achieve multi-gigabit transmission over 1 mm core diameter graded-index and step-index plastic optical fibers for distances up to 50 meters is reported in this paper. By employing a simple intensity-modulated direct-detection system with pulse amplitude or digital multi-tone modulation techniques, low-cost transceivers and easy to install large-core POFs, it is demonstrated that multi-gigabit transmission up to 10 Gbit/s over 1-mm core diameter POF infrastructure is feasible. The results presented in this paper were obtained in the EU FP7 POF-PLUS project, which focused on applications in different scenarios, such as in next-generation in-building residential networks and in datacom applications

    Effects of Service Disciplines in G/GI/s Queueing Systems

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    Transient extremal properties of some service disciplines are established in the G=GI=s queueing system for the minimization and maximization of the expectations of the Schur convex functions, convex symmetric functions and the sums of convex functions of the waiting times, response times, lag times and latenesses. When resequencing is required in the system, the FCFS and LCFS disciplines are shown to minimize and maximize, respectively, the expectations of any increasing functions of the end-to-end delays. All of these results are presented in terms of stochastic orderings. The paper concludes with extensions of the results to the stationary regime and to tandem as well as general queueing networks. Keywords : Queueing System, Service Discipline, Stochastic Ordering, Sample Path Analysis, Lateness, End-to-End Delay. This work was supported in part by the National Science Foundation under grant ASC 88-8802764. y The work of this author was also partially supported by CEC DG-XIII u..
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