125,832 research outputs found
Data for: ‘On the Road Again’: A 118 Country Panel Analysis of Gasoline and Diesel Demand
No full textRoad fuel (motor gasoline & diesel) real price index (base year 2005). Prices weighted by motor gasoline and diesel in final road transport consumption. Unbalanced data for 118 countries, 1978-2016. This index was used in Appendix B of Liddle, B. and H. Huntington (2020). ‘On the Road Again’: A 118 Country Panel Analysis of Gasoline and Diesel Demand. Transportation Research A: Policy and Practice. Please cite accordingly
Data for: Leap-Frogging and Energy Consumption: A Country Panel Analysis
No full textThis is the expanded dataset used in the addendum to Liddle & Huntington 2020. Please cite this data as:
Liddle, B. & Huntington, H. 2020. There’s Technology Improvement, but is there Economy-wide Energy Leap-Frogging? A Country Panel Analysis.
Accepted at World Development
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Data for: ‘On the Road Again’: A 118 Country Panel Analysis of Gasoline and Diesel Demand
No full textRoad fuel (motor gasoline & diesel) real price index (base year 2005). Prices weighted by motor gasoline and diesel in final road transport consumption. Unbalanced data for 118 countries, 1978-2016. This index was used in Appendix B of Liddle, B. and H. Huntington (2020). ‘On the Road Again’: A 118 Country Panel Analysis of Gasoline and Diesel Demand. Transportation Research A: Policy and Practice. Please cite accordingly
The garden where the praties grow [music] : song, old irish melody /
No full textS. & B. 4197a (Publisher number). Cover title.; No. 3.; Sung by Mr. Plunket Greene.; Pl. no.: S. & B. 4197a.; Also available online http://nla.gov.au/nla.mus-vn2381939
Neonatal presentation of a child with Liddle syndrome, South Africa
No full textDATA AVAILABILITY : Data supporting the findings of this study are available within the article.INTRODUCTION : Liddle syndrome is an autosomal dominantly inherited disorder usually arising from single mutations of the genes that encode for the alpha, beta and gamma epithelial sodium channel (ENaC) subunits. This leads to refractory hypertension, hypokalaemia, metabolic alkalosis, hyporeninaemia and hypoaldosteronism, through over-activation of the ENaC. CASE PRESENTATION : We describe a 5-day old neonate who presented with severe hypernatraemic dehydration requiring admission to Steve Biko Academic Hospital in South Africa in 2012. Further evaluation revealed features in keeping with Liddle syndrome. Two compound heterozygous mutations located at different subunits encoding the ENaC were detected following genetic sequencing done in 2020. The severe clinical phenotype observed here could be attributed to the synergistic effect of these known pathological mutations, but may also indicate that one of the other variants detected has hitherto undocumented pathological effects. MANAGEMENT AND OUTCOME : This child’s treatment course was complicated by poor adherence to therapy, requiring numerous admissions over the years. Adequate blood pressure control was achieved only after the addition of amiloride at the end of 2018, which raised the suspicion of an ENaC abnormality. CONCLUSION : To our knowledge, this is the first Liddle syndrome case where a combined effect from mutations resulted in severe disease. This highlights the importance of early recognition and management of this highly treatable genetic disease to prevent the grave sequelae associated with long-standing hypertension. Whole exome sequencing may assist in the detection of known mutations, but may also unveil new potentially pathological variants. WHAT THIS STUDY ADDS : This study highlights the importance of developing a high index of suspicion of tubulopathy such as Liddle syndrome for any child presenting with persistent hypertension associated with hypokalaemic metabolic alkalosis.http://www.ajlmonline.orgChemical PathologyPaediatrics and Child Healt
A regional regime? : regeneration in the North East of England
No full textThis dissertation is set in the North East (NE) of England and demonstrates how an experimental form of elite governance, characterised by multi-level, intra and inter-agency negotiation and co-ordination developed within complex and ambiguous socio-political structures and traditional hierarchies to deal with unmet social and economic needs. This emergent form of entrepreneurial governance has resulted from a poorly institutionalised field of regeneration, and allowed elites to seek autonomy by adapting national policies to specifically regional projects. A top-down, managerialist form of governance, it is not entirely democratic or open to public participation, but strategically contingent on global and other constraints. Central to an understanding of regeneration is the way strategies are formulated and implemented.
This regime, with a broader mix of enterprising public servants and politically minded business and other interests, has coalesced over a long period to respond entrepreneurially to the consequences of globalisation and uneven development, and the failure of national and regional policies. A legacy of decline has created a strategic, cohesive and identifiably exclusive regime of actors, who act in the region’s interests.
This regime is unlike the static or re-constructive regimes prevalent in other regions, rather it blends the positive aspects of traditional regional decision making with a more innovative approach. Democratic forms of managing regional space have gradually been replaced by a more adaptable and flexible form more suited to modern day and future needs. Power and influence shift dynamically over time, space and initiative, activities are legitimised by absorbing state officials into activities, and being in close proximity to civic society. As part of the history of change, and embedded in the social system, elites interact formally and informally
Airway Surface Liquid Volume Regulation Determines Different Airway Phenotypes in Liddle Compared with βENaC-overexpressing Mice
No full textStudies in cystic fibrosis patients and mice overexpressing the epithelial Na+ channel β-subunit (βENaC-Tg) suggest that raised airway Na+ transport and airway surface liquid (ASL) depletion are central to the pathogenesis of cystic fibrosis lung disease. However, patients or mice with Liddle gain-of-function βENaC mutations exhibit hypertension but no lung disease. To investigate this apparent paradox, we compared the airway phenotype (nasal versus tracheal) of Liddle with CFTR-null, βENaC-Tg, and double mutant mice. In mouse nasal epithelium, the region that functionally mimics human airways, high levels of CFTR expression inhibited Liddle epithelial Nat channel (ENaC) hyperfunction. Conversely, in mouse trachea, low levels of CFTR failed to suppress Liddle ENaC hyperfunction. Indeed, Na+ transport measured in Ussing chambers (“flooded” conditions) was raised in both Liddle and βENaC-Tg mice. Because enhanced Na+ transport did not correlate with lung disease in these mutant mice, measurements in tracheal cultures under physiologic “thin film” conditions and in vivo were performed. Regulation of ASL volume and ENaC-mediated Na+ absorption were intact in Liddle but defective in βENaC-Tg mice. We conclude that the capacity to regulate Na+ transport and ASL volume, not absolute Na+ transport rates in Ussing chambers, is the key physiologic function protecting airways from dehydration-induced lung disease
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