3,363 research outputs found
On the Sherlocks, Jane Coleman and County Kildare in the Eighteen Forties
Full text linkIn the late 1980s and early 1990s the author acquired about 30,000 letters written mainly in the 1840s. These pertained to estates throughout Ireland managed by the firm of James Robert Stewart and Joseph Kincaid, hereafter denoted SK. Until the letters – called the SK correspondence in what follows – became the author’s property, they had not seen light of day since the 1840s. Addressed mainly to the firm’s office in Dublin, they were written by landlords, tenants, the partners in SK, local agents, etc. After about 200 years in operation as a land agency, the firm in which members of the Stewart family were the principal partners – Messrs J. R. Stewart & Son(s) from the mid- 1880s onwards – ceased operations in the mid-1980s. Since 1994 the author has been researching the SK correspondence of the 1840s. It gives many new insights into economic and social conditions in Ireland during the decade of the great famine, and into the operation of Ireland’s most important land agency during those years. It is intended ultimately to publish details on several of the estates managed by SK in a study more comprehensive than the present article, in book form. The proposed title is Landlords, tenants, famine: business of an Irish land agency in the 1840s, a draft of which has now been completed. A majority of the letters in that study are on themes some of which one might expect - rents, distraint (seizure of assets in lieu of rent); ‘voluntary’ surrender of land in return for ‘compensation’ upon quitting quietly; formal ejectment (a matter of last resort on estates managed by SK); landlordassisted emigration (on a scale much more extensive than most historians of Ireland in the 1840s appear to believe); petitions from tenants; complaints by tenants, both about other tenants and about local agents; landlord-financed and other relief of distress both before and during the great famine; major works of improvement (on almost all of the estates managed by SK which have been investigated in detail in the draft book); applications by SK, on behalf of landlords, for government loans to finance improvements; recommendations of agricultural advisers hired by SK, etc. Thus, most of the SK correspondence is about aspects of estate management. But the firm of SK was not only a manager of land. The correspondence reveals only two estates in Kildare, each of them relatively small, managed by SK in the 1840s. These were the lands of the Sherlocks near Naas and of Jane Coleman in the Kilcullen district. The correspondence on these properties differs substantively from most of those discussed in detail in the draft of Landlords, tenants, famine: first, it is relatively small in quantity, and secondly, it contains relatively little on the core aspects of estate management indicated above. Much of that on the Sherlocks focuses on misfortunes among family members, while the correspondence on Jane Coleman highlights the benevolence of that proprietor.
NLINLS: a Differential Evolution based nonlinear least squares Fortran 77 program
Full text linkThis paper provides the list of Fortran 77 codes of nonlinear least squares using Differential Evolution as the minimizer algorithm. It has been tested on a number of difficult nonlinear least squares problems (taken from NIST, USA including CPC-X Software challenge problems). Help on how to use the program also is provided.Nonlinear least squares; Differential Evolution; Fortran 77
Progress and Distress on the Stratford Estate in Clare during the Eighteen Forties
Full text linkIn the late 1980s and early 1990s, the author acquired about 30,000 letters written mainly in the 1840s. These pertained to estates throughout Ireland managed by James Robert Stewart and Joseph Kincaid, hereafter denoted SK. Until the letters - called the SK correspondence in what follows - became the author’s property, they had not seen light of day since the 1840s. Addressed mainly to the SK office in Dublin, they were written mainly by landlords, tenants, the partners in SK, local agents, etc. After about 200 years in operation as a land agency, the firm in which members of the Stewart family were the principal partners - Messrs J. R. Stewart & Son(s) from the mid-1880s onwards -- ceased business in the mid-1980s. Since 1994 the author has been researching the SK correspondence of the 1840s. It gives many new insights into economic and social conditions in Ireland during the decade of the great famine, and into the operation of Ireland’s most important land agency during those years. It is intended ultimately to publish details on several of the estates managed by SK in book form. The proposed title is Landlords, Tenants, Famine: Business of an Irish Land Agency in the 1840s, a draft of which has now been completed. A majority of the letters in the larger study from which the present article is drawn are on themes some of which one might expect - rents, distraint (seizure of assets in lieu of rent) ; ‘voluntary’ surrender of land in return for ‘compensation’ upon peacefully quitting; formal ejectment (a matter of last resort on estates managed by SK); landlord-assisted emigration (on a scale much more extensive than most historians of Ireland in the 1840s appear to believe); petitions from tenants; complaints by tenants, both about other tenants and local agents; major works of improvement (on almost all of the estates managed by SK); applications by SK, on behalf of proprietors, for government loans to finance improvements; recommendations of agricultural advisers hired by SK, ete. Thus, most of the SK correspondence is about aspects of estate management. It seems, in the 1840s, that the only estate in Clare managed by SK was that of the elderly Col. Stratford. Although the files on the relatively small Stratford estate are much less extensive than those on some of the estates investigated in detail in the draft of Landlords, Tenants, Famine, they do refer to most of the core aspects of estate management mentioned above. But in the case of the Clare estate, the material on some of those themes is extremely thin.
SK channels deteriorate hypoxic ventricular arrhythmia
Full text linkThe molecular and electrophysiological mechanisms of acute ischemic ventricular arrhythmias in hypertrophied hearts are not well known. We hypothesized that small-conductance Ca2+-activated K+ (SK) channels are activated during hypoxia via the Ca2+/calmodulin-dependent protein kinase II (CaMKII)-dependent pathway. We used normotensive Wistar-Kyoto (WKY) rats and spontaneous hypertensive rats (SHRs) as a model of cardiac hypertrophy. The inhibitory effects of SK channels and ATP-sensitive K+ channels on electrophysiological changes and genesis of arrhythmias during simulated global hypoxia (GH) were evaluated. Hypoxia-induced abbreviation of action potential duration (APD) occurred earlier in ventricles from SHRs versus. WKY rats. Apamin, a SK channel blocker, prevented this abbreviation in SIIRs in both the early and delayed phase of GH, whereas in WKY rats only the delayed phase was prevented. In contrast, SHRs were less sensitive to glibenclamide, a ATP-sensitive K+ channel blocker, which inhibited the APD abbreviation in both phases of GH in WKY rats. SK channel blockers (apamin and UCL-1684) reduced the incidence of hypoxia-induced sustained ventricular arrhythmias in SHRs but not in WKY rats. Among three SK channel isoforms. SK2 channels were directly coimmunoprecipitated with CaMKII phosphorylated at Thr(286) (p-CaMKII). We conclude that activation of SK channels leads to the APD abbreviation and sustained ventricular arrhythmias during simulated hypoxia, especially in hypertrophied hearts. This mechanism may result from p-CaMKII-bound SK2 channels and reveal new molecular targets to prevent lethal ventricular arrhythmias during acute hypoxia in cardiac hypertrophy. NEW & NOTEWORTHY We now show a new pathophysiological role of small-conductance Ca2+-activated K+ channels, which shorten the action potential duration and induce ventricular arrhythmias during hypoxia. We also demonstrate that small-conductance Ca2+-activated K+ channels interact with phosphorylated Ca2+/calmodulin-dependent protein kinase II at Thr(286) in hypertrophied hearts
The note on Slavic words on *x-/*sk-
Full text linkU članku se daje jedno novo grupiranje praslavenskih riječi koje sadrže usporedne korijene sa sk- i x-. Za neke se od tih riječi nude nove etimologije i ukazuje na moguće toponomastičke odraze.The author discusses the relation between initial *x- and *sk in Proto-Slavic. Some new or renewed etymologies are given. It seems that some roots have traces in toponymy
<i>Sk wtf7-GFP</i> and <i>Sk wtf15-GFP</i> are expressed in spores.
No full text(A) Representative images of Sk Wtf7-GFP localization in spores generated by diploids heterozygous for both Sk wtf7-GFP (green) and nsp1-mCherry (magenta; nucleoporin marker). (B) Tetrad generated from a diploid heterozygous for Sk wtf15-GFP. We linearly unmixed these images (see Materials and methods, S9 Fig). We adjusted the brightness and contrast differently for each image and smoothed them using Gaussian blur. Scale bar represents 5 μm. TL, transmitted light.</p
Glosa do wyroku Trybunału Konstytucyjnego z 18 października 2023 r., SK 23/19
No full textThe author presents a partially critical commentary on the Constitutional Tribunal’s judgment of October 18, 2023 (case SK 23/19), in which the Tribunal held that regulations leading to differentiation in real estate tax rates depending on whether a garage is located within a residential building or is a separate structure, are inconsistent with the Constitution of the Republic of Poland. The commented judgment could have represented a significant step toward rectifying the real estate taxation system, were it not for constitutional doubts of a strictly fundamental nature, ranging from the admissibility of the complaint itself to formal and procedural objections concerning the composition of the adjudicating panel
Verification of the validity of clathrin-SK channels protein complex.
No full text<p>(A) Verification of the validity of the protein complex by BN-PAGE supershift assays. Placental lysates were incubated with SK channel protein 2 antibody (Ab) and resolved by BN-PAGE. A supershift band was indicated by arrow; no supershift was observed when lysates were incubated with normal IgG. (B) Copurification of clathrin and SK channel protein 2 protein complex from placental by co-immunoprecipitation. Placental protein lysates were either incubated with a clathrin-specific antibody (anti-clathrin) or a preimmunisation IgG pool (as negative control), then subject to SDS PAGE and western blot analyses. (C) Immunohistochemical analysis of the colocalization of clathrin and SK channel protein 2 in trophoblastic layer of placental. Immunohistochemical localization of SK channel protein 2 (left), clathrin (middle), and colocalization of clathrin and SK channel protein 2 (right).</p
Keli šaknies -sk-, -šk- veiksmažodžiai
No full textStraipsnyje analizuojami keli šaknies -sk-, -šk- veiksmažodžiai. Atsižvelgiant į tai, kad lietuvių kalboje šaknies finalės priebalsių grupės spirantas + k/g traktuojama priklausomai nuo pozicijos prieš balsį arba priebalsį, pvz. megz-C : mezg-V, panašios metatezės būtų tikėtina ir veiksmažodžiuose su priesaga -sėti po veliarinio priebalsio, t. y. *mirskėti vietoj mirksėti, *džiuzgėtis vietoj džiugsėtis. Jos nebuvimas, pasak autoriaus, rodo, kad čia turimi naujadarai. Minėta metateze autorius bando paaiškinti ir du pavyzdžius, šaknyje turinčius -sk-, t. y. viskėti, -a, -ėjo „judėti, krutėti į visas puses (paprastai būnant vienoje vietoje)” ir tuskėti, -a, -ėjo „bildėti; plakti (apie širdį); kulti“ bei reikšti, -ia „turėti reikšmę, žymėti ką nors; perteikti, atskleisti kokį turinį; perduoti žodžiais; kilti aikštėn, rastis kokiam reiškiniui, ypatybei“. Reikšminiai žodžiai: Veiksmažodis; Šaknis; Verb; Root of the wordSeveral verbs with -sk-, -šk- in the root are analysed in the article. Taking into account the fact that spirant + k/g in the final consonant cluster of the root in the Lithuanian language is treated depending on its position: before a vowel or a consonant, for example, megz-C : mezg-V, a similar metathesis should be expected in verbs with suffix -sėti after a velar consonant, i.e. *mirskėti instead of mirksėti, *džiuzgėtis instead of džiugsėtis. According to the author, its absence shows that the words are neologisms. The author uses the said metathesis in his attempts to explain two more examples, with -sk- in the root, i.e. viskėti, -a, -ėjo “move to all sides (usually by staying in one place)” and tuskėti, -a, -ėjo “beat; throb (referring to the heart); hammer” and reikšti, -ia “have a meaning, denote something; convey, reveal certain content; convey verbally; appear, emerge (referring to a certain phenomenon, quality)”
COMPETITIVE RISK MANAGEMENT OF SERVICES IN HANDICRAFTS BUSINESS, NEPAL: SK HANDICRAFTS
Full text linkThe main motive of this thesis was to identify the competitive risk and the approaches to manage those risk. The case company for the thesis is SK handicrafts which is located at Thamel, Kathmandu, Nepal. As my case company is a type of small scale industry. The author is targeting the difficulties which the company will suffer when they will import and export their handicrafts products in the developing country like Nepal. Nepal is a small country located in the continent of Asia. It is surrounded by the two gigantic and developed countries like India and China. The ambition for the thesis is to jewel the competitive risk and the problems which the small-scale industries like SK handicrafts will face including its exporting of products especially to European market, competitors in Nepal.
The research on competitive risk management was conducted based on handicraft business in Nepal. The case company is SK handicraft exports. Not only for the thesis the author is much interested to do his own business in near future so the main reason behind my research is my dedication towards entrepreneurship. The author has made the thesis so simple that it is not hard for other to understand. The author has described about the indication and examine the risk things that may occur at any time and any situation. So, regarding what are the pre-cure for removing such risk from the company so where the company can achieve the further goals. I am doing research how does SK handicrafts products will increase in the local and foreign level; how can we support the small-scale enterprise like SK handicrafts to grow bigger in Asian and European market and what are its competitive management methods to do their business run properly. The author had made a clear view of first the description what actual my table of contents is then after in the second paragraph I have described how the description are interrelated to my case company SK handicrafts
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