4,680,067 research outputs found
HongJun Jang
No full text학위논문(박사)--아주대학교 일반대학원 :약학과,2020. 2I. Introductions .......................................................................................................... 1
I.1. 3-Oxygenated Tetrahydrofuranoids Natural Products ................................. 2
I.1.1. Mono-THFs ........................................................................................ 2
I.1.2. Fused Bis-THFs .................................................................................. 7
I.1.3. Adjacent Bis-THFs ............................................................................. 9
I.1.4. THF-Containing Macrolides ............................................................ 12
I.1.5. Mono-THF fused with Medium-Sized Ether Ring ........................... 14
I.2. C19 Nematocidal Tetrahydrofuranoids Marine Oxylipids .......................... 17
I.2.1. Introduction: Determination of C19 Nematocidal Tetrahydrofuranoids
Oxylipids.................................................................................................... 17
I.2.2. Biosynthetic Pathway of C19 Nematocidal Tetrahydrofuranoids
Oxylipids.................................................................................................... 19
I.3. Previous Synthesis of C19 Nematocidal Tetrahydrofuranoids Marine
Oxylipids .......................................................................................................... 23
I.3.1. Williams Synthesis of (±)-1a (1984) ................................................ 27
I.3.2. Takano Synthesis of (+)-1a (1985) ................................................... 29
I.3.3. Gurjar Synthesis of (+)-1a (1990) .................................................... 30
I.3.4. Chikashita Synthesis of (+)-1a (1993) ............................................. 31
I.3.5. Wang Synthesis of (+)-1a (1998) ..................................................... 32
I.3.6. Mori Synthesis of (+)-1a (1999) ...................................................... 34
I.3.7. Martin Synthesis of (+)-1a and (+)-1b (2000,2001) ........................ 35
I.3.8. Lowary Synthesis of (+)-1b (2001) .................................................. 37
I.3.9. Yoda Synthesis of (+)-1b (2001) ...................................................... 39
I.3.10. Pradilla Synthesis of (+)-1a (2007, 2009) ...................................... 40
I.3.11. Britton Synthesis of (+)-1a and (+)-1b (2009) ............................... 42
I.3.12. McErlean Synthesis of (−)-1a and (−)-1b (2011) ........................... 44
I.3.13. Spilling Synthesis of (+)-1a and (+)-1b (2012) ............................. 45
I.3.14. Song Synthesis of (+)-1b (2013) .................................................... 47
II. Result and Discussions ....................................................................................... 49
II.1. Previous Studies on Amide Enolate Alkylation ........................................ 49
II.1.1. Kim’s Divergent Construction of 2,5-cis- and 2,5-trans-Disubstituted
THFs by Intramolecular Amide Enolate or Nitrile Anion Alkylation ....... 49
II.1.2. Kim’s Protecting Group-Dependent Intermolecular Amide Enolate
Alkylation .................................................................................................. 51
II.2. Intramolecular Protecting Group-Dependent Amide Enolate Alkylation . 53
II.2.1. Substrate Scope for IAEA Reaction ................................................ 54
II-3. Total Synthesis of C19 Nematocidal Tetrahydrofuranoids Oxylipids 1a and
1b ................................................................................................................ 59
II-3-1. Retrosynthetic Plan ......................................................................... 59
II-3-2. Construction of key 2,5-trans- and 2,5-cis-THF intermediates 3a and
3b ............................................................................................................... 61
II-3-3. Determination the Relative Stereochemistries of IAEA Adducts in
Scheme 25 and 26 by Chemical Correlations ............................................ 69
II-3-4. Construction of 2,3-trans-2,5-trans- and 2,3-trans-2,5-cis-THFs 3c
and 3d ........................................................................................................ 71
II-3-5. Determination the Relative Stereochemistries of IAEA Adducts in
Scheme 31 and 32 by Chemical Correlations ............................................ 75
II-3.6. Completion of the Total Synthesis of 1a and 1b ............................ 77
III. Conclusions ....................................................................................................... 80
IV. Exprimentals ...................................................................................................... 81
V. References ........................................................................................................ 195DoctoralThe concise, highly stereoselective, substrate-controlled asymmetric total syntheses of both 2,5-trans- and 2,5-cis-tetrahydrofuranoid nematocidal oxylipids from the Australian brown algae Notheia anomala have been accomplished in a stereodivergent fashion. The highly stereoselective intramolecular amide enolate alkylation strategy provides access to both stereoisomers of the 3-hydroxy-2,5- disubstituted tetrahydrofuran core of these marine natural products through chelate and nonchelate control, which is driven by the C(3)-hydroxy protecting group. This approach offers an optional and highly stereoelective access to any of the eight possible stereoisomers of the 2,5-disubstituted-3-oxygenated tetrahydrofuran skeleton, an important structural feature which is present in many biologically active natural products
Assessment of Self-Archiving in Institutional Repositories: Depositorship and Full-Text Availability
No full textThis research evaluates the success of open access self-archiving in several well-known institutional repositories. Two assessment factors have been applied to examine the current practice of self-archiving: depositorship and the availability of full text. This research discovers that the rate of author self-archiving is low and that the majority of documents have been deposited by a librarian or administrative staff. Similarly, the rate of full-text availability is relatively low, except for Australian repositories. By identifying different practices of self-archiving, repository managers can create new strategies for the operation of their repositories and the development of archiving policies
Discovering and reconciling semantic conflicts : a data mining perspective
No full textIncludes bibliographical references (p. 20).Hongjun Lu ... [et al.]
Information Literacy and Librarian-Faculty Collaboration: A Model for Success:
No full textIn the age of information explosion and technological advancement, issues of information storage, organization, access, and evaluation have become necessarily important in our societies. Addressing issues of information literacy and designing how they can be best integrated in students' learning process are of critical importance. Library professionals in the United States, particularly in the academia, have realized the importance of information literacy and have attempted in various ways to address these issues. The ultimate goal is to make information literacy an integral part of the academic curriculum, thus helping students to succeed not only during their years in college but also for their lifelong career choices. This article will look at ways of how information literacy can best be incorporated into students' academic experience, and how this process can make students' learning meaningful and successful. Specifically, the author will examine the model of librarian-faculty collaboration in integrating information literacy into the curriculum, as demonstrated in the Ohio Five Colleges' Information Literacy Program.Publisher version of this article is available at: http://www.white-clouds.com/iclc/cliej/cl24.ht
Anomalously High Lithium Storage in Three-Dimensional Graphene-like Ordered Microporous Carbon Electrodes
No full textZeolite-templated
carbon, having a three-dimensional graphene-like
ordered microporous structure with high electrical conductivity, is
a fascinating anode material for Li-ion batteries (LIBs). Herein,
we report an extremely high Li capacity of 2950 mA h g–1 (equivalent to Li1.3/C), which is 7.9 times the maximum
capacity of graphite, Li/C6. This is equivalent to the
crowded packing of 20 Li+ per pore with 0.9 nm diameter.
Approximately 59% of the capacity was reversible. According to the
characterizations by electron energy loss spectroscopy, 7Li NMR, and 13C NMR, most of the Li species existed as
Li+ within the carbon micropores. Contrary to the often-made
assumption, only a small amount of solid–electrolyte interphase
layers was detected at the external surface of the carbon particles
but not inside the micropores. The anomalously high Li capacity is
attributed to the extremely narrow pore environment, where Li+ would be difficult to be fully solvated. Tailoring of the
carbon pores to a subnanometric range would therefore be exciting
for future advancement of LIBs
Zhou yi lüe li
No full text王弼, 韓康伯注 ; 孔穎達正義.綫裝, 1函.框19.7x13.1公分, 9行21字, 小字雙行同. 白口, 無魚尾, 四周單邊. 版心中鐫"易疏"及卷次, 下記刻工.分上,下經 ; 卷一至三為上經, 卷四至九為下經.出版項據《明代版本圖錄初編》推定.卷一至六由王弼注, 卷七至九由韓康伯注.With: 經典釋文 : 周易音義 / 陸德明撰 -- 周易略例 / 王弼撰.鈐有"呂氏樂房藏書", "得良館藏書記"印.Xian zhuang, 1 han.Kuang 19.7 x 13.1 gong fen, 9 hang 21 zi, xiao zi shuang hang tong. Bai kou, wu yu wei, si zhou dan bian. Ban xin zhong juan "Yi shu" ji juan ci, xia ji ke gong.Fen shang, xia jing ; juan yi zhi san wei shang jing, juan si zhi jiu wei xia jing.Chu ban xiang ju "Ming dai ban ben tu lu chu bian" tui ding.Juan yi zhi liu you Wang Bi zhu, juan qi zhi jiu you Han Kangbo zhu.Wang Bi, Han Kangbo zhu ; Kong Yingda zheng yi.With: Jing dian shi wen : Zhou yi yin yi / Lu Deming zhuan -- Zhou yi lüe li / Wang Bi zhuan.Qian you "Lü shi Le fang cang shu", "De liang guan cang shu ji" yin
From Simulation to Bedside: the Missing Link in Pediatric Training Research [Response to Letter]
No full textHongjun Ba, Lingling Xu, Huimin Peng, Yufen Gu, Yijuan Li, Xiaoyun Jiang, Xiaoyu Li, Shujuan Li Pediatric Department, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, People’s Republic of ChinaCorrespondence: Xiaoyu Li, Email [email protected] Shujuan Li, Email [email protected]
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