9,837 research outputs found
TW-01, a piperazinedione-derived compound, inhibits Ras-mediated cell proliferation and angioplasty-induced vascular restenosis
No full textPurpose: Vascular smooth muscle cell (VSMC) proliferation plays a critical role in the pathogenesis of atherosclerosis and restenosis. This study investigated piperazinedione derived compound TW-01-mediated inhibitory effects on VSMC proliferation and intimal hyperplasia.
Methods: Cell proliferation was determined using [H-3]-thymidine incorporation and MTT assay; cell cycle distribution was measured using flow cytometry; proteins and mRNA expression were determined using western blotting and RT-PCR analyses; DNA binding activity of nuclear factor-kappa B (NF-kappa B), as measured using enzyme linked immunosorbent assays (ELISA); in vivo effects of TW-01 were determined using balloon angioplasty in the rat.
Results: TW-01 significantly inhibited cell proliferation. At the concentrations used, no cytotoxic effects were observed. Three predominant signaling pathways were inhibited by TW-01: (a) extracellular signal-regulated kinase (ERK)1/2 mitogen-activated protein kinase (MAPK) activation and its downstream effectors of c-fos, c-jun, and c-myc; (b) DNA binding activity of nuclear factor-kappa B (NF-kappa B); and, (c) Akt/protein kinase B (PKB) and cell cycle progression. Furthermore, TW-01 also inhibited Ras activation, a shared upstream event of each of these signaling cascades. In vascular injury studies, oral administration of TW-01 significantly suppressed intimal hyperplasia induced by balloon angioplasty.
Conclusion: The present study suggests that TW-01 might be a potential candidate for atherosclerosis treatment. (C) 2016 Elsevier Inc. All rights reserved
Effects of Organic Lithium Salt Ultrathin Films on the Electron Injection Efficiency in OLED
No full textWe investigated the effects of the ultrathin film of a new cathode underlayer material, lithium tert-butyl cyclopentadienide (Li-TBCPD), on the electron injection efficiency and performance of the Alq3-based OLED. The current density-voltage-luminance (I-V-L) and the luminous efficiency characteristics of the [ITO/alpha-NPB (40 nm)/Alq3 (60 nm)/Li-TBCPD (1.0 nm)/Al] device were examined. The device with the Li-TBCPD/Al bilayer cathode demonstrated the current density of 360A/m(2) at 12V and the maximum luminance of 8,100 cd/m(2), while the device with the LiF/Al cathode showed 70A/m(2) and 5,800 cd/m(2), respectively. This improvement seems to originate from the relatively lower bond dissociation energy of Li-TBCPD and hence the easiness of lithium layer formation beneath the aluminum cathode.X111sciescopu
TDRP-TW instances
No full textConsidering the commercial interest and attention on both trucks and drones carried by trucks for last-mile parcel deliveries, we introduce the TDRP-TW. Solving the TDRP-TW necessitates finding the cost-minimizing routes. Each TDRP-TW network includes a number of customers and one depot housing a fleet of truck–drone combinations. The network is denoted by an undirected complete graph in which the nodes represent the depot and customers, and the arcs represent the possible moves of trucks and drones. The depot is the only parcel source. The truck–drone combination includes one truck carrying several drones. All customer demand should be satisfied. Customer demand cannot be split. Customers are classified into two types: truck customer (TC) or drone customer (UC). Each TC should be serviced by one truck, and each UC should be serviced by one drone. The number of drones carried by each truck is assumed to be the same. A vehicle in use may be a single truck or drone, or a truck–drone combination. Each truck–drone combination works in a “paired” modality. A drone can carry several parcels to serve more than one customer. It is assumed that there are enough trucks and drones. Along its route, a truck can dispatch and retrieve the carried drones only at a TC, which is referred to as the satellite. A drone can be retrieved by its truck at a satellite, or can return directly to the depot.
We choose the test instances from the Solomon (1987) VRPTW benchmark problems with 100 customers and convert them to TDRP-TW instances.
Let nc denote the number of customers included in the TDRP-TW network. The nc customers are classified into TCs and UCs. Parameter p denotes the percentage of UCs in the nc customers, and p = 25%, 50% or 75%. All customer time windows are scale down by the same constant. The demand of a TC or a UC is a random number in the range of (0, 50 kg) or (0, 2.5 kg), respectively.
When nc < 100, the converted instances are specified as small- and medium-scale instances. Each of the small- and medium-scale instances is denoted by C“nc”-25, C“nc”-50, or C“nc”-75; and C“nc”-25, C“nc”-50, or C“nc”-75 has the percentage of UCs 25%, 50%, or 75%, respectively. When nc = 100, the converted instances are specified as large-scale instances. Each of the large-scale instances is denoted by “name of VRPTW benchmark instance”-75, which has the percentage of UCs 75%
The Influence of Implementation of TW-DRGs on the Hospital Management
No full textIncrease in the cost of medical care services has become an important issue in many countries that have implemented national health insurance, including Taiwan. On July of 2002, the National Health Insurance of Taiwan implemented a global budgeting system for all hospital payments. It was hoped that such a system would control the increase of medical expenses within a certain expected range. However, in the absence of reasonable payment bases and effective utilization management and control mechanism, the outcome of implementing this new payment system has been difficult to measure. Therefore, the National Health Insurance (NHI) studied the possibility of implementing DRGs (diagnosis related groups) for all in-patient payments.
To evaluate the impact of the new payment system, the medicinal datas collected 1 year before and after implementation of TW-DRGs were analyzed. The tested target is an orthopaedic department in a Public Medical Center. The tested items including average of days in hospital, medical costs, application of National insurance, and sub-item total knee replacement (TKR) and total hip replacement (THR). For overall investigation of the tested orthopaedic department, our findings revealed that implementation of TW-DRGs significantly diminished the average of days in hospital and the average of medical costs. However, implementation of TW-DRGs showed slight influence on the National Health Insurance Application. As to investigate common surgeries, TKR and THR, only the average of days in hospital of TKR was significantly decreased by implementation of TW-DRGs. In addition, other specific TW-DRGs numbered items were also examined to determine the alteration of the factors described above. Our results showed that implementation of TW-DRGs significantly diminished the days in hospital, the medical cost, and the National Health Insurance Application for the selected TW-DRGs numbered items. However, the quality in health care didn\ue2t have significant change after implementation of TW-DRGs. More complete data pools are needed for the more precise analysis to evaluate the influence of TW-DRGs system on the management of hospital and other medical factors in Taiwan
Nadere verfijning DUROSTA-model: Toetsing H/Tw-parameter en aanpassing t.b.v. porositeitsverschillen en strandtransporten
No full textTeneinde het DUROSTA-model verder te verbeteren zijn de effecten modellering nader onderzocht en is de schaalgrootheid H/Tw nader bekeken.TAW/EN
Subtraction of the t t ¯ contribution in tW b ¯ production at the one-loop level
No full textAbstract The tW b ¯ production contributes to the real corrections to the tW cross section. It would interfere with the top quark pair production, causing difficulties in a clear definition of the tW b ¯ events. The subtraction of the t t ¯ contributions has been performed in the diagram removal or diagram subtraction schemes for the tree-level processes. However, these schemes rely on the ability to identify the double resonant diagrams and thus can not be extended to loop diagrams. We propose a new scheme to subtract the t t ¯ contributions by power expansion of the squared amplitude in the resonant region. In order to cancel the infra-red divergences of the loop amplitudes, a widely used method is to introduce the dipole counter-terms, an ingredient in calculations of the full next-to-leading order QCD corrections. In our scheme, these counter-terms are also power-expanded. As a proof of principle, we calculate the one-loop correction to the d d ¯ → b ¯ Wt process, and present the invariant mass distribution of the W b ¯ system
Development of a rotor model for the numerical simulation of helicopter exterior flow-fields
No full textIncludes bibliographical references (leaves 84-85).A numerical methodology is developed to model the effect of a rotor on the surrounding flow-field. The model calculates the time-averaged aerodynamic forces exerted on the air by the fan blades within the blade-swept region, and permits the user to specify blade properties such as cross-sectional profile and orientation at a particular radial and azimuthal location. The calculated forces are included as source terms within the Reynolds-averaged Navier-Stokes equations for an incompressible fluid, which are solved by the commercial CFD solver, FLUENT. The effects of turbulence are incorporated through the use of Launder and Spalding's k-g turbulence model. This method is selected as being the most efficient use of the resources available, giving the economic advantages of a steady simulation, while allowing radial and azimuthal variations of rotor characteristics. In order to validate the accuracy of the numerical model for both aligned and non-aligned inflow conditions, results are compared with experimental data reported for an axial flow fan. Agreement between experimental and numerical results is excellent to good. Fan static pressure rise is closely predicted by the numerical solution, while fan power consumption and fan static efficiency are under and over-predicted respectively. This error may be attributed to frictional losses not accounted for in the numerical model. These include physical rotational instabilities, leading to increased mechanical losses, and tip effects due to the clearance between the fan blade tips and the fan casing. Trends are nevertheless consistently predicted by the numerical model for inflow angles up to 45°, and for the range of blade pitch settings used. The adverse effect of off-axis inflow on the fan static pressure rise is numerically predicted, while fan power consumption is found to remain independent of inflow angle, as had been experimentally observed. The rotor model is finally integrated with the fuselage of the CIRSTEL (Combined Infra-Red Suppression and Tail rotor Elimination) prototype in an analysis of the helicopter exterior flow-field. No experimental data for this configuration was available for validation purposes. However, the model is used in the simulation of several common helicopter flight conditions. Results are presented graphically, and generally indicate good agreement with physically observed phenomena
Third body effects in the period changes of two Algol binaries: V342 Aql and TW Lac
Get PDF32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEYThe O - C diagrams of two Algol-type eclipsing binaries V342 Aql and TW Lac have been analyzed with the least-squares method by using all available minima times. The period changes in their O - C diagrams have been discussed with respect to the Light-Time Effect (LITE) that originates from gravitational influence of a third body. New LITE elements, orbital periods and possible minimum masses of third bodies are given.Turkish Phys So
Increasing science, technology, engineering, and mathematics skills using Project Lead the Way
Get PDFIncludes bibliographical references
Route to 100 TW Ti: Sapphire laser at repetitive mode
No full textWe demonstrated a 100 TW-class femtosecond Ti: sapphire laser running at repetition rate of 0.1 Hz by adding a stage amplifier in the 20 TW/10 Hz laser facility (XL-II). Pumping the new stage amplifier with the 25 J green Nd:glass laser, we successfully upgraded the laser energy to 3.4 J with duration of 29 fs, corresponding to a peak power of 117 TW
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