5,064 research outputs found
[David Mitchell and Descendants]
No full textCopy of "David Mitchell and Descendants" originally written by Thomas Mitchell, Jr. The manuscript starts with David Mitchell, possibly a Revolutionary soldier, and details what is known about his life and those of his descendants. The record ends with the marriage of his widow, Sarah Patterson Mitchell Frear, to Abraham Frear. It states that she was the mother and grandmother of many Frears and Mitchells in the family. After the record, there is a note about the original manuscript's author; it was then copied by Ora Osterhout
STK11 Prevents Invasion Through STAT3/5 and FAK Repression in Cutaneous Melanoma
Full text linkThe serine/threonine kinase 11 (STK11/LKB1) is a tumor suppressor involved in metabolism and cell motility. In BRAFV600E melanoma, STK11 is inactivated by ERK and RSK, preventing it from binding and activating AMPK and promoting melanoma cell proliferation. Although STK11 mutations occur in 5-10% of cutaneous melanoma, few functional studies have been performed. By knocking out STK11 with CRISPR/Cas9 in two human BRAF-mutant melanoma cell lines, we found that STK11-loss reduced the sensitivity to a BRAF inhibitor (BRAFi). More strikingly, STK11 loss led to an increased invasive phenotype in both 3-dimensional spheroids and in vivo zebrafish xenograft models. STK11 overexpression consistently reverted the invasive phenotype.
Interestingly, STK11 knockout increased invasion also in an NRAS-mutant melanoma cell line. Furthermore, while STK11 was expressed in primary human melanoma tumors, its expression significantly decreased in melanoma metastases especially in brain metastases. In the STK11-knockout cells we observed increased activating phosphorylation of STAT3/5 and FAK. Using inhibitors of STAT3/5 and FAK, we reverted the invasive phenotype in both BRAF and NRAS mutated cells. Our findings confirm an increased invasive phenotype upon STK11-inactivation in BRAF and NRAS-mutant cutaneous melanoma that can be targeted by STAT3/5 and FAK-inhibition
In the Garden, Danielle Mitchell, Spring 2020
No full textDanielle Mitchell is a rising senior from Compton, California majoring in anthropology and sociology. She is a gifted writer who conducted very special interviews in SIS Seminar
Hall Street, Danielle Mitchell, Spring 2020
No full textDanielle Mitchell is a rising senior from Compton, California majoring in anthropology and sociology. She is a gifted writer who conducted very special interviews in SIS Seminar
Peer Interview Script, Danielle Mitchell, Spring 2020
Full text linkDanielle Mitchell is a rising senior from Compton, California majoring in anthropology and sociology. She is a gifted writer who conducted very special interviews in SIS Seminar
Excerpts of Interviews with Peers, Danielle Mitchell, Spring 2020
Full text linkDanielle Mitchell is a rising senior from Compton, California majoring in anthropology and sociology. She is a gifted writer who conducted very special interviews in SIS Seminar
David Mitchell on Cloud Atlas
No full textAuthor David Mitchell joined LMU via Skype to discuss his novel, Cloud Atlas
Local Church Week Pastor Andre Mitchell
No full textPastor Andre Mitchell, Pastor, Author, CEO, Deliverance Temple/Andre Mitchell Ministries, Muncie, IN, speaks on how connecting with other believers is important to your faith for Local Church Week
Letter from Carl Hayden to Bishop Walter Mitchell
No full textLetter from Carl Hayden to Walter Mitchell on building a Union Chapel in the Grand Canyon
W. F. Mitchell
No full textEarlier this year, an article was published in the News Bulletin
(February 2012) on the background of Captain Boyns Hedley
Hocking, a dentist who became one of the first casualties in the
bombing of Darwin in 1942. The author, W F Mitchell, has kindly
provided a summary of the 70th anniversary activities held in
Darwin in February 2012 to commemorate this significant event in
the Northern Territory?s historyDate:2012-09News Bulletin no. 413, p. 36 - 37
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