16 research outputs found
Treatments for Adolescents Affected by Eating Disorders: A Systematic Review of Literature
No full textA systematic literature review (analysis) for treatment options for patients diagnosed with eating disorders or predisposed to risk behaviors. Eating disorders are a mental health concern that affects many adolescents, who are more at risk due to certain behaviors such as body dissatisfaction or distortion, circadian rhythm disorders, or other diagnoses of mental/physical health such as obesity, poor nutrition, anxiety, depression, for example. This review is for the purpose of awareness of evidence-based practice in treatment and how care of patients in treatment plans can be improved in order to provide the best quality.Nursin
A cognitive approach to studying the development of preschool aggression
No full textThe study of aggressive behavior has received a great deal of attention in the development literature. Although it is clear that aggression appears early in development, and childhood aggression is a well-known predictor of future engagement in maladaptive behavior, research on aggressive behavior with preschool-aged children is still limited. Improving our knowledge about what motivates children to engage in aggressive behavior is vital in developing effective strategies and interventions aimed at reducing childhood aggression. In Study 1 we documented the incidence of physical, verbal, and relational acts of aggression in preschool-aged children. The results of Study 1 highlight the surprising complexity and context of aggressive behavior in this young age group. In Study 2, we successfully designed and implemented a new task aimed at assessing patterns of social information processing in preschool-aged children. Results of Study 2 demonstrate that problematic patterns of social information processing in preschoolers are associated with higher teacher ratings of proactive and reactive physical aggression. In Study 3 we examined how children's theory of mind abilities, along with their social information processing, contribute to young children's aggressive behavior. Results from Study 3 demonstrate that the relationship between patterns of social information processing and aggressive behavior differ as a function of children's theory of mind, with theory of mind performance mediating the relationship between children's patterns of social information processing and their aggressive behavior. More specifically, problematic responding to questions assessing patterns of social information processing, coupled with poor performance on select Theory of Mind items was related to higher levels of physical aggression. Likewise, appropriate social information processing patterns, coupled with good performance on select Theory of Mind items was related to higher levels of relational aggression.Ph.D.Includes bibliographical referencesby Kaleigh Matthew
Embodied Reimagining: A Queer Mapping of Identity Performances in Percy Jackson Fan Fiction
No full textThis thesis delves into the multimodal landscape of fan fiction communities, focusing on the characters Nico and Annabeth in Percy Jackson fan fiction pieces. This study illuminates fan fiction\u27s significance beyond mere entertainment through a comprehensive examination of reader-author dynamics and a detailed analysis of transformative works, particularly those reimagining characters like Annabeth. By uncovering fan fiction\u27s role as a space for queer exploration, individual empowerment, and communal interaction, this research underscores its transformative potential in fostering creativity and challenging conventional narratives of representation. Drawing on perspectives from queer theory, Black feminist thought, and gender performance studies, this project highlights fan fiction\u27s capacity to facilitate personal expression, critical inquiry, and community building. However, it also acknowledges the challenges within fan fiction spaces and the ongoing evolution of this inquiry. Moving forward, this research aims to contribute to a deeper understanding of fan fiction\u27s enduring relevance and impact on individual agency and cultural discourse
Addressing complexities in MPM modeling of calibration chamber cone penetrometer tests in homogenous and highly interlayered soils
No full textCone penetrometer tests (CPTs) are used to characterize soil for a variety of geotechnical engineering applications, including earthquake-induced liquefaction triggering assessment. Numerical modeling of CPTs is frequently used to better understand soil behavior, soil-penetrometer interaction, and engineering estimates made from CPT data. However, calibrating and validating numerical CPT simulations with experimental calibration chamber (CC) data can be challenging. Specifically, uncertainties in the interpretation of laboratory strength and compression data compound with uncertainties in the CC testing and the assumptions made when developing the numerical model. This article provides a comprehensive review of uncertainties in the calibration and validation of CPT numerical simulations performed in homogenous sand, homogenous clay, and layered sand-clay soil profiles, comparing numerical results with well-documented experimental calibration chamber tests performed at Deltares. In particular, the Material Point Method (MPM) is used to perform the numerical analyses. A framework is presented to assess how uncertainty in the numerical model output is attributed to each input parameter. It is demonstrated that uncertainties can be explored numerically. Finally, recommendations for future experimental and numerical studies of CPTs are provided.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Dynamics of Structure
History Real or Feigned : Tolkien, Scott, and Poetry\u27s Place in Fashioning History
No full textMost critics of The Lord of the Rings correlate Tolkien\u27s work to ancient texts, like Beowulf, the Elder Edda, and medieval romances. While the connection between these traditional materials and Tolkien is valid, it neglects a key feature of Tolkien\u27s work and one of the author\u27s desires, which was to fashion a sort of history that felt as real as any other old story. Moreover, it glosses over the rather obvious point that Tolkien is writing a novel, or at any rate a long work of prose fiction that owes a good deal to the novel tradition. Therefore, through careful attention to the formal textures of Tolkien\u27s work, melding together both genre criticism and formal analysis (and with a sound understanding of literary history), I argue that Tolkien\u27s work follows a more modern vein and aligns with the nineteenth-century historical novel, the genre pioneered by Sir Walter Scott. The projects of Tolkien and Scott parallel one another in many respects that deserve critical attention. This essay begins the discussion by addressing just one, somewhat surprising, point of comparison: the writers\u27 use of poetry. I observe that Tolkien and Scott utilized poetry in similar ways, and I parse the poems into three distinct categories: low culture poems, high culture poems, and poems which straddle the divide between the two. All of this demonstrates how each piece of poetry, written in an antique style, saturates the texts with historic atmosphere and depth. This lends a sense of authenticity and realism to Scott\u27s works, and later it buttresses Tolkien\u27s attempts to foster the dust of history and create an illusion of authenticity and realism for Middle Earth\u27s (imaginary) past
Engineering a Co-Culture of Bacteria and Yeast for the Production of Renewable p-Coumaric Acid
No full textabstract: p-Coumaric acid is used in the food, pharmaceutical, and cosmetic industries due to its versatile properties. While prevalent in nature, harvesting the compound from natural sources is inefficient, requiring large quantities of producing crops and numerous extraction and purification steps. Thus, the large-scale production of the compound is both difficult and costly. This research aims to produce p-coumarate directly from renewable and sustainable glucose using a co-culture of Yeast and E. Coli. Methods used in this study include: designing optimal media for mixed-species microbial growth, genetically engineering both strains to build the production pathway with maximum yield, and analyzing the presence of p-Coumarate and its pathway intermediates using High Performance Liquid Chromatography (HPLC). To date, the results of this project include successful integration of C4H activity into the yeast strain BY4741 ∆FDC1, yielding a strain that completely consumed trans-cinnamate (initial concentration of 50 mg/L) and produced ~56 mg/L p-coumarate, a resting cell assay of the co-culture that produced 0.23 mM p-coumarate from an initial L-Phenylalanine concentration of 1.14 mM, and toxicity tests that confirmed the toxicity of trans-cinnamate to yeast for concentrations above ~50 mg/L. The hope for this project is to create a feasible method for producing p-Coumarate sustainably
UAS Literary & Arts Journal
No full textProof copy provided by Tidal Echoes.Tidal Echoes presents an annual showcase of writers and artists who share one thing in common: a life surrounded by the rainforests and waterways of Southeast Alaska.What Have We Become? Vol. 5 / Galanin, Nicholas -- A Note From Kaleigh Lambert / Lambert, Kaleigh -- A Note From Thomas Bay / Bay, Thomas -- A Note From Andrew Lounsbury / Lounsbury, Andrew -- A Note From Emily Wall / Wall, Emily -- Sub 5 / Mundy, Joel -- Sub 1 / Mundy, Joel -- Another Morning like This / Johnson, Tina M. -- Hardest to Love /Johnson, Tina M. -- Reasons Why Pregnancy is Not My Idea of a Good Decision / Wendel, Courtney -- This Year in Haiku (a poem for you) / Dornbirer, McKenzie -- Clean Get-Away / Stokes, Richard -- Deflection of the Racism Curve / Stokes, Richard -- On Prince of Wales Island / Wilburn, Evelyn J. -- Frontier Justice / Elgie, Brooke -- Researching in the Woods / Kugo, Yoko -- Blueberry / Blefgen, Linda -- Nightfall / Boesser, Sara -- Alisa on the Flume / Helmar, Patrice -- Jalapeño & Cherry / Helmar, Patrice -- Answer the Subway Minstrel / Helmar, Patrice -- Clair on the Bus / Helmar, Patrice -- Reading the Waves / Kiffer, Dave -- Burial at Sea / Kiffer, Dave -- Interview with Featured Artist Nicholas Galanin / Lounsbury, Andrew -- I Killed and Indian Today / Galanin, Nicholas -- What Have We Become / Galanin, Nicholas -- I Killed an Indian Today 2 / Galanin, Nicholas -- What Have We Become? Vol. 5 / Galanin, Nicholas -- Indian River / Ingallinera, Kathy -- Underworld / Trainor, Amanda -- Winter Raven Totem / Blefgen, Linda -- Tactical Warfare / Boucher, Jacqueline -- Morning Stories / Eriksen, Christy NaMee -- Two Times the Girl / Eriksen, Christy NaMee -- Haiku Stand: Justice, for Allie / Eriksen, Christy NaMee -- You Bring Out the Korean Adoptee in Me / Eriksen, Christy NaMee -- The Heritage of Adam / Radford, Richard -- Search Engine / Lane, Ashia -- Color Guard / Dauenhauer, Nora Marks -- Red Dogs and Onions / Dauenhauer, Richard -- Life Support / Dauenhauer, Richard -- Atonement 2009 / Dauenhauer, Richard -- Ravens Rue The Day / Cramer, Anna -- Maggie at the Greek Festival / Helmar, Patrice -- King / Campbell, Jack -- Sitka Harbor at Sunset / Cramer, Anna -- Blue Glacier / Girven, Wendy -- Kiss Me / Lane, Ashia -- Wade / Lane, Ashia -- Sitka Blacktail in Fall Meadow / Wendel, Courtney -- Bull Orca / Wendel, Courtney -- Aloha / Glanin, Nicholas -- Raven and the First Immigrant / Galanin, Nicholas -- Imaginary Indian Series / Galanin, Nicholas -- Devilish / Galanin, Nicholas -- What Have We Become? Vol. 4 / Galanin, Nicholas -- Love Birds / Galanin, Nicholas -- Anti Hero / Galanin, Nicholas -- Killer Whale Bracelet / Galanin, Nicholas -- Love Birds 3 / Galanin, Nicholas -- Chameleon Ring / Galanin, Nicholas -- Strings / Galanin, Nicholas -- Killer Whale / Galanin, Nicholas -- French Graffiti / Laster, Kate -- Love and the Immune System / Laster, Kate -- XIII / Laster, Kate -- Interview with Heather Lende / Lounsbury, Andrew -- Ruth’s Last Fairy Ride / Lende, Heather -- Sweet Caroline / Lende, Heather -- Singing Together With One Voice / Lende, Heather -- Running Beach / Campbell, Norman -- Burying Jack, June 2008 / Lende, Heather -- Brigid’s light: A Break from Rain / Christianson, Kersten -- 7 the first time we kissed / Holloway, Robyn -- Me and Tui at 13 / Holloway, Robyn -- Sunday school / Holloway, Robyn -- Amber, Lydia, and John / Bausler, Katie -- My Core / Hoffman, Anna -- Cranberry Juice-A Family Ordeal / Hoffman, Anna -- Brown Fat Old / Buffalo, T.M. -- Wait / Fisk, Chalise -- The Shimmering Forest / Morrison, Richard -- Forgotten / Morrison, Richard -- Turn at Martin’s / Pillsbury, Kent -- Smelting Rainbows / Pillsbury, Kent -- Burning Man / Fisk, Chalise -- I’m no daddy’s girl / Fisk, Chalise -- Paper Doll / Haight, Lauren -- For Poppy / McCauley, Roberta -- For Mammy / McCauley, Roberta -- The Catch / Vaida, Catelin -- Last Days of War / Prescott, Vivian Faith -- Act Like a Man / Prescott, Vivian Faith -- Shift Change at the Theatre / Pillsbury, Kent -- Kotzebue Harvest / Merk, William S. -- Echo Canyon / Merk, William S. -- Marbled Murrelet Chick About 23 Days Old / Armstrong, Bob -- Ice Ice Baby / Rivera, Edward -- Medicine Man / Galanin, Nicholas -- Knowledge / Galanin, Nicholas -- Author & Artist Biographies -- What Have We Become? Vol. 3 / Galanin, Nichola
Investigation and validation of the use of surface enhanced Raman spectroscopy for minimally invasive, affordable detection of Alzheimer's disease biomarkers
No full textThere is an unmet need for affordable, minimally invasive detection methods ofAlzheimer’s disease (AD) biomarkers. Amyloid-β oligomers (AβOs) are highly correlated to disease onset and progression. However, their low concentration in blood has hindered their quantification in clinical settings. Surface enhanced Raman spectroscopy (SERS) based sensing platforms are an ideal choice for diagnostics, due to their ultra-high sensitivity and multiplexed detection capability. It was hypothesized that a SERS-based sensing platform could offer high enough sensitivity to enable detection of AβOs at the concentration at which they are expected to exist in blood. To ensure the development of a diagnostic tool with highest sensitivity and lowest deviation, different factors that impact the SERS signal were investigated. SERS in a tensorial technique, so the XYZ spatial orientation of the molecules impacts the resulting spectrum. Nanostars have demonstrated ultra-high sensitivity when used in SERS tags, so two different nanostar morphologies with different surface chemistries were studied. Three analytes, crystal violet, 4- aminothiophenol, and thiophenol, were selected as Raman reporters. It was found that analyte orientation changes can result in SERS signal intensity changes, depending on the surface chemistry of the nanoparticle, the analyte-nanoparticle mode of interaction, and preferred bond angle between analyte and nanoparticle surface, which could be mistaken as due to analyte concentration changes, impacting the reliability of the sensor. Through this study, one nanostar morphology, the 6-branched nanostar, demonstrated higher enhancement factor and lower coefficient of variation, and was therefore selected to synthesize the SERS tag for AβO capture and detection. The lower deviation in signal afforded by these stars is attributed to the uniform spike length, width, and number of spikes per star. Nanoparticle morphology is a key factor in the resulting enhancement factor and deviation of a SERS tag. Conventional methods of nanoparticle visualization consist of electron microscopy, which are 2D imaging techniques. When a 2D image is taken of a 3D object, valuable morphological information is lost. A 3D reconstruction technique would be highly advantageous in extracting nanoparticle features in all dimensions. 3D TEM is a method that enables 3D visualization of nanoparticles, but there are a number of limitations to this method. Few particles can be imaged at a time, and a small total volume can be analyzed by this method. This method does not expose internal morphology, due to the fact that the particle is imaged from different angles, rather than taking cross sectional images. FIB-SEM can be used to acquire images for 3D reconstruction, but to the best of our knowledge, reconstructions of particles smaller than 500 nm has not been achieved. In addition, there are many types of particles, such as porous particles or silica particles, that are difficult to reconstruct by the classic thresholding method due to voxel misidentification. FIB-SEM is applied here to enable reconstruction of particles down to 167 nm in diameter, core-shell structures, hollow, and porous silica particles. This is enabled by the high resolution of acquired images with a voxel size of 5 nm x 5 nm x 5 nm. The final chapter reviews the design and validation of an indirect SERS-based sensor for ultra-sensitive detection of AβOs. Unique capture of the oligomeric form of Aβ is enabled through the implementation of an aptamer that has demonstrated sensitivity and selectivity to AβOs, but not to monomeric or fibrillar Aβ. The sensor is then applied to a low concentration of AβOs in F-12 cell culture media, used to prepare AβOs from the monomeric state, and artificial cerebrospinal fluid (aCSF). Sensitivity at pg/mL concentrations was demonstrated in both systems. Next, the concentration of AβOs was varied in F-12. A good correlation was established between the concentration of AβOs and SERS peak intensity at 1440 cm-1, corresponding to the δ(CH) + ν(CC) vibrational modes. The R2 value is 0.9776 when plotted on a log(x) scale, where x is the oligomer concentration. An inverse correlation, rather than a direct correlation, is established between peak intensity and AβO concentration under these conditions. This is attributed to continuous aggregation of Aβ, which is most rapid at elevated concentrations, resulting in a final concentration that is different from the initial concentration. A high deviation is observed at the intermediate AβO concentrations, which was hypothesized to be attributed to the aggregation during the AβO incubation period with the sensor surface. Therefore, Aβ aggregation behavior at incubation conditions (one hour at room temperature) was investigated with three different solutions, aCSF, F-12, and phosphate buffered saline (PBS), using dynamic light scattering (DLS). It was found that AβOs aggregate at a much faster rate in F-12 than aCSF and PBS, and that aggregation is most rapid at higher initial AβO concentrations. Overall, the work presented here highlights experimental factors that can impact the reliability of a SERS sensor, expands the 3D reconstruction capabilities using FIB-SEM to allow for reconstructions of particles smaller than 200 nm in diameter, and establishes SERS as a useful tool in detecting low concentrations of AβOs.Ph.D.Includes bibliographical reference
Performing Arts Programming for Disadvantaged Youth: An Analysis of Effective Marketing Strategies
No full textabstract: This thesis research aims to define, identify, and promote community theatre as a “third space� for disadvantaged youth. A third space is defined by the Oxford dictionary as “...the in-between, or hybrid, spaces, where the first and second spaces work together to generate a new third space. First and second spaces are two different, and possibly conflicting, spatial groupings where people interact physically and socially: such as home (everyday knowledge) and school (academic knowledge)� (Oxford Dictionary, 2021). For disadvantaged youth, the creation of a third space in the theatre can give them a safe environment away from issues they may have at home or at school, it can further their learning about themselves and others, and it can also help those youth feel a sense of belonging to a community larger than themselves. Because of these benefits, it is clear that performing arts programs can offer a great impact on disadvantaged youth; however, many theatre companies struggle to market their programming to said communities. This may be in part, due to low marketing budgets, no specificity in labor resources dedicated to youth programming, or ineffective marketing strategies and tactics. This research aims to provide tangible recommendations for youth programmers to better involve their target audience. (abstract
Performing Arts Programming for Disadvantaged Youth: An Analysis of Effective Marketing Strategies
No full textabstract: This thesis research aims to define, identify, and promote community theatre as a “third space� for disadvantaged youth. A third space is defined by the Oxford dictionary as “...the in-between, or hybrid, spaces, where the first and second spaces work together to generate a new third space. First and second spaces are two different, and possibly conflicting, spatial groupings where people interact physically and socially: such as home (everyday knowledge) and school (academic knowledge)� (Oxford Dictionary, 2021). For disadvantaged youth, the creation of a third space in the theatre can give them a safe environment away from issues they may have at home or at school, it can further their learning about themselves and others, and it can also help those youth feel a sense of belonging to a community larger than themselves. Because of these benefits, it is clear that performing arts programs can offer a great impact on disadvantaged youth; however, many theatre companies struggle to market their programming to said communities. This may be in part, due to low marketing budgets, no specificity in labor resources dedicated to youth programming, or ineffective marketing strategies and tactics.
In order to ideate marketing recommendations for these organizations, primary research was conducted to determine the attitudes and beliefs revolving around youth participation in community theatre, as well as the current marketing strategies and tactics being utilized by programmers. Participants included program managers of youth theatre programs, as well as youth participants from several major cities in the U. S. The secondary research aims to better understand the target demographic (disadvantaged youth), the benefits derived from participation in arts programming, and marketing strategies for the performing arts. Following data analysis are several recommendations for the learning, planning, and implementation of marketing strategies for theatre programmers. (abstract
