103 research outputs found
“Blockade of Nitric Oxide Overproduction and Oxidative Stress by Nigella Sativa Oil Attenuates Morphine-Induced Tolerance” by Abdel-Zaher et al.
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Un análisis de la aischrología en los Anécdota (Historia Secreta) de Procopio
No full textThe study of the terminology used by Procopius in the Anecdota (“unpublished writings”), commonly known as the Secret History (Historia Arcana) –which constitutes a form of invective against Justinian and his wife Theodora– offers an insight into the axiology of the culture of the Eastern Roman Empire in the 6th century AD. This paper analyzes the rhetorical elements of aischrology against the emperor and his wife in the work, establishing the Anecdota as an essential source for exploring the cultural values of the period. First, a lexical search is carried out through a classification of the aischrological elements used by Procopius to denigrate the figures of Justinian and Theodora. Then, the semantic interrelationships of the terms present in the text are analyzed, showing the conceptual dependence articulated by the author, thus achieving the composition of a unified and holistic invective discourse of greater forcefulness against the emperor. In effect, this analysis aims to highlight, in addition to the Procopius's rhetorical and compositional resources, some moral conceptions shared between the author and the recipients of the discourse.El estudio de la terminología utilizada por Procopio en los Anécdota (“escritos inéditos”), conocidos comúnmente como la Historia Secreta (Historia Arcana) –que constituye una forma de invectiva frente Justiniano y su esposa Teodora–, ofrece una aproximación a la axiología de la cultura del Imperio Romano de Oriente en el siglo VI d. C. En este trabajo se analizan los elementos retóricos de la aischrología contra el emperador y su esposa en la obra, lo que permite establecer a los Anécdota como una fuente insoslayable para la exploración de los valores culturales del periodo. En primer lugar, se realiza un rastreo léxico a través de una clasificación de los elementos ‘aischrológicos’ empleados por Procopio para denostar las figuras de Justiniano y Teodora. Luego, se analizan las interrelaciones semánticas de los términos presentes en el texto, mostrando la dependencia conceptual articulada por el autor, logrando así la composición de un discurso invectivo unificado y holístico de mayor contundencia frente al emperador. En efecto, este análisis pretende evidenciar, además de los recursos retóricos y compositivos de Procopio, algunas concepciones morales compartidas entre el autor y los receptores del discurso
Post-docetaxel therapy in castration resistant prostate cancer - the forest is growing in the desert.
No full textIn Europe, prostate cancer is the most common cancer among men with 382.000 new cases and 89.000 deaths annually. Historically, androgen deprivation therapy and docetaxel based chemotherapy were the only treatments able to improve survival. Two studies have been published during last few months regarding the management of castration resistant prostate cancer (CRPC) progressed after docetaxel: for the first time second line therapies have been demonstrated to improve prognosis of these patients. The relevance of these trials is the reintroduction of chemotherapy and hormonal therapy in a disease once considered chemotherapy and castration resistant. All these data may change the traditional approach to CRPC but no evidences have came out from recently closed or ongoing clinical trials about the therapeutic algorithm. How to get oriented in this forest? We propose that patient's conditions, response and toxicities reported with previous treatments and, above all, dynamics and evolution of disease may influence the choice of subsequent therapies in docetaxel progressed CRPC. © The Author(s), 2012
Discovering ante litteram models of writing that heals and saves. After Giuseppe Berto, Marianna Procopio
No full textIf the theories that came from America could have had no influence on Berto’s Il male oscuro, an established and successful author in whom I accidentally discovered for the first time an ante litteram model of narrative medicine, much less could they have had on the writing of a rather singular book, published in Padua 1962, with the title Diario e altri testi. The book consists of four parts. The text that interests us is contained in the first of them, subtitled Malattia e morte della madre, and divided into several unnumbered chapters. The author is Marianna Procopio. An atypical case from a literary point of view, Marianna was a housewife born at the end of the nineteenth century in Calabria, with an education that stopped at the third grade, and she wrote for the first time in her life at the age of fifty, after a trauma caused by the death of her mother. This event broke Marianna’s life into two parts
that would never be reunited again and rises in her mind to the disturbing grandeur of an epochal era, placing all the rest of the events in a ‘relative’ time that was either before or after it. Wandering around the rooms of the house in vain search for a presence that is such only in her imagination and dreams, Marianna finds in fixing memories on paper, in reviewing the moments that slowly led her mother to death, in continuously updating the calendar of the anniversary, a catharsis from the suffering that is offered by the liberating function of writing. Marianna Procopio’s Diary is therefore the second ante litteram narrative
medicine model I discovered
L'imperfetto narrativo in greco: registro, genere letterario e diacronia
No full textNelle opere narrative greche antiche, così come nelle opere narrative composte in molte altre lingue, le forme di passato perfettivo aoristico (gli indicativi aoristi) sono usate per far progredire la narrazione. Esse denotano sequenze di eventi in primo piano ordinati dal punto di vista temporale. Le forme di passato imperfettivo (gli imperfetti) sono usate, invece, per designare eventi in secondo piano, come descrizioni o commenti dell'autore. Tuttavia, in greco antico, le forme di passato imperfettivo possono essere impiegate in contesti perfettivi per far progredire la narrazione della sequenza principale di eventi. Tali forme di imperfetto sono chiamate "imperfetti narrativi". Lo scopo di questa tesi è fornire una descrizione dello sviluppo diacronico dell'imperfetto narrativo nelle opere letterarie greche. La tesi mira, inoltre, a costruire un corpus esaustivo di diversi testi narrativi greci, con lo scopo di osservare come gli imperfetti narrativi siano utilizzati nei testi letterari greci antichi e bizantini. I testi scelti sono: il primo libro delle Storie di Tucidide; il primo libro delle Storie di Polibio; il primo libro delle Antichità romane di Dionigi di Alicarnasso; il Vangelo di Luca; la Storia lausiaca di Palladio; l'Historia monachorum in Aegypto; il primo libro della Storia di Procopio di Cesarea; i primi due libri delle Storie di Agazia; i primi due libri dell'Alessiade di Anna Comnena; i versi da 1 a 700 delle redazioni H e P della Cronaca della Morea. I testi scelti sono diversi per epoca e registro: questa scelta è stata operata in modo da osservare se l'epoca di composizione e il registro delle opere interagiscono con l'uso dell'imperfetto narrativo. Nelle opere tardoantiche e bizantine analizzate, l'uso dell'imperfetto narrativo sembra interagire con il registro dei testi. Inoltre, in tutti i periodi presi in considerazione in questa tesi, esiste una forte connessione tra il parametro azionale della duratività e l'uso di forme di imperfetto narrativo.In Ancient Greek narrative texts, as well as in other languages, aoristic past forms (aorist indicatives) are used to "push forward" the narration. They are used to denote temporally sequential foregrounded events. On the contrary, imperfective past forms (imperfects) are used to denote backgrounded events, such as descriptions or comments made by the author. However, in Ancient Greek, imperfective past forms can be used in perfective contexts to "push forward" the narration of the main sequence of events. Such an imperfect form is called "narrative imperfect". The aim of this thesis is to provide a description of the diachronic development of the narrative imperfect in Greek literary texts and to build a comprehensive corpus of several narrative literary texts in order to investigate how narrative imperfects are used in both Ancient and Byzantine Greek narrative texts. The texts which have been chosen are: the first book of Thucydides' Histories, the first book of Polybius' Histories, the first book of Dionysius' Roman Antiquities, the Gospel of Luke, Palladius' Historia Lausiaca, the Historia monachorum in Aegypto, the first book of Procopius' Wars, the first two books of Agathias' Histories, the first two books of Anna Comnene's Alexiad, and the first 700 verses of the Chronicle of Morea (version H and version P). The texts which have been chosen are different by age and register, in order to investigate whether the age of composition and the register of the text interact with the use of the narrative imperfect. In Late-Antique and Byzantine Greek, the use of narrative imperfect forms seems to interact with the register of the texts. In all the periods that are under investigation in this thesis, there is also a strong connection between the actional parameter of durativity and the use of narrative imperfect forms, with durative verbs using the narrative imperfect much more frequently than punctual verbs
PREVENZIONE DELLE SORDITA' INFANTILI L'IPOACUSIA COME MALATTIA OGGETTO DI SCREENING
No full textLa sordità infantile si conferma essere uno dei defict neurologici ancora oggi più frequenti nel nostro Paese, rappresentando una patologia a grande impatto sociale.Questa tesi, classificando ed indicando quali sono le cause di ipoacusia infantile, vuole, mediante la prevenzione delle sordità infantili, ricordare ed informare quale problema si sta affrontando e quali sono le problematiche legate ad esso. Attraverso gli screening uditivi infantili, pio, che vengono ormai adottati in tutto il mondo, è stato possibile dimostrare che gli interventi riabilitativi messi in atto a pochissimi mesi di vita permettono un recupero ben al di là di ogni più rosea aspettativa. Valutando, infine, i costi ed i benefici della prevenzione, servendosi di una ricerca svolta per l'Istituto Italiano di Medicina e Salute, si è voluto mettere in evidenza come nol nostro Paese al fronte del problema sordità infantile vi sono ancora pochi lavori sull'argomento. Lo scopo di questa tesi è quello d'invogliare tutti, dagli specialisti, media, direttori ed amministratori sanitari, politici, ai cittadini a fare prevenzione in modo da poter evitare o ridimensionare patologie, in questo caso le sordità, che possono essere "sconfitte" ancor prima di poterlo diventare
Gyro-less solutions to enhance star tracker functionalities at high tumbling rate
No full textLAUREA MAGISTRALENell'ambito dell'ingegneria spaziale, i sensori stellari rappresentano componenti fondamentali dell’AOCS. La loro rilevanza aumenterebbe se fosse possibile farli operare a velocità angolari elevate, fino a 10 gradi al secondo, sostituendo potenzialmente i costosi giroscopi o fungendo da backup in caso di malfunzionamenti. Condotta tra settembre 2023 e marzo 2024, la ricerca svolta presso Leonardo S.p.A. mira a migliorare la resilienza e l'efficienza dei veicoli spaziali. Lo studio prevede modifiche sia hardware che software per ottimizzare le prestazioni del sensore stellare in condizioni dinamiche. Mentre gli aggiornamenti hardware mirano principalmente a ridurre il rumore nel rivelatore APS, svolti da Leonardo S.p.A., le metodologie software sono sviluppate nell'ambito della ricerca di tesi. Essa si concentra su tre aree di interesse: la determinazione della velocità angolare utilizzando campi stellari ad alte velocità e la compensazione delle distorsioni dell'immagine dovute all'effetto "rolling shutter" durante la AAD, l'esplorazione di metodi di filtraggio per minimizzare gli errori nel calcolo della velocità angolare durante la modalità di "tracking". Gli algoritmi della AAD sono progettati per essere compatibili con le configurazioni dei sensori reali, tenendo conto delle limitazioni hardware e dei vincoli temporali. Oltre ai progressi tecnologici, questa ricerca affronta le sfide pratiche dell'integrazione delle innovazioni all'interno del prodotto. I risultati attesi includono una comprensione delle limitazioni attuali dei sensori stellari ad alta velocità angolare e l'identificazione di metodi per la determinazione precisa dell'assetto e della velocità in tali condizioni, garantendo una performance affidabile. Inoltre, lo studio prevede un'analisi dell'adattabilità pratica di questi metodi a configurazioni reali, facilitata dalla collaborazione con l'azienda. Nel complesso, questa tesi offre un contributo significativo all'AOCS. Le metodologie proposte promettono potenziali risparmi sui costi e un aumento dell'affidabilità, contribuendo così al progresso nell'esplorazione e nella navigazione spaziale.In the realm of space technology, star trackers are key components within the AOCS. Their significance is magnified by the potential to function at high angular velocities (up to 10 deg/s), potentially replacing costly gyroscopes or serving as backups in case of failure. Conducted between September 2023 and March 2024, research undertaken at Leonardo S.p.A. is driven by the aim to enhance spacecraft resilience and efficiency. This study's framework encompasses both hardware and software modifications to improve star tracker performance under high dynamics conditions. While hardware upgrades primarily target noise reduction in the APS detector, conducted by Leonardo S.p.A., software methodologies are effectively developed within the research. Three focal points include precise angular velocity determination using star fields at high angular rates and compensation for image distortions due to the "rolling shutter" effect during AAD, exploring filtering methods to minimise errors in angular velocity calculation during tracking mode. AAD algorithms are designed for practical compatibility with real-world sensor configurations, considering hardware constraints and execution time limitations. Beyond technological advancements, this research tackles the practical challenges of implementing innovations within stringent hardware parameters and operational time frames. Anticipated findings encompass a comprehensive understanding of current limits in high angular velocity star trackers and innovative methods for precise attitude and velocity determination under such conditions, ensuring reliable celestial tracking. Additionally, the study foresees insights into the practical adaptability of these methods to real setups fostered by close collaboration with the company. Overall, this thesis presents a substantial contribution to AOCS. The proposed methodologies promise potential cost savings and heightened reliability, thus contributing to advancements in space exploration and navigation
Procopio Serpotta e la tecnica dello stucco: un episodio sconosciuto a Monreale, iconografia, attribuzione
No full textThis paper intends to present a church located in the heart of the city of Monreale - Maria SS. degli Agonizzanti - hidden from the tourist road, but mostly neglected by art history studies of Sicily. Its interior decoration, thanks to a recent restoration, offers the opportunity to discover the iconographic program tied to the purpose of its construction: the site of a religious confraternity with the aim of offering alms, care of the sick and the burial of the dead. This study provides iconographic and stylistic comparisons between the stucco sculptures of the church of Monreale with those of the artistic activity of Procopio Serpotta (1679-1755). These comparisons leave no doubt about the authorship and the realization by the sculptor, until now never confirmed with certainty. Furthermore, these sculptures and the entire iconographic program and theological have been studied in this paper with the allegories of the book of Cesare Ripa Iconologia, published for the first time in Rome in 1593, the most extensive repertory of allegorical images taken in the visual arts. The great success of this work - the author of five editions of living, eighteen posthumous seventeenth, eighteenth fifteen - marks the modern revival of interest in the world of symbols and images that, combined with the word of men of letters, they become in effect a new language. It was Donald Garstang to rediscover critically Giacomo Serpotta (1656-1732) and his school of plasterers with the publication of the monograph in English, written in 1984 by passionate and admired full participation of important contributions documentaries, even without a direct knowledge of some works within the island
Procopio Serpotta e la tecnica dello stucco: un episodio sconosciuto a Monreale, iconografia, attribuzione
No full textThis paper intends to present a church located in the heart of the city of Monreale - Maria SS. degli Agonizzanti - hidden from the tourist road, but mostly neglected by art history studies of Sicily. Its interior decoration, thanks to a recent restoration, offers the opportunity to discover the iconographic program tied to the purpose of its construction: the site of a religious confraternity with the aim of offering alms, care of the sick and the burial of the dead. This study provides iconographic and stylistic comparisons between the stucco sculptures of the church of Monreale with those of the artistic activity of Procopio Serpotta (1679-1755). These comparisons leave no doubt about the authorship and the realization by the sculptor, until now never confirmed with certainty. Furthermore, these sculptures and the entire iconographic program and theological have been studied in this paper with the allegories of the book of Cesare Ripa Iconologia, published for the first time in Rome in 1593, the most extensive repertory of allegorical images taken in the visual arts. The great success of this work - the author of five editions of living, eighteen posthumous seventeenth, eighteenth fifteen - marks the modern revival of interest in the world of symbols and images that, combined with the word of men of letters, they become in effect a new language. It was Donald Garstang to rediscover critically Giacomo Serpotta (1656-1732) and his school of plasterers with the publication of the monograph in English, written in 1984 by passionate and admired full participation of important contributions documentaries, even without a direct knowledge of some works within the island
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