22 research outputs found

    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

    No full text
    Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation

    A Gated Recurrent Unit Deep Learning Model to Detect and Mitigate Distributed Denial of Service and Portscan Attacks

    No full text
    Nowadays, it is common for applications to require servers to run constantly and aim as close as possible to zero downtime. The slightest failure might cause significant financial losses and sometimes even lives. For this reason, security and management measures against network threats are fundamental and have been researched for years. Software-defined networks (SDN) are an advancement in network management due to their centralization of the control plane, as it facilitates equipment setup and administration over the local network. However, this centralization makes the controller a target to denial of service attacks (DoS). In this study, we aim to develop a network anomaly detection and mitigation system that uses gated recurrent unit (GRU) neural networks combined with fuzzy logic. The neural network is trained to forecast future traffic, and anomalies are detected when the forecasting fails. The system is designed to operate in software-defined networks since they provide network flow information and tools to manage forwarding tables. We also demonstrate how the neural network&#x2019;s hyperparameters affect the detection module. The system was tested using two datasets: one with emulated traffic generated by the data communication and networking research group called Orion, from computer science department at state university of Londrina, and CICDDoS2019, a well-known dataset by the anomaly detection community. The results show that GRU networks combined with fuzzy logic are a viable option to detect anomalies in SDN and possibly in other anomaly detection applications. The system was compared with other deep learning techniques
    corecore