162,289 research outputs found
Jung Seok Lee
No full text학위논문(석사)--아주대학교 일반대학원 :분자과학기술학과,2006. 2수용액 상에서 자발적으로 마이셀을 형성하는 양친매성 고분자는 약물전달 시스템의 응용분야에서 널리 연구되고 있다. 그러나 여러가지 약의 효능이 동시에 필요한 상처 부위를 치료하는 경우, 마이셀에 한가지 약물을 담아 전달하는 시스템의 한계가 드러나고 있다. 이에 본 연구의 목적은 헤파린을 함유하고 있는 마이셀을 개발하여 두가지 약을 동시에 전달하는 운반체를 만드는 데 있다.
양친매성 고분자인 테트로닉과 카프로락톤 및 주석계 촉매를 벌크 중합하여 테트로닉-카프로락톤 공중합체를 제조한 후, EDC/NHS 결합체로써 헤파린을 공유결합시켜 테트로닉-폴리락타이드-헤파린 공중합체를 합성하였다. 합성된 고분자의 구조와 물리화학적 특성은 핵자기공명분광법 (1H-NMR), 적외선 분광법 (FT-IR), 젤투과크로마토그래피법 (GPC)을 이용하여 분석하였다. 공유결합된 헤파린의 양은 측정 결과, 0.44㎍/㎍ 으로 계산되었으며, 헤파린의 활성은 결합되지 않은 상태의 헤파린에 비해 43.6% 에 해당하는 것으로 분석되었다. 또한, 합성된 고분자가 단백질 전달 운반체로써 적절한지 평가하기 위하여, 임계 마이셀 농도 (CMC)와 마이셀의 크기, 약물 저장 효율, 그리고 체외에서의 약물 방출 경향 등을 조사하였다.
본 연구는 헤파린을 함유한 고분자 마이셀을 성공적으로 개발하였으며, 개발된 약물 운반체는 다양한 단백질과 소수성 약물을 효율적으로 전달하는 시스템에 적합하므로, 약제학과 조직공학에서 높은 유용성을 가지고 있음을 알 수 있다.Ⅰ. INTRODUCTION
A. Polymeric micelle
1. Chemical nature of polymeric micelles
2. Mechanism of micelle formation
3. Pharmaceutical applications
B. Heparin
1. Structure of heparin
2. Medical importance of heparin
3. Interaction of heparin with proteins
C. Protein delivery
1. Protein folding and aggregation
2. Importance of protein delivery
D. Tetronic？？ 1307 as a polymer surfactant
E. Poly (ε-caprolactone) (PCL)
F. Objectives
Ⅱ. EXPERIMENTS
A. Materials
B. Synthesis of Tetronic？？-PCL-heparin
C. Characterizations of Tetronic？？-PCL-heparin
D. Heparin analysis
E. Micelle preparation and characterizations
F. Measurement of drug loading efficiency
G. Release kinetics test
H. Protein activity test of bFGF
Ⅲ. RESULTS AND DISCUSSION
A. Synthesis and characterizations of Tetronic？？-PCL
-heparin
B. Quantitative analysis and activity test of heparin
C. Micelle preparation and characterizations ∙
D. Drug loading efficiency
E. In vitro release profiles
F. Protein activity test of bFGF
Ⅳ. CONCLUSIONS
Ⅴ. REFERENCES
Abstract (in Korean)Maste
Neural Signals Related to Outcome Evaluation Are Stronger in CA1 than CA3
Full text linkWe have shown previously that CA1 conveys significant neural signals necessary to update value of the chosen target, namely chosen value and reward signals. To better understand hippocampal neural processes related to valuation, we compared chosen value- and reward-related neural activity between the CA3 and CA1 regions. Single units were recorded with tetrodes from the dorsal CA3 and CA1 regions of rats performing a dynamic foraging task, and chosen value- and reward-related neural activity was estimated using a reinforcement learning model and multiple regression analyses. Neural signals for chosen value and reward converged in both CA3 and CA1 when a trial outcome was revealed. However, these neural signals were stronger in CA1 than CA3. Consequently, neural signals for reward prediction error and updated chosen value were stronger in CA1 than CA3. Together with our previous finding that CA1 conveys stronger value signals than the subiculum, our results raise the possibility that CA1 might play a particularly important role among hippocampal subregions in evaluating experienced events. © 2017 Lee, Huh, Lee, Ghim, Lee and Jung. © 2017 Lee, Huh, Lee, Ghim, Lee and Jung. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Copyright © 2017 Lee, Huh, Lee, Ghim, Lee and Jung. This is an open-access article
distributed under the terms of the Creative Commons Attribution License (CC BY).
The use, distribution or reproduction in other forums is permitted, provided the
original author(s) or licensor are credited and that the original publication in this
journal is cited, in accordance with accepted academic practice. No use, distribution
or reproduction is permitted which does not comply with these terms.1221Nsciescopu
sj-docx-1-npx-10.1177_1934578X211068606 - Supplemental material for A new Butenolide Derivative from the Brown Alga <i>Sargassum micracanthum</i>
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sj-docx-1-tam-10.1177_17588359231189421 – Supplemental material for Pretreatment endocrine symptoms and recurrence-free survival among young premenopausal patients with breast cancer: a prospective cohort study
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ACR883714 Supplemetal Material5 - Supplemental material for Comparison of tissue tracking assessment by cardiovascular magnetic resonance for cardiac amyloidosis and hypertrophic cardiomyopathy
No full textSupplemental material, ACR883714 Supplemetal Material5 for Comparison of tissue tracking assessment by cardiovascular magnetic resonance for cardiac amyloidosis and hypertrophic cardiomyopathy by Hye Na Jung, Sung Mok Kim, Jeong Hyun Lee, Yiseul Kim, Sang-Chol Lee, Eun-Seok Jeon, Hwan Seok Yong and Yeon Hyeon Choe in Acta Radiologica</p
ACR883714 Supplemetal Material4 - Supplemental material for Comparison of tissue tracking assessment by cardiovascular magnetic resonance for cardiac amyloidosis and hypertrophic cardiomyopathy
No full textSupplemental material, ACR883714 Supplemetal Material4 for Comparison of tissue tracking assessment by cardiovascular magnetic resonance for cardiac amyloidosis and hypertrophic cardiomyopathy by Hye Na Jung, Sung Mok Kim, Jeong Hyun Lee, Yiseul Kim, Sang-Chol Lee, Eun-Seok Jeon, Hwan Seok Yong and Yeon Hyeon Choe in Acta Radiologica</p
ACR883714 Supplemetal Material7 - Supplemental material for Comparison of tissue tracking assessment by cardiovascular magnetic resonance for cardiac amyloidosis and hypertrophic cardiomyopathy
No full textSupplemental material, ACR883714 Supplemetal Material7 for Comparison of tissue tracking assessment by cardiovascular magnetic resonance for cardiac amyloidosis and hypertrophic cardiomyopathy by Hye Na Jung, Sung Mok Kim, Jeong Hyun Lee, Yiseul Kim, Sang-Chol Lee, Eun-Seok Jeon, Hwan Seok Yong and Yeon Hyeon Choe in Acta Radiologica</p
ACR883714 Supplemetal Material3 - Supplemental material for Comparison of tissue tracking assessment by cardiovascular magnetic resonance for cardiac amyloidosis and hypertrophic cardiomyopathy
No full textSupplemental material, ACR883714 Supplemetal Material3 for Comparison of tissue tracking assessment by cardiovascular magnetic resonance for cardiac amyloidosis and hypertrophic cardiomyopathy by Hye Na Jung, Sung Mok Kim, Jeong Hyun Lee, Yiseul Kim, Sang-Chol Lee, Eun-Seok Jeon, Hwan Seok Yong and Yeon Hyeon Choe in Acta Radiologica</p
ACR883714 Supplemetal Material6 - Supplemental material for Comparison of tissue tracking assessment by cardiovascular magnetic resonance for cardiac amyloidosis and hypertrophic cardiomyopathy
No full textSupplemental material, ACR883714 Supplemetal Material6 for Comparison of tissue tracking assessment by cardiovascular magnetic resonance for cardiac amyloidosis and hypertrophic cardiomyopathy by Hye Na Jung, Sung Mok Kim, Jeong Hyun Lee, Yiseul Kim, Sang-Chol Lee, Eun-Seok Jeon, Hwan Seok Yong and Yeon Hyeon Choe in Acta Radiologica</p
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