26,391 research outputs found
Dr. Lee Chia Kuang cipta perisian baharu Dematel Digraph
Full text linkPenyelidik dari Fakulti Pengurusan Industri (FPI), Universiti Malaysia Pahang (UMP), Dr. Lee Chia Kuang, 35, telah mencipta perisian baharu iaitu Dematel Digraph
Dr. Lee Chia Kuang invents new software Dematel Digraph
Full text linkA lecturer from the Faculty of Industrial Management (FPI), Universiti Malaysia Pahang (UMP), Dr. Lee Chia Kuang, 35, created a new software called Dematel Digraph
DEMAEX SIM Simulator inovasi terbaharu Dr. Lee Chia Kuang
Full text linkGAMBANG, 15 Jun 2021 - DEMAEX-SIM atau dikenali sebagai DEMATEL EXCEL Simulator adalah inovasi terbaharu daripada penyelidik dan pensyarah kanan, Fakulti Pengurusan Industri, Universiti Malaysia Pahang (UMP), Dr. Lee Chia Kuang, 36 tahun
Evaporation in fen wetlands
Full text linkWicken Fen represents a remnant of the once extensive peat fenlands of East Anglia, which survived large-scale drainage efforts intended to bring land into agricultural production due to its importance within the local economy and subsequently as a site of interest to scientists. Wicken Fen is managed so as to conserve a variety of habitats lost as a result of drainage and therefore does not represent a truly natural environment. Traditional management practices on Sedge Fen, the largest part of Wicken Fen, involve maintaining a 3 – 4 year harvesting cycle and controlling soil water levels. Previous hydrological studies of Wicken Fen have determined that soil water levels are strongly influenced by precipitation and evapotranspiration. The evaporative flux at Sedge Fen is commonly estimated by using meteorological data within empirical formulae such as the Penman Monteith equation owing to measurement difficulties. Furthermore, there has been little investigation of the evaporative loss from fens within the UK. This study aims to investigate the evaporative loss from Sedge Fen so as to better inform hydrological management and to describe evapotranspiration estimation techniques which may be employed at other fen sites. Eddy covariance measurements demonstrated that evapotranspiration from Sedge Fen was typically less than reference evapotranspiration estimates. Evapotranspiration estimates may be improved by consideration of surface parameters which can be described using meteorological data. Meteorological differences existed between Sedge Fen and the surrounding area, resulting in differing evapotranspiration estimates depending on where data was collected. Evapotranspiration measurements were used within a simple water budget model of Sedge Fen and demonstrated the lateral movement of soil water, a hydrological flux previously assumed to be of little consequence within the hydrological balance of Sedge Fen
Preparation and Properties of Poly(acrylic acid) Oligomer Stabilized Superparamagnetic Ferrofluid
No full textProfesor Madya Ts. Dr. Lee Chia Kuang cipta pendekatan baharu pembelajaran risiko projek melalui modul Risk Ready
Full text linkPEKAN, 16 Julai 2025 – Menyedari perubahan drastik dalam landskap pendidikan global sejak pandemik melanda pada awal tahun 2020, Pensyarah Fakulti Pengurusan Industri (FPI), Universiti Malaysia Pahang Al-Sultan Abdullah (UMPSA), Profesor Madya Ts. Dr. Lee Chia Kuang mengambil inisiatif membangunkan sebuah modul pembelajaran yang inovatif dan adaptif terhadap keperluan semasa.
Menurut Profesor Madya Ts. Dr. Lee, modul yang dikenali sebagai Risk Ready: Micro Credential in Project Risk Management ini dirangka bagi menangani cabaran pembelajaran dalam talian yang dihadapi pelajar dalam bidang teknikal seperti pengurusan projek dan pengurusan risiko
Preparation of Thermor-esponsive Core-Shell Copolymer Latex with Potential Use in Drug Targeting
No full textEmprego da tecnologia supercrítica para a valorização do resíduo de semente de chia (Salvia hispanica)
Full text linkDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Alimentos, Florianópolis, 2014.A chia (Salvia hispanica) é uma planta cultivada nas Américas do Sul e Central, cuja semente é fonte de antioxidantes naturais e ácidos graxos essenciais. O presente estudo avaliou a obtenção de extratos de torta de chia, subproduto proveniente da extração do óleo de chia. Foram aplicadas as técnicas a baixa pressão como extração em Soxhlet (SOX), ultrassom (US) e maceração (MAC) utilizando etanol (EtOH), hexano (Hex) e acetato de etila (EtOAc) como solventes, a fim de comparar com o processo de extração supercrítica (ESC). As operações de ESC foram realizadas com pressões de 150 bar a 300 bar e temperaturas de 40 °C e 50 °C empregando o CO2 como solvente. Também foi realizada a aplicação de EtOH e EtOAc como cossolventes no processo de ESC em concentrações de 2,5 até 7,5 %. O processo de extração supercrítica sequencial (ESC-S) foi estudado, o qual possui duas etapas de extração, com uma despressurização rápida do sistema entre a primeira e a segunda etapa. A construção da curva cinética e modelagem matemática de processos de ESC e ESC-S foram executadas, além da estimativa de custos de manufatura da instalação de uma unidade industrial de ESC. Todos os extratos obtidos foram submetidos a análises de atividade antioxidante (método ABTS), teor de fenólicos totais (TFT), perfil de ácidos graxos e atividade antimicrobiana. Nas extrações a baixa pressão, os maiores rendimentos foram obtidos utilizando SOX com EtOH (15,4 ± 0,4 %). Nas ESC com CO2 puro, a pressão de 300 bar permitiu alcançar rendimentos de até 10,6 ± 0,2 %, na maior temperatura estudada. A utilização de cossolvente causou aumento no rendimento de extração (11,3 ± 0,1% utilizando EtOH a 7,5%). Os extratos obtidos em extrações a baixa pressão com EtOH e EtOAc obtiveram os melhores valores de TFT e atividade antioxidante. A utilização de cossolvente afetou positivamente os resultados de TFT e atividade antioxidante dos extratos de ESC. O perfil de ácidos graxos dos extratos confirmou altos teores de ácido linoleico e a-linolênico em todos os extratos testados. Extratos obtidos pelas diferentes técnicas mostraram atividade antimicrobiana contra B. cereus. A ESC-S com despressurização rápida teve efeito positivo com relação ao rendimento, onde foi atingido rendimento de 8,7 ± 0,2%, estatisticamente igual ao rendimento obtido em ESC na mesma condição, porém reduzindo o tempo de extração pela metade. A realização da segunda etapa de ESC-S utilizando EtOH 7,5% ocasionou um aumento no TFT dos extratos obtidos. O modelo que melhor se ajustou as curvas experimentais foi o modelo de Martínez et al. (2003). Segundo o modelo de Sovová (1994), para os processos de ESC e primeira etapa de ESC-S, o mecanismo de convecção foi mais representativo. Na segunda etapa de ESC-S o mecanismo de difusão também mostrou representatividade. A ESC-S quando realizada até a etapa de despressurização (ESC-Desp) mostrou ser um processo economicamente viável e lucrativo para aplicação em escala industrial, com valores de extrato competitivos com os valores de mercado, gerando extratos de alta qualidade em um menor tempo de processo.Abstract : Chia (Salvia hispanica) is a plant cultivated in South and Central America, whose the seed is a source of natural antioxidants and essential fatty acids. The present study evaluated the extracts attainment from chia seed cake, which is a byproduct from chia seed oil extraction process. It were applied low-pressure techniques, like Soxhlet extraction (SOX), ultrasound assisted extraction (US) and maceration (MAC) using ethanol (EtOH), hexane (Hex) and ethyl acetate (EtOAc) and as solvents with the objective of comparing with the high pressure process, performed by supercritical fluid extraction (SFE). SFE were performed at pressures from 150 to 300 bar and temperatures of 40 °C and 50 °C, using CO2 as solvent. It was also performed an application of EtOH and EtOAc as cosolvents on SFE process, using concentrations from 2.5 to 7.5%. A sequential supercritical fluid extraction (S-SFE) process was studied, wich includes two steps of extraction, with a fast depressurization of the system between the first and the second step of extraction. The kinetic extraction curves of SFE and S-SFE processes were built and mathematical models adjusted the experimental data. It were also performed an estimative of manufacturing costs from installing a supercritical fluid extraction industrial unit. All extracts was submitted to antioxidant analysis (ABTS method), total phenolics content (TPC), fatty acids profile and antimicrobial analysis. Among low-pressure extraction, the highest yield was achieved using SOX with EtOH (15.4 ± 0.4 %). Among the SFE assays using pure CO2, the pressure of 300 bar allowed to achieve yields up to 10.6 ± 0.2 %, in the highest tested temperature. The use of a cosolvent caused increase in yield (11.3 ± 0.1% using EtOH 7,5%). Extracts obtained by lowpressure techniques using EtOH and EtOAc showed the best values of TPC and antioxidant activity. The using of a cosolvent affected in a positive way the results of TPC and antioxidant activity of SFE extracts. The fatty acids profile of the extracts confirmed the high content of linoleic and a-linolenic acids in all tested extracts. Extracts obtained by different techniques showed antimicrobial activity against B. cereus. SSFE process with fast depressurization caused a positive effect in yield, achieving a yield of 8.7 ± 0.2%, statiscally equal to the yield obtained by SFE using the same condition, but reducing the extraction time by half. The performance of the S-SFE second step using EtOH 7.5% caused an increase in the TPC of the obtained extracts. Martínez et al (2003) was the model which best-adjusted experimental data. According to Sovová s model (1994), in S-SFE first step and SFE processes, the convection mechanism was more representative. In the S-SFE second step, the diffusion mechanism showed to be representative. S-SFE process, when realized until the depressurization step (SFE-Desp), showed to be an economically viable and profitable process on an industrial scale application, with values of extract competitive with market values, generating high quality extracts in a shorter process time
Reviewing Ligand-Based Rational Drug Design: The Search for an ATP Synthase Inhibitor
No full textFollowing major advances in the field of medicinal chemistry, novel drugs can now be designed systematically, instead of relying on old trial and error approaches. Current drug design strategies can be classified as being either ligand- or structure-based depending on the design process. In this paper, by describing the search for an ATP synthase inhibitor, we review two frequently used approaches in ligand-based drug design: The pharmacophore model and the quantitative structure-activity relationship (QSAR) method. Moreover, since ATP synthase ligands are potentially useful drugs in cancer therapy, pharmacophore models were constructed to pave the way for novel inhibitor designs
Synthesis and Morphology of Fe3O4/polystyrene/poly(isopropylacrylamide-co-methyl acrylate acid) Magnetic Composite Latex - 2,20-Azobis (2-methylpropionamidine) Dihydrochloride as Initiator
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