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Leptin in intestinal inflammation: good and bad gut feelings.
Leptin has a the potent effect on T cell mediated intestinal autoimmunity and may have a role in the development of such diseases
Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines.
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression.
Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses.
Chronic esposure to Helicobacter pylori impairs dendritic cell function and inhibits Th1 development
Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice.
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