169,992 research outputs found
Jnanavapi tra etnografia e storia: note di una ricerca su un pozzo sacro al centro dei pellegrinaggi locali di Varanasi
No full textPrincipio da qui; da colui che è stato negli ultimi anni, ed è tuttora, centro, voce narrante, informante,6 soggetto e oggetto di ricerca, presso cui converge una serie di percorsi di studio di cui vorrei fornire in questa sede una trama generale, al fine di presentare i vari temi di indagine, i possibili sviluppi di una ricerca incentrata su Jñānavāpī
Transposed sacred places in Varanasi: connecting local sites to pan-Indian places of pilgrimage
No full textDual descent regularization algorithms in variable exponent Lebesgue spaces for imaging
No full textWe consider one-step iterative algorithms to solve ill-posed inverse problems in the framework of variable exponent Lebesgue spaces Lp(·) . These unconventional spaces are particular (non-Hilbertian) Banach spaces which can induce adaptive local regularization in the resolution of inverse problems. We first study gradient descent iteration schemes in Banach spaces, where the classical Riesz theorem does not hold and, consequently, primal and dual spaces are no longer isometrically isomorphic. In particular, we prove that gradient methods in Banach spaces can be fully explained
and understood in the context of proximal operator theory, with appropriate norm or Bregman distances as proximity measure, which shows a deep connection between regularization iterative schemes and convex optimization. We review the key concept of duality map, and provide an explicit formula of the duality map for the space Lp(·).
Then we apply the Landweber and the Conjugate Gradient methods, extended to Banach setting, to solve deblurring imaging problems in Lp(·) and propose an effective strategy to select the point-wise variable exponent function p(·). Our numerical tests show the advantages of considering variable exponent Lebesgue spaces w.r.t. both the standard L2 Hilbert and the constant exponent Lebesgue space Lp, in terms of both reconstruction quality and convergence speed
OPG/RANKL system imbalance in a case of hepatitis C-associated osteosclerosis: the pathogenetic key?
No full textHepatitis C-associated osteosclerosis (HCAO) is an impressive example of acquired diffuse osteosclerosis in adults, recently described in ten patients infected with hepatitis C virus (HCV). Its hallmark is a painful and generalized increase of bone mass. Bone biopsies show enhanced accretion rate, usually without histological abnormalities. The HCAO pathogenesis is hitherto unknown. HCV might induce a slow bone cell infection and the production of bone growth factors, such as insulin-like growth factors. Recently, receptor activator of nuclear factor-kappaB (RANK), its ligand (RANKL), and soluble decoy receptor osteoprotegerin (OPG) have been identified as a pivotal cytokine system in the bone remodeling control. We describe the 11th case of HCAO. Notably, the patient's bone biopsy showed the presence of a high number of OPG-positive osteoblasts, a slight increase of RANKL-positive stromal cells, and a dramatic reduction of the osteoclasts. Moreover, OPG serum levels were increased. These findings reported here for the first time are consistent with a pathogenetic role of the OPG/RANKL system imbalance in HCAO
Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
No full textAlthough osteolysis is a common complication in patients with multiple myeloma (MM), the biologic mechanisms involved in the pathogenesis of MM-induced bone disease are poorly understood. Two factors produced by stromal-osteoblastic cells seem critical to the regulation of bone resorption: osteoprotegerin (OPG) and its ligand (OPGL). OPGL stimulates osteoclast differentiation and activity, whereas OPG inhibits these processes. The present study investigated whether myeloma cells affect physiologic OPG/OPGL balance in the bone marrow (BM) environment. Ten human myeloma cell lines and myeloma cells isolated from 26 consecutive patients with MM failed to express OPGL and only rarely produced a low amount of OPG. In a coculture system, human myeloma cells up-regulated OPGL expression but strongly down-regulated OPG production in preosteoblastic (preOB) or stromal cells (BMSCs) of primary human BM at the mRNA and protein levels. This effect, which was dependent on cell-to-cell contact between myeloma cells and BMSCs or preOB, partially involved the integrin VLA-4. In addition, overexpression of OPGL mRNA occurred in ex vivo BM cultures obtained from MM patients as compared with healthy donors, and immunohistochemical staining performed on BM biopsy specimens showed an increase of OPGL and a reduction of OPG expression in MM patients as compared with healthy subjects. In summary, these data indicate that myeloma cells affect the OPG/OPGL ratio in the BM environment and tend to confirm that the OPG/OPGL system is involved in the pathogenesis of MM-induced bone disease
Human myeloma cells upregulate RANKL and downregulate OPG in bone environment: evidence of OPG/RANKL imbalance in multiple myeloma patients
No full textArthroscopy treatment for radiocarpal arthritis in a calf=Artroscopia in corso di artrite radiocarpica in una vitella
No full textThe clinical signs, diagnosis and successful surgical treatment of bacterial arthritis in a calf in Italy [date not given] are described
Linear FDEM subsoil data inversion in Banach spaces
No full textThe applicative motivation of this paper is the reconstruction of some electromagnetic features of the earth superficial layer by measurements taken above the ground. We resort to frequency domain electromagnetic data inversion through a well-known linear integral model by considering three different collocation methods to approximate the solution of the continuous problem as a linear combination of linearly independent functions. The discretization leads to a strongly ill-conditioned linear system. To overcome this difficulty, an iterative regularization method based on Landweber iterations in Banach spaces is applied to reconstruct solutions which present discontinuities or have a low degree of smoothness. This kind of solutions are common in many imaging applications. Several numerical experiments show the good performance of the algorithm in comparison to other regularization techniques
Supplemental Data from: Sphingosine 1-phosphate induces cAMP/PKA-independent phosphorylation of the cAMP response element-binding protein (CREB) in granulosa cells
No full textThis document accompanies and supplements the following manuscript: “Sphingosine 1-phosphate induces cAMP/PKA-independent phosphorylation of the cAMP response element-binding protein (CREB) in granulosa cells” by Paradiso E, Lazzaretti C, Sperduti S, Antoniani F, Fornari G, Brigante G, Di Rocco G, Tagliavini S, Trenti T, Morini D, Falbo AI, Villani MT, Nofer J-R, Simoni M, Potì* F, Casarini L.<br
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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