6 research outputs found
Hundreds of variants clustered in genomic loci and biological pathways affect human height
No full textMost common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1), but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait(2,3). The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
No full textObesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation
Notion, nature and extent of consent in international arbitration
No full textPhDArbitration is a consensual and private mechanism of dispute resolution which leads to
an enforceable arbitral award. In the traditional field of commercial arbitration the
agreement to arbitrate is considered to be the cornerstone of arbitration. On the other
hand, in the international context, arbitration has become increasingly used in other
areas, like investment arbitration and sport arbitration, where the consensual nature of
arbitration appears to be different.
At the beginning of the study it will be underlined that, when speaking about the
consensual nature of arbitration, one needs to differentiate between consensual as one of
the essential criteria for arbitration’s qualification and consent as a condition for the
validity of the arbitration agreement. This differentiation is especially important in sport
arbitration where, between the athletes and sport organisations, there is often induced
consent rather than bargained consent. By sustaining that the consensual character of
arbitration needs to be differentiated, but not abandoned, the thesis clearly takes a
contractual, or better, a consensual approach. It is preferable to speak of a consensual
approach, because the agreement to arbitrate does not always take the form of an
arbitration agreement in the traditional sense. This is particularly the case in investment
arbitration.
This thesis is a comparative study. However, not only a comparison of national laws
and different arbitration rules will be undertaken, but the thesis will also consider the
evolution of arbitration by discussing the implications that evolution has had on the
perception of the consensual character of arbitration. Moreover, and above all, the main
body of the thesis will be dedicated to a comparison focused on the consent issues of the
three main areas where arbitration is nowadays used in an international context:
commercial arbitration, investment arbitration and sport arbitration. It will be stressed
that, although already in the classical area of commercial arbitration, the structures of
arbitrations may be of different types, ranging from bi-party situations to multiparty
scenarios, and might play a role when considering the consensual nature of arbitration,
this becomes even clearer when one analyses the other fields of arbitration. The thesis
then also takes into account that, in the various phases of the arbitral process, the
expectations with regard to the consensual character of arbitration may be different.
In the thesis it will be argued that the reason the consensual nature of arbitration
evolved over time, and the reason that it is different among the various fields of
arbitration, might be seen in the fact that there is an inherent tension between the
contractual and the jurisdictional side of arbitration. In this situation of “inherent
tension” consent may be perceived as being more or less present. Nevertheless, the
“intensity” of consent does not affect the basically consensual character of arbitration.
While the four traditional theories (jurisdictional, contractual, mixed/hybrid and
autonomous) used to explain the juridical nature of arbitration focus rather on the
relationship between State and arbitration, the thesis attempts to indicate other solutions
which seem to be more able to explain the use of arbitration in the different areas/fields
where arbitration is expected to resolve disputes
ITER test blanket module error field simulation experiments at DIII-D
No full textExperiments at DIII-D investigated the effects of magnetic error fields similar to those expected from proposed ITER test blanket modules (TBMs) containing ferromagnetic material. Studied were effects on: plasma rotation and locking, confinement, L–H transition, the H-mode pedestal, edge localized modes (ELMs) and ELM suppression by resonant magnetic perturbations, energetic particle losses, and more. The experiments used a purpose-built three-coil mock-up of two magnetized ITER TBMs in one ITER equatorial port. The largest effect was a reduction in plasma toroidal rotation velocity v across the entire radial profile by as much as Δv/v ~ 60% via non-resonant braking. Changes to global Δn/n, Δβ/β and ΔH98/H98 were ~3 times smaller. These effects are stronger at higher β. Other effects were smaller. The TBM field increased sensitivity to locking by an applied known n = 1 test field in both L- and H-mode plasmas. Locked mode tolerance was completely restored in L-mode by re-adjusting the DIII-D n = 1 error field compensation system. Numerical modelling by IPEC reproduces the rotation braking and locking semi-quantitatively, and identifies plasma amplification of a few n = 1 Fourier harmonics as the main cause of braking. IPEC predicts that TBM braking in H-mode may be reduced by n = 1 control. Although extrapolation from DIII-D to ITER is still an open issue, these experiments suggest that a TBM-like error field will produce only a few potentially troublesome problems, and that they might be made acceptably small
The cost-effectiveness of national training systems in developing countries
No full textThis paper reviews the literature on the cost-effectiveness of different modes of occupational training, focusing primarily on employer-sited training, occupational training within formal education, and out of school center-based training. The literature can be divided into two categories: studies which have attempted to measure in quantitative terms the benefits and costs of different modes of training, and qualitative studies which have examined non-measurable aspects of cost-effectiveness. Among the conclusions brought to light are: that schools should be responsible for teaching basic skills and the theoretical aspects of vocational training, and employers should be responsible for the practical end - with on-the-job training supplemented in some cases by training at training centers. Institutionalized pre-employment training for entry-level jobs is less cost-effective - despite wishful thinking that it provides an easy solution to the problems of mass youth unemployment.Teaching and Learning,Curriculum&Instruction,Vocational&Technical Education,Gender and Education,Primary Education
Milo Canopener (October 1, 2021)
No full textAn archive of the Milo Canopener.The University of Lethbridge Library received permission from the Archives at Milo Library to digitize and display this content.Milo Can Opener Canada Post Agmt. # 40607518
Box 12, Milo, AB T0L1L0
October 2021
Edition No. 375 MILO LIBRARY N/C
I
MBS The Milo Can Opener
Just across a road from Milo you can find all sorts of evidence of our economy. When I
first moved here as a city boy, I can’t tell you the number of times I looked at something
and asked “What is that, and what’s the thing on the back?” Or the front, or the side, or
what it was pulling. Now, after more than a decade, I know most of those answers, and
carry a satisfying respect for what they are, what they cost, and the skills and hard work
of the men and women who operate them,
Photo and commentary by Cameron Klem
A Community Newsletter published by Volunteers
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•t iIlIlI
the
* COUNTRY FARMHOUSE
Gifts, Antiques and Collectibles
With A Taste of Rural Alberta
We are open Wednesdays, Thursdays & Fridays
from 11:00 a.m. to 2:30 p.m.
Please call for reservation.
Call 403-734-2593 business hours
and 587-727-7000 when we’re not open.
Box 10
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TOJ OSO
from Cluny Hilltop
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’/? mile north
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Ph. 403-734-2593
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Hair Salon Stylists at Country Farmhouse:
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Repair shop & mobile mechanic
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Office: (403) 599-0003
Fax: (403) 599-3990
Mobile: (403) 485-8516
Sc cccRvirpc:
Heavy & Light Duty Mechanic / Tire Sales - Oils & hydraulic hoses
[email protected] Box 163
Cell (403) 485-9607 Milo AB
TOL 1L0
Marks
Trucking, Gravel
OHfield Maintenance and Construction
[email protected]
Oilfield Services Inc.
Norm Stokes
Welding
General & Oilfield Repair
* New & Used Steel Sales
Custom Built Trailers
* B-Pressure Welding
Norm- Phone 403-792-2255
Cell 403-485-0365
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<
HEATHER TRUCKING
WARREN HEATHER
CATTLE
HAY
DECK WORK
GRAVEL HAULING
PHONE-403-599-2132
CELL-403-485-8200
BOX 178
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Work; 403-599-3826
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Lloyd Deitz
Alternative Grain Marketing Solutions
Container and Transloading Facility
MTin
SEED CLEANING
ASSOCIATION LTD.
599-2150
Cleaner Seed is Sown.
Cleaner Crops are Grown.
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Trucking - Grain & Hay Hauling
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Interior:
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repairs
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Serving Milo, and Surrounding Area
1 ires, Repairs, and Vehicle Accessories
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■ ........J.....
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Canada's Forage Seed Innovator
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VILLAGE OF MILO ALBERTA
200 Centre Street,
Box 65, Milo AB, TOL 1L0
Phone:(403) 599-3883
OFFICE HOURS
Due to Covid-19 restrictions
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011:403-850-4424
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“Haye you tried turning it off and on again?”
Dr. Michael McKee DMD
Clinic Hours:
MONDAY (reception only) 9 a.m.—12 noon
TUESDAY and WEDNESDAY
8:30 A.M.—3:30 P.M.
Grant Turner.
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NEW LOCATION
95 Centre Str. East, Vulcan
(next to Furniture Villa)
PtrA03’Zi85’265Z1
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Services include exams. dental cleanings. crowns/bridges.
root canals. extractions. fillings. teeth whitening.
« Implants, and more
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CERTIFIED GENERAL ACCOUNTANT
Diane Krystalowich C.G.A.
111 - 2nd Street South 403-485-2681
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aArrowwood
S Pharmacy
Basil Akalonu
Pharmacist
Prompt Prescription Filling
Branded Drugs available
Free Medication Delivery
Easy Prescription Transfer
Free Seasonal Flu Shots & Immunization
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Phone: 403 534-3333
Text: 403 803-3457
www.arrowwoodpharmacy.com
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Hours: Monday - Friday 9:00 a.m. - 5:00 p.m.
Saturday 10:00 a.m. - 2:00 p.m.
view experience eyecare differently
•x o
DR. GEORGE LISCOMBE
NANTON
(403) 646-3111
uww. ar ro woodgospe/c/turc/i. ca
Vulcan Nanton
118 Centre St. 2219 -20* St.
(403)485-2177 (403)646-3200
JF*. Dr. Glenn Gorlock JE ** / jA. ■
Liscombe
Chiropractic Clinic SLdUxccX |(aL0v
Lw o/n& tLe. oAjuu
Every Sunday!
Contemporary worship service
11:00am - 12:15pm
VULCAN
(403) 485-6005
The 34th Milo Terry Fox Run was another resounding success.
This event does not occur without the support of our many sponsors and
volunteers. The smiles on the kids' faces was a
true reward. Thank you to the following for
making it a success.
The Elevator-Lloyd Deitz
Milo Hotel- Robert & Darlene Phillips
Milo & District Ag Society
Milo Lions Club
Milo Fitness Center
Keith & Donna Deitz
Monner Farms - Chad & Amy, Barry & Joanne
Gary & Mona Middlestead
Community volunteers- Barb and Ian Godkin, Cam Klem, Cindy Monner, Frances
Thompson, Jana Bartsch, Chad & Amy Monner
To date we have collected 6,540.00, and I am still collecting pledges if anyone
would like to donate. You can drop it off at the Library or contact me directly at
403-599-3771. - Joanne Monner
As with the rest of the
run, innovation was
needed to pull the
event off, so a scaled
down display was made
and Joanne Monner
manned the
registration. We missed
you Linda Booth.
Frances Thompson
served burgers that
were cooked at home
by Barb and Ian Godkin then put into sauce and kept hot at the Fitness Center.
The Milo Hotel
and Ts Saloon
Stop in and visit our bar.
We have offsales as well.
Wing Night cancelled
until further notice.
The Dangers of Public WiFi:
Important Do’s and Don’ts
Restaurants and cafes are open for dine-in. Business travel is resuming.
Remote workers are ready to stretch their legs and venture outside. Whether
on a plane or seated al fresco, more people are working on the go again. And
to get work done between boarding passes and breadsticks, they're
connecting to public WiFi. But are they aware of the dangers of public WiFi?
Is it safe for employees to use open WiFi? And if you do find yourself logging
on to a new network, what can you do to secure your and your employer’s
data while you work?
Do use password-protected WiFi
A secured WiFi connection that requires a password to use is safer than
public, unsecured WiFi. It may be more convenient to connect to an open
network instantly. But a private network hosted by a cafe or hotel eliminates
the risk of a hacker offering free WiFi to lure in cyber victims. So, always
check if there is a private WiFi network, and ask for the password.
Don’t send sensitive data in cleartext
Attackers can set up man-in-the-middle attacks or other methods of cyber
espionage on public WiFi. To reduce risk, avoid handling or sending sensitive
data whenever possible. That means steering clear of financial data, Pll
(Personal Identifiable Information), credentials and passcodes, and any
restricted or confidential information until you're back on a secured network.
Do use a VPN
A virtual private network, or VPN, allows you to establish a secure,
protected connection to a corporate network. Even if you’re on public WiFi,
the VPN provides an extra layer of security and makes it more difficult for
cybercriminals to snoop. Many businesses have a VPN for employee use, but
you can also download one yourself. With the amount of work and
entertainment happening online, a VPN is now almost as basic as anti-virus
protection.
Don’t auto-connect to public WiFi
Auto-connecting to WiFi can feel convenient. An instant connection
wherever you go! But, it comes with hidden dangers, so turn off auto-connect
for both WiFi and Bluetooth. Then, each time you’re in a new location, you
can intentionally choose which network you want to use.
Do connect with HTTPS
HTTP and HTTPS are similar protocols that display web data on your
device. (You can see what you are using by looking at the beginning text in
the address box at the top of your Internet browser.) But, there’s one crucial
difference: HTTPS (S for Secure) is a more secure, more advanced version.
It keeps passwords private and is a safer connection so that other
confidential information stays, well, confidential. So, when you are on public
WiFi, check if the website you're using is HTTPS. If it isn't, wait until you’re
back on a secured, private network before logging in or sending any data to
that website.
Do use a password manager and SSO (Single Secure
Sign-on)
Passwords are so mundane that we forget how critical they are to our
online security. Unfortunately, public WiFi can expose us to attacks that allow
cybercriminals to steal passwords. That's why it's essential to use a different
password on every single website. A password manager simplifies the
creation and management of strong passwords for all of your online
accounts.
Don’t neglect device security
Security at the individual device level is essential, too. Keep software, in
particular Internet browsers, and apps up-to-date. Updates have important
security and bug fixes, so apply an update when one is available. Also, run
anti malware software to spot malicious activity on your device. Don’t click
links or open attachments from people you don’t know or seem out of
character. Remember that links in apps like Facebook are not automatically
safe - far from it in fact. And if you think you've spotted some unusual activity,
investigate right away, and get help if you're not sure what you’re dealing
with.
With a few simple precautions, you can safely and conveniently work or
entertain yourself while on the go, even when public WiFi is the only
connection available. Get a password manager to start beefing up your
password security and use our steps above to work safely from anywhere.
By Amber Steel of LastPass - edited by Cameron Klem
HEHMWiFI <______ _ ,________________ )
>ilo library .ardw5>
Milo Library >VI
"X“
This month’s Book
Club read is is Echo
Mountain by Lauren
Wolk. When twelveyear-
old Ellie and her
family lose livelihood
and move to a mountain
cabin in 1934, she
quickly learns to be an
outdoors woman and,
when needed, a healer.
Next month’s meeting
will be Thursday, October
28th at 7 pm.
Recommendations
from book club members:
The Brilliant Life of
Eudora Honeysett by
Annie Lyons
The Cellist by Daniel
Silva
The Wife Stalker by
Liv Constantine
Such a Quiet Place by
Megan Miranda
The Hunted by Roz
Nay
What She Knew by
Gilly MacMillan
The Bone Code by
Kathy Reichs
Local Connected Author
Donates Books to Milo Library
Requesting Proceeds
go to Buying More Picture
Books for our Collection.
a, »!•«>> !.«•
Sherry Lee (Monner) wrote a
book about a bear’s favourite
activity of celebrating special
occasions with friends under the
crabapple tree for her 2 grandchildren.
Chinook Arch Libraries
were offered to purchase them first,
and we have 3 books remaining.
Contact the library if you would like
one for 15.00.
Reliable, high-speed internet
access coming soon to
a library near you
Telus Smart Hubs available
to borrow from local
libraries
For years, public libraries
have been a reliable source of
internet access for those without.
Fifteen libraries within the
Chinook Arch Regional Library
System are now taking
further steps to bridge the
digital divide thanks to the
Telus Smart Hub Library Program.
The participating libraries
will begin loaning Smart
Hubs - devices that provide
fixed, high-speed internet acOctober
2021
CHINOOK A Pp'LJ BEGIOHAL
? ! I \ I I UBRARV SYSTEM
cess with no installation required
- to library patrons.
Telus’ Smart Hub Library Program
enables more Canadians
to have access to the people,
resources, and tools they need
to succeed in a connected world.
“For TELUS, this is a meaningful
step in bridging the digital divide
and ensuring all Canadians have
access to the people, resources,
and tools they need to succeed
in an all-connected world,” says
Theresa Lynn, TELUS general
manager for Alberta central and
south. “The Smart Hub Library
Program extends the internet
connectivity that many libraries
provide to their patrons, beyond
the walls of the library and into
the homes of those who need it
most. We will continue to find
New Purchases
ADULT FICTION
Once Upon a Time in Hollywood
by Quentin Tarantino, The Grim
Reader by
Kate Carlisle,
Hostage by
Claire Mackintosh,
The
House Guests
by Emilie
Richards, A
Postcard
From Paris
by Alex
Brown, Love
Your Life by
Sophie Kinsella,
The
Clockmaker’s
Wife by Daisy
Room by Megan
Goldin, Still
Here by Amy
Stuart, The
Collector’s
Daughter by Gill
Francis, Change Your Mind , Heal
Your Body by Anna Parkinson,
1001 Wedding Ideas by Tricia
Spencer, Pretty Happy Healthy
Ways to Love Your Body by Kate
Hudson, How to Grill by Steven
Raichlen
TWAINS
Paul, Apples
Never Fall by
Liane Moriarty
FICTION
Hot Cocoa Heart
by Suzanne Nelson,
My Secret
Guide to Paris by
Lisa Schroeder,
Tell Me by Joan
Wood, Fight Night by Miriam Bauer
Toews, And Then You Were
Gone by R.J. Jacobs, The Silent
Ones by K L Slater, The Escape
ADULT NON-FICTION
A Field Guide to Common Riparian
Plants
of Alberta by
Greg Hale,
The Little
Prisoner by
Jane Elliott,
Alberta Craft
Beer Guide
by Erica
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Friends of
Milo Library
JUNIOR KIT
Disney Princess Magical Tales
JR. GRAPHIC NOVEL
The Baby-Sitters Club
Kristy and the Snobs by
Chan Chau
EASY READER
Nothing Fits a Dinosaur
by Jonathan Fenske
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' s-:5 F . PICTUREBOOK
The Berenstain Bears -
Bears on Time by
Mike Berenstain
Exciting Changes are Coming
to the Library
This will be my last newsletter after
almost 20 years, and I feel very privileged
to have been able to provide library
service to this community.
I would like to thank Tracy Mozill, Amy
Monner and Charity Lewis for their
dedication in making the Milo Library
run so smoothly. I want to wish them
well in their future endeavors.
I am very happy to be handing the Library
Manager job to Celia Lahd. I look
forward to the new and exiting things
she will bring to the Library and am
confident the community will embrace
her as they did me so long ago. She is
way more qualified than I ever was.
It’s been a pleasure!
Joanne Monner
(Continued from front page)
creative solutions to close the digital
divide. It’s just the right thing to do.”
Beginning in early October, Smart Hubs
can be borrowed from your local library
in t
