53 research outputs found
Dedicated Autonomous Wildlife Guardian Final Report
No full textAE3200 - Design Synthesis ExerciseAerospace Engineerin
"Who are you?" Poetic Metalepsis in the Work of Anne Carson
No full textBeing both a scholar and a poet, Anne Carson (°1950) seems to wear two hats at all times. There is consensus among critics that Carson’s juxtaposition of the poetic and academic in her writing lies at the heart of what makes her work innovative (e.g. Stanton, Upton), yet the techniques that underlie this hybrid quality seem to have received less critical attention thus far. In this paper, I therefore propose to take Gillian Sze’s statement that “Carson’s use of the archive, in both her capacity as scholar and poet, participates in […] an ‘inventive’ poetics of error” (73, original emphasis) as a productive starting point to investigate how Carson achieves a poetic, deliberately ‘erroneous’ flow of ideas. This flow combines discovery, typical of the scholar, with poetic creativity (cf. Sze 68). As a working hypothesis, this paper posits that Carson makes use of metalepsis to this end, which I first adapt to the domain of poetry by building on Gérard Genette’s definition of the term. Next, the analysis considers strategies that underlie poetic metalepsis as applied to Carson’s Glass and God (1998) and Men in the Off Hours (2000). These include, most notably, the use of multiple voices, as well as of interpunction, misquotations, metacommentaries, and metaleptic entanglements of worlds. The paper concludes that when the friction between three different types of voices—i.e. scholarly, lyric, and personified (through the use of characters)—peaks, poetic metalepsis occurs, which in turn spurs readers into an affective, embodied understanding that recognises the role played by the body and intersubjective relations in human cognition (cf. Kukkonen and Caracciolo). In this way, Carson’s poetry suggests that freethinking cannot exist without the affective dimension characteristic of the lyric: the affective is part of the analytic, since profound knowledge cannot exist without this intuitive aspect. Works cited Carson, Anne. Glass and God. Jonathan Cape, 1998. ---. Men in the Off Hours. Jonathan Cape, 2000. Genette, Gérard. Narrative Discourse: An Essay in Method. 1972. Translated by Jane E. Lewin, Cornell UP, 1980. Kukkonen, Karin, and Marco Caracciolo. “Introduction: What Is the ‘Second Generation’?” STYLE, vol. 48, no. 3, 2014, pp. 261–74. Stanton, Robert. “‘I am writing this to be as wrong as possible to you’: Anne Carson’s Errancy.” Anne Carson, special issue of Canadian Literature, no. 176, 2003, pp. 28-43. Sze, Gillian. “Erring and Whatever.” Anne Carson / Antiquity, edited by Laura Jansen, Bloomsbury Academic, 2021, pp. 63-74. Upton, Lee. Defensive Measures: The Poetry of Niedecker, Bishop, Glück, and Carson. Bucknell UP, 2005
How can we reduce morbidity after robot‐assisted radical cystectomy with intracorporeal neobladder? A report on postoperative complications by the European Association of Urology Robotic Urology Section Scientific Working Group
No full textrobotic neobladde
Rate of profit, business cycles and capital accumulation in U.K. industry, 1959-1981. Economic Papers No. 35, November 1984. II/95/84-EN
No full textHeterozygous loss-of-function SEC61A1 mutations cause autosomal-dominant tubulo-interstitial and glomerulocystic kidney disease with anemia
No full textAutosomal-dominant tubulo-interstitial kidney disease (ADTKD) encompasses a group of disorders characterized by renal tubular and interstitial abnormalities, leading to slow progressive loss of kidney function requiring dialysis and kidney transplantation. Mutations in UMOD, MUC1, and REN are responsible for many, but not all, cases of ADTKD. We report on two families with ADTKD and congenital anemia accompanied by either intrauterine growth retardation or neutropenia. Ultrasound and kidney biopsy revealed small dysplastic kidneys with cysts and tubular atrophy with secondary glomerular sclerosis, respectively. Exclusion of known ADTKD genes coupled with linkage analysis, whole-exome sequencing, and targeted re-sequencing identified heterozygous missense variants in SEC61A1-c.553A>G (p.Thr185Ala) and c.200T > G (p.Val67Gly)-both affecting functionally important and conserved residues in SEC61. Both transiently expressed SEC6A1A variants are delocalized to the Golgi, a finding confirmed in a renal biopsy from an affected individual. Suppression or CRISPR-mediated deletions of sec61al2 in zebrafish embryos induced convolution defects of the pronephric tubules but not the pronephric ducts, consistent with the tubular atrophy observed in the affected individuals. Human mRNA encoding either of the two pathogenic alleles failed to rescue this phenotype as opposed to a complete rescue by human wild-type mRNA. Taken together, these findings provide a mechanism by which mutations in SEC61A1 lead to an autosomal-dominant syndromic form of progressive chronic kidney disease. We highlight protein translocation defects across the endoplasmic reticulum membrane, the principal role of the SEC61 complex, as a contributory pathogenic mechanism for ADTKD
Coronavirus enteritis bij pups /
No full textMaster of Veterinary Medicine in de diergeneeskunde: gezelschapsdiere
Routine Preoperative CT Scanning of Patients with Anorectal Sepsis is not Useful. A Retrospective Cohort Study
No full textBackground:
The use of preoperative imaging in anorectal abscesses (AA) is still debated. It is customary to treat AA based solely on clinical findings. Several short- and long-term sequelae of AA have been described such as abscess persistence, recurrence, and anal fistula formation. The current literature does not clarify whether additional preoperative imaging is beneficial.
Objectives:
This study aims to investigate whether performing a preoperative computed tomography (CT) scan influences the outcome after drainage and AA recurrence.
Design:
Retrospective cohort study.
Settings:
Patient files.
Patients (Materials) and Methods:
All consecutive patients undergoing AA drainage between January 2015 and January 2020 were studied retrospectively. The patients who underwent a preoperative computed tomography (preCTI) were compared to those without preoperative imaging (noCTI).
Main Outcome Measures:
Abscess persistence requiring re-intervention and AA recurrence.
Sample size:
Two-hundred and nineteen patients were included in this study.
Results:
Preoperative CT scans were performed in 93 patients. The median length of stay was 1 day. The overall median follow-up duration was 56 days. Male and obese patients were more likely to undergo preoperative CT scans. There was no difference in re-intervention for abscess persistence or recurrence. More drains were placed in the preCTI group (P = .0001), and postoperative antibiotics were administered more often (P = .0008) in this group.
Conclusion:
Routine preoperative CT imaging in acute anorectal sepsis has no benefit in terms of outcomes, namely abscess persistence or recurrence after 30 days. In the preCTI group, an additional drain was placed in a greater number of cases, and postoperative antibiotics were administered more frequently
Infectious diarrhea after allogeneic hematopoietic cell transplantation assessed by a multiplex polymerase chain reaction assay
No full textObjectives: To determine the incidence of infectious diarrhea after allogeneic hematopoietic cell transplantation (HCT) using a multiplex polymerase chain reaction assay and assess risk factors for developing infectious diarrhea. Methods: This was a single-center retrospective study of 140 consecutive allogeneic HCT recipients. Infectious diarrhea was assessed using a laboratory-developed multiplex polymerase chain reaction the first year after transplantation. Results: The incidence rate of infectious diarrhea episodes was 47 per 100 person-years, with the highest rate observed in the pre-engraftment phase. Most episodes were seen as nosocomial infections (38%) and most affected patients (82%) had only one episode of infectious diarrhea. The cumulative incidence of at least one episode of infectious diarrhea was 32% after 1 year. Nonrelapse mortality was higher in transplant recipients with at least one episode of infectious diarrhea (hazard ratio (HR) 2.02, 95% CI = 1.07-3.80). The most frequently observed pathogens were Clostridium difficile, adenovirus, Enteropathogenic Escherichia coli, and Campylobacter jejuni. Patients with acute lower gastrointestinal graft-vs-host disease stage 3 or 4 (HR 3.68, 95% CI = 1.57-8.63) conferred a higher risk for a first infectious diarrhea episode. Conclusion: Infectious diarrhea after allogeneic HCT was seen in about one-third of the patients, mostly as nosocomial infection in the pre-engraftment phase. (c) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/
Improved Clinical Outcome of COVID-19 in Hematologic Malignancy Patients Receiving a Fourth Dose of Anti-SARS-CoV-2 Vaccine: An EPICOVIDEHA Report
No full textnon present
Pre-operative trans-catheter arterial chemo-embolization increases hepatic artery thrombosis after liver transplantation - a retrospective study
No full textLittle is known about non-surgical risk factors for Hepatic Artery Thrombosis (HAT) after Liver Transplantation (LT). We determined risk factors for HAT occurring within 90 days post-LT and analyzed the effect of HAT on graft and patient survival. Donor and recipient demographics, surgery-related data, and outcome in transplants complicated by thrombosis (HAT+) and their matched controls (HAT-) were compared. Risk factors were assessed by univariate logistic regression. Median (IQR) is given. 25 HAT occurred among 1035 adult LT (1/1997-12/2014) and 50 controls were manually matched. Donor and recipient demographics were similar. Pre-LT Trans-catheter Arterial Chemo Embolization (TACE) was more frequent in HAT+ (HAT+ 20% vs HAT- 4%, p=0.037). HAT+ had longer implantation [HAT+ 88 min (76-108) vs HAT- 77 min (66-93), p=0.028] and surgery times [HAT+ 6.25 h (5.18-7.47) vs HAT- 5.25 h (4.33-6.5), p=0.001]. Early graft dysfunction and sepsis was more frequent in HAT+ and hospitalization longer. TACE had the greatest odds ratio in unadjusted analysis (OR: 6, 95%CI: 1.07-33.53, p=0.03). All but 7 grafts were lost after HAT (HAT+ 72% vs HAT- 36%, p=0.003), however, patient survival was unaffected (HAT+ 79.8% vs HAT- 76%, p=0.75). LT candidates undergoing TACE are at risk of developing HAT early after transplant. This article is protected by copyright. All rights reserved.sponsorship: JP received unrestricted educational grants from Roche and Astellas. DM is a senior researcher funded by the FWO - Vlaanderen. JP, DM and IJ are holders of a CAF chair for abdominal transplant surgery research. (Roche, Astellas, FWO - Vlaanderen)status: Publishe
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