1,354,557 research outputs found
Lasorsa Giovani — Demografia
No full textCailar A. Lasorsa Giovani — Demografia. In: Population, 9ᵉ année, n°1, 1954. p. 154
Lasorsa Giovanni — Statistica del lavoro
No full textC A. Lasorsa Giovanni — Statistica del lavoro. In: Population, 17ᵉ année, n°4, 1962. pp. 787-788
Lasorsa Giovanni — Statistica del lavoro
No full textC A. Lasorsa Giovanni — Statistica del lavoro. In: Population, 17ᵉ année, n°4, 1962. pp. 787-788
Littérature moderne : des phrases plus courtes ?
No full textPour les lecteurs d'aujourd'hui, Love Story, d'Éric Segal publié en 1970, semble plus facile à lire qu'Ivanhoé, de Walter Scott publié en 1819. À partir de cette observation, Wayne A. Danielson et Dominic L. Lasorsa, professeurs de Journalisme à l'université du Texas (Austin) ont étudié l'évolution du style dans le roman anglais et américain des 240 dernières années. Cet article, qui met en évidence le fait que dans la littérature moderne les phrases sont plus courtes, est extrait de Journal of Reading, paru en décembre 1989.Danielson Wayne A., Lasorsa Dominic L. Littérature moderne : des phrases plus courtes ?. In: Communication et langages, n°87, 1er trimestre 1991. pp. 5-11
Multi-criteria decision analysis to redesign an Italian Clinical Engineering Service under specific needs and regulation requirements
No full textThe aim of this study is to fulfill the need of reengineering the Clinical Engineering Service in an Italian ASL (Local Health Authority) located in Sardinia, in accordance with the Italian regulations for healthcare.
Even if methods for processes redesigning in healthcare organizations are available in the literature, there are no recent evidences of their application in Clinical Engineering Services.
Among the multi-criteria techniques, in this work PAPRIKA was used, since it is an easy-to-use and intuitive method for multi- criteria decision making, based on decision-makers’ preferences.
We identified the decision makers’ criteria to be fulfilled and four different preference levels for each criterion, as inputs of the method. Moreover four different scenarios were identified and, for each scenario and criterion, the decision makers selected the most suitable level. In order to reduce the number of pairwise comparisons among the preference levels associated to the identified criteria, the online software 1000minds, implementing the PAPRIKA method, was used.
After 460 steps, the software allowed to rank the four possible scenarios. The application of the method allowed choosing the best solution for the ASL and it represents a good way for decision making, even though the number of questions is still high
La migrazione delle prove INVALSI di Matematica da PP a CBT. Uno studio sulle prove di pre-test per la II superiore
Get PDFQuesto articolo dà conto dei risultati di una sperimentazione INVALSI per il passaggio da prove cartacee a prove computer based condotta nella campagna di pre-test del 2016 di matematica del livello 10. Scopo dello studio è il confronto fra la somministrazione cartacea e quella computer based della stessa prova, sia in relazione alla stima dell’abilità degli studenti sia in relazione al comportamento degli item in termini di parametri di difficoltà, di indice di discriminatività e di percentuale di risposte omesse. A un campione rappresentativo a livello nazionale degli studenti di livello 10 è stata somministrata una prova di matematica in modalità computer based e a un campione parallelo la stessa prova in modalità cartacea. I risultati mostrano che la prova in formato computer based risulta mediamente più difficile della prova in formato cartaceo. Non ci sono invece differenze significative nella stima dell’abilità degli studenti.This article describes an INVALSI trial for passing from paper based tests to computer-based tests conducted in the 2016 math pre-test campaign for the second class of the secondary school (level 10). The purpose of the study is to compare paper & pencil and computer-based delivery of the same test, in relation to the student's ability and to the item functioning in terms of difficulty (b), discrimination (Id), and percentage of missing. A nationally representative sample of 10th grade students was administered computer-based mathematics test. In addition a parallel sample of students was administered the same test in paper & pencil mode. The results show that test in computer-based mode was significantly harder statistically than the paper-based test. There are no significant differences in the estimated student's ability
Technology and Service Assessment Tools in Healthcare
No full textThe role of clinical engineers is rapidly changing and the economic constraints have pulled them towards new responsibilities to manage. Particularly, the assessment of health technologies has covered one of the most important areas among clinical engineers’ duties. Different techniques and methodologies for technology assessment and improvement are available in the literature and they are currently in use within hospitals and healthcare facilities. However, scientific research and practical needs seem to be misaligned, causing misuse of scientific results due to the lack of tools easy-to-use from practical perspective.
This thesis aims at integrating methodologies, even derived from different sectors, for providing standardized and versatile tools that overcome the current issues, providing healthcare facility with a path to follow for choosing the best methodology to be used in diverse situations.
Different case studies are presented, in order to cover the wide range of possibilities within health technology assessment (HTA). Particularly, technology assessment was performed on medical devices using both Hospital-Based HTA for an existing technology and horizon scanning for designing an innovative solution. Then the assessment was extended to hospital services, with particular attention to clinical engineering services, using Multi-Criteria Decision Analysis. Process improvement methodologies were also considered and applied to sterilization service that was also studied and assessed integrating the classical HTA approach with Multi-Criteria Decision Analysis.
These studies allowed to identify a path useful from practical perspective and based on scientific approach aimed at helping healthcare professionals and clinical engineers to choose the best methodology in accordance to specific constraints and needs of particular situations
Cisplatin handover between copper transporters: the effect of reducing agents
No full textCopper (Cu) transporters emerged as key factors at the basis of the biological response to antitumor platinum (Pt) drugs, which are among the most potent and broadly used chemotherapeutics. ATP7A and ATP7B (the Menkes and Wilson disease proteins, respectively) appear to be implicated in promoting tumor cell resistance to cisplatin. Cu-ATPases could bind the drug and, with the alleged involvement of the chaperone ATOX1, contribute to cell detoxification and survival. Here, we report the spectroscopic characterization of cisplatin binding to ATOX1 and MNK1, the first metal-binding domain of ATP7A, in the presence of the physiological reducing agent glutathione, a sulfur-containing molecule responsible for the majority of Pt detoxification in the cytosol. Under conditions mimicking the cellular environment, we show that cisplatin transfer from ATOX1 to MNK1 does not occur at a detectable rate. These results appear to contradict other literature data which, however, were obtained in the presence of exogenous reducing agents such as tris(2-carboxyethyl)phosphine (TCEP) having good coordinating ability for soft metal ions (such as Pt) and strong trans-labilizing effect. A better understanding of Pt drug processing by Cu trafficking proteins under physiological conditions may help to answer key issues, such as drug availability in tumor cells and resistance
La migrazione delle prove INVALSI di Matematica da PP a CBT. Uno studio sulle prove di pre-test per la II superiore
No full textQuesto articolo dà conto dei risultati di una sperimentazione INVALSI per il passaggio da prove cartacee a prove computer based condotta nella campagna di pre-test del 2016 di matematica del livello 10. Scopo dello studio è il confronto fra la somministrazione cartacea e quella computer based della stessa prova, sia in relazione alla stima dell’abilità degli studenti sia in relazione al comportamento degli item in termini di parametri di difficoltà, di indice di discriminatività e di percentuale di risposte omesse. A un campione rappresentativo a livello nazionale degli studenti di livello 10 è stata somministrata una prova di matematica in modalità computer based e a un campione parallelo la stessa prova in modalità cartacea. I risultati mostrano che la prova in formato computer based risulta mediamente più difficile della prova in formato cartaceo. Non ci sono invece differenze significative nella stima dell’abilità degli studenti.This article describes an INVALSI trial for passing from paper based tests to computer-based tests conducted in the 2016 math pre-test campaign for the second class of the secondary school (level 10). The purpose of the study is to compare paper & pencil and computer-based delivery of the same test, in relation to the student's ability and to the item functioning in terms of difficulty (b), discrimination (Id), and percentage of missing. A nationally representative sample of 10th grade students was administered computer-based mathematics test. In addition a parallel sample of students was administered the same test in paper & pencil mode. The results show that test in computer-based mode was significantly harder statistically than the paper-based test. There are no significant differences in the estimated student's ability
Multi-criteria decision analysis to redesign an Italian Clinical Engineering Service under specific needs and regulation requirement
No full textThe aim of this study is to fulfill the need of reengineering the Clinical Engineering Service in an Italian ASL (Local Health Authority) located in Sardinia, in accordance with the Italian regulations for healthcare.
Even if methods for processes redesigning in healthcare organizations are available in the literature, there are no recent evidences of their application in Clinical Engineering Services.
Among the multi-criteria techniques, in this work PAPRIKA was used, since it is an easy-to-use and intuitive method for multi- criteria decision making, based on decision-makers’ preferences.
We identified the decision makers’ criteria to be fulfilled and four different preference levels for each criterion, as inputs of the method. Moreover four different scenarios were identified and, for each scenario and criterion, the decision makers selected the most suitable level. In order to reduce the number of pairwise comparisons among the preference levels associated to the identified criteria, the online software 1000minds, implementing the PAPRIKA method, was used.
After 460 steps, the software allowed to rank the four possible scenarios. The application of the method allowed choosing the best solution for the ASL and it represents a good way for decision making, even though the number of questions is still high
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