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Hukum mengkonsumsi laron studi komparatif antara pendapat Madzhab Maliki dan Madzhab Syafi’i
Dengan ditemukannya berbagai macam kemajuan dalam bidang teknologi, tuntutan akan pemanfaatan sumber daya alam baru pun semakin besar, namun agama islam sangat memperhatikannya bagi pemeluknya dalam mengkonsumsi makanan yang baik dan halal, makanan halal ini adalah sesuatu yang di perbolehkan untuk di konsumsi menurut syariat islam.
Salahsatu pemanfaatan yang telah dilakukan masyarakat terhadap bahan makanan yang sebelumnya tidak pernah dilakukan adalah pemanfaatan laron. Perbedaan pendapat beberapa ulama terhadap konsumsi laron sangat beragam, ada yang mengharamkan ada pula yang menghaklalkan bahkan sebagian pendapat menyebutkan bahwa hukum konsumsi laron masih dalam posisi perbedaan pendapat (khilafiyah) sehingga penetapan hukumnya masih mubah (boleh).
Penelitian ini bertujuan untuk mengetahui pendapat mazhab Maliki dan madzhab Syafi'i serta menganalisa analisa Fiqh Muqaran dalam masalah Hukum Mengkonsumsi Laron.
Kerangka berfikir yang melandasi penelitian ini adalah melihat fenomena yang terjadi di lapangan dalam hal pemanfaatan laron sebagai konsumsi, sedangkan hal demikian merupakan permasalahan baru yang tidak disebutkan secara eksplisit di dalam alquran dan Sunnah, sehingga untuk menyikapinya harus bersandarkan kepada teori Maslahah mursalah yang difatwakan oleh imam madzhab yang sudah jelas kapasitasnya dalam menentukan hukum.
Penelitian ini bersifat deskriptif yang berupa studi komparatif yaitu menggambarkan, menjelaskan, dan menganalisis beberapa hal yang berkaitan dengan masalah yang diteliti, kemudian membandingkan diantara keduanya.
Hasil Penelitian menunjukkan bahwa mazhab Maliki dan mazhab Syafi'i mengenai laron sebagai makanan, mazhab Maliki melmbolehkannya karena laron mengandung banyak manfaat. Sebaliknya mazhab Syafi'i berpendapat haram, karena laron merupakan hewan yang menjijikan. Mazhab Maliki menggunakan metode Istinbat ta'lili yg diarahkan untuk menemukan illat qiiyasli sedangkan metode Istinbat Mazhab Syafi'i menggunakan metode ilstinbat ta'lili yang di arahkan pada penemuan illat syar'i.
Kata Kunci: Hukum Konsumsi, Laron, Madzhab Syafi’i dan Malik
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Abnormalities of the axial and proximal appendicular skeleton in adults with Laron syndrome (growth hormone insensitivity)
To investigate abnormalities in the skeleton (with the exclusion of the skull, cervical spine, hands and feet) in patients with Laron syndrome, who have an inborn growth hormone resistance and congenital insulin-like growth factor-1 (IGF-1) deficiency.
The study group was composed of 15 untreated patients with Laron syndrome (seven male and eight female) aged 21-68 years. Plain films of the axial and appendicular skeleton were evaluated retrospectively for abnormalities in structure and shape. The cortical width of the long bones was evaluated qualitatively and quantitatively (in the upper humerus and mid-femur), and the cortical index was calculated and compared with published references. Measurements were taken of the mid-anteroposterior and cranio-caudal diameters of the vertebral body and spinous process at L3, the interpedicular distance at L1 and L5, and the sacral slope. Thoracic and lumbar osteophytes were graded on a 5-point scale. Values were compared with a control group of 20 healthy persons matched for age.
The skeleton appeared small in all patients. No signs of osteopenia were visible. The cortex of the long bones appeared thick in the upper limbs in 11 patients and in the lower limbs in four. Compared with the reference values, the cortical width was thicker than average in the humerus and thinner in the femur. The vertebral diameters at L3 and the interpedicular distances at L1 and L5 were significantly smaller in the patients than in the control subjects (P<0.001); however, at L5 the canal was wider, relative to the vertebral body. The study group had a higher rate of anterior osteophytes in the lumbar spine than the controls had, and their osteophytes were also significantly larger. In the six patients for whom radiographs of the upper extremity in its entirety were available on one film, the ulna appeared to be rotated. In one 22-year-old man, multiple epiphyses were still open.
Congenital IGF-1 deficiency leads to skeletal abnormalities characterized by small bones, narrow spinal canal, and delayed bone age. The limitation in elbow distensibility common to patients with Laron syndrome may be related to a marked retroversion of the humeral head
Fractionation Studies on Plasma of Normals and Patients with Laron Dwarfism and Hypopituitary Gigantism
The molecular size of immunoreactive human growth hormone (IR-HGH) in serum and the relationship of IR-HGH to sulfation factor (SF) require further investigation. Sera obtained from normal volunteers, patients with Laron-type dwarfism, and hypopituitary patients with gigantism were fractionated on large columns of Sephadex. The IR-HGH in normal serum was found in a molecular size range similar to extracted pituitary HGH (epHGH), as well as in a larger and a smaller molecular size. Laron dwarf plasma had a similar molecular size IR-HGH distribution when compared with normal serum. Sera from hypopituitary patients with gigantism showed an increased relative amount of small IR-HGH compared with normal serum. SF activity was recovered in normal serum but not in other sera fractions. SF activity appeared mainly in the molecular size range less than 17 000 and another peak was noted in the molecular size area greater than 55 000.This study further supports the existence of IR-HGH in a large and a small molecular size in normal serum. IR-HGH in Laron dwarf serum appears similar in molecular size to normal serum IR-HGH. The relative increase in small IR-HGH in hypopituitary patients with gigantism requires further investigation. SF activity appears in a molecular size different from epHGH in normal serum, the main peak being in a smaller molecular size area, with a lesser peak in a larger size area. </jats:p
Considerations on hGH and Gonadotropins Incretion in Prepubertal and Pubertal Obese Children
Dr. Duane M. Jackson, Morehouse College, July 2011
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A homozygous nonsense mutation of the human growth hormone receptor gene in a Sardinian boy with Laron-type dwarfism
Laron-type dwarfism (LTD) is an autosomal recessive disorder due to mutations in the GH receptor (GHR) gene, We report the case of a Sardinian boy affected by LTD in which we found by direct genomic sequencing a nonsense mutation in the fourth ex-on of the GHR gene (R43X) that determines a premature termination in the protein translation process. As the result of the absence of the extracellular portion of the GHR this patient had undetectable GH binding protein, This molecular defect is identical to that observed in other patients with LTD of mediterranean origin
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
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Dr. Glendon Swarthout
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Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
Following an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
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