1,115,733 research outputs found
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
No full textGenetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10<sup>−11</sup>; odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28–1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes
Exploring responsible innovation of large technological systems in society
No full textThis introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book describes responsible innovation in terms of both the innovation process and the innovation outcome, and in doing so it focuses on historical cases of innovation in large societally relevant technological systems. It illustrates how responsible innovation can be defined by discussing how it is applied or can be applied in specific cases of societally relevant large technological systems. The book focuses on large societally relevant, technological systems, most contributions take a systems perspective in which social and technological aspects are explored in combination. It explores how responsible the innovation process was during three episodes of wind power development: the American farm windmill between 1850 and 1880 in the USA, the direct current electricity wind turbine between 1890 and 1910 in Denmark, and the alternating current electricity wind turbine between 1940 and 1990 in the USA.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Economics of Technology and InnovationValues Technology and InnovationEnergie and Industri
Large animal and surgery complex - 6
No full textLarge Animal Medicine and Surgery Complexphotograph date: Unknow
Large-Scale In Situ Visualization of Raleigh-Taylor Instability with Ascent and VTK-m
No full textHighlight of a Large-Scale In Situ Visualization of Raleigh-Taylor Instability with Ascent and VTK-m. The 97.8 billion element simulation ran across 16,384 GPUs on 4,096 Sierra Compute Nodes to guide the development of sub-grid models to capture instability effects with less computation. The visualization and analysis used the same resources as the simulation and scaled to the entire machine
Dynamic of large particles embedded in shear flows
No full textLarge particles () immersed in a closed turbulent flow tend to explore in a non-uniformly way the cavity in which they are placed. Here we study the slow dynamics of large particles (with various size) advected in closed turbulent flows at different Reynolds numbers. We investigate the spatial sampling experienced by large particles in two fully turbulent closed flows generated between counter-rotating disks (so called von Karman flow), focusing in the slow frequency's (, where is the rotation rate of the driving impellers) and characterize the power spectrum of the slow fluctuations of particles position. Both considered flows share a common feature : the presence of a shear region dividing two mean re-circulation regions ; however the spatial symmetries and the temporal behaviors of both setups are very different. The principal result in this research is that despite these differences both flows exhibit a well defined slow dynamical behavior that can be identified in Fourier space. We report on the universal characteristics of such slow motion
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
No full textFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
Large eddy simulations of weakly heated stratocumulus top boudary layer
No full textPerforming Large Eddy Simulations (LES) of marine stratocumulus in the weakly heated boundary layer is an opportunity to evaluate the relative importance of radiative cooling and of a wind shear in cloud top region on cloud structure. It is shown that cooling due to longwave radiation influences the convective circulation in the atmospheric boundary layer and counteracts dilution caused by the wind shear
Large scale circulation in turbulent Rayleigh-Bénard convection
No full textStatistical properties of turbulent Rayleigh-Bénard convection (RBC) are investigated experimentally in a cylindrical cell of aspect ratio one. We specifically analyze the large scale circulation of RBC based on measurements of temperature fluctuations by small Ge sensors placed inside the cell. The resulting dependencies of Reynolds numbers on Rayleigh number up to 2x10^13 are compared to available theoretical and experimental results for similar geometries
Similarities between 2D and 3D convection for large Prandtl number
No full textUsing direct numerical simulations of Rayleigh-B\'enard convection (RBC), we perform a comparative study of the spectra and fluxes of energy and entropy for large and infinite Prandtl numbers in two (2D) and three (3D) dimensions. We observe close similarities between the 2D and 3D RBC, in particular the kinetic energy spectrum , and the entropy spectrum exhibits a dual branch with a dominant spectrum. We showed that the dominant Fourier modes in the 2D and 3D flows are very close
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