726,061 research outputs found
D-GridMST: Clustering Large Distributed Spatial Databases
No full textIn this paper, we will propose a distributable clustering algorithm, called Distributed-GridMST (D-GridMST), which deals with large distributed spatial databases. D-GridMST employs the notions of multi-dimensional cube to partition the data space involved and uses density criteria to extract representative points from spatial databases, based on which a global MST of representatives is constructed. Such a MST is partitioned according to users clustering specification and used to label data points in the respective distributed spatial database thereafter. Since only the compact information of the distributed spatial databases is transferred via network, D-GridMST is characterized by small network transferring overhead. Experimental results show that D-GridMST is effective since it is able to produce exactly the same clustering result as that produced in centralized paradigm, making D-GridMST a promising tool for clustering large distributed spatial databases
Large-scale analysis of human heavy chain V(D)J recombination patterns-6
No full textNd NP sequences, and comparison to germline complexity of each gene segment family.<p><b>Copyright information:</b></p><p>Taken from "Large-scale analysis of human heavy chain V(D)J recombination patterns"</p><p>http://www.immunome-research.com/content/4/1/3</p><p>Immunome Research 2008;4():3-3.</p><p>Published online 27 Feb 2008</p><p>PMCID:PMC2275228.</p><p></p
Large-scale analysis of human heavy chain V(D)J recombination patterns-2
No full textBoth the VD and DJ junctions fit to a zero-inflated negative binomial distribution.<p><b>Copyright information:</b></p><p>Taken from "Large-scale analysis of human heavy chain V(D)J recombination patterns"</p><p>http://www.immunome-research.com/content/4/1/3</p><p>Immunome Research 2008;4():3-3.</p><p>Published online 27 Feb 2008</p><p>PMCID:PMC2275228.</p><p></p
Large-scale analysis of human heavy chain V(D)J recombination patterns-4
No full textGene sets.<p><b>Copyright information:</b></p><p>Taken from "Large-scale analysis of human heavy chain V(D)J recombination patterns"</p><p>http://www.immunome-research.com/content/4/1/3</p><p>Immunome Research 2008;4():3-3.</p><p>Published online 27 Feb 2008</p><p>PMCID:PMC2275228.</p><p></p
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
No full textGenetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10<sup>−11</sup>; odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28–1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes
Large-scale analysis of human heavy chain V(D)J recombination patterns-5
No full textP and NP gene sets, and comparison to germline complexity of each gene segment family. The germline complexity refers to the number of segments within the locus assigned to each family.<p><b>Copyright information:</b></p><p>Taken from "Large-scale analysis of human heavy chain V(D)J recombination patterns"</p><p>http://www.immunome-research.com/content/4/1/3</p><p>Immunome Research 2008;4():3-3.</p><p>Published online 27 Feb 2008</p><p>PMCID:PMC2275228.</p><p></p
Large-scale analysis of human heavy chain V(D)J recombination patterns-3
No full textdistribution, and calculated both the maximum likelihood estimators plotted at (r, p) and the corresponding confidence regions.<p><b>Copyright information:</b></p><p>Taken from "Large-scale analysis of human heavy chain V(D)J recombination patterns"</p><p>http://www.immunome-research.com/content/4/1/3</p><p>Immunome Research 2008;4():3-3.</p><p>Published online 27 Feb 2008</p><p>PMCID:PMC2275228.</p><p></p
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