264,861 research outputs found
De Aequali Statuum Imperii Origine Et Progressu
No full textGießen, Univ., Jur. Diss., 1732Enth.: 2 Beitr. von I. P. I. F. G. R. u. H. T. Satorius, sowie1 Gedicht von I. P. Hombergk.Fingerprint nach Ex. der GWLB Hannover und der ULB Sachsen-AnhaltSignaturformel nach Ex. der GWLB Hannover und der ULB Sachsen-Anhalt : [2], A-E4Vorlageform des Erscheinungsvermerks: Giessae, Typis Eberh. Henr. Lammers, Acad. Typogr
De Odiosis In Iure
No full textGießen, Univ., Jur. Diss., 1746Autopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Giessae Typis Eberh. Henr. Lammers, Acad. Typogr
De aurium prurigine sive morbosco discentium in ecclesia statu ac tempore a Paulo II. Tim., IV praedicto et praesertim a reformatione Lutheri conspicuo
No full textGießen, Univ., Theol. Disp., 1717Vorlageform des Erscheinungsvermerks: Recusa & aucta 1719. Giessae, Apud Vidvam I. R. Vvlpii & E. H. Lammers, Ac. Typ
Repliek I
No full textThe author\u27s reply to a critique of his book, Het Koninklijk Instituut voor de Marine (The Royal Naval Institute, no publisher, 1963), a study which combined participant observation (Lammers was trained at the Institute as a naval reserve officer) and a survey. Kruijer\u27s main objection was that Lammers overestimated the results of his survey at the expense of his participant observation. It is objected that: (1) the result of the comparison depends on the definition of the concept of \u27hyp,\u27 and (2) the general \u27equality\u27 of participant observation (ie with surveys) is not at issue in this case. I. Langnas
The Mr 30,000-33,000 major protein components of the lateral elements of synaptonemal complexes of the rat
No full textSynaptonemal complexes (SCs) are intranuclear structures which are formed during meiotic prophase between homologous chromosomes. The SC consists of two protein-rich axes, either of which is found at the basis of one of the homologous chromosomes. These axes, called lateral elements (LEs), are connected along their entire length by so-called transverse filaments. Between and parallel to the LEs runs a third element, called central element. The assembly and disassembly of SCs take place in a period during which a number of important events takes place at the chromosomal level: condensation, pairing, recombination and segregation of homologous chromosomes. The possible involvement of the SC in these events is an importnat topic in the research program of our section. This thesis focusses on the possible function of the LE and its components (Chapter 1). The experimental work described in this thesis (Chapters 2-5) concerns the characterization of the LE-components with relative electrophoretic mobilities of 30,000 and 33,000 (the M r 30,000-33,000 components).The isolation of cDNAs encoding the M r 30,000-33,000 components is described in Chapter 2. The isolation took place by screening of an expression cDNA-library with an affinity-purified polyclonal antiserum. The largest cDNA, 2A4, encodes a protein with a predicted molecular mass of 29.7 kDa, which we have termed s ynaptonemal c omplex p rotein 3 (SCP3). A polyclonal antiserum raised against SCP3 recognizes only the M r 30,000-33,000 components on a westernblot of SC-protein and exhibits a similar immunological localisation as monoclonal antibodies and a polyclonal antiserum raised against the M r 30,000-33,000 components. The deduced amino acid sequence shows that SCP3 is a potential ATP-binding protein and that the C-terminal half of the protein is capable of forming an amphipaticα-helix. Moreover, part of the amino acid sequence exhibits considerable homology to the predicted protein products of two members of a gene familiy of X-linked lymphocyte-regulated ( Xlr ) genes.We conclude that cDNA 2A4 encodes at least one of the M r 30,000-33,000 components and that SCP3 is a major component of the LEs of the rat. We speculate that the homology between SCP3 and two products of Xlr genes might be connected to a function of both types of protein in processes which share the common purpose of blocking certain recombination events.The M r 30,000- and the 33,000 component are closely related according to their almost identical peptide maps and the fact that all isolated antibodies always recognize both proteins. A first step to elucidate the difference between these two components and the level at which such a difference arises is described in the addendum to Chapter 2. We conclude that the M r 30,000-33,000 components are probably encoded by a single gene and a single messenger RNA and that the difference between the two components arises during or after translation. Mechanisms by which this could be achieved are discussed. A practical problem which arises here is that N-terminal sequencing of the two components by means of standard techniques is not possible.When SC-protein is separated by means of two-dimensional gel electrophoresis (2D-electrophoresis) and the gel is subsequently blotted and the blot used for immunological detection of the M r 30,000-33,000 components, a large number of variants, differing in isoelectric point and relative electrophoretic mobility can be discerned. In Chapter 3 experiments are described which were performed to determine (i) the nature of the differences between the variants and (ii) possible changes in the observed pattern on 2D-gels during subsequent stages of meiotic prophase. We conclude that differences in the number of attached phosphate groups are largely responsible for the existence of different variants of the M r 30,000 as well as the M r 33,000 component. Moreover, we observed a change in the phosphorylation pattern between early- and midpachytene, probably because of the addition of one phosphate group to all variants. We speculate that the phosphorylation pattern observed as early as zygotene is the result of the action of a kinase which responds to DNA-damage.The presence of the LEs at the bases of the chromatin of the homologous chromosomes prompted us to investigate whether points of contact exist between LEs and the chromatin, and if so, which LE-components and DNA-sequences are involved (Chapter 4). Based on crosslinking experiments in vivo of chromatin from mouse spermatocytes, we assumed that the M r 30,000-33,000 components are bound to DNA or at least associated with DNA. By immunoprecipitation of protein-DNA complexes, obtained after crosslinking in vivo of mouse spermatocytes, with antibodies raised against the M r 30,000-33,000 components as well as against isolated SCs, a region was identified within a 120 kbp gene cluster as a SC - a ssociated r egion (SCAR). This SCAR colocalizes with a so-called 'matrix attachment region' (MAR). We also developed a method by which specific binding of DNA-fragments to the SC can be tested in vitro . By means of this method we show that MARs from different organisms bind specifically to rat SCs. We conclude that the organisation of the chromatin during meiotic prophase shows a certain similarity to those during mitosis and interphase.After it was determined that the M r 30,000-33,000 components are probably bound to DNA in vivo , we have further analysed the possible DNA-binding of these proteins as well as SCP3 in vitro (Chapter 5). Because of the insolubility of SCP3 in aqueous solutions, these studies were carried out by means of the Southwestern blotting technique. We conclude that SCP3 binds to DNA in vitro and shows a preference for single-stranded DNA. From a comparison of different single-stranded DNA substrates we conclude that SCP3 probably favours binding to single-stranded DNA which adopts a spatial conformation caused by intra- or intermolecular interactions. In similar experiments the M r 30,000-33,000 components also exhibit a preference for single-stranded DNA, although the variants which caary the most phosphate residues show no detectable DNA-binding at all. Based on the assumption that in the situation in vivo the M r 30,000-33,000 components would exhibit a similar type of DNA-binding as in vitro , we speculate on the (temporal) existence of single-stranded DNA during meiotic prophase.Finally, I present a summary on what is known about the M r 30,000-33,000 components at the beginning of the general discussion (Chapter 6). Then I discuss a model which describes the chromatin organization during meiotic prophase, in which I particularly point at the modifications which, starting from a general organization pattern, are necessary for the proper progress of the processes of pairing, recombination and segregation of homologous chromosomes. Within this model I discuss the possible involvement of components of the SC. After that I focuss on the function of the M r 30,000-33,000 components in this model. I propose that the M r 30,000-33,000 components play a role in the structural organization of the chromosomes, in such a manner that recombination between sister chromatids is inhibited temporarily and cohesion between sister chromatids is maintained as long as this is needed.</p
A 248 Mariakirken i Bergen, malerier og epitafier : Epitafium over familien Lammers (inventar nr. 5) : undersøkelser og behandling
No full textOppdragsgiver: Bergen kirkelige fellesrådI 2009 ble det iverksatt en omfattende restaurering av Mariakirkens bygg. Som en følge av bygningsarbeidet ble det, i samråd med Riksantikvaren (RA), anbefalt at kirkens inventar ble demontert og oppbevart utenfor kirken i byggeperioden. Kirken ble åpnet etter restaureringen juni 2015. Inventar nr. 5, Epitafium over familien Lammers, ble demontert, tilstandsvurdert og fotografert i kirken våren 2010 av malerikonservatorer fra Universitetet i Stavanger, Arkeologisk museum (AM). Arbeidet besto ved den anledning i fotodokumentasjon før sikring av løs maling, skriftlig tilstandsvurdering med stipulert behandlingsomfang og kostnader, samt fotodokumentasjon av maleriets for- og bakside etter forsidebeskyttelse. Dette arbeidet dannet grunnlag for påkrevd behandling av maleriet. Tilstandsrapport med fotodokumentasjon er å finne som vedlegg til AM oppdragsrapport 2011/20: Mariakirken i Bergen. Inventar. Oppsummeringsrapport.
Denne rapporten omfatter arbeid utført etter at maleriet ble påført forsidebeskyttelse. Dokumentasjon av maleriets tilstand før og etter forsidebeskyttelse er vedlagt oppdragsrapport 2011/20
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
On the duality principle by Casazza, Kutyniok, and Lammers
No full textThe R-dual sequences of a frame {f i } i∈I , introduced by Casazza, Kutyniok and Lammers in (J. Fourier Anal. Appl. 10(4):383–408, 2004), provide a powerful tool in the analysis of duality relations in general frame theory. In this paper we derive conditions for a sequence {ω j } j∈I to be an R-dual of a given frame {f i } i∈I . In particular we show that the R-duals {ω j } j∈I can be characterized in terms of frame properties of an associated sequence {n i } i∈I . We also derive the duality results obtained for tight Gabor frames in (Casazza et al. in J. Fourier Anal. Appl. 10(4):383–408, 2004) as a special case of a general statement for R-duals of frames in Hilbert spaces. Finally we consider a relaxation of the R-dual setup of independent interest. Several examples illustrate the results
Dissertatio Inauguralis De Poenitentia Horatii Philosophica Ab Insolito Tonitru Provocata Carminum Libro I. Ode XXXIV.
No full textFaget tysk og den kulturpolitiske udfordring fra nazismen i Tyskland
No full textAnalyse af hvorledes faget tysk stillede sig til udfordringen fra nazisme
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